saccharin has been researched along with Sinusitis in 19 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Sinusitis: Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of erythromycin (EM) on mucociliary transport function assessed by saccharin test and clinical symptoms were studied in 19 patients with sinobronchial syndrome (SBS)." | 7.68 | [Effect of erythromycin on mucociliary transport and clinical symptoms in patients with sinobronchial syndrome]. ( Fujimura, M; Matsuda, T; Myou, S; Nishi, K; Ooka, T, 1993) |
| "The use of the drug Sinupret extract not only contributes to a more rapid improvement in the general well-being of patients and a decrease in the severity of complaints, but also leads to an improvement in the objective picture of the disease (rhinoscopy, the results of anterior active rhinomanometry, saccharin test) compared with the control group, favorably affects the quality life of patients, causes a decrease in economic and social costs against the background of the development of acute viral rhinosinusitis." | 4.31 | [Possibilities of usage of modern herbal medicinal product in the treatment of patients with acute viral rhinosinusitis]. ( Nikiforova, AN; Nikiforova, GN; Shevchik, EA; Svistushkin, VM; Toldanov, AV; Zolotova, AV, 2023) |
| "We investigated the therapeutic effects of trehalose and saccharin on macrophage IL-1β production and eosinophilia in the mouse model of ECRS with myeloid cell-specific autophagy-related gene 7 (Atg7) deletion." | 4.12 | Sweet taste receptor agonists attenuate macrophage IL-1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells. ( Choi, GE; Choi, WS; Jang, YJ; Kim, HS; Kim, SJ; Lee, J; Park, HJ; Yi, E, 2022) |
| "To determine the correlation between rhinosinusitis symptoms as assessed by the Sino-Nasal Outcomes Test-20 (SNOT-20) and mucociliary clearance as assessed by the saccharin method." | 3.73 | Relationship between rhinosinusitis symptoms and mucociliary clearance time. ( Boatsman, JE; Calhoun, KH; Ryan, MW, 2006) |
| "The saccharin test was used to measure mucociliary clearance in 50 patients with symptoms of chronic sinusitis." | 3.70 | The effect of endoscopic sinus surgery on mucociliary clearance in patients with chronic sinusitis. ( Elwany, S; Gamaee, R; Hisham, M, 1998) |
| "The incidence of sinusitis and septal deviation, nasal airway resistance, nasal mucociliary function by saccharin test, and ciliary beating frequency were examined." | 3.69 | Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency. ( Amitani, R; Ishikawa, Y, 1994) |
| " Saccharine tests performed prior to and after the catheterization in patients with acute and chronic sinusitis confirmed inhibition of transport function of nasal ciliated epithelium (TF) in these affections." | 3.69 | [Impact of controlled pressure on ciliary transport in the nasal epithelium]. ( Derzhavina, LL; Kozlov, VS, 1997) |
| " To evaluate the value of the saccharin test and a photoelectrical in-vitro method for measurement of ciliary beat frequency for clinical routine diagnosis, we studied twenty patients suffering from acute sinusitis (aged 19-64) and twenty healthy non-smokers (aged 19-50)." | 3.68 | [Nasal mucociliary transport time and ciliary beat frequency in healthy probands and patients with sinusitis]. ( Karnitzki, G; Mlynski, B; Mlynski, G, 1993) |
| "The effect of erythromycin (EM) on mucociliary transport function assessed by saccharin test and clinical symptoms were studied in 19 patients with sinobronchial syndrome (SBS)." | 3.68 | [Effect of erythromycin on mucociliary transport and clinical symptoms in patients with sinobronchial syndrome]. ( Fujimura, M; Matsuda, T; Myou, S; Nishi, K; Ooka, T, 1993) |
