saccharin and Pregnancy studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
" We present simple methods for combining dose information from the study of interest with dose-response data from other epidemiologic studies or animal studies to derive plausible hypothesized effect levels."	2.39	Resolving discrepancies among studies: the influence of dose on effect size. ( Hertz-Picciotto, I; Neutra, RR, 1994)
"The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life."	1.91	Transplacental Transport of Artificial Sweeteners. ( Duvald, CS; Greibe, E; Hoffmann-Lücke, E; Leth-Møller, M; Ovesen, PG; Pedersen, M; Stampe, S, 2023)
"The neurobiological basis of memory deficits after prenatal alcohol exposure (PAE) is often linked to structural and functional alterations in the medial temporal lobe, including the hippocampus."	1.51	Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task. ( Clark, BJ; Davies, S; Goss, J; Hamilton, DA; Sanchez, LM; Savage, DD; Wagner, J, 2019)
"Vinclozolin is a fungicide used on food crops with human exposure estimated at approximately 2 microg/kg/day from ingestion; occupational exposure, however, may be greater."	1.31	Behavioral responses of rats exposed to long-term dietary vinclozolin. ( Delclos, KB; Ferguson, SA; Flynn, KM; Newbold, RR, 2001)
"Saccharin preference was then examined in separate groups of adult males that received either a 0."	1.29	Gender and intrauterine position influence saccharin preference in mice. ( Bushong, ME; Mann, MA, 1994)
"Body weights were significantly depressed in NaS-treated litters by 4 days after birth, and were 35% lower than controls by 30 days when the animals were killed."	1.28	Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth. ( Cohen, SM; Ellwein, LB; Garland, EM; Khachab, M; Kraft, PL; Patil, K; Shapiro, R, 1991)
"The major microphthalmia are frequent."	1.27	[Ocular lesions induced by saccharin and its pollutants in the rat fetus]. ( Colson, A; Lederer, J; Michiels, J, 1984)
"The saccharin litters were mainly characterized by a slowering in the body growth evolution."	1.26	Saccharin- or quinine-induced changes in the rat pups following prolonged ingestion by the dam. ( Lapointe, G; Nosal, G, 1979)
" Since conversion to cyclohexylamine (CHA) was found to occur in many of the rats, particularly in the higher dosage groups, it was included as an added insult in the diets of about half the animals during the last quarter of the 2-year test period."	1.25	Chronic toxicity study of cyclamate: saccharin (10: 1) in rats. ( Carson, S; Cox, GE; Oser, BL; Sternberg, SS; Vogin, EE, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (61.73)	18.7374
1990's	11 (13.58)	18.2507
2000's	9 (11.11)	29.6817
2010's	6 (7.41)	24.3611
2020's	5 (6.17)	2.80

Article	Year
Inactive pharmaceutical ingredients : implications for pregnancy. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2007,Winter, Volume: 14, Issue:1 Topics: Abnormalities, Drug-Induced; Adjuvants, Pharmaceutic; Canada; Drug Compounding; Drug Labeling; Drug-	2007
Toxicology of saccharin. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:5 Topics: Animals; Biological Assay; Drug Contamination; Female; Fetus; Humans; Legislation, Drug; Male; Pregn	1984
Resolving discrepancies among studies: the influence of dose on effect size. Epidemiology (Cambridge, Mass.), 1994, Volume: 5, Issue:2 Topics: Aspirin; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Ethylene Oxide; Female;	1994
The mutagenicity of saccharin. Mutation research, 1975, Volume: 32, Issue:1 Topics: Animals; Calcium; Cell Count; Cells, Cultured; Chromosome Aberrations; Cytogenetics; Drosophila; Fem	1975
