saccharin has been researched along with Obesity in 51 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1." | 9.30 | A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019) |
| "This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey." | 7.83 | Aspartame intake is associated with greater glucose intolerance in individuals with obesity. ( Brown, RE; Kuk, JL, 2016) |
| " Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1." | 5.30 | A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019) |
| "Results suggest that long-term intakes of aspartame, saccharin, or diet soda may increase AT deposition and risk of incident obesity independent of diet quality or caloric intake." | 4.31 | Long-term aspartame and saccharin intakes are related to greater volumes of visceral, intermuscular, and subcutaneous adipose tissue: the CARDIA study. ( Carr, JJ; Jacobs, DR; Lees, SJ; Lewis, CE; Shikany, JM; Steffen, BT; Steffen, LM; Terry, JG; Yi, SY; Zhou, X, 2023) |
| "This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey." | 3.83 | Aspartame intake is associated with greater glucose intolerance in individuals with obesity. ( Brown, RE; Kuk, JL, 2016) |
| " Since obesity is linked to altered experience of food reward and to perturbations of nutrient sensing, we investigated flavor-nutrient learning in rats made obese using a high fat/high carbohydrate (HFHC) choice model of diet-induced obesity (ad libitum lard and maltodextrin solution plus standard rodent chow)." | 3.81 | Enhanced flavor-nutrient conditioning in obese rats on a high-fat, high-carbohydrate choice diet. ( Myers, KP; Wald, HS, 2015) |
| " To investigate whether nutritional status affects the preference for palatable solutions and alters sweet taste receptor gene expression in rats, we measured saccharin intake and preference using a two-bottle preference test, and changes in body weight, plasma leptin levels, and gene expression for the sweet taste receptor in taste buds in high-fat diet-induced obese rats and chronically diet-restricted rats." | 3.76 | Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds. ( Chen, K; Li, J; Lv, B; Suo, Y; Wang, Q; Yan, J, 2010) |
| "A single systemic injection of bipiperidyl mustard (BPM) in the adult rat produces brain lesions and associated obesity without hyperphagia." | 3.67 | Altered plasma insulin and glucose after obesity-producing bipiperidyl brain lesions. ( Berthoud, HR; Powley, TL, 1985) |
| "Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes." | 1.91 | Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice. ( Bernier, A; de Lartigue, G; Rourk, K; Singh, A, 2023) |
| "The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life." | 1.91 | Transplacental Transport of Artificial Sweeteners. ( Duvald, CS; Greibe, E; Hoffmann-Lücke, E; Leth-Møller, M; Ovesen, PG; Pedersen, M; Stampe, S, 2023) |
| "The risk of a person getting cancer from ingesting saccharin is compared with the risk of ingesting additional calories which cause excess body weight." | 1.26 | Relative risks of saccharin and calorie ingestion. ( Cohen, BL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (41.18) | 18.7374 |
| 1990's | 5 (9.80) | 18.2507 |
| 2000's | 4 (7.84) | 29.6817 |
| 2010's | 13 (25.49) | 24.3611 |
| 2020's | 8 (15.69) | 2.80 |
| Authors | Studies |
|---|---|
| Stampe, S | 2 |
| Leth-Møller, M | 2 |
