saccharin has been researched along with Drug Withdrawal Symptoms in 35 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In present study, effects of sucrose and sugar-substitute (saccharin) exposures and withdrawal on depression and anxiety-like behavior in type 2 diabetic mice were assessed." | 7.91 | Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects. ( Chail, M; Kumar, M, 2019) |
| "In present study, effects of sucrose and sugar-substitute (saccharin) exposures and withdrawal on depression and anxiety-like behavior in type 2 diabetic mice were assessed." | 3.91 | Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects. ( Chail, M; Kumar, M, 2019) |
| " In this study, we subjected these rats to several long-term administration protocols suggested to favour the development of alcohol dependence, including multiple alcohol concentrations or sweetened alcohol solutions (ethanol 10% or 20%+saccharin), and deprivation periods." | 1.32 | The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence. ( Jones, BC; Mormède, P; Terenina-Rigaldie, E, 2004) |
| "The study of alcohol abuse traditionally has placed great emphasis on the development of tolerance and dependence as key factors." | 1.29 | Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. ( Heinrichs, SC; Hyytiä, P; Koob, GF; Schulteis, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 10 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haake, RM | 1 |
| West, EA | 1 |
| Wang, X | 1 |
| Carelli, RM | 1 |
| Grim, TW | 1 |
| Park, SJ | 1 |
| Schmid, CL | 1 |
| Laprairie, RB | 1 |
| Cameron, M | 1 |
| Bohn, LM | 1 |
| Kumar, M | 1 |
| Chail, M | 1 |
| Freet, CS | 1 |
| Ballard, SM | 1 |
| Alexander, DN | 1 |
| Cox, TA | 1 |
| Imperio, CG | 1 |
| Anosike, N | 1 |
| Carter, AB | 1 |
| Mahmoud, S | 1 |
| Ruiz-Velasco, V | 1 |
| Grigson, PS | 2 |
| Holtz, NA | 2 |
| Radke, AK | 2 |
| Zlebnik, NE | 1 |
| Harris, AC | 1 |
| Carroll, ME | 5 |
| Wang, L | 1 |
| Shen, M | 1 |
| Jiang, C | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Dreumont-Boudreau, SE | 1 |
| Dingle, RN | 1 |
| Alcolado, GM | 1 |
| Lolordo, VM | 1 |
| Mach, JL | 1 |
| La Nasa, RM | 1 |
| Newman, JL | 1 |
| Kozlov, AP | 1 |
| Nizhnikov, ME | 1 |
| Varlinskaya, EI | 1 |
| Spear, NE | 1 |
| Nyland, JE | 1 |
| Gewirtz, JC | 1 |
| Kohl, EA | 1 |
| Johnson, KM | 1 |
| LaNasa, RM | 1 |
| Werme, M | 1 |
| Hermanson, E | 1 |
| Carmine, A | 1 |
| Buervenich, S | 1 |
| Zetterström, RH | 1 |
| Thorén, P | 1 |
| Ogren, SO | 1 |
| Olson, L | 1 |
| Perlmann, T | 1 |
| Brené, S | 1 |
| Hori, H | 1 |
| Fujii, W | 1 |
| Hatanaka, Y | 1 |
| Suwa, Y | 1 |
| Belozertseva, IV | 1 |
| Sukhotina, IA | 1 |
| Vossen, JM | 1 |
| Bespalov, AY | 1 |
| Zakharova, E | 1 |
| Malyshkin, A | 1 |
| Kashkin, V | 1 |
| Neznanova, O | 1 |
| Sukhotina, I | 1 |
| Danysz, W | 1 |
| Bespalov, A | 1 |
| Terenina-Rigaldie, E | 1 |
| Jones, BC | 1 |
| Mormède, P | 1 |
| Blednov, YA | 1 |
| Walker, D | 1 |
| Martinez, M | 1 |
| Harris, RA | 1 |
| Toalston, JE | 1 |
| Oster, SM | 1 |
| Kuc, KA | 1 |
| Pommer, TJ | 1 |
| Murphy, JM | 1 |
| Lumeng, L | 1 |
| Bell, RL | 1 |
| McBride, WJ | 1 |
| Rodd, ZA | 1 |
| Pillai, NP | 1 |
| Ramaswamy, S | 1 |
| Gopalakrishnan, V | 1 |
| Ghosh, MN | 1 |
| Le Magnen, J | 2 |
| Marfaing-Jallat, P | 2 |
| Miceli, D | 1 |
| Crawford, D | 1 |
| Baker, TB | 1 |
| Carmona, GN | 1 |
| Rodefer, JS | 1 |
| Schulteis, G | 1 |
| Hyytiä, P | 1 |
| Heinrichs, SC | 1 |
| Koob, GF | 1 |
| Rudski, J | 1 |
| Gurmankin, C | 1 |
| Vitiello, MV | 1 |
| Woods, SC | 1 |
| Lieblich, I | 1 |
| Yirmiya, R | 1 |
| Liebeskind, JC | 1 |
| Villaneuva, HF | 1 |
| James, JR | 2 |
| Arezo, S | 2 |
| Rosecrans, JA | 2 |
| Chan, AW | 1 |
| Langan, MC | 1 |
| Leong, FW | 1 |
| Penetrante, ML | 1 |
| Schanley, DL | 1 |
| Villanueva, HF | 1 |
| Samson, HH | 1 |
| Falk, JL | 1 |
| Parker, L | 1 |
| Failor, A | 1 |
| Weidman, K | 1 |
| Jacquet, YF | 1 |
| Cicero, TJ | 1 |
| Snider, SR | 1 |
| Perez, VJ | 1 |
| Swanson, LW | 1 |
35 other studies available for saccharin and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Drug-induced dysphoria is enhanced following prolonged cocaine abstinence and dynamically tracked by nucleus accumbens neurons.
