saccharin has been researched along with Neoplasms in 58 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present simple methods for combining dose information from the study of interest with dose-response data from other epidemiologic studies or animal studies to derive plausible hypothesized effect levels." | 2.39 | Resolving discrepancies among studies: the influence of dose on effect size. ( Hertz-Picciotto, I; Neutra, RR, 1994) |
| "For some of the more common cancers in this country, it is thought that individuals can exert a certain amount of control over his or her own cancer risk through diet and lifestyle." | 1.27 | Nutrition and diet. ( Newell, GR, 1983) |
| "If bladder cancer is caused by agents present in the urine, as is widely believed, this mechanism may also protect against carcinogenesis." | 1.27 | Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis. ( Anderson, K; Kaufman, JE; Parsons, CL, 1987) |
| "Dietary components related to cancer include dietary fat, fiber, fruits and vegetables, protein, alcohol, vitamins, and minerals." | 1.26 | Nutrition and the etiology of cancer. ( Newell, GR, 1982) |
| "A greater proportion of users among cancer patients than among controls was noted only for cancer of the stomach among women." | 1.26 | Use of artificial sweeteners by cancer patients. ( Morrison, AS, 1979) |
| "The risk of a person getting cancer from ingesting saccharin is compared with the risk of ingesting additional calories which cause excess body weight." | 1.26 | Relative risks of saccharin and calorie ingestion. ( Cohen, BL, 1978) |
| "Deaths from cancer (128) were significantly fewer than expected (168), mainly because of a deficit in the number of deaths from cancers related to smoking (cancers of the buccal cavity and pharynx, oesophagus, respiratory system, and bladder)." | 1.26 | Cancer mortality and saccharin consumption in diabetics. ( Adelstein, AM; Armstrong, B; Donovan, JW; Lea, AJ; Ruttle, S; White, GC, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (60.34) | 18.7374 |
| 1990's | 9 (15.52) | 18.2507 |
| 2000's | 4 (6.90) | 29.6817 |
| 2010's | 6 (10.34) | 24.3611 |
| 2020's | 4 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Rami, M | 1 |
| Winum, JY | 1 |
| Innocenti, A | 1 |
| Montero, JL | 1 |
| Scozzafava, A | 1 |
| Supuran, CT | 6 |
| Moeker, J | 1 |
| Peat, TS | 1 |
| Bornaghi, LF | 1 |
| Vullo, D | 1 |
| Poulsen, SA | 2 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Fulgoni, VL | 2 |
| Drewnowski, A | 2 |
| Pavanello, S | 1 |
| Moretto, A | 1 |
| La Vecchia, C | 1 |
| Alicandro, G | 1 |
| Leitans, J | 1 |
| Kazaks, A | 1 |
| Bogans, J | 1 |
| Akopjana, I | 1 |
| Ivanova, J | 1 |
| Zalubovskis, R | 1 |
| Tars, K | 1 |
| D'Ascenzio, M | 2 |
| Secci, D | 2 |
| Carradori, S | 2 |
| Zara, S | 1 |
| Guglielmi, P | 2 |
| Cirilli, R | 1 |
| Pierini, M | 1 |
| Poli, G | 1 |
| Tuccinardi, T | 1 |
| Angeli, A | 1 |
| Mahon, BP | 2 |
| Hendon, AM | 1 |
| Driscoll, JM | 1 |
| Rankin, GM | 1 |
| McKenna, R | 2 |
| Khan, SA | 1 |
| Okoh, CO | 1 |
| Florio, R | 1 |
| Mollica, A | 1 |
| Ceruso, M | 1 |