| Greibe, E | 2 |
| Hoffmann-Lücke, E | 2 |
| Pedersen, M | 2 |
| Ovesen, P | 1 |
| Iizuka, K | 1 |
| Conz, A | 1 |
| Salmona, M | 1 |
| Diomede, L | 1 |
| Singh, A | 1 |
| Rourk, K | 1 |
| Bernier, A | 1 |
| de Lartigue, G | 1 |
| Duvald, CS | 1 |
| Ovesen, PG | 1 |
| Steffen, BT | 1 |
| Jacobs, DR | 1 |
| Yi, SY | 1 |
| Lees, SJ | 1 |
| Shikany, JM | 1 |
| Terry, JG | 1 |
| Lewis, CE | 1 |
| Carr, JJ | 1 |
| Zhou, X | 1 |
| Steffen, LM | 1 |
| Batten, SR | 1 |
| Hicks, KB | 1 |
| Dwoskin, LP | 1 |
| Beckmann, JS | 1 |
| Thankachan, SN | 1 |
| Ilamaran, M | 1 |
| Ayyadurai, N | 1 |
| Shanmugam, G | 1 |
| Durán Agüero, S | 1 |
| Angarita Dávila, L | 1 |
| Escobar Contreras, MC | 1 |
| Rojas Gómez, D | 1 |
| de Assis Costa, J | 1 |
| Higgins, KA | 1 |
| Mattes, RD | 1 |
| Carlin, J | 1 |
| Hill-Smith, TE | 1 |
| Lucki, I | 1 |
| Reyes, TM | 1 |
| Abbott, A | 1 |
| Khan, SA | 1 |
| Wald, HS | 1 |
| Myers, KP | 1 |
| Lockie, SH | 1 |
| Dinan, T | 1 |
| Lawrence, AJ | 1 |
| Spencer, SJ | 1 |
| Andrews, ZB | 1 |
| Kuk, JL | 1 |
| Brown, RE | 1 |
| Taraschenko, OD | 1 |
| Rubbinaccio, HY | 1 |
| Maisonneuve, IM | 1 |
| Glick, SD | 1 |
| Bursey, RG | 1 |
| Weitlaner, W | 1 |
| Chen, K | 1 |
| Yan, J | 1 |
| Suo, Y | 1 |
| Li, J | 1 |
| Wang, Q | 1 |
| Lv, B | 1 |
| Swithers, SE | 2 |
| Martin, AA | 1 |
| Clark, KM | 1 |
| Laboy, AF | 1 |
| Davidson, TL | 2 |
| le Roux, CW | 1 |
| Bueter, M | 1 |
| Theis, N | 1 |
| Werling, M | 1 |
| Ashrafian, H | 1 |
| Löwenstein, C | 1 |
| Athanasiou, T | 1 |
| Bloom, SR | 1 |
| Spector, AC | 1 |
| Olbers, T | 1 |
| Lutz, TA | 1 |
| Sample, CH | 1 |
| Furudono, Y | 1 |
| Ando, C | 1 |
| Kobashi, M | 1 |
| Yamamoto, C | 1 |
| Yamamoto, T | 1 |
| Gilbertson, TA | 1 |
| Liu, L | 1 |
| Kim, I | 1 |
| Burks, CA | 1 |
| Hansen, DR | 1 |
| Kramer, TH | 1 |
| Sclafani, A | 2 |
| Kindya, K | 1 |
| Pezner, M | 1 |
| Xenakis, S | 1 |
| Louis-Sylvestre, J | 1 |
| Le Magnen, J | 1 |
| van Dusseldorp, M | 1 |
| Parker, DR | 1 |
| Gonzalez, S | 1 |
| Derby, CA | 1 |
| Gans, KM | 1 |
| Lasater, TM | 1 |
| Carleton, RA | 1 |
| Bailey, CJ | 1 |
| Day, C | 1 |
| Knapper, JM | 1 |
| Turner, SL | 1 |
| Flatt, PR | 1 |
| Thiele, TE | 1 |
| van Dijk, G | 1 |
| Yagaloff, KA | 1 |
| Fisher, SL | 1 |
| Schwartz, M | 1 |
| Burn, P | 1 |
| Seeley, RJ | 1 |
| Rosenman, K | 1 |
| Walker, AR | 1 |
| Cohen, BL | 1 |
| Vialettes, B | 1 |
| Mann, GV | 1 |
| Marks, HE | 1 |
| Davison, C | 1 |
| Mathieu, A | 1 |
| Liebermeister, H | 1 |
| Orlik, P | 1 |
| Wagner, MW | 1 |
| Levin, BE | 2 |
| Sullivan, AC | 1 |
| Mann, J | 1 |
| Ionescu, E | 1 |
| Rohner-Jeanrenaud, F | 1 |
| Proietto, J | 1 |
| Rivest, RW | 1 |
| Jeanrenaud, B | 1 |
| Berthoud, HR | 1 |
| Powley, TL | 1 |
| Storlien, LH | 1 |
| Albert, DJ | 1 |
| Hamilton, CL | 1 |
| Levison, MJ | 1 |
| Frommer, GP | 1 |
| Vance, WB | 1 |
| Nisbett, RE | 1 |
| Hanson, LR | 1 |
| Harris, A | 1 |
| Stair, A | 1 |
| Miller, R | 1 |
| White, LW | 1 |
| Schwartz, HJ | 1 |
| Gold, RM | 1 |
| Proulx, DM | 1 |
| Guy-Grand, B | 1 |
| Dorf, G | 1 |
| Duchier, J | 1 |
| Aimez, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determination of Perinatal Exposure to Non-caloric Sweeteners. Implications for the Development of Preferences for Sweet Taste, and Weight Gain During the First Year of Life[NCT03972176] | 315 participants (Anticipated) | Observational [Patient Registry] | 2019-07-31 | Not yet recruiting | |||
