saccharin has been researched along with Experimental Neoplasms in 55 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 5.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| "Saccharin is known to have a tumor-promoting effect on bladder cancer in rats, but its mechanism of action is unknown." | 3.66 | Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens. ( Kakizoe, T; Kawachi, T; Komatsu, H; Niijima, T; Sugimura, T, 1981) |
| " However, sodium saccharin dosing did not result in an increased incidence of tumors in either the bladder or liver and is therefore not considered to be a promoter of carcinogenesis at these sites in the mouse." | 1.28 | The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene. ( Dooley, KL; Frederick, CB; Kadlubar, FF; Kodell, RL; Sheldon, WG, 1989) |
| "The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has already led to a greater knowledge of its pathogenesis." | 1.27 | Modifying factors in urinary bladder carcinogenesis. ( Fukushima, S; Hasegawa, R; Imaida, K; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " 1) Physical modifiers: Route of administration, medium (vehicle) of carcinogens, detergents, dosage (concentration), period (frequency) of administration, exposure time, and condition of mucus." | 1.27 | [Experimental carcinogenesis of the stomach and its modifiers]. ( Takahashi, M, 1983) |
| " Generally, carcinogenicity is a result of the intrinsic property of a chemical and is independent of dosage and duration of exposure; however, the detection of carcinogenicity is dose-related." | 1.26 | Experimental identification of genitourinary carcinogens. ( Sontag, JM, 1980) |
| " None of the incidences or numbers of these lesions were significantly different in any of the other saccharin-treated groups when compared to the group treated with BBN alone except for the incidences of two types of hyperplasias in the female rats dosed with 10,000 ppm saccharin." | 1.26 | Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. ( Hagiwara, A; Imaida, K; Ito, N; Nakanishi, K; Shibata, M; Tatematsu, M, 1980) |
| "The commonest neoplasm found was squamous cell carcinoma of the forestomach in groups III and IV." | 1.26 | Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination. ( Gothoskar, SV; Pai, SR; Shirke, AJ, 1981) |
| "Saccharin was considerably more potent as a promoting agent than was tryptophan, inducing higher incidences of bladder tumors and having a shorter latent period." | 1.26 | Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. ( Arai, M; Cohen, SM; Friedell, GH; Jacobs, JB, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (92.73) | 18.7374 |
| 1990's | 3 (5.45) | 18.2507 |
| 2000's | 1 (1.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soudah, B | 1 |
| Green, U | 2 |
| Schneider, P | 2 |
| Althoff, J | 3 |
| Ludwig, KW | 1 |
| Niles, RM | 1 |
| Arnold, DL | 1 |
| Sims, J | 1 |
| Renwick, AG | 1 |
| Fukushima, S | 8 |
| Hagiwara, A | 3 |
| Ogiso, T | 3 |
| Shibata, M | 2 |
| Ito, N | 10 |
| Greenfield, RE | 1 |
| Ellwein, LB | 1 |
| Cohen, SM | 8 |
| Sontag, JM | 1 |
| Hirose, M | 3 |
| Shirai, T | 3 |
| Tsuda, H | 2 |
| Murasaki, G | 1 |
| Nakanishi, K | 6 |
| Hasegawa, R | 2 |
| Imaida, K | 3 |
| Takahashi, M | 1 |
| Tatematsu, M | 2 |
| Tamano, S | 1 |
| Caruthers, JM | 1 |
| Bonneville, MA | 1 |
| Hicks, RM | 5 |
| Ray-Chaudhuri, R | 1 |
| Currens, M | 1 |
| Iype, PT | 1 |
| Okuda, M | 1 |
| Nakanowatari, J | 1 |
| Hatano, A | 1 |
| Deutsch-Wenzel, R | 1 |
| Brune, H | 1 |
| Friedell, GH | 2 |
| Jacobs, JB | 2 |
| Pai, SR | 1 |
| Shirke, AJ | 1 |
| Gothoskar, SV | 1 |
| Upton, AC | 1 |
| Kakizoe, T | 1 |
| Komatsu, H | 1 |
| Niijima, T | 1 |
| Kawachi, T | 1 |
| Sugimura, T | 1 |
| Hooson, J | 1 |
| Grasso, P | 1 |
| Chowaniec, J | 2 |
| Arai, M | 2 |
| Demers, DM | 1 |
| Theiss, JC | 1 |
| Arnold, LJ | 1 |
| Shimkin, MB | 2 |
| Williams, GM | 1 |
| Whysner, J | 1 |
| Jacobson, MF | 1 |
| Farber, E | 1 |
| Clapp, R | 1 |
| Irie, M | 1 |
| Asami, S | 1 |
| Nagata, S | 1 |
| Miyata, M | 1 |
| Kasai, H | 1 |
| Newell, GR | 1 |
| Hoover, RN | 1 |
| Kolbye, AC | 1 |
| Morrison, AB | 1 |
| Shubik, P | 2 |
| Boyland, E | 1 |
| Cook, CE | 1 |
| Cardesa, A | 1 |
| Pour, P | 1 |
| Frederick, CB | 1 |
| Dooley, KL | 1 |
| Kodell, RL | 1 |
| Sheldon, WG | 1 |
| Kadlubar, FF | 1 |
| Schoenig, GP | 1 |
| Wang, CY | 1 |
| Bertram, JS | 1 |
| Stoner, GD | 1 |
| Kniazeff, AJ | 1 |
| Weisburger, JH | 1 |
| Weisburger, EK | 1 |
| Gori, GB | 1 |
| Ershoff, BH | 1 |
| Bajwa, GS | 1 |
| Holmberg, B | 1 |
| Schmähl, D | 1 |
| Chowaniec, AJ | 1 |
| Wakefield, JS | 1 |
| Bryan, GT | 1 |
| Yoshida, O | 1 |
11 reviews available for saccharin and Experimental Neoplasms
| Article | Year |
|---|---|
Luminal plasma membrane alterations in bladder cancer.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Cilia; FANFT; Intercellular Junctions; Methylnit | 1980 |
Multistage carcinogenesis in the urinary bladder.
