saccharin has been researched along with Hyperplasia in 33 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer." | 7.67 | Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 7.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 5.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| "Sodium saccharin, at high doses in the diet, has been reported to cause hyperplasia of the forestomach (squamous portion of stomach), at the limiting ridge in F344 rats, in addition to its potential to induce proliferative effects on the urinary bladder epithelium." | 3.68 | Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach. ( Cohen, SM; Garland, EM; Masui, T; Wang, CY, 1990) |
| " Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer." | 3.67 | Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 3.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| " The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk." | 1.30 | Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998) |
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 1.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (84.85) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagiwara, A | 5 |
| Fukushima, S | 7 |
| Kitaori, M | 1 |
| Shibata, M | 3 |
| Ito, N | 9 |
| Sakata, T | 2 |
| Shirai, T | 1 |
| Hasegawa, R | 6 |
| Cohen, SM | 11 |
| Greenfield, RE | 3 |
| Ellwein, LB | 2 |
| Anderström, C | 1 |
| Johansson, SL | 1 |
| Ogiso, T | 1 |
| Suzuki, T | 2 |
| Murasaki, G | 7 |
| Arai, M | 2 |
| Nakanowatari, J | 1 |
| Hibino, T | 1 |
| Okuda, M | 1 |
| Nakanishi, K | 3 |
| Imaida, K | 2 |
| Tatematsu, M | 3 |
| Tamano, S | 1 |
| El-Gerzawi, S | 1 |
| Heatfield, BM | 1 |
| Trump, BF | 1 |
| Hicks, RM | 3 |
| Tsuda, H | 1 |
| Miyata, Y | 1 |
| Nakatsuka, T | 1 |
| Cano, M | 1 |
| St John, MK | 1 |
| Garland, EM | 3 |
| Khachab, M | 1 |
| Calabrese, EJ | 1 |
| Baldwin, LA | 1 |
| Yu, A | 1 |
| Hashimura, T | 1 |
| Nishio, Y | 1 |
| Kanamaru, H | 1 |
| Fukuzawa, S | 1 |
| Yoshida, O | 2 |
| Okamura, T | 1 |
| Masui, T | 2 |
| St John, M | 1 |
| Wang, CY | 1 |
| Knowles, MA | 2 |
| Jani, H | 2 |
| Norman, JT | 1 |
| Howlett, AR | 1 |
| Spacey, GD | 1 |
| Hodges, GM | 1 |
| Bittard, M | 1 |
| Anderson, RL | 2 |
| Lefever, FR | 2 |
| Maurer, JK | 2 |
| Wakefield, JS | 1 |
| Chowaniec, J | 1 |
| Bryan, GT | 1 |
3 reviews available for saccharin and Hyperplasia
| Article | Year |
|---|---|
Promotion in bladder cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Cyclophosphamide; Humans; Hyperplasia; Mice; Neo | 1982 |
[Prognosis of primary tumors of the bladder].
Topics: Aged; Alkylating Agents; Amines; Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Clofi | 1985 |
Artificial sweeteners as urinary bladder carcinogens.
Topics: Administration, Oral; Animals; Carcinogens; Carcinoma; Carcinoma, Papillary; Cattle; Cricetinae; Cyc | 1971 |
30 other studies available for saccharin and Hyperplasia
| Article | Year |
|---|---|
Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Topics: Animals; Aspartame; Butylhydroxybutylnitrosamine; Diterpenes; Diterpenes, Kaurane; Glucosides; Hyper | 1984 |
Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine in F344 rats.
Topics: Allopurinol; Animals; Ascorbic Acid; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Drug Sy | 1984 |
Urinary bladder carcinogenesis.
Topics: Animals; Carcinogens; FANFT; Hyperplasia; Male; Models, Biological; Rats; Rats, Inbred F344; Regener | 1984 |
The combined effect of mechanical trauma and phenacetin or sodium saccharin on the rat urinary bladder.
Topics: Animals; Body Weight; Feeding Behavior; Female; Hyperplasia; Male; Phenacetin; Rats; Rats, Inbred St | 1983 |
Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Topics: Acetazolamide; Allopurinol; Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Carci | 1983 |
Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin.
Topics: Agglutination; Animals; Carcinogens; Concanavalin A; Cyclophosphamide; Dose-Response Relationship, D | 1984 |
Differences in susceptibility to sodium saccharin among various strains of rats and other animal species.
Topics: Animals; Body Weight; Cricetinae; Guinea Pigs; Hyperplasia; Male; Mesocricetus; Rats; Rats, Inbred A | 1983 |
Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration.
Topics: Animals; Autoradiography; Cell Division; Freezing; Hyperplasia; Male; Microscopy, Electron, Scanning | 1983 |
Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinoma, Papillary; Dose-Response Relationship, Drug; Femal | 1980 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
N-Methyl-N-nitrosourea and saccharin: effects on epithelium of normal human urinary bladder in vitro.
Topics: Cocarcinogenesis; Culture Techniques; Epithelium; Humans; Hyperplasia; Methylnitrosourea; Nitrosoure | 1982 |
Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclophosphamide; FANFT; Hyperplasia; Male; Rats; Rats, In | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxy-propyl)-nitrosamine.
Topics: Animals; Caffeine; DNA; Epithelium; Female; Hyperplasia; Nitrosamines; Rats; Saccharin; Urinary Blad | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation.
Topics: Animals; Dose-Response Relationship, Drug; Hyperplasia; Male; Microscopy, Electron, Scanning; Rats; | 1981 |
Saccharin-induced hyperplasia of the rat urinary bladder.
Topics: Animals; Cell Division; DNA; Hyperplasia; Male; Rats; Saccharin; Urinary Bladder | 1980 |
Effect of sodium saccharin on the neonatal rat bladder.
Topics: Animals; Animals, Newborn; Autoradiography; Body Weight; Carcinogens; Cell Division; DNA; DNA Replic | 1995 |
Can the concept of hormesis Be generalized to carcinogenesis?
Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos | 1998 |
Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Hyperplasia; Male; Masoprocol; Papilloma; Rats; Rats, Inbred | 1992 |
Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet.
Topics: Animals; Carcinoma; Drinking; Drug Evaluation, Preclinical; FANFT; Hyperplasia; Male; Papilloma; Rat | 1991 |
Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach.
Topics: Animal Feed; Animals; Diet; Dose-Response Relationship, Drug; Hyperplasia; Male; Random Allocation; | 1990 |
Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.
Topics: Animals; Cyclamates; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscopy, Electron, Scann | 1986 |
Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclamates; Epithelium; Femal | 1986 |
Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
Topics: Animals; Cyclamates; Cyclophosphamide; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscop | 1987 |
Effect of inherent urine output on the response of male rats to 7.5% dietary sodium saccharin.
Topics: Animals; Body Weight; Cecum; Diet; Diuresis; Drinking; Eating; Epithelium; Hyperplasia; Indican; Mal | 1987 |
The effect of various saccharin forms on gastro-intestinal tract, urine and bladder of male rats.
Topics: Animals; Body Weight; Calcium; Cecum; Hyperplasia; Male; Polyuria; Potassium; Rats; Rats, Inbred Str | 1988 |
The effect of different salts of saccharin on the rat urinary bladder.
Topics: Animals; Calcium; Cell Cycle; Diarrhea; Epithelium; Feces; Hyperplasia; Potassium; Rats; Saccharin; | 1986 |
Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Freezing; Hyperplasia; Male; Rats; Rats, In | 1985 |
Letter: Co-carcinogenic action of saccharin in the chemical induction of bladder cancer.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Hyperplasia; N | 1973 |