| The Effect of Low Calorie Sweetener Consumption on Body Weight, Body Composition, Appetite, and Energy Intake[NCT02928653] | 187 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
| Adherence of Reporting Energy Intake by a Novel Food Photo Recognition Dietary Assessment App on Morbid Obese Subjects Scheduled for Bariatric Surgery[NCT04600596] | 54 participants (Actual) | Observational | 2019-06-01 | Completed | |||
| A Randomised Controlled Trial of a Duodenal Sleeve Bypass Device (EndoBarrier)Compared With Standard Medical Therapy for the Management of Obese Subjects With Type 2 Diabetes[NCT02459561] | 170 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| [NCT00005151] | 0 participants | Observational | 1980-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for saccharin and Obesity
| Article | Year |
|---|---|
Is the Use of Artificial Sweeteners Beneficial for Patients with Diabetes Mellitus? The Advantages and Disadvantages of Artificial Sweeteners.
Topics: Animals; Aspartame; Cohort Studies; Diabetes Mellitus; Humans; Obesity; Saccharin; Sweetening Agents | 2022 |
Effect of Non-Nutritive Sweeteners on the Gut Microbiota.
Topics: Animals; Diet; Gastrointestinal Microbiome; Humans; Non-Nutritive Sweeteners; Obesity; Saccharin | 2023 |
Noncaloric Sweeteners in Children: A Controversial Theme.
Topics: Aspartame; Child; Cyclamates; Energy Intake; Food Additives; Humans; Obesity; Risk Assessment; Sacch | 2018 |
Artificial sweeteners: safe or unsafe?
Topics: Aspartame; Diabetes Mellitus, Type 2; Dipeptides; Humans; Neoplasms; Obesity; Saccharin; Sucrose; Sw | 2015 |
Benefits of saccharin: a review.
Topics: Body Weight; Dental Caries; Diabetes Mellitus; Drug Compounding; Humans; Hyperlipidemias; Obesity; S | 1978 |
Dietary advice for diabetics: a perspective from the United Kingdom.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diet, Sodium-Restricted; Dietary Carbohydra | 1986 |
2 trials available for saccharin and Obesity
| Article | Year |
|---|---|
A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.
Topics: Adult; Aspartame; Beverages; Body Mass Index; Body Weight; Diet; Dietary Sucrose; Diterpenes, Kauran | 2019 |
Gastric bypass reduces fat intake and preference.
Topics: Animals; Dietary Fats; Eating; Energy Intake; Female; Food Preferences; Gastric Bypass; Gastroplasty | 2011 |
Gastric bypass reduces fat intake and preference.
Topics: Animals; Dietary Fats; Eating; Energy Intake; Female; Food Preferences; Gastric Bypass; Gastroplasty | 2011 |
Gastric bypass reduces fat intake and preference.
Topics: Animals; Dietary Fats; Eating; Energy Intake; Female; Food Preferences; Gastric Bypass; Gastroplasty | 2011 |
Gastric bypass reduces fat intake and preference.
Topics: Animals; Dietary Fats; Eating; Energy Intake; Female; Food Preferences; Gastric Bypass; Gastroplasty | 2011 |
43 other studies available for saccharin and Obesity
| Article | Year |
|---|---|
Artificial Sweeteners in Breast Milk: A Clinical Investigation with a Kinetic Perspective.
Topics: Cyclamates; Female; Humans; Lactation; Milk, Human; Obesity; Potassium; Pregnancy; Saccharin; Sweete | 2022 |
Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose Intolerance; High Fructose Corn Syrup; M | 2023 |
Transplacental Transport of Artificial Sweeteners.