Cyclamates: a review of the current position. Current medical research and opinion, 1975, Volume: 3, Issue:4 Topics: Animals; Carcinogens; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Diabetes Mellitus, Type 1;	1975
Cyclamate still to the fore. Food and cosmetics toxicology, 1972, Volume: 10, Issue:2 Topics: Amines; Animals; Blood Pressure; Carbon Isotopes; Chromosome Aberrations; Cricetinae; Cyclamates; Cy	1972
The cyclamate story unfolds. Food and cosmetics toxicology, 1970, Volume: 8, Issue:5 Topics: Animals; Behavior, Animal; Body Weight; Cyclamates; Embryo, Mammalian; Enzyme Induction; Female; Gro	1970

Article	Year
Artificial Sweeteners in Breast Milk: A Clinical Investigation with a Kinetic Perspective. Nutrients, 2022, Jun-25, Volume: 14, Issue:13 Topics: Cyclamates; Female; Humans; Lactation; Milk, Human; Obesity; Potassium; Pregnancy; Saccharin; Sweete	2022
Maternal exposure of rats to sodium saccharin during gestation and lactation on male offspring†. Biology of reproduction, 2023, 01-14, Volume: 108, Issue:1 Topics: Animals; Estradiol; Female; Humans; Lactation; Male; Maternal Exposure; Pregnancy; Prenatal Exposure	2023
Development and Relative Validation of a Food Frequency Questionnaire to Assess Non-Nutritive Sweeteners Intake among Pregnant Women in Santiago, Chile: A Pilot Study. Nutrients, 2023, May-29, Volume: 15, Issue:11 Topics: Adult; Aspartame; Chile; Female; Glucosides; Humans; Non-Nutritive Sweeteners; Pilot Projects; Pregn	2023
Transplacental Transport of Artificial Sweeteners. Nutrients, 2023, Apr-25, Volume: 15, Issue:9 Topics: Amniotic Fluid; Cesarean Section; Child; Cyclamates; Female; Humans; Obesity; Pregnancy; Saccharin;	2023
Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task. Behavioural brain research, 2019, 03-15, Volume: 360 Topics: Analysis of Variance; Animals; Discrimination, Psychological; Disease Models, Animal; Ethanol; Femal	2019
Prenatal ethanol exposure attenuates sensitivity to the aversive effects of ethanol in adolescence and increases adult preference for a 5% ethanol solution in males, but not females. Alcohol (Fayetteville, N.Y.), 2019, Volume: 79 Topics: Age Factors; Alcohol Drinking; Animals; Avoidance Learning; Central Nervous System Depressants; Cond	2019
Consumption of non-caloric sweeteners among pregnant Chileans: a cross-sectional study. Nutricion hospitalaria, 2019, Aug-26, Volume: 36, Issue:4 Topics: Adult; Aspartame; Chile; Cross-Sectional Studies; Cyclamates; Diterpenes, Kaurane; Female; Glucoside	2019
Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats. Toxicology, 2013, Sep-06, Volume: 311, Issue:1-2 Topics: Animals; Animals, Newborn; Dioxins; Endocrine Disruptors; Female; Male; Polychlorinated Biphenyls; P	2013
Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development. Behavioural brain research, 2010, Dec-06, Volume: 214, Issue:1 Topics: Animals; Cerebral Cortex; Cytoskeletal Proteins; Ethanol; Female; Gene Expression Regulation, Develo	2010
The role of social isolation in ethanol effects on the preweanling rat. Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1 Topics: Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Depressants; Corticosterone;	2012
The number of male pups within a litter of NMRI mice is associated with the dam's food preferences late in pregnancy. Psychoneuroendocrinology, 2003, Volume: 28, Issue:3 Topics: Animals; Appetite; Eating; Female; Food Preferences; Gestational Age; Litter Size; Male; Maternal Be	2003
Effects of a saccharin and cyclamate mixture on rat embryos. Veterinary and human toxicology, 2003, Volume: 45, Issue:3 Topics: Administration, Oral; Animals; Blastocyst; Cell Division; Cyclamates; Drug Synergism; Embryo, Mammal	2003
