Page last updated: 2024-11-04

saccharin and Neoplasms

saccharin has been researched along with Neoplasms in 58 studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" We present simple methods for combining dose information from the study of interest with dose-response data from other epidemiologic studies or animal studies to derive plausible hypothesized effect levels."2.39Resolving discrepancies among studies: the influence of dose on effect size. ( Hertz-Picciotto, I; Neutra, RR, 1994)
"For some of the more common cancers in this country, it is thought that individuals can exert a certain amount of control over his or her own cancer risk through diet and lifestyle."1.27Nutrition and diet. ( Newell, GR, 1983)
"If bladder cancer is caused by agents present in the urine, as is widely believed, this mechanism may also protect against carcinogenesis."1.27Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis. ( Anderson, K; Kaufman, JE; Parsons, CL, 1987)
"Dietary components related to cancer include dietary fat, fiber, fruits and vegetables, protein, alcohol, vitamins, and minerals."1.26Nutrition and the etiology of cancer. ( Newell, GR, 1982)
"A greater proportion of users among cancer patients than among controls was noted only for cancer of the stomach among women."1.26Use of artificial sweeteners by cancer patients. ( Morrison, AS, 1979)
"The risk of a person getting cancer from ingesting saccharin is compared with the risk of ingesting additional calories which cause excess body weight."1.26Relative risks of saccharin and calorie ingestion. ( Cohen, BL, 1978)
"Deaths from cancer (128) were significantly fewer than expected (168), mainly because of a deficit in the number of deaths from cancers related to smoking (cancers of the buccal cavity and pharynx, oesophagus, respiratory system, and bladder)."1.26Cancer mortality and saccharin consumption in diabetics. ( Adelstein, AM; Armstrong, B; Donovan, JW; Lea, AJ; Ruttle, S; White, GC, 1976)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199035 (60.34)18.7374
1990's9 (15.52)18.2507
2000's4 (6.90)29.6817
2010's6 (10.34)24.3611
2020's4 (6.90)2.80

Authors

AuthorsStudies
Rami, M1
Winum, JY1
Innocenti, A1
Montero, JL1
Scozzafava, A1
Supuran, CT6
Moeker, J1
Peat, TS1
Bornaghi, LF1
Vullo, D1
Poulsen, SA2
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Fulgoni, VL2
Drewnowski, A2
Pavanello, S1
Moretto, A1
La Vecchia, C1
Alicandro, G1
Leitans, J1
Kazaks, A1
Bogans, J1
Akopjana, I1
Ivanova, J1
Zalubovskis, R1
Tars, K1
D'Ascenzio, M2
Secci, D2
Carradori, S2
Zara, S1
Guglielmi, P2
Cirilli, R1
Pierini, M1
Poli, G1
Tuccinardi, T1
Angeli, A1
Mahon, BP2
Hendon, AM1
Driscoll, JM1
Rankin, GM1
McKenna, R2
Khan, SA1
Okoh, CO1
Florio, R1
Mollica, A1
Ceruso, M1
Akdemir, A1
Sobolev, AP1
Dybing, E1
Weihrauch, MR1
Diehl, V1
Newell, GR3
Sandler, RS1
Graham, S1
El-Mofty, MM1
Sadek, IA1
Essawy, AE1
Smith, JC1
Blumsack, JT1
Bilek, FS1
Spector, AC1
Hollander, GR1
Baker, DL1
Downs, TD1
Frankowski, RF1
Lederer, J1
Murasaki, G1
Greenfield, RE1
Cohen, SM5
Upton, AC1
Brown, AL1
Wright, SC1
Zhong, J1
Larrick, JW1
Hertz-Picciotto, I1
Neutra, RR1
Degnan, FH1
Flamm, WG1
Vesely, DL1
Levey, GS1
Arlin, M1
Eisenstadt, ME1
Morrison, AS1
Marx, JL1
Coustou, F1
Meneely, GR1
Shubik, P1
Cohen, BL1
Speth, G1
Hicks, RM1
Chowaniec, J1
Armstrong, B1
Lea, AJ1
Adelstein, AM1
Donovan, JW1
White, GC1
Ruttle, S1
Cook, CE1
Coulston, F1
McCheaney, EW1
Goldberg, L1
Mahaney, FX1
Garland, EM1
Ellwein, LB3
Krewski, D1
Wigle, D1
Clayson, DB1
Howe, GR1
Kaufman, JE1
Anderson, K1
Parsons, CL1
Jungmann, G1
Rudali, G1
Bigwood, EJ1