Topics: Amniotic Fluid; Cesarean Section; Child; Cyclamates; Female; Humans; Obesity; Pregnancy; Saccharin; | 2023 |
Long-term aspartame and saccharin intakes are related to greater volumes of visceral, intermuscular, and subcutaneous adipose tissue: the CARDIA study.
Topics: Adipose Tissue; Adiposity; Adult; Aspartame; Female; Humans; Male; Obesity; Saccharin; Sweetening Ag | 2023 |
Toward isolating reward changes in diet-induced obesity: A demand analysis.
Topics: Animals; Diet, High-Fat; Male; Models, Economic; Obesity; Rats; Reward; Saccharin; Sucrose; Weight G | 2020 |
Insights into the effect of artificial sweeteners on the structure, stability, and fibrillation of type I collagen.
Topics: Aspartame; Collagen Type I; Diabetes Mellitus; Fibril-Associated Collagens; Humans; Obesity; Sacchar | 2020 |
Reversal of dopamine system dysfunction in response to high-fat diet.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Diet, High-Fat; Dieta | 2013 |
Sugar substitutes linked to obesity.
Topics: Animals; Glucose Intolerance; Healthy Volunteers; Humans; Intestinal Mucosa; Intestines; Mice; Obesi | 2014 |
Enhanced flavor-nutrient conditioning in obese rats on a high-fat, high-carbohydrate choice diet.
Topics: Animal Feed; Animals; Choice Behavior; Conditioning, Psychological; Diet, High-Fat; Dietary Fats; Di | 2015 |
Diet-induced obesity causes ghrelin resistance in reward processing tasks.
Topics: Animals; Cocaine; Conditioning, Operant; Diet, High-Fat; Dopamine; Dopamine Uptake Inhibitors; Ghrel | 2015 |
Aspartame intake is associated with greater glucose intolerance in individuals with obesity.
Topics: Adult; Aged; Aspartame; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Energy Intake; Fema | 2016 |
18-methoxycoronaridine: a potential new treatment for obesity in rats?
Topics: Animal Feed; Animals; Appetite Regulation; Conditioning, Operant; Dopamine; Dose-Response Relationsh | 2008 |
Letter to Fowler et al., 2008. No valid association between artificial sweeteners and weight gain.
Topics: Aspartame; Body Mass Index; Hispanic or Latino; Humans; Obesity; Reproducibility of Results; Risk Fa | 2009 |
["Light" products cause obesity even more. US study: artificial sweeteners create hunger].
Topics: Animals; Appetite; Child; Energy Intake; Humans; Hunger; Obesity; Overweight; Rats; Saccharin; Sweet | 2010 |
Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds.
Topics: Animals; Body Weight; Diet; Dietary Fats; Feeding Behavior; Food Deprivation; Food Preferences; Gene | 2010 |
Body weight gain in rats consuming sweetened liquids. Effects of caffeine and diet composition.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Diet, Fat-Restricted; Dietary Fats; Dietary Su | 2010 |
Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.
Topics: Animals; Body Weight; Diet, High-Fat; Eating; Energy Intake; Female; Male; Obesity; Rats; Rats, Spra | 2013 |
The role of orexigenic neuropeptides in the ingestion of sweet-tasting substances in rats.
Topics: Animals; Feeding Behavior; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Models | 2005 |
Fatty acid responses in taste cells from obesity-prone and -resistant rats.
Topics: Animals; Delayed Rectifier Potassium Channels; Dietary Fats; Eating; Fatty Acids; Food Preferences; | 2005 |
Conditioned taste aversion in lean and obese rats with ventromedial hypothalamic knife cuts.
Topics: Animals; Body Weight; Chlorides; Conditioning, Classical; Extinction, Psychological; Female; Hypotha | 1983 |
Sucrose and polysaccharide induced obesity in the rat.
Topics: Animals; Dietary Carbohydrates; Food Preferences; Humans; Hyperphagia; Male; Obesity; Polysaccharide | 1984 |
Palatability and preabsorptive insulin release.
Topics: Animals; Diet; Food Preferences; Hunger; Insulin; Male; Mouth Mucosa; Obesity; Quinine; Rats; Rats, | 1980 |
[Consumption of sugar substitutes by (obese) children: not hazardous to their health].