Repeated exposures to gustatory stimuli produce habituation or positive contrast effects in perinatal rats. Developmental psychobiology, 2004, Volume: 44, Issue:3 Topics: Animals; Animals, Newborn; Behavior, Animal; Cues; Embryo, Mammalian; Female; Habituation, Psychophy	2004
In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation. Toxicology and applied pharmacology, 2005, May-15, Volume: 205, Issue:1 Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Animals, Suckling; Aromatase; Brain; Brain C	2005
Nicotine self-administration, extinction responding and reinstatement in adolescent and adult male rats: evidence against a biological vulnerability to nicotine addiction during adolescence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:4 Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Conditioning, Operan	2008
Taste aversion learning in preweanling rats exposed to alcohol prenatally. Teratology, 1984, Volume: 29, Issue:3 Topics: Animals; Animals, Newborn; Avoidance Learning; Chlorides; Conditioning, Psychological; Ethanol; Fema	1984
[Ocular lesions induced by saccharin and its pollutants in the rat fetus]. Journal francais d'ophtalmologie, 1984, Volume: 7, Issue:5 Topics: Animals; Benzoates; Cataract; Coloboma; Drug Contamination; Eye; Eye Abnormalities; Female; Micropht	1984
Saccharin preferences in food deprived aging rats are altered as a function of perinatal drug exposure. Physiology & behavior, 1983, Volume: 30, Issue:6 Topics: Aging; Analysis of Variance; Animals; Body Weight; Drinking; Female; Fetus; Food Deprivation; Food P	1983
Studies of saccharin and cyclohexylamine in a coupled microsomal activating/embryo culture system. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1983, Volume: 21, Issue:5 Topics: Animals; Biotransformation; Culture Techniques; Cyclohexylamines; DNA; Embryo, Mammalian; Female; Ma	1983
Prenatal alcohol exposure alters adult expression of sexually dimorphic behavior in the rat. Science (New York, N.Y.), 1984, May-25, Volume: 224, Issue:4651 Topics: Age Factors; Animals; Discrimination Learning; Ethanol; Female; Food Preferences; Gestational Age; M	1984
Tissue levels of saccharin in the rat during two-generation feeding studies. Toxicology and applied pharmacology, 1982, Mar-15, Volume: 62, Issue:3 Topics: Aging; Animals; Animals, Newborn; Female; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; R	1982
Intra-uterine exposure to saccharin and risk of bladder cancer in man. International journal of cancer, 1982, May-15, Volume: 29, Issue:5 Topics: Adult; Denmark; Female; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Risk; Saccharin;	1982
[Intrauterine exposure to saccharine and risk of cancer of the bladder in man]. Ugeskrift for laeger, 1982, May-17, Volume: 144, Issue:20 Topics: Adult; Age Factors; Denmark; Female; Humans; Male; Maternal-Fetal Exchange; Pregnancy; Saccharin; St	1982
Absence of carcinogenic response to cyclamate and saccharin in Sprague-Dawley rats after transplacental application. Arzneimittel-Forschung, 1980, Volume: 30, Issue:11 Topics: Animals; Carcinogens; Cyclamates; Female; Maternal-Fetal Exchange; Pregnancy; Rats; Saccharin	1980
Saccharin and society. The American journal of medicine, 1981, Volume: 71, Issue:1 Topics: Aged; Carcinogens; Child; Female; Humans; Legislation, Food; Male; Pregnancy; Risk; Saccharin; Unite	1981
The apparent inhibition of urothelial DNA synthesis in neonatal rats by dietary saccharin. Cancer letters, 1981, Volume: 13, Issue:3 Topics: Animals; Animals, Newborn; Autoradiography; Cell Division; Diet; DNA; Female; Fetus; Male; Maternal-	1981
