saccharin and Glucose Intolerance studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

Research Excerpts

Excerpt	Relevance	Reference
"Short-term saccharin consumption at maximum acceptable levels is not sufficient to alter gut microbiota or induce glucose intolerance in apparently healthy humans and mice."	9.41	High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice. ( Anderson, M; Blakeslee, JJ; Crouch, AL; Dupont, LM; Gomes-Dias, L; Hatzakis, E; Kyriazis, GA; LaMoia, TE; Peterson, SN; Pratley, RE; Serna, V; Serrano, J; Sharma, V; Smith, KR; Tang, F; Vargova, V; Yi, F, 2021)
"This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey."	7.83	Aspartame intake is associated with greater glucose intolerance in individuals with obesity. ( Brown, RE; Kuk, JL, 2016)
"Short-term saccharin consumption at maximum acceptable levels is not sufficient to alter gut microbiota or induce glucose intolerance in apparently healthy humans and mice."	5.41	High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice. ( Anderson, M; Blakeslee, JJ; Crouch, AL; Dupont, LM; Gomes-Dias, L; Hatzakis, E; Kyriazis, GA; LaMoia, TE; Peterson, SN; Pratley, RE; Serna, V; Serrano, J; Sharma, V; Smith, KR; Tang, F; Vargova, V; Yi, F, 2021)
" On the other hand, acesulfame-potassium (Ace-K) and saccharin have similar binding characteristics to each other but, while Ace-K may increase incretin secretion and glucose responses in humans, there are no data on saccharin except in rats, which show impaired glucose tolerance after chronic administration."	4.95	The impact of low and no-caloric sweeteners on glucose absorption, incretin secretion, and glucose tolerance. ( Chan, CB; Hashemi, Z; Subhan, FB, 2017)
"This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey."	3.83	Aspartame intake is associated with greater glucose intolerance in individuals with obesity. ( Brown, RE; Kuk, JL, 2016)
"Metformin, a frontline therapy for type 2 diabetes and related metabolic diseases, results in variable outcomes."	1.91	Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice. ( Bernier, A; de Lartigue, G; Rourk, K; Singh, A, 2023)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (66.67)	24.3611
2020's	2 (33.33)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors[NCT03032640]		102 participants (Actual)	Interventional	2017-01-26	Completed
Changes in Gut Microbiota and Postprandial GLP-1 Concentration Due to Sucralose Consumption[NCT06094894]		40 participants (Anticipated)	Interventional	2023-06-01	Recruiting
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility[NCT02890108]		10 participants (Anticipated)	Interventional	2016-08-31	Recruiting
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis[NCT02580435]		520 participants (Anticipated)	Observational	2015-12-31	Not yet recruiting
Effects of Sucralose on Insulin Sensitivity, Pancreatic Response and Appetite Regulating Hormones[NCT02589002]		66 participants (Actual)	Interventional	2015-07-31	Completed
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)[NCT03407079]	Phase 2	26 participants (Actual)	Interventional	2018-04-05	Suspended (stopped due to The status was on admin hold with the prev. PI. The new PI (Dr. Joseph) would like to continue to keep the study on admin hold until after reviewing the study)
A Randomized Controlled Trial of the Effect of Replacing Sugar-sweetened Beverages With Non-nutritive Sweetened Beverages or Water on Gut Microbiome and Metabolic Outcomes: STOP Sugars NOW Trial[NCT03543644]		81 participants (Actual)	Interventional	2018-05-31	Completed
The Effect of Regular Consumption of Low/No Calorie Sweeteners on Glycemic Response and Glucagon Like Peptide-1 Secretion in Healthy Adults: A Randomized Controlled Trial[NCT04904133]		42 participants (Actual)	Interventional	2019-04-02	Completed
Changes in Insulin Sensitivity in Liver and Esqueletal Muscle Due to Sucralose Consumption[NCT04182464]		24 participants (Actual)	Interventional	2019-11-01	Completed
Effect of Acute or Chronic Ingestion of Sucralose on Serum Insulin in Young and Healthy Adults: a Randomized, Double-blind, Placebo-controlled Trial[NCT03703141]		95 participants (Actual)	Interventional	2016-09-27	Completed
Metabolic Effects of Non-nutritive Sweeteners[NCT02413424]		38 participants (Actual)	Interventional	2015-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Non-Nutritive Sweetened Beverages Impair Therapeutic Benefits of Metformin in Prediabetic Diet-Induced Obese Mice. Nutrients, 2023, May-25, Volume: 15, Issue:11 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose Intolerance; High Fructose Corn Syrup; M	2023
Sugar substitutes linked to obesity. Nature, 2014, Sep-18, Volume: 513, Issue:7518 Topics: Animals; Glucose Intolerance; Healthy Volunteers; Humans; Intestinal Mucosa; Intestines; Mice; Obesi	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, Oct-09, Volume: 514, Issue:7521 Topics: Animals; Anti-Bacterial Agents; Aspartame; Body Weight; Diet, High-Fat; Dietary Fats; Feces; Female;	2014
Aspartame intake is associated with greater glucose intolerance in individuals with obesity. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2016, Volume: 41, Issue:7 Topics: Adult; Aged; Aspartame; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Energy Intake; Fema	2016

saccharin and Glucose Intolerance

Research Excerpts

Research

Studies (6)

Authors

Clinical Trials (11)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Singh, A	1
Rourk, K	1
Bernier, A	1
de Lartigue, G	1
Serrano, J	1
Smith, KR	1
Crouch, AL	1
Sharma, V	1
Yi, F	1
Vargova, V	1
LaMoia, TE	1
Dupont, LM	1
Serna, V	1
Tang, F	1
Gomes-Dias, L	1
Blakeslee, JJ	1
Hatzakis, E	1
Peterson, SN	1
Anderson, M	1
Pratley, RE	1
Kyriazis, GA	1
Chan, CB	1
Hashemi, Z	1
Subhan, FB	1
Abbott, A	1
Suez, J	1
Korem, T	1
Zeevi, D	1
Zilberman-Schapira, G	1
Thaiss, CA	1
Maza, O	1
Israeli, D	1
Zmora, N	1
Gilad, S	1
Weinberger, A	1
Kuperman, Y	1
Harmelin, A	1
Kolodkin-Gal, I	1
Shapiro, H	1
Halpern, Z	1
Segal, E	1
Elinav, E	1
Kuk, JL	1
Brown, RE	1