| "Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)." | 3.67 | Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985) |
| "Guaifenesin therapy was associated with improved SNOT-16 scores, although there was not a detectable improvement in MCT." | 2.71 | Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy. ( Calhoun, KH; Rosen, EJ, 2005) |
| "Rhinosinusitis is a common post-RT side-effect in NPC patients." | 1.32 | Nasal and paranasal sinus changes after radiotherapy for nasopharyngeal carcinoma. ( Al-Badawy, S; Kamel, R; Kandil, T; Khairy, A; Sabry, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Chitsuthipakorn, W | 1 |
| Kanjanawasee, D | 1 |
| Hoang, MP | 1 |
| Seresirikachorn, K | 1 |
| Snidvongs, K | 1 |
| Lee, J | 1 |
| Kim, SJ | 1 |
| Choi, GE | 1 |
| Yi, E | 1 |
| Park, HJ | 1 |
| Choi, WS | 1 |
| Jang, YJ | 2 |
| Kim, HS | 1 |
| Svistushkin, VM | 1 |
| Nikiforova, GN | 1 |
| Toldanov, AV | 1 |
| Zolotova, AV | 1 |
| Shevchik, EA | 1 |
| Nikiforova, AN | 1 |
| Kamel, R | 1 |
| Al-Badawy, S | 1 |
| Khairy, A | 1 |
| Kandil, T | 1 |
| Sabry, A | 1 |
| Rosen, EJ | 1 |
| Calhoun, KH | 2 |
| Boatsman, JE | 1 |
| Ryan, MW | 1 |
| Ishikawa, Y | 2 |
| Amitani, R | 2 |
| Karnitzki, G | 1 |
| Mlynski, G | 1 |
| Mlynski, B | 1 |
| Nishi, K | 1 |
| Myou, S | 1 |
| Ooka, T | 1 |
| Fujimura, M | 1 |
| Matsuda, T | 1 |
| Mahakit, P | 1 |
| Pumhirun, P | 1 |
| Lindberg, S | 1 |
| Cervin, A | 1 |
| Runer, T | 1 |
| Kozlov, VS | 1 |
| Derzhavina, LL | 1 |
| Fang, SY | 1 |
| Jin, YT | 1 |
| Elwany, S | 1 |
| Hisham, M | 1 |
| Gamaee, R | 1 |
| Myong, NH | 1 |
| Park, KH | 1 |
| Koo, TW | 1 |
| Kim, HG | 1 |
| Kawano, M | 1 |
| Honjo, I | 1 |
| Golhar, S | 1 |
| Stanley, PJ | 1 |
| Wilson, R | 1 |
| Greenstone, MA | 1 |
| Mackay, IS | 1 |
| Cole, PJ | 1 |
| Jakubíková, J | 1 |
| Kapellerová, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison[NCT00626366] | 18 participants (Actual) | Interventional | 2008-03-12 | Completed | |||
| Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?[NCT01239199] | 86 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CT scan scored for distribution contrast delivered by nasal spray or drops within subsets in the nasal cavity. The sinonasal cavity was divided into twenty-one subsites on each side of the nasal cavity. The interpreters scored for the presence (1) or absence (0) of contrast from the nasal spray or nasal drops within each subsite. Left and right sides were interpreted separately for a possible total score of 0-42 for each CT scan. (NCT00626366)
Timeframe: 2 months
| Intervention | nasal cavities (right and left sides) (Number) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nasal vestibule | Inferior upper nasal vault | Superior upper nasal vault | Anterior floor of nose | Anterior inferior meatus | Anterior inferior nasal cavity | Posterior floor of nose | Posterior inferior meatus | Posterior inferior nasal cavity | Anterior middle nasal cavity | Anterior olfactory cleft | Posterior middle nasal cavity | Posterior olfactory cleft | Anterior middle meatus | Anterior ethmoid | Osteomeatal complex | Posterior middle meatus | Posterior ethmoid | Frontal recess | Sphenoethmoid recess | Nasopharynx | |
| Nasal Drops | 17 | 17 | 6 | 4 | 0 | 6 | 0 | 1 | 1 | 5 | 4 | 4 | 4 | 2 | 1 | 1 | 1 | 2 | 2 | 4 | 2 |
| Nasal Spray | 18 | 16 | 0 | 12 | 16 | 15 | 9 | 9 | 3 | 3 | 1 | 2 | 1 | 4 | 2 | 2 | 2 | 1 | 0 | 2 | 8 |
1 review available for saccharin and Sinusitis
| Article | Year |
|---|---|
Benefits of nasal saline treatment in acute rhinosinusitis: Systematic review and meta-analysis.