Saccharin--bitter aftertaste? The New England journal of medicine, 1980, Mar-06, Volume: 302, Issue:10 Topics: Adult; Age Factors; Animals; Carcinogens; Child; Female; Fetus; Humans; Male; Middle Aged; Pregnancy	1980
Chronic toxicity and carcinogenicity to the urinary bladder of sodium saccharin in the in utero-exposed rat. Toxicology and applied pharmacology, 1980, Jun-15, Volume: 54, Issue:1 Topics: Animals; Body Weight; Carcinogens; Eating; Female; Maternal-Fetal Exchange; Organ Size; Pregnancy; R	1980
Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress. Pharmacology, biochemistry, and behavior, 1995, Volume: 50, Issue:3 Topics: Animals; Choice Behavior; Female; Infusion Pumps, Implantable; Male; Maze Learning; Naltrexone; Narc	1995
Effects of neonatal ethanol exposure on saccharin consumption. Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:1 Topics: Animals; Brain; Female; Fetal Alcohol Spectrum Disorders; Food Preferences; Gestational Age; Male; P	1995
Gender and intrauterine position influence saccharin preference in mice. Hormones and behavior, 1994, Volume: 28, Issue:3 Topics: Animals; Appetite; Dose-Response Relationship, Drug; Female; Food Preferences; Gonadal Steroid Hormo	1994
Effects of dietary iron and folate supplementation on the physiological changes produced in weanling rats by sodium saccharin exposure. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1993, Volume: 31, Issue:10 Topics: Animals; Animals, Newborn; Blood Chemical Analysis; Diet; Female; Folic Acid; Iron; Iron Deficiencie	1993
Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. Journal of the American Dietetic Association, 1993, Volume: 93, Issue:7 Topics: Adult; Animals; Aspartame; Child; Cyclamates; Dietetics; Dipeptides; Female; Fructose; Humans; Pregn	1993
Prenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats. Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:4 Topics: Analgesics, Opioid; Animals; Delayed-Action Preparations; Female; Food Preferences; Male; Morphine;	1996
Reproductive toxicology. Sodium saccharin. Environmental health perspectives, 1997, Volume: 105 Suppl 1 Topics: Animals; Birth Weight; Dose-Response Relationship, Drug; Drinking; Female; Litter Size; Male; Mice;	1997
Ketamine blocks a taste recognition memory in fetal rats. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3 Topics: Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Female; Fetus; Ketamine; Male; Pregnan	2000
Paradoxical effects of ketamine on the memory of fetuses of different ages. Brain research. Developmental brain research, 2001, Mar-29, Volume: 127, Issue:1 Topics: Age Factors; Animals; Animals, Newborn; Antimanic Agents; Avoidance Learning; Brain; Critical Period	2001
Behavioral responses of rats exposed to long-term dietary vinclozolin. Journal of agricultural and food chemistry, 2001, Volume: 49, Issue:3 Topics: Administration, Oral; Animal Feed; Animals; Behavior, Animal; Body Weight; Drinking Behavior; Female	2001
Private industry. Bulletin of the New York Academy of Medicine, 1978, Volume: 54, Issue:4 Topics: Animals; Drug and Narcotic Control; Female; Food Additives; Humans; Industry; Infant, Newborn; Male;	1978
Saccharin- or quinine-induced changes in the rat pups following prolonged ingestion by the dam. Biology of the neonate, 1979, Volume: 36, Issue:5-6 Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Birth Weight; Female; Male; Maternal-Fetal E	1979
Blood alcohol level and caloric intake in the gravid rat as a function of diurnal period, trimester, and vehicle. Pharmacology, biochemistry, and behavior, 1978, Volume: 8, Issue:4 Topics: Alcoholism; Animals; Body Weight; Circadian Rhythm; Diet; Energy Intake; Ethanol; Female; Fetus; Hum	1978