Reviews

17 reviews available for saccharin and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence.
    Regulatory toxicology and pharmacology : RTP, 2023, Volume: 139

    Topics: Aspartame; Humans; Neoplasms; Saccharin; Sugars; Sweetening Agents

2023
Artificial sweeteners: safe or unsafe?
    JPMA. The Journal of the Pakistan Medical Association, 2015, Volume: 65, Issue:2

    Topics: Aspartame; Diabetes Mellitus, Type 2; Dipeptides; Humans; Neoplasms; Obesity; Saccharin; Sucrose; Sw

2015
Development and implementation of the IPCS conceptual framework for evaluating mode of action of chemical carcinogens.
    Toxicology, 2002, Dec-27, Volume: 181-182

    Topics: Carcinogens; Cyclohexenes; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Humans; Limonen

2002
Artificial sweeteners--do they bear a carcinogenic risk?
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:10

    Topics: Aspartame; Case-Control Studies; Cyclamates; Epidemiologic Studies; Humans; Neoplasms; Risk Factors;

2004
Diet and cancer: food additives, coffee, and alcohol.
    Nutrition and cancer, 1983, Volume: 4, Issue:4

    Topics: Aflatoxins; Animals; Coffee; Ethanol; Flavoring Agents; Food Additives; Food Coloring Agents; Food P

1983
Dietary factors in the prevention of cancer.
    Transplantation proceedings, 1984, Volume: 16, Issue:2

    Topics: Alcohol Drinking; Ascorbic Acid; Coffee; Diet; Dietary Fats; Humans; Neoplasms; Risk; Saccharin; Veg

1984
Influence of repair processes on dose-response models.
    Drug metabolism reviews, 1982, Volume: 13, Issue:5

    Topics: Animals; Carcinogens; DNA Repair; Dose-Response Relationship, Drug; Kinetics; Models, Biological; Ne

1982
[Sweetening agents: saccharin--cyclamate and its metabolites--aspartame].
    Revue medicale de la Suisse romande, 1980, Volume: 100, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Aspartame; Chromosome Aberrations; Cricetinae; Cyclamates; Cyc

1980
Resolving discrepancies among studies: the influence of dose on effect size.
    Epidemiology (Cambridge, Mass.), 1994, Volume: 5, Issue:2

    Topics: Aspirin; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Ethylene Oxide; Female;

1994
Cell proliferation and carcinogenesis.
    Drug metabolism reviews, 1998, Volume: 30, Issue:2

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Humans; Neoplasms; Neoplasms, Experiment

1998
Cyclamates: a review of the current position.
    Current medical research and opinion, 1975, Volume: 3, Issue:4

    Topics: Animals; Carcinogens; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Diabetes Mellitus, Type 1;

1975
Cancer enhancement by cell proliferation.
    Progress in clinical and biological research, 1992, Volume: 374

    Topics: Animals; Cell Division; FANFT; Humans; Models, Biological; Neoplasms; Rats; Saccharin; Urinary Bladd

1992
Genetic errors, cell proliferation, and carcinogenesis.
    Cancer research, 1991, Dec-15, Volume: 51, Issue:24

    Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Carcinogens; Cell Division; DNA Replication; Humans;

1991
The health risks of saccharin revisited.
    Critical reviews in toxicology, 1990, Volume: 20, Issue:5

    Topics: Animals; Humans; Neoplasms; Risk Factors; Saccharin

1990
Role of epidemiology in health risk assessment.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1990, Volume: 120

    Topics: Canada; Epidemiologic Methods; Formaldehyde; Health Status Indicators; Humans; Neoplasms; Risk Manag

1990
Saccharin--a European assessment.
    Food and cosmetics toxicology, 1973, Volume: 11, Issue:6

    Topics: Animals; Cricetinae; Drug Contamination; Europe; Humans; Hydrogen-Ion Concentration; Legislation, Dr

1973

Other Studies

41 other studies available for saccharin and Neoplasms

ArticleYear
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
    Bioorganic & medicinal chemistry letters, 2008, Jan-15, Volume: 18, Issue:2

    Topics: Amines; Carbonic Anhydrase Inhibitors; Copper; Heterocyclic Compounds; Isoenzymes; Neoplasms; Sulfon

2008
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.
    Journal of medicinal chemistry, 2014, Apr-24, Volume: 57, Issue:8

    Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Drug

2014
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
    Nutrients, 2022, Nov-22, Volume: 14, Issue:23

    Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac

2022
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
    Nutrients, 2022, Nov-22, Volume: 14, Issue:23

    Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac

2022
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
    Nutrients, 2022, Nov-22, Volume: 14, Issue:23

    Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac

2022
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
    Nutrients, 2022, Nov-22, Volume: 14, Issue:23

    Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac

2022
Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
    ChemMedChem, 2023, Nov-16, Volume: 18, Issue:22

    Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Human

2023
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.
    Journal of medicinal chemistry, 2020, 03-12, Volume: 63, Issue:5

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Car

2020
Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
    Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

    Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cryst

2015
Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?
    Future oncology (London, England), 2015, Volume: 11, Issue:15

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Neopl

2015
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.
    Journal of enzyme inhibition and medicinal chemistry, 2017, Volume: 32, Issue:1

    Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Molecular Structure; Neoplasms; Protein

2017
Sweeteners: how the brands measure up.
    Consumer reports, 2007, Volume: 72, Issue:10

    Topics: Animals; Aspartame; Carbohydrates; Consumer Behavior; Humans; Neoplasms; Rats; Saccharin; Sucrose; S

2007
Nutrition and the etiology of cancer.
    Primary care, 1982, Volume: 9, Issue:3

    Topics: Animals; Carcinogens; Diet; Dietary Fiber; Female; Food Additives; Food Analysis; Food Preservation;

1982
Nutrition and diet.
    Cancer, 1983, Jun-15, Volume: 51, Issue:12 Suppl

    Topics: Animals; Carcinogens; Diet; Dietary Fats; Dietary Fiber; Energy Intake; Humans; Neoplasms; Nitrites;

1983
Nyctotheroides puytoraci as a new protozoan test animal for detecting the carcinogenicity of saccharin, cyclamate, or bracken fern (Pteridium aquilinum).
    Folia morphologica, 1983, Volume: 31, Issue:2

    Topics: Animals; Bufonidae; Ciliophora; Cyclamates; Drug Evaluation, Preclinical; Neoplasms; Plants; Sacchar

1983
Radiation-induced taste aversion as a factor in cancer therapy.
    Cancer treatment reports, 1984, Volume: 68, Issue:10

    Topics: Abdomen; Ageusia; Animals; Conditioning, Classical; Drinking Behavior; Food; Humans; Male; Neoplasms

1984
Food additives and coffee as risk factors.
    Progress in clinical and biological research, 1983, Volume: 132D

    Topics: Animals; Butylated Hydroxytoluene; Coffee; Food Additives; Humans; Neoplasms; Nitrites; Rats; Risk;

1983
Alterations in the rat kidney associated with sodium saccharin feeding.
    Toxicology letters, 1982, Volume: 12, Issue:4

    Topics: Animals; Body Weight; Cyclophosphamide; Kidney Diseases; Male; Neoplasms; Rats; Rats, Inbred F344; S

1982
Preventive medicine in the workplace--prospects for the 1980s.
    Journal of occupational medicine. : official publication of the Industrial Medical Association, 1981, Volume: 23, Issue:8

    Topics: Accidents, Occupational; Animals; Humans; Neoplasms; Neoplasms, Experimental; Neoplasms, Radiation-I

1981
The meaning of risk assessment.
    Oncology, 1980, Volume: 37, Issue:4

    Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Allowable

1980
Inhibition of apoptosis as a mechanism of tumor promotion.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1994, Volume: 8, Issue:9

    Topics: Animals; Apoptosis; Carcinogens; DDT; Diethylstilbestrol; Leukemia P388; Leukemia, Promyelocytic, Ac

1994
The great saccharin snafu.
    Consumer reports, 1977, Volume: 42, Issue:7

    Topics: Canada; Humans; Legislation, Drug; Neoplasms; Saccharin; United States; United States Food and Drug

1977
Living with and reforming the Delaney Clause.
    Food and drug law journal, 1995, Volume: 50, Issue:2

    Topics: Carcinogens; Cyclamates; Diethylstilbestrol; Food Additives; Food Supply; Food Technology; Humans; N

1995
Saccharin inhibits guanylate cyclase activity: possible relationship to carcinogenesis.
    Biochemical and biophysical research communications, 1978, Apr-28, Volume: 81, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Guanylate Cyclase; Male; Neoplasms; Rats; Saccharin; Urin

1978
Controversies in nutrition: a brief review.
    The Nursing clinics of North America, 1979, Volume: 14, Issue:2

    Topics: Colonic Neoplasms; Coronary Disease; Dental Caries; Dietary Carbohydrates; Dietary Fats; Dietary Fib