Topics: Affect; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavi | 2019 |
The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes.
Topics: Analgesics, Opioid; Animals; Brain; Choice Behavior; Male; Mice; Mice, Inbred C57BL; Morphine; Quini | 2018 |
Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects.
Topics: Animals; Anxiety; Brain; Depression; Diabetes Mellitus, Experimental; Female; Male; Mice; Reward; Sa | 2019 |
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.
Topics: Animals; Behavior, Addictive; Calcium Channels; Cells, Cultured; Cocaine; Cocaine-Related Disorders; | 2015 |
Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake.
Topics: Animals; Animals, Outbred Strains; Electric Stimulation; Food Preferences; Genetic Predisposition to | 2015 |
Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Central Amygdaloid Nucleus; Corticotropin-Releasing Horm | 2016 |
Conditioned flavor avoidance as a measure of withdrawal in rats chronically exposed to a caffeine solution.
Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Central Nervous Syste | 2008 |
Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys.
Topics: Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Female; Food | 2009 |
The role of social isolation in ethanol effects on the preweanling rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Central Nervous System Depressants; Corticosterone; | 2012 |
A drug-paired taste cue elicits withdrawal and predicts cocaine self-administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Anim | 2013 |
Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake.
Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Breeding; Emotions; Female; Male; Morphine; Morph | 2013 |
Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase.
Topics: Administration, Oral; Animals; Choice Behavior; Estrous Cycle; Female; Impulsive Behavior; Macaca mu | 2013 |
Decreased ethanol preference and wheel running in Nurr1-deficient mice.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Dinucleotide Repeats; DNA-Binding Pro | 2003 |
Effects of fusel oil on animal hangover models.
Topics: Alcohol Drinking; Alcoholic Beverages; Alcohols; Animals; Avoidance Learning; Conditioning, Classica | 2003 |
Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats.
Topics: Aggression; Animals; Behavior, Addictive; Choice Behavior; Female; Food Deprivation; Male; Rats; Rat | 2004 |
The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats.
Topics: Acamprosate; Animals; Choice Behavior; Ethanol; Male; Memantine; Naloxone; Naltrexone; Narcotic Anta | 2004 |
The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; E | 2004 |
Reduced alcohol consumption in mice lacking preprodynorphin.
Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Operant; Dynorphins; Et | 2006 |
Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Opera | 2008 |
Effect of cholinergic agonists and antagonists on morphine withdrawal induced aversion to saccharin drinking in rats.
Topics: Animals; Drinking Behavior; Humans; Male; Morphine Dependence; Parasympatholytics; Parasympathomimet | 1984 |
A bioassay of ethanol-dependence in rats.
Topics: Alcoholism; Animals; Conditioning, Psychological; Humans; Male; Rats; Saccharin; Substance Withdrawa | 1980 |
Alcohol dependence and taste-mediated learning in the rat.
Topics: Alcoholism; Animals; Conditioning, Operant; Humans; Learning; Male; Rats; Saccharin; Stress, Psychol | 1982 |
Phencyclidine (PCP) self-administration and withdrawal in rhesus monkeys: effects of buprenorphine and dizocilpine (MK-801) pretreatment.
Topics: Animals; Buprenorphine; Dizocilpine Maleate; Macaca mulatta; Male; Phencyclidine; Saccharin; Self Ad | 1994 |
Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Drug Tolerance; Ethanol; Male; Motivation; Rats; Rats, Wistar | 1996 |
Withdrawal of presession saccharin suppresses food-maintained responding in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drinking; Feeding Behavior | 1998 |
Evidence for withdrawal from caffeine by rats.
Topics: Animals; Avoidance Learning; Caffeine; Humans; Male; Rats; Saccharin; Substance Withdrawal Syndrome | 1977 |
Ethanol-induced taste aversion in ethanol-dependent and normal rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Avoidance Learning; Conditioning, Operant; Ethanol; Humans; M | 1979 |
Intake of and preference for sweet solutions are attenuated in morphine-withdrawn rats.
Topics: Animals; Drinking; Drug Tolerance; Endorphins; Female; Food Preferences; Morphine; Rats; Rats, Inbre | 1991 |
Withdrawal from nicotine fails to produce a conditioned taste aversion to saccharine in rats and mice.
Topics: Animals; Avoidance Learning; Male; Mice; Mice, Inbred ICR; Morphine Dependence; Nicotine; Rats; Rats | 1990 |
Partial cross-dependence on ethanol in mice dependent on chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Ethanol; Flumazenil; Generalization, Stimulus; Male; Mice; Mice, Inbred C | 1990 |
Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats.
Topics: Animals; Avoidance Learning; Choice Behavior; Conditioning, Psychological; Male; Nicotine; Rats; Rat | 1990 |
Alteration of fluid preference in ethanol-dependent animals.
Topics: Animals; Body Weight; Diet; Drinking Behavior; Ethanol; Glucose; Humans; Male; Rats; Saccharin; Subs | 1974 |
Conditioned preferences in the rat with an unnatural need state: morphine withdrawal.
Topics: Acetates; Animals; Appetite; Avoidance Learning; Conditioning, Psychological; Drinking Behavior; Fem | 1973 |
Conditioned aversion during morphine maintenance in mice and rats.
Topics: Animals; Avoidance Learning; Body Weight; Conditioning, Classical; Dose-Response Relationship, Drug; | 1973 |
Physical dependence on and tolerance to alcohol in the rat.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Eth | 1971 |