Food additives (natural and synthetic). Cancer, 1979, Volume: 43, Issue:5 Suppl Topics: Animals; Basidiomycota; Carcinogens; Cooking; Drug Evaluation, Preclinical; Female; Food Additives;	1979
Histological examination of perinatal eye development in the rat after ingestion of sodium cyclamate and sodium saccharin during pregnancy. Food and cosmetics toxicology, 1978, Volume: 16, Issue:1 Topics: Animals; Cyclamates; Eye; Female; Maternal-Fetal Exchange; Pregnancy; Rats; Saccharin; Sodium	1978
Spontaneous abortion and the use of sugar substitutes (saccharin). American journal of obstetrics and gynecology, 1978, Mar-15, Volume: 130, Issue:6 Topics: Abortion, Spontaneous; Adolescent; Adult; Body Weight; Female; Humans; Mutagens; Pregnancy; Risk; Sa	1978
The fate of [14C]saccharin in man, rat and rabbit and of 2-sulphamoyl[14C]benzoic acid in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1977, Volume: 7, Issue:4 Topics: Administration, Oral; Animals; Benzoates; Drug Administration Schedule; Feces; Female; Humans; Injec	1977
Synthetic sweetners: cyclamates, saccharin, aspartame. The Medical letter on drugs and therapeutics, 1975, Jul-18, Volume: 17, Issue:15 Topics: Animals; Aspartame; Aspartic Acid; Beverages; Cyclamates; Cyclohexylamines; Diet, Reducing; Dipeptid	1975
Chronic toxicity study of cyclamate: saccharin (10: 1) in rats. Toxicology, 1975, Volume: 4, Issue:3 Topics: Animals; Behavior, Animal; Body Weight; Cyclamates; Cyclohexylamines; Diet; Drug Combinations; Femal	1975
Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages. Mutation research, 1975, Volume: 29, Issue:2 Topics: Animals; Corpus Luteum; Cyclamates; Cyclophosphamide; Embryo Implantation; Estrus; Female; Fetal Dea	1975
Conditioned stress responses by pregnant and/or lactating mice reduce immune responses of their offspring after weaning. Brain, behavior, and immunity, 1992, Volume: 6, Issue:1 Topics: Animals; Conditioning, Classical; Female; Immunity, Maternally-Acquired; Immunologic Deficiency Synd	1992
Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1991, Volume: 29, Issue:10 Topics: Animals; Body Weight; Female; Liver; Male; Nutritional Status; Pregnancy; Prenatal Exposure Delayed	1991
Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1991, Volume: 29, Issue:10 Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Folic Acid; Liver; Male; Nutritional	1991
The present lack of evidence for unique rodent germ-cell mutagens. Mutation research, 1989, Volume: 212, Issue:1 Topics: Animals; Cadmium; Cadmium Chloride; Cyclohexylamines; Diethylhexyl Phthalate; Ethanol; Female; Germ	1989
Taste responses in the parabrachial pons of male, female and pregnant rats. Brain research bulletin, 1989, Volume: 23, Issue:3 Topics: Action Potentials; Animals; Female; Food Preferences; Male; Mathematics; Pons; Pregnancy; Pregnancy,	1989
Saccharin and aspartame: are they safe to consume during pregnancy? The Journal of reproductive medicine, 1988, Volume: 33, Issue:8 Topics: Adult; Animals; Aspartame; Dipeptides; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy	1988
Saccharin and aspartame. Are they safe to consume during pregnancy? The Journal of reproductive medicine, 1988, Volume: 33, Issue:1 Topics: Aspartame; Aspartic Acid; Dipeptides; Female; Humans; Methanol; Phenylalanine; Pregnancy; Saccharin	1988
Effects of prenatal testosterone propionate treatment on saccharin preference of adult rats exposed to ethanol in utero. Physiology & behavior, 1987, Volume: 39, Issue:2 Topics: Animals; Eating; Ethanol; Female; Food Preferences; Male; Osmolar Concentration; Pregnancy; Prenatal	1987