| Akdemir, A | 1 |
| Sobolev, AP | 1 |
| Dybing, E | 1 |
| Weihrauch, MR | 1 |
| Diehl, V | 1 |
| Newell, GR | 3 |
| Sandler, RS | 1 |
| Graham, S | 1 |
| El-Mofty, MM | 1 |
| Sadek, IA | 1 |
| Essawy, AE | 1 |
| Smith, JC | 1 |
| Blumsack, JT | 1 |
| Bilek, FS | 1 |
| Spector, AC | 1 |
| Hollander, GR | 1 |
| Baker, DL | 1 |
| Downs, TD | 1 |
| Frankowski, RF | 1 |
| Lederer, J | 1 |
| Murasaki, G | 1 |
| Greenfield, RE | 1 |
| Cohen, SM | 5 |
| Upton, AC | 1 |
| Brown, AL | 1 |
| Wright, SC | 1 |
| Zhong, J | 1 |
| Larrick, JW | 1 |
| Hertz-Picciotto, I | 1 |
| Neutra, RR | 1 |
| Degnan, FH | 1 |
| Flamm, WG | 1 |
| Vesely, DL | 1 |
| Levey, GS | 1 |
| Arlin, M | 1 |
| Eisenstadt, ME | 1 |
| Morrison, AS | 1 |
| Marx, JL | 1 |
| Coustou, F | 1 |
| Meneely, GR | 1 |
| Shubik, P | 1 |
| Cohen, BL | 1 |
| Speth, G | 1 |
| Hicks, RM | 1 |
| Chowaniec, J | 1 |
| Armstrong, B | 1 |
| Lea, AJ | 1 |
| Adelstein, AM | 1 |
| Donovan, JW | 1 |
| White, GC | 1 |
| Ruttle, S | 1 |
| Cook, CE | 1 |
| Coulston, F | 1 |
| McCheaney, EW | 1 |
| Goldberg, L | 1 |
| Mahaney, FX | 1 |
| Garland, EM | 1 |
| Ellwein, LB | 3 |
| Krewski, D | 1 |
| Wigle, D | 1 |
| Clayson, DB | 1 |
| Howe, GR | 1 |
| Kaufman, JE | 1 |
| Anderson, K | 1 |
| Parsons, CL | 1 |
| Jungmann, G | 1 |
| Rudali, G | 1 |
| Bigwood, EJ | 1 |
17 reviews available for saccharin and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence.
Topics: Aspartame; Humans; Neoplasms; Saccharin; Sugars; Sweetening Agents | 2023 |
Artificial sweeteners: safe or unsafe?
Topics: Aspartame; Diabetes Mellitus, Type 2; Dipeptides; Humans; Neoplasms; Obesity; Saccharin; Sucrose; Sw | 2015 |
Development and implementation of the IPCS conceptual framework for evaluating mode of action of chemical carcinogens.
Topics: Carcinogens; Cyclohexenes; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Humans; Limonen | 2002 |
Artificial sweeteners--do they bear a carcinogenic risk?
Topics: Aspartame; Case-Control Studies; Cyclamates; Epidemiologic Studies; Humans; Neoplasms; Risk Factors; | 2004 |
Diet and cancer: food additives, coffee, and alcohol.
Topics: Aflatoxins; Animals; Coffee; Ethanol; Flavoring Agents; Food Additives; Food Coloring Agents; Food P | 1983 |
Dietary factors in the prevention of cancer.
Topics: Alcohol Drinking; Ascorbic Acid; Coffee; Diet; Dietary Fats; Humans; Neoplasms; Risk; Saccharin; Veg | 1984 |
Influence of repair processes on dose-response models.
Topics: Animals; Carcinogens; DNA Repair; Dose-Response Relationship, Drug; Kinetics; Models, Biological; Ne | 1982 |
[Sweetening agents: saccharin--cyclamate and its metabolites--aspartame].
Topics: Abnormalities, Drug-Induced; Animals; Aspartame; Chromosome Aberrations; Cricetinae; Cyclamates; Cyc | 1980 |
Resolving discrepancies among studies: the influence of dose on effect size.
Topics: Aspirin; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Ethylene Oxide; Female; | 1994 |
Cell proliferation and carcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Humans; Neoplasms; Neoplasms, Experiment | 1998 |
Cyclamates: a review of the current position.