Topics: Acute Disease; Adult; Chronic Disease; Humans; Quality of Life; Rhinitis; Saccharin; Saline Solution | 2022 |
2 trials available for saccharin and Sinusitis
| Article | Year |
|---|---|
Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy.
Topics: Adult; Double-Blind Method; Expectorants; Female; Guaifenesin; HIV Infections; Humans; Male; Middle | 2005 |
Application of endoscopic sinus surgery to primary atrophic rhinitis? A clinical trial.
Topics: Adolescent; Adult; Bacterial Infections; Endoscopy; Female; Follow-Up Studies; Humans; Klebsiella In | 1998 |
16 other studies available for saccharin and Sinusitis
| Article | Year |
|---|---|
Sweet taste receptor agonists attenuate macrophage IL-1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Eosinophilia; Inflammation; Macrophages; Mice; Sacchar | 2022 |
[Possibilities of usage of modern herbal medicinal product in the treatment of patients with acute viral rhinosinusitis].
Topics: Acute Disease; Humans; Phytotherapy; Plant Extracts; Rhinitis; Saccharin; Sinusitis; Treatment Outco | 2023 |
Nasal and paranasal sinus changes after radiotherapy for nasopharyngeal carcinoma.
Topics: Adolescent; Adult; Aged; Carcinoma; Child; Edema; Endoscopy; Female; Humans; Male; Middle Aged; Muco | 2004 |
Relationship between rhinosinusitis symptoms and mucociliary clearance time.
Topics: Adult; Cross-Sectional Studies; Humans; Mucociliary Clearance; Quality of Life; Rhinitis; Saccharin; | 2006 |
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency.
Topics: Adolescent; Adult; Airway Resistance; Child; Child, Preschool; Cleft Palate; Female; Humans; Inciden | 1994 |
[Nasal mucociliary transport time and ciliary beat frequency in healthy probands and patients with sinusitis].
Topics: Acute Disease; Adult; Female; Fourier Analysis; Humans; Image Processing, Computer-Assisted; Male; M | 1993 |
[Effect of erythromycin on mucociliary transport and clinical symptoms in patients with sinobronchial syndrome].
Topics: Adult; Aged; Aged, 80 and over; Bronchitis; Erythromycin; Female; Humans; Male; Middle Aged; Mucocil | 1993 |
A preliminary study of nasal mucociliary clearance in smokers, sinusitis and allergic rhinitis patients.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Mucociliary Clearance; Nasal Mucosa; Rhi | 1995 |
Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways.
Topics: Chronic Disease; Humans; Mucociliary Clearance; Nasal Mucosa; Nitric Oxide; Respiratory Tract Infect | 1997 |
[Impact of controlled pressure on ciliary transport in the nasal epithelium].
Topics: Adolescent; Adult; Chronic Disease; Epithelium; Female; Humans; Male; Middle Aged; Mucociliary Clear | 1997 |
The effect of endoscopic sinus surgery on mucociliary clearance in patients with chronic sinusitis.
Topics: Adolescent; Adult; Biopsy, Needle; Endoscopy; Female; Humans; Male; Mucociliary Clearance; Nasal Muc | 1998 |
Mucociliary transport and histologic characteristics of the mucosa of deviated nasal septum.
Topics: Adult; Analysis of Variance; Case-Control Studies; Female; Humans; Male; Microscopy, Electron, Scann | 2002 |
The cause of nasal sinusitis in patients with cleft palate.
Topics: Cleft Palate; Female; Humans; Male; Maxillary Sinus; Mucociliary Clearance; Nasal Mucosa; Nasal Sept | 1989 |
Nasal mucus clearance.
Topics: Adolescent; Adult; Bronchiectasis; Female; Humans; Kartagener Syndrome; Male; Mucus; Nasal Mucosa; N | 1986 |
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh | 1985 |
[Changes in mucociliary transport in sinusitis in children].
Topics: Adolescent; Child; Child, Preschool; Cilia; Humans; Mucus; Respiratory System; Saccharin; Sinusitis | 1985 |