In utero-exposure to saccharin: a threat? Cancer letters, 1986, Volume: 32, Issue:2 Topics: Adult; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Sacc	1986
Prenatal stress feminizes adult male saccharin preference and maze learning: antagonism by propranolol. Monographs in neural sciences, 1986, Volume: 12 Topics: Animals; Disorders of Sex Development; Female; Food Preferences; Learning; Male; Pregnancy; Pregnanc	1986
Severe early malnutrition and DRL performance in the rat. Physiology & behavior, 1986, Volume: 38, Issue:5 Topics: Animals; Conditioning, Operant; Discrimination Learning; Efficiency; Female; Male; Pregnancy; Pregna	1986
Saccharin. Review of safety issues. Council on Scientific Affairs. JAMA, 1985, Nov-08, Volume: 254, Issue:18 Topics: American Medical Association; Animals; Child; Cricetinae; Female; Haplorhini; Humans; Male; Mice; Pr	1985
Absence of estrogenic activity in some drugs commonly used during pregnancy. Biological research in pregnancy and perinatology, 1986, Volume: 7, Issue:1 Topics: Acetaminophen; Animals; Diethylstilbestrol; Dose-Response Relationship, Drug; Estrogens; Female; In	1986
Effects on mouse embryos of in utero exposure to saccharin: teratogenic and chromosome effects. Archives of toxicology, 1985, Volume: 56, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Embryo, Mammalian; Female; Mice; Mice,	1985
Norepinephrine-facilitated eating: reduction in saccharin preference and conditioned flavor preferences with increase in quinine aversion. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:6 Topics: Animals; Avoidance Learning; Conditioning, Operant; Eating; Female; Food Deprivation; Food Preferenc	1985
Prenatal nicotine affects fetal testosterone and sexual dimorphism of saccharin preference. Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:3 Topics: Animals; Choice Behavior; Female; Fetus; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rat	1985
Mutagenicity studies of saccharin in mice. Bulletin of environmental contamination and toxicology, 1974, Volume: 12, Issue:2 Topics: Animals; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Embryo Implantation;	1974
Nasal clearance in monozygotic twins. The American review of respiratory disease, 1974, Volume: 110, Issue:3 Topics: Adult; Female; Humans; Humidity; Male; Mucus; Nasal Mucosa; Nasopharynx; Nose; Pregnancy; Saccharin;	1974
A comparison of nasal and tracheobronchial clearance. Archives of environmental health, 1974, Volume: 29, Issue:5 Topics: Aerosols; Bronchi; Cilia; Female; Humans; Mucous Membrane; Nasal Mucosa; Particle Size; Polytetraflu	1974
Induction of dominant lethals in mice by sodium saccharin. The Indian journal of medical research, 1972, Volume: 60, Issue:4 Topics: Animals; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Male; Mice; Mice, Inbred CBA; Mutation	1972
The gustatory sense in foetal sheep during the last third of gestation. The Journal of physiology, 1973, Volume: 231, Issue:2 Topics: Acetates; Action Potentials; Ammonium Chloride; Animals; Chorda Tympani Nerve; Female; Fructose; Ges	1973
Placental transmission and fetal distribution of saccharin. American journal of obstetrics and gynecology, 1971, Sep-15, Volume: 111, Issue:2 Topics: Amniotic Fluid; Animals; Brain Chemistry; Carbon Isotopes; Female; Fetus; Haplorhini; Kidney; Liver;	1971
[Chemical sweetening agents--an environmental hazard for the embryo]. Wiener medizinische Wochenschrift (1946), 1972, Jun-17, Volume: 122, Issue:25 Topics: Abnormalities, Drug-Induced; Carbon Isotopes; Chromosome Aberrations; Chromosome Disorders; Cyclamat	1972