Topics: Animals; Carcinogens; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Diabetes Mellitus, Type 1; | 1975 |
Cancer enhancement by cell proliferation.
Topics: Animals; Cell Division; FANFT; Humans; Models, Biological; Neoplasms; Rats; Saccharin; Urinary Bladd | 1992 |
Genetic errors, cell proliferation, and carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Carcinogens; Cell Division; DNA Replication; Humans; | 1991 |
The health risks of saccharin revisited.
Topics: Animals; Humans; Neoplasms; Risk Factors; Saccharin | 1990 |
Role of epidemiology in health risk assessment.
Topics: Canada; Epidemiologic Methods; Formaldehyde; Health Status Indicators; Humans; Neoplasms; Risk Manag | 1990 |
Saccharin--a European assessment.
Topics: Animals; Cricetinae; Drug Contamination; Europe; Humans; Hydrogen-Ion Concentration; Legislation, Dr | 1973 |
41 other studies available for saccharin and Neoplasms
| Article | Year |
|---|---|
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Topics: Amines; Carbonic Anhydrase Inhibitors; Copper; Heterocyclic Compounds; Isoenzymes; Neoplasms; Sulfon | 2008 |
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Drug | 2014 |
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac | 2022 |
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac | 2022 |
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac | 2022 |
No Association between Low-Calorie Sweetener (LCS) Use and Overall Cancer Risk in the Nationally Representative Database in the US: Analyses of NHANES 1988-2018 Data and 2019 Public-Use Linked Mortality Files.
Topics: Aspartame; Cross-Sectional Studies; Energy Intake; Female; Humans; Neoplasms; Nutrition Surveys; Sac | 2022 |
Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Human | 2023 |
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Car | 2020 |
Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cryst | 2015 |
Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Neopl | 2015 |
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Molecular Structure; Neoplasms; Protein | 2017 |
Sweeteners: how the brands measure up.
Topics: Animals; Aspartame; Carbohydrates; Consumer Behavior; Humans; Neoplasms; Rats; Saccharin; Sucrose; S | 2007 |
Nutrition and the etiology of cancer.
Topics: Animals; Carcinogens; Diet; Dietary Fiber; Female; Food Additives; Food Analysis; Food Preservation; | 1982 |
Nutrition and diet.
Topics: Animals; Carcinogens; Diet; Dietary Fats; Dietary Fiber; Energy Intake; Humans; Neoplasms; Nitrites; | 1983 |
Nyctotheroides puytoraci as a new protozoan test animal for detecting the carcinogenicity of saccharin, cyclamate, or bracken fern (Pteridium aquilinum).
Topics: Animals; Bufonidae; Ciliophora; Cyclamates; Drug Evaluation, Preclinical; Neoplasms; Plants; Sacchar | 1983 |
Radiation-induced taste aversion as a factor in cancer therapy.
Topics: Abdomen; Ageusia; Animals; Conditioning, Classical; Drinking Behavior; Food; Humans; Male; Neoplasms | 1984 |
Food additives and coffee as risk factors.
Topics: Animals; Butylated Hydroxytoluene; Coffee; Food Additives; Humans; Neoplasms; Nitrites; Rats; Risk; | 1983 |
Alterations in the rat kidney associated with sodium saccharin feeding.
Topics: Animals; Body Weight; Cyclophosphamide; Kidney Diseases; Male; Neoplasms; Rats; Rats, Inbred F344; S | 1982 |
Preventive medicine in the workplace--prospects for the 1980s.
Topics: Accidents, Occupational; Animals; Humans; Neoplasms; Neoplasms, Experimental; Neoplasms, Radiation-I | 1981 |
The meaning of risk assessment.
Topics: Animals; Biological Assay; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Allowable | 1980 |
Inhibition of apoptosis as a mechanism of tumor promotion.
Topics: Animals; Apoptosis; Carcinogens; DDT; Diethylstilbestrol; Leukemia P388; Leukemia, Promyelocytic, Ac | 1994 |
The great saccharin snafu.
