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saccharin and Hyperplasia

saccharin has been researched along with Hyperplasia in 33 studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
" Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer."7.67Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984)
"Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection."7.67Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985)
" None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin."5.26Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980)
"Sodium saccharin, at high doses in the diet, has been reported to cause hyperplasia of the forestomach (squamous portion of stomach), at the limiting ridge in F344 rats, in addition to its potential to induce proliferative effects on the urinary bladder epithelium."3.68Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach. ( Cohen, SM; Garland, EM; Masui, T; Wang, CY, 1990)
" Ulceration of the bladder, induced by cyclophosphamide (CP) or freezing, followed by sodium saccharin in the diet results in the induction of bladder cancer."3.67Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin. ( Cohen, SM; Hasegawa, R; Murasaki, G; Suzuki, T, 1984)
"Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection."3.67Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985)
" The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk."1.30Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998)
" None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin."1.26Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199028 (84.85)18.7374
1990's5 (15.15)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hagiwara, A5
Fukushima, S7
Kitaori, M1
Shibata, M3
Ito, N9
Sakata, T2
Shirai, T1
Hasegawa, R6
Cohen, SM11
Greenfield, RE3
Ellwein, LB2
Anderström, C1
Johansson, SL1
Ogiso, T1
Suzuki, T2
Murasaki, G7
Arai, M2
Nakanowatari, J1
Hibino, T1
Okuda, M1
Nakanishi, K3
Imaida, K2
Tatematsu, M3
Tamano, S1
El-Gerzawi, S1
Heatfield, BM1
Trump, BF1
Hicks, RM3
Tsuda, H1
Miyata, Y1
Nakatsuka, T1
Cano, M1
St John, MK1
Garland, EM3
Khachab, M1
Calabrese, EJ1
Baldwin, LA1
Yu, A1
Hashimura, T1
Nishio, Y1
Kanamaru, H1
Fukuzawa, S1
Yoshida, O2
Okamura, T1
Masui, T2
St John, M1
Wang, CY1
Knowles, MA2
Jani, H2
Norman, JT1
Howlett, AR1
Spacey, GD1
Hodges, GM1
Bittard, M1
Anderson, RL2
Lefever, FR2
Maurer, JK2
Wakefield, JS1
Chowaniec, J1
Bryan, GT1

Reviews

3 reviews available for saccharin and Hyperplasia

ArticleYear
Promotion in bladder cancer.
    Carcinogenesis; a comprehensive survey, 1982, Volume: 7

    Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Cyclophosphamide; Humans; Hyperplasia; Mice; Neo

1982
[Prognosis of primary tumors of the bladder].
    Journal d'urologie, 1985, Volume: 91, Issue:6

    Topics: Aged; Alkylating Agents; Amines; Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Clofi

1985
Artificial sweeteners as urinary bladder carcinogens.
    Archives of environmental health, 1971, Volume: 23, Issue:1

    Topics: Administration, Oral; Animals; Carcinogens; Carcinoma; Carcinoma, Papillary; Cattle; Cricetinae; Cyc

1971

Other Studies

30 other studies available for saccharin and Hyperplasia

ArticleYear
Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
    Gan, 1984, Volume: 75, Issue:9

    Topics: Animals; Aspartame; Butylhydroxybutylnitrosamine; Diterpenes; Diterpenes, Kaurane; Glucosides; Hyper

1984
Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine in F344 rats.
    Gan, 1984, Volume: 75, Issue:11

    Topics: Allopurinol; Animals; Ascorbic Acid; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Drug Sy

1984
Urinary bladder carcinogenesis.
    IARC scientific publications, 1984, Issue:56

    Topics: Animals; Carcinogens; FANFT; Hyperplasia; Male; Models, Biological; Rats; Rats, Inbred F344; Regener

1984
The combined effect of mechanical trauma and phenacetin or sodium saccharin on the rat urinary bladder.
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 1983, Volume: 91, Issue:5

    Topics: Animals; Body Weight; Feeding Behavior; Female; Hyperplasia; Male; Phenacetin; Rats; Rats, Inbred St

1983
Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1983, Volume: 21, Issue:1

    Topics: Acetazolamide; Allopurinol; Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Carci

1983
Distinction by concanavalin A agglutination between ulceration and repair of rat bladder epithelium induced by freezing or cyclophosphamide and the effect of sodium saccharin.
    Cancer research, 1984, Volume: 44, Issue:1

    Topics: Agglutination; Animals; Carcinogens; Concanavalin A; Cyclophosphamide; Dose-Response Relationship, D

1984
Differences in susceptibility to sodium saccharin among various strains of rats and other animal species.
    Gan, 1983, Volume: 74, Issue:1

    Topics: Animals; Body Weight; Cricetinae; Guinea Pigs; Hyperplasia; Male; Mesocricetus; Rats; Rats, Inbred A