1979
Private industry.
    Bulletin of the New York Academy of Medicine, 1978, Volume: 54, Issue:4

    Topics: Animals; Drug and Narcotic Control; Female; Food Additives; Humans; Industry; Infant, Newborn; Male;

1978
Use of artificial sweeteners by cancer patients.
    Journal of the National Cancer Institute, 1979, Volume: 62, Issue:6

    Topics: Aged; Cyclamates; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Neoplasms; Saccharin; Sw

1979
Tumor promoters: carcinogenesis gets more complicated.
    Science (New York, N.Y.), 1978, Aug-11, Volume: 201, Issue:4355

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro

1978
Carcinogenic risk of products used in the pharmaceutical and related industries.
    IARC scientific publications, 1979, Issue:25

    Topics: Aerosols; Aflatoxins; Asbestos; Carcinogens; Coloring Agents; Cosmetics; Cyclamates; Drug Industry;

1979
More on saccharin.
    American family physician, 1979, Volume: 20, Issue:2

    Topics: Animals; Neoplasms; Rats; Research Design; Saccharin

1979
Saccharin and cancer.
    JAMA, 1979, Nov-16, Volume: 242, Issue:20

    Topics: Animals; Humans; Neoplasms; Rats; Saccharin; Sodium; Solubility

1979
Food additives (natural and synthetic).
    Cancer, 1979, Volume: 43, Issue:5 Suppl

    Topics: Animals; Basidiomycota; Carcinogens; Cooking; Drug Evaluation, Preclinical; Female; Food Additives;

1979
Relative risks of saccharin and calorie ingestion.
    Science (New York, N.Y.), 1978, Mar-03, Volume: 199, Issue:4332

    Topics: Diet; Energy Intake; Humans; Neoplasms; Obesity; Risk; Saccharin

1978
Policy statement. Saccharin.
    Diabetes, 1978, Volume: 27, Issue:8

    Topics: Animals; Diabetes Mellitus; Food Additives; Humans; Neoplasms; Research; Saccharin; Societies, Medic

1978
Waiting for a philosopher king: making cancer policy until certainty arrives.
    Texas reports on biology and medicine, 1978, Volume: 37

    Topics: Animals; Carcinogens, Environmental; Disease Models, Animal; Drug Evaluation, Preclinical; Environme

1978
American ban on saccharin.
    British medical journal, 1977, Mar-19, Volume: 1, Issue:6063

    Topics: Animals; Humans; Neoplasms; Rats; Saccharin; United States

1977
Saccharin and cancer.
    The New England journal of medicine, 1977, Sep-08, Volume: 297, Issue:10

    Topics: Humans; Legislation, Drug; Neoplasms; Risk; Saccharin; United States; United States Food and Drug Ad

1977
Cancer mortality and saccharin consumption in diabetics.
    British journal of preventive & social medicine, 1976, Volume: 30, Issue:3

    Topics: Adult; Age Factors; Aged; Coronary Disease; Diabetes Complications; Diabetes Mellitus; England; Fema

1976
Long-term administration of artificial sweeteners to the rhesus monkey (M. mulatta).
    Food and cosmetics toxicology, 1975, Volume: 13, Issue:2

    Topics: Animals; Behavior, Animal; Cyclamates; Female; Macaca mulatta; Neoplasms; Saccharin; Sweetening Agen

1975
Saccharin's link to human cancer questioned.
    Journal of the National Cancer Institute, 1992, May-06, Volume: 84, Issue:9

    Topics: Animals; Humans; Neoplasms; Rats; Saccharin; Species Specificity

1992
Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis.
    Urology, 1987, Volume: 30, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Animals; Bacterial Adhesion; Cyclamates; Glycosaminoglycans; Kynurenine;

1987
[Results of the International Symposium on Sweetening Agents].
    Zeitschrift fur Allgemeinmedizin, 1974, Feb-10, Volume: 50, Issue:4

    Topics: Animals; Congresses as Topic; Cyclamates; Female; Germany, West; Humans; Male; Neoplasms; Rats; Sacc

1974
[The cancer-risk in man from synthetic sweetening agents].
    La Presse medicale, 1971, Mar-13, Volume: 79, Issue:13

    Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N

1971
The cyclamate story--what kind of lesson do we get out of it as regards problems of food additive control in general?
    Bibliotheca nutritio et dieta, 1971, Volume: 16

    Topics: Animals; Carcinogens; Cyclamates; Food Additives; Mice; Neoplasms; Rats; Saccharin; United States; U

1971