Topics: Animals; Cricetinae; Cyclamates; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; | 1980 |
Promotion in bladder cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Cyclophosphamide; Humans; Hyperplasia; Mice; Neo | 1982 |
Epigenetic carcinogens: evaluation and risk assessment.
Topics: Animals; Butylated Hydroxyanisole; Carcinogens; Cyclohexenes; DNA; Humans; Limonene; Neoplasms, Expe | 1996 |
Cell proliferation and carcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Humans; Neoplasms; Neoplasms, Experiment | 1998 |
Status report on saccharin in humans.
Topics: Animals; Drug Evaluation, Preclinical; Epidemiologic Methods; Female; Humans; Male; National Institu | 1978 |
Cyclamates: a review of the current position.
Topics: Animals; Carcinogens; Carcinoma, Papillary; Cyclamates; Cyclohexylamines; Diabetes Mellitus, Type 1; | 1975 |
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogen | 1986 |
Neoplastic transformation in cell cultures: in-vitro/in-vivo correlations.
Topics: Animals; Antigens, Neoplasm; Ascorbic Acid; Biotransformation; Calcium; Carcinogens; Cell Adhesion; | 1985 |
[Chemical factors and cancer of the bladder].
Topics: Amines; Aniline Compounds; Animals; Benzopyrenes; Coffee; Cyclamates; Female; Guinea Pigs; Humans; H | 1974 |
Artificial sweeteners as urinary bladder carcinogens.
Topics: Administration, Oral; Animals; Carcinogens; Carcinoma; Carcinoma, Papillary; Cattle; Cricetinae; Cyc | 1971 |
44 other studies available for saccharin and Experimental Neoplasms
| Article | Year |
|---|---|
Neoplastic lesions in the urinary tract of Wistar rats after treatment with N-methyl-N-nitrosourea (MNU) and artificial sweeteners.
Topics: Animals; Calcium Carbonate; Cyclamates; Drug Synergism; Female; Methylnitrosourea; Neoplasms, Experi | 1981 |
Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cells, Cultured; Cyclic AMP; Kinetics; Melanins; Melanoma; Mice; Neoplasms, Experimental; P | 1980 |
Two-generation saccharin bioassays.
Topics: Animals; History of Medicine; Neoplasms, Experimental; Rats; Research Design; Saccharin; Urinary Bla | 1983 |
The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat.
Topics: Animals; Cecum; Dose-Response Relationship, Drug; Feces; Indican; Intestines; Male; Neoplasms, Exper | 1983 |
Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.
Topics: Acetazolamide; Allopurinol; Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Carci | 1983 |
A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; FANFT; Mathematics; Mitosis; Models, Biologica | 1984 |
Experimental identification of genitourinary carcinogens.
Topics: Amines; Animals; Carcinogens; Cricetinae; Dogs; Epidemiologic Methods; Female; Haplorhini; Humans; M | 1980 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi | 1981 |
Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder.
Topics: Animals; Cocarcinogenesis; Diet; FANFT; Growth; Male; Neoplasms, Experimental; Rats; Saccharin; Thia | 1983 |
Modifying factors in urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cell Transformation, Neoplastic; Neoplasms, Expe | 1983 |
Promotion in urinary bladder carcinogenesis.
Topics: Animals; Cell Division; Cocarcinogenesis; FANFT; Neoplasms, Experimental; Rats; Saccharin; Ulcer; Ur | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
[Experimental carcinogenesis of the stomach and its modifiers].
Topics: Age Factors; Animals; Cricetinae; Diet; Dogs; Male; Methylnitronitrosoguanidine; Mice; Neoplasms, Ex | 1983 |
Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinoma, Papillary; Dose-Response Relationship, Drug; Femal | 1980 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Enhancement of sister-chromatid exchanges by tumour promoters.