1983
Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration.
    Cancer research, 1983, Volume: 43, Issue:1

    Topics: Animals; Autoradiography; Cell Division; Freezing; Hyperplasia; Male; Microscopy, Electron, Scanning

1983
Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
    Journal of the National Cancer Institute, 1980, Volume: 65, Issue:5

    Topics: Animals; Butylhydroxybutylnitrosamine; Carcinoma, Papillary; Dose-Response Relationship, Drug; Femal

1980
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
    Journal of the National Cancer Institute, 1982, Volume: 68, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N

1982
N-Methyl-N-nitrosourea and saccharin: effects on epithelium of normal human urinary bladder in vitro.
    Journal of the National Cancer Institute, 1982, Volume: 69, Issue:3

    Topics: Cocarcinogenesis; Culture Techniques; Epithelium; Humans; Hyperplasia; Methylnitrosourea; Nitrosoure

1982
Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
    Cancer research, 1982, Volume: 42, Issue:1

    Topics: Animals; Cell Division; Cocarcinogenesis; Cyclophosphamide; FANFT; Hyperplasia; Male; Rats; Rats, In

1982
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
    Carcinogenesis; a comprehensive survey, 1982, Volume: 7

    Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas

1982
Effects of caffeine and saccharin on DNA in the bladder epithelium of rats treated with N-butyl-N-(3-carboxy-propyl)-nitrosamine.
    Chemico-biological interactions, 1980, Volume: 29, Issue:3

    Topics: Animals; Caffeine; DNA; Epithelium; Female; Hyperplasia; Nitrosamines; Rats; Saccharin; Urinary Blad

1980
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
    Gan, 1980, Volume: 71, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia;

1980
Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Hyperplasia; Male; Microscopy, Electron, Scanning; Rats;

1981
Saccharin-induced hyperplasia of the rat urinary bladder.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Animals; Cell Division; DNA; Hyperplasia; Male; Rats; Saccharin; Urinary Bladder

1980
Effect of sodium saccharin on the neonatal rat bladder.
    Scanning microscopy, 1995, Volume: 9, Issue:1

    Topics: Animals; Animals, Newborn; Autoradiography; Body Weight; Carcinogens; Cell Division; DNA; DNA Replic

1995
Can the concept of hormesis Be generalized to carcinogenesis?
    Regulatory toxicology and pharmacology : RTP, 1998, Volume: 28, Issue:3

    Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos

1998
Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:9

    Topics: Animals; Butylhydroxybutylnitrosamine; Hyperplasia; Male; Masoprocol; Papilloma; Rats; Rats, Inbred

1992
Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet.
    Cancer research, 1991, Apr-01, Volume: 51, Issue:7

    Topics: Animals; Carcinoma; Drinking; Drug Evaluation, Preclinical; FANFT; Hyperplasia; Male; Papilloma; Rat

1991
Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1990, Volume: 28, Issue:7

    Topics: Animal Feed; Animals; Diet; Dose-Response Relationship, Drug; Hyperplasia; Male; Random Allocation;

1990
Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.
    Carcinogenesis, 1986, Volume: 7, Issue:5

    Topics: Animals; Cyclamates; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscopy, Electron, Scann

1986
Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
    Carcinogenesis, 1986, Volume: 7, Issue:12

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclamates; Epithelium; Femal

1986
Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
    Laboratory investigation; a journal of technical methods and pathology, 1987, Volume: 57, Issue:4

    Topics: Animals; Cyclamates; Cyclophosphamide; Epithelium; Female; Hyperplasia; Methylnitrosourea; Microscop

1987
Effect of inherent urine output on the response of male rats to 7.5% dietary sodium saccharin.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1987, Volume: 25, Issue:9

    Topics: Animals; Body Weight; Cecum; Diet; Diuresis; Drinking; Eating; Epithelium; Hyperplasia; Indican; Mal

1987
The effect of various saccharin forms on gastro-intestinal tract, urine and bladder of male rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1988, Volume: 26, Issue:8

    Topics: Animals; Body Weight; Calcium; Cecum; Hyperplasia; Male; Polyuria; Potassium; Rats; Rats, Inbred Str

1988
The effect of different salts of saccharin on the rat urinary bladder.
    Cancer letters, 1986, Volume: 30, Issue:3

    Topics: Animals; Calcium; Cell Cycle; Diarrhea; Epithelium; Feces; Hyperplasia; Potassium; Rats; Saccharin;

1986
Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.
    Cancer research, 1985, Volume: 45, Issue:4

    Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Freezing; Hyperplasia; Male; Rats; Rats, In

1985
Letter: Co-carcinogenic action of saccharin in the chemical induction of bladder cancer.
    Nature, 1973, Jun-08, Volume: 243, Issue:5406

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Hyperplasia; N

1973