saccharin has been researched along with Precancerous Conditions in 9 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Saccharin is known to have a tumor-promoting effect on bladder cancer in rats, but its mechanism of action is unknown." | 3.66 | Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens. ( Kakizoe, T; Kawachi, T; Komatsu, H; Niijima, T; Sugimura, T, 1981) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pereira, MA | 1 |
| Herren, SL | 1 |
| Britt, AL | 1 |
| Tsuda, H | 1 |
| Fukushima, S | 4 |
| Imaida, K | 1 |
| Kurata, Y | 1 |
| Ito, N | 3 |
| Shirai, T | 2 |
| Nakanishi, K | 1 |
| El-Gerzawi, S | 1 |
| Heatfield, BM | 1 |
| Trump, BF | 1 |
| Hirose, M | 1 |
| Okuda, M | 1 |
| Nakanowatari, J | 1 |
| Hatano, A | 1 |
| Kakizoe, T | 1 |
| Komatsu, H | 1 |
| Niijima, T | 1 |
| Kawachi, T | 1 |
| Sugimura, T | 1 |
| Uwagawa, S | 1 |
| Hasegawa, R | 1 |
| Ogawa, K | 1 |
| Norman, JT | 1 |
| Howlett, AR | 1 |
| Spacey, GD | 1 |
| Hodges, GM | 1 |
| Hicks, RM | 1 |
| Wakefield, JS | 1 |
| Chowaniec, J | 1 |
9 other studies available for saccharin and Precancerous Conditions
| Article | Year |
|---|---|
Effect of dibutylnitrosamine and saccharin on glutamyl transpeptidase-positive foci and liver cancer.
Topics: Animals; Cocarcinogenesis; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
N-Methyl-N-nitrosourea and saccharin: effects on epithelium of normal human urinary bladder in vitro.
Topics: Cocarcinogenesis; Culture Techniques; Epithelium; Humans; Hyperplasia; Methylnitrosourea; Nitrosoure | 1982 |
Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cyclamates; FANFT; Male; Neoplasms, Experimental | 1982 |
Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.
Topics: Animals; Butylhydroxybutylnitrosamine; Cell Aggregation; Cell Membrane; Cocarcinogenesis; Concanaval | 1981 |
Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis.
Topics: Animals; Ascorbic Acid; Drug Synergism; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Sacc | 1990 |
Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
Topics: Animals; Cyclamates; Cyclophosphamide; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscop | 1987 |
Letter: Co-carcinogenic action of saccharin in the chemical induction of bladder cancer.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Hyperplasia; N | 1973 |