Topics: Animals; Cell Cycle; Cell Line; Crossing Over, Genetic; Deoxyglucose; Dose-Response Relationship, Dr | 1982 |
Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cyclamates; FANFT; Male; Neoplasms, Experimental | 1982 |
Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats.
Topics: Animals; Body Weight; Carcinogens; Cyclamates; Drug Synergism; Eating; Female; Methylnitrosourea; Ne | 1980 |
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; FANFT; Male; Neoplasms, Experimental; Rats; | 1981 |
Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination.
Topics: Animals; Areca; Carcinogens; Carcinoma, Squamous Cell; Diet; Female; Gastrointestinal Neoplasms; Mal | 1981 |
Preventive medicine in the workplace--prospects for the 1980s.
Topics: Accidents, Occupational; Animals; Humans; Neoplasms; Neoplasms, Experimental; Neoplasms, Radiation-I | 1981 |
Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.
Topics: Animals; Butylhydroxybutylnitrosamine; Cell Aggregation; Cell Membrane; Cocarcinogenesis; Concanaval | 1981 |
Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat.
Topics: Animals; Body Weight; Drinking; Eating; Female; Kidney; Methylnitrosourea; Neoplasms, Experimental; | 1980 |
Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Caffeine; Cocarcinogenesis; Male; Microscopy, Electron; Neopl | 1980 |
Effect of sodium saccharin and L-tryptophan on rat urine during bladder carcinogenesis.
Topics: Animals; Blood Glucose; FANFT; Glycosuria; Natriuresis; Neoplasms, Experimental; Rats; Saccharin; Tr | 1981 |
Effect of commercial saccharin preparations on urethan-induced lung tumorigenesis in strain A mice.
Topics: Adenoma; Animals; Cocarcinogenesis; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Experimen | 1980 |
Re: Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer.
Topics: Animals; Carcinogens; Case-Control Studies; Haplorhini; Neoplasms, Experimental; Research Design; Sa | 1998 |
Classical conditioning of oxidative DNA damage in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Avoidance Learning; Carcinogens; Conditioning, Classical; Deox | 2000 |
Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis.
Topics: Animals; Epithelium; FANFT; Male; Microscopy, Electron, Scanning; Microvilli; Neoplasms, Experimenta | 1979 |
Sugar substitutes.
Topics: Animals; Aspartame; Cricetinae; Cyclamates; Humans; Male; Mice; Neoplasms, Experimental; Rats; Sacch | 1979 |
Urinary bladder carcinogenesis: initiation-promotion.
Topics: Animals; Cocarcinogenesis; FANFT; Humans; Neoplasms, Experimental; Rats; Saccharin; Schistosomiasis; | 1979 |
Food additives (natural and synthetic).
Topics: Animals; Basidiomycota; Carcinogens; Cooking; Drug Evaluation, Preclinical; Female; Food Additives; | 1979 |
Saccharin: from carcinogen to promoter.
Topics: Animals; Biotransformation; Cocarcinogenesis; Neoplasms, Experimental; Saccharin; Urinary Bladder Ne | 1979 |
The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
Topics: 2-Naphthylamine; Animals; Carcinogens; Carcinogens, Environmental; Carcinoma, Transitional Cell; Cyc | 1977 |
A chronic study of artificial sweeteners in Syrian golden hamsters.
Topics: Animals; Carcinogens; Cricetinae; Cyclamates; Drug Administration Schedule; Female; Male; Neoplasms, | 1975 |
The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H | 1989 |
The effects of saccharin on the development of neoplastic lesions initiated with n-methyl-n-nitrosourea.
Topics: Animals; Drug Interactions; Methylnitrosourea; Mice; Neoplasms, Experimental; Saccharin | 1988 |
Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats.
Topics: Animals; Esophageal Neoplasms; FANFT; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Mal | 1986 |
Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.
Topics: Alkylating Agents; Allyl Compounds; Animals; Antineoplastic Agents; Biological Assay; Busulfan; Buta | 1973 |
Inhibitory effect of sodium cyclamate and sodium saccharin on tumor induction by 2-acetylaminofluorene in rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinoma, Hepatocellular; Cyclamates; Ear Canal; Ear Ne | 1974 |
[Lack of carcinogenic effects of cyclamate, cyclohexylamine, and saccharine in rats].
Topics: Animals; Body Weight; Cyclamates; Cyclohexylamines; Female; Male; Neoplasms, Experimental; Rats; Sac | 1973 |
Proceedings: Histology of tumour formation in the bladder of rats receiving dietary saccharin and a single dose of N-methyl N-nitrosourea.
Topics: Animals; Diet; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Saccharin; Urinary Bladder Neop | 1974 |
Some sweetness left.
Topics: Academies and Institutes; Animals; Benzoates; Cyclamates; Foodborne Diseases; Lung Neoplasms; Mice; | 1970 |