Topics: Canada; Humans; Legislation, Drug; Neoplasms; Saccharin; United States; United States Food and Drug | 1977 |
Living with and reforming the Delaney Clause.
Topics: Carcinogens; Cyclamates; Diethylstilbestrol; Food Additives; Food Supply; Food Technology; Humans; N | 1995 |
Saccharin inhibits guanylate cyclase activity: possible relationship to carcinogenesis.
Topics: Animals; Dose-Response Relationship, Drug; Guanylate Cyclase; Male; Neoplasms; Rats; Saccharin; Urin | 1978 |
Controversies in nutrition: a brief review.
Topics: Colonic Neoplasms; Coronary Disease; Dental Caries; Dietary Carbohydrates; Dietary Fats; Dietary Fib | 1979 |
Private industry.
Topics: Animals; Drug and Narcotic Control; Female; Food Additives; Humans; Industry; Infant, Newborn; Male; | 1978 |
Use of artificial sweeteners by cancer patients.
Topics: Aged; Cyclamates; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Neoplasms; Saccharin; Sw | 1979 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
Carcinogenic risk of products used in the pharmaceutical and related industries.
Topics: Aerosols; Aflatoxins; Asbestos; Carcinogens; Coloring Agents; Cosmetics; Cyclamates; Drug Industry; | 1979 |
More on saccharin.
Topics: Animals; Neoplasms; Rats; Research Design; Saccharin | 1979 |
Saccharin and cancer.
Topics: Animals; Humans; Neoplasms; Rats; Saccharin; Sodium; Solubility | 1979 |
Food additives (natural and synthetic).
Topics: Animals; Basidiomycota; Carcinogens; Cooking; Drug Evaluation, Preclinical; Female; Food Additives; | 1979 |
Relative risks of saccharin and calorie ingestion.
Topics: Diet; Energy Intake; Humans; Neoplasms; Obesity; Risk; Saccharin | 1978 |
Policy statement. Saccharin.
Topics: Animals; Diabetes Mellitus; Food Additives; Humans; Neoplasms; Research; Saccharin; Societies, Medic | 1978 |
Waiting for a philosopher king: making cancer policy until certainty arrives.
Topics: Animals; Carcinogens, Environmental; Disease Models, Animal; Drug Evaluation, Preclinical; Environme | 1978 |
American ban on saccharin.
Topics: Animals; Humans; Neoplasms; Rats; Saccharin; United States | 1977 |
Saccharin and cancer.
Topics: Humans; Legislation, Drug; Neoplasms; Risk; Saccharin; United States; United States Food and Drug Ad | 1977 |
Cancer mortality and saccharin consumption in diabetics.
Topics: Adult; Age Factors; Aged; Coronary Disease; Diabetes Complications; Diabetes Mellitus; England; Fema | 1976 |
Long-term administration of artificial sweeteners to the rhesus monkey (M. mulatta).
Topics: Animals; Behavior, Animal; Cyclamates; Female; Macaca mulatta; Neoplasms; Saccharin; Sweetening Agen | 1975 |
Saccharin's link to human cancer questioned.
Topics: Animals; Humans; Neoplasms; Rats; Saccharin; Species Specificity | 1992 |
Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis.
Topics: 3-Hydroxyanthranilic Acid; Animals; Bacterial Adhesion; Cyclamates; Glycosaminoglycans; Kynurenine; | 1987 |
[Results of the International Symposium on Sweetening Agents].
Topics: Animals; Congresses as Topic; Cyclamates; Female; Germany, West; Humans; Male; Neoplasms; Rats; Sacc | 1974 |
[The cancer-risk in man from synthetic sweetening agents].
Topics: Animals; Carcinoma, Hepatocellular; Cyclamates; Female; Liver Neoplasms; Lung Neoplasms; Lymphoma, N | 1971 |
The cyclamate story--what kind of lesson do we get out of it as regards problems of food additive control in general?
Topics: Animals; Carcinogens; Cyclamates; Food Additives; Mice; Neoplasms; Rats; Saccharin; United States; U | 1971 |