Hormonal and developmental influences on rat saccharin preferences. Journal of comparative and physiological psychology, 1969, Volume: 69, Issue:2 Topics: Age Factors; Animals; Behavior, Animal; Drinking Behavior; Estrogens; Estrus; Feeding Behavior; Fema	1969
Hormonal modulation of responsiveness to an aversive taste stimulus in rats. Physiology & behavior, 1970, Volume: 5, Issue:3 Topics: Age Factors; Animals; Behavior, Animal; Castration; Drinking Behavior; Drug Synergism; Estradiol; Fe	1970

saccharin and Pregnancy

Research Excerpts

Research

Studies (81)

Authors

Reviews

Trials

Other Studies

Authors	Studies
Halasa, BC	1
Sylvetsky, AC	1
Conway, EM	1
Shouppe, EL	1
Walter, MF	1
Walter, PJ	1
Cai, H	1
Hui, L	1
Rother, KI	1
Stampe, S	2
Leth-Møller, M	2
Greibe, E	2
Hoffmann-Lücke, E	2
Pedersen, M	2
Ovesen, P	1
Godoi, AR	1
Fioravante, VC	1
Santos, BM	1
Martinez, FE	1
Pinheiro, PFF	1
López-Arana, S	1
Peralta, R	1
Sambra, V	1
Abrigo, K	1
Prado, G	1
Cáceres, P	1
Carvajal, B	1
Gotteland, M	1
Duvald, CS	1
Ovesen, PG	1
Sanchez, LM	1
Goss, J	1
Wagner, J	1
Davies, S	1
Savage, DD	2
Hamilton, DA	2
Clark, BJ	1
Gore-Langton, JK	1
Spear, LP	1
Fuentealba Arévalo, F	1
Espinoza Espinoza, J	1
Salazar Ibacahe, C	1
Durán Agüero, S	1
Lilienthal, H	1
Heikkinen, P	1
Andersson, PL	1
Viluksela, M	1
Candelaria-Cook, FT	1
Akers, KG	1
Rice, JP	1
Maes, LI	1
Rosenberg, M	1
Valenzuela, CF	1
Kozlov, AP	1
Nizhnikov, ME	1
Varlinskaya, EI	1
Spear, NE	1
Moles, A	1
Rizzi, R	1
D'Amato, FR	1
Damasceno, DC	1
Goncalves, MA	1
Durante, LC	1
Castro, NC	1
Moura, CH	1
Oliveira, CB	1
Mickley, GA	3
Kenmuir, CL	2
Dengler-Crish, CM	1
McMullen, C	1
McConnell, A	1
Valentine, E	1
Ikeda, M	1
Mitsui, T	1
Setani, K	1
Tamura, M	1
Kakeyama, M	1
Sone, H	1
Tohyama, C	1
Tomita, T	1
Finkelstein, Y	1
Rezvani, M	1
Garcia-Bournissen, F	1
Nurmohamed, L	1
Koren, G	1
Shram, MJ	1
Funk, D	1
Li, Z	1
Lê, AD	1
Riley, EP	2
Barron, S	2
Driscoll, CD	1
Chen, JS	1
Arnold, DL	1
Colson, A	1
Lederer, J	1
Michiels, J	1
Martin, JC	2
Martin, DC	2
Sigman, G	2
Day-Pfeiffer, H	1
Kitchin, KT	1
Ebron, MT	1
McGivern, RF	3
Clancy, AN	1
Hill, MA	1
Noble, EP	1
Sweatman, TW	1
Renwick, AG	2
Jensen, OM	2
Kamby, C	2
Schmähl, D	1
Habs, M	1
Nightingale, EO	1
Robbins, FC	1
Lawson, T	1
Hertzog, P	1
Hoover, R	1
Taylor, JM	1
Weinberger, MA	1
Friedman, L	1
Keshet, GI	1
Weinstock, M	1
Razani, LJ	1
Gallegos, RA	1
Bushong, ME	1
Mann, MA	1
Hertz-Picciotto, I	1
Neutra, RR	1
Garland, EM	3
Shapiro, R	3
Wehner, JM	1
Johnson, LS	1
Mattson, BJ	2
Khachab, M	2
Asamoto, M	1
Cohen, SM	3
Gagin, R	1
Cohen, E	1
Shavit, Y	1
Remmers-Roeber, DR	2
Crouse, C	2
Peluso, R	1
Dengler, CM	1
Flynn, KM	1
Delclos, KB	1
Newbold, RR	2
Ferguson, SA	1
Eisenstadt, ME	1
Lapointe, G	1
Nosal, G	1
Radow, B	1
Shubik, P	1
Luckhaus, G	1
Machemer, L	2
Kline, J	1
Stein, ZA	1
Susser, M	1
Warburton, D	1
Ball, LM	1
Williams, RT	1
Kramers, PG	1
Cook, CE	1
Oser, BL	1
Carson, S	1
Cox, GE	1
Vogin, EE	1
Sternberg, SS	1
Lorke, D	1
Gorczynski, RM	1
Kraft, PL	2
Patil, K	1
Ellwein, LB	1
Parr, JM	1
Adler, ID	1
Ashby, J	1
Di Lorenzo, PM	1
Monroe, S	1
Nabors, LO	1
London, RS	1
Holcomb, C	1
Poland, RE	2
Cohen-Addad, N	1
Chatterjee, M	1
Bekersky, I	1
Blumenthal, HP	1
Taylor, AN	1
Branch, BJ	1
Raum, WJ	1
Finger, S	1
Almli, CR	1
Green, L	1
Wolf, C	1
Morgane, PJ	1
Isenhower, WD	1
Cefalo, RC	1
Korach, KS	1
McLachlan, JA	1
Dropkin, RH	1
Salo, DF	1
Tucci, SM	1
Kaye, GI	1
Matthews, JW	1
Gibson, EL	1
Booth, DA	1
Lichtensteiger, W	1
Schlumpf, M	1
Srám, RJ	1
Zudová, Z	1
Andersen, I	2
Camner, P	2
Jensen, PL	2
Philipson, K	2
Proctor, DF	2
Rao, MS	1
Qureshi, AB	1
Bradley, RM	1
Mistretta, CM	1
Pitkin, RM	1
Reynolds, WA	1
Filer, LJ	1
Kling, TG	1
Göttinger, E	1
Wade, GN	2
Zucker, I	2