Topics: Adolescent; Aspartame; Child; Child, Preschool; Energy Metabolism; Humans; Obesity; Saccharin; Sugar | 1994 |
Dietary factors in relation to weight change among men and women from two southeastern New England communities.
Topics: Adult; Body Mass Index; Body Weight; Cohort Studies; Cross-Sectional Studies; Diet; Dietary Sucrose; | 1997 |
Antihyperglycaemic effect of saccharin in diabetic ob/ob mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Homeostasis; | 1997 |
Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion.
Topics: Administration, Oral; alpha-MSH; Amygdala; Animals; Avoidance Learning; Body Weight; Cerebral Ventri | 1998 |
The relative risks of saccharin and sucrose ingestions.
Topics: Adult; Energy Intake; Female; Humans; Longevity; Obesity; Saccharin; Sucrose | 1979 |
Relative risks of saccharin and calorie ingestion.
Topics: Diet; Energy Intake; Humans; Neoplasms; Obesity; Risk; Saccharin | 1978 |
[Synthetic sweetening agents: current controversy].
Topics: Animals; Carcinogens; Cyclamates; Diabetes Mellitus; Dose-Response Relationship, Drug; France; Human | 1978 |
Saccharin--sweet and dangerous.
Topics: Food Additives; Humans; Obesity; Saccharin; United States; United States Food and Drug Administratio | 1977 |
Hyperinsulinemia: effects on body weight, obesity and motivated behaviors.
Topics: Adipose Tissue; Age Factors; Animals; Body Composition; Body Weight; Electroshock; Female; Hyperinsu | 1976 |
[Differences in taste assessment of sweeteners by normal and overweight persons].
Topics: Adult; Aged; Body Weight; Cyclamates; Diet, Reducing; Female; Humans; Male; Mathematics; Middle Aged | 1976 |
Defective cerebral glucose utilization in diet-induced obese rats.
Topics: Animals; Autoradiography; Brain; Deoxyglucose; Diet; Disease Susceptibility; Glucose; Male; Obesity; | 1991 |
Differences in saccharin-induced cerebral glucose utilization between obesity-prone and -resistant rats.
Topics: Animals; Autonomic Nervous System; Brain; Deoxyglucose; Glucose; Male; Obesity; Rats; Rats, Inbred S | 1989 |
Taste-induced changes in plasma insulin and glucose turnover in lean and genetically obese rats.
Topics: Animals; Autonomic Nervous System; Glucose; Insulin; Insulin Secretion; Liver; Male; Metabolic Clear | 1988 |
Altered plasma insulin and glucose after obesity-producing bipiperidyl brain lesions.
Topics: Administration, Oral; Animals; Blood Glucose; Brain Diseases; Deoxyglucose; Eating; Glucose; Injecti | 1985 |
The effect of VMH lesions, lateral cuts and anterior cuts of food intake, activity level, food motivation, and reactivity to taste.
Topics: Animals; Body Weight; Conditioning, Operant; Diet; Eating; Feeding and Eating Disorders; Feeding Beh | 1972 |
An observation of long-term experimental obesity and diabetes mellitus in the monkey.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diet; Fructose; Glycosuria; Hypothalamus; | 1972 |
Palatability and caloric density as determinants of food intake in hyperphagic and normal rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Diet; Dietary Carbohydrates; Eatin | 1973 |
Taste responsiveness, weight loss, and the ponderostat.
Topics: Animals; Body Weight; Dietary Fats; Disease Models, Animal; Drinking; Eating; Feeding Behavior; Food | 1973 |
A case of episodic urticaria due to saccharin ingestion.
Topics: Allergens; Bronchial Spasm; Diphenhydramine; Drug Hypersensitivity; Female; Hirsutism; Humans; Obesi | 1974 |
Bait-shyness acquisition is impaired by VMH lesions that produce obesity.
Topics: Animal Nutritional Physiological Phenomena; Animals; Apomorphine; Avoidance Learning; Behavior, Anim | 1972 |
[Dietetics and nutrition in 1972].
Topics: Adipose Tissue; Alcoholic Intoxication; Anorexia Nervosa; Caffeine; Calcium; Catecholamines; Coffee; | 1972 |