saccharin has been researched along with Disease Models, Animal in 98 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice." | 7.96 | Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. ( Derer, S; Ibrahim, SM; Künstner, A; Pagel, R; Rupp, J; Sina, C; Sünderhauf, A; Wagner, AE, 2020) |
| "For acute nausea, the potential of cannabinoid pretreatment(s) to reduce LiCl-induced nausea paired with saccharin was evaluated in a subsequent drug free taste reactivity test, followed by a taste avoidance test." | 7.81 | Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping. ( Limebeer, CL; Parker, LA; Rock, EM, 2015) |
| "Chronic social defeat stress for 21 days induced physiological and behavioral depression-relevant deficits and blunted response of dopaminergic and to some extent, serotonergic neurons to cocaine challenge in females." | 7.77 | Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. ( Debold, JF; Holly, EN; Miczek, KA; Shimamoto, A, 2011) |
| "This study examined whether rats can simultaneously learn to associate lithium chloride (LiCl)-induced nausea with both contextual and intravascular taste cues." | 7.77 | Simultaneous conditioning of "gaping" responses and taste avoidance in rats injected with LiCl and saccharin: examining the role of context and taste cues in the rodent model of anticipatory nausea. ( Cloutier, CJ; Cross-Mellor, SK; Kavaliers, M; Ossenkopp, KP, 2011) |
| " Experiment 2 compared the effects of chronic administration of cannabis-derived Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD) and cannabigerol (CBG) in these models." | 5.39 | Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. ( Dashney, B; Limebeer, CL; O'Brien, LD; Parker, LA; Rock, EM; Segsworth, B; Wills, KL, 2013) |
| " In contrast, nongenotoxic chemicals, such as chemicals causing urinary calculi or sodium saccharin and related sodium and potassium salts, frequently are carcinogenic only at high doses and/or only in specific species." | 4.79 | Human relevance of animal carcinogenicity studies. ( Cohen, SM, 1995) |
| " Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice." | 3.96 | Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. ( Derer, S; Ibrahim, SM; Künstner, A; Pagel, R; Rupp, J; Sina, C; Sünderhauf, A; Wagner, AE, 2020) |
| "These data suggest that an alcohol drinking history induces maladaptive behaviors, such as drinking in spite of negative consequences, a pattern not seen with saccharin." | 3.91 | Innate and Acquired Quinine-Resistant Alcohol, but not Saccharin, Drinking in Crossed High-Alcohol-Preferring Mice. ( Carron, CR; Grahame, NJ; Houck, CA; Millie, LA, 2019) |
| " Saccharin-based anhedonia and maternal aggression were increased and lactation was also impaired on day 16 of lactation." | 3.81 | Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression. ( Babb, JA; Bradburn, S; Carini, LM; Murgatroyd, CA; Nephew, BC; Taliefar, M, 2015) |
| " Since obesity is linked to altered experience of food reward and to perturbations of nutrient sensing, we investigated flavor-nutrient learning in rats made obese using a high fat/high carbohydrate (HFHC) choice model of diet-induced obesity (ad libitum lard and maltodextrin solution plus standard rodent chow)." | 3.81 | Enhanced flavor-nutrient conditioning in obese rats on a high-fat, high-carbohydrate choice diet. ( Myers, KP; Wald, HS, 2015) |
| "For acute nausea, the potential of cannabinoid pretreatment(s) to reduce LiCl-induced nausea paired with saccharin was evaluated in a subsequent drug free taste reactivity test, followed by a taste avoidance test." | 3.81 | Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping. ( Limebeer, CL; Parker, LA; Rock, EM, 2015) |
| "Arginine vasopressin (AVP) is considered to be an etiologic hormone in motion sickness (MS)." | 3.81 | AVP modulation of the vestibular nucleus via V1b receptors potentially contributes to the development of motion sickness in rat. ( Jiang, ZL; Li, JC; Liu, HX; Tang, GR; Xu, LH; Yang, JJ, 2015) |
| " Conditioned taste anorexia to saccharin solution and behavior score were used to observe the differences in MS sensitivity between two types of mice." | 3.80 | The comparison of sensitivity of motion sickness between retinal degeneration fast mice and normal mice. ( Bian, K; Ge, XS; Shi, ZH; Wang, XC; Xue, JH; Yang, GQ; Zhang, L; Zhang, ZM, 2014) |
| "Methamphetamine abuse and human immunodeficiency virus (HIV) infection induce neuropathological changes in corticolimbic brain areas involved in reward and cognitive function." | 3.80 | Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice. ( Hubbard, DT; Kesby, JP; Markou, A; Semenova, S, 2014) |
| " The 2-bottle saccharin preference test for anhedonia revealed that dietary ZS also did not improve depression-like behaviors." | 3.78 | Use of zinc as a treatment for traumatic brain injury in the rat: effects on cognitive and behavioral outcomes. ( Cope, EC; Levenson, CW; Morris, DR; Scrimgeour, AG, 2012) |
| "Chronic social defeat stress for 21 days induced physiological and behavioral depression-relevant deficits and blunted response of dopaminergic and to some extent, serotonergic neurons to cocaine challenge in females." | 3.77 | Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. ( Debold, JF; Holly, EN; Miczek, KA; Shimamoto, A, 2011) |
| "This study examined whether rats can simultaneously learn to associate lithium chloride (LiCl)-induced nausea with both contextual and intravascular taste cues." | 3.77 | Simultaneous conditioning of "gaping" responses and taste avoidance in rats injected with LiCl and saccharin: examining the role of context and taste cues in the rodent model of anticipatory nausea. ( Cloutier, CJ; Cross-Mellor, SK; Kavaliers, M; Ossenkopp, KP, 2011) |
| "The conditioned gaping model of nausea in rats was used to compare the CB(1) receptor antagonist/inverse agonist, AM251, and the CB(1) receptor neutral antagonists, AM6527 (centrally and peripherally active) and AM6545 (peripherally active), in potentiating conditioned gaping produced by lithium chloride (LiCl) solution." | 3.76 | Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats. ( Bedard, H; Lang, ST; Limebeer, CL; Makriyannis, A; Ossenkopp, KP; Parker, LA; Vemuri, VK, 2010) |
| " Additional experiments assessed the influence of (i) adulteration with quinine of the alcohol solution (Experiment 2) and (ii) concurrent presentation of a saccharin solution (Experiment 3) on alcohol drinking under the CA10% and IA20% conditions." | 3.76 | Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol. ( Carai, MA; Colombo, G; Fantini, N; Gessa, GL; Lobina, C; Loi, B; Maccioni, P, 2010) |
| " Body weight gain, saccharin preference test and open field test were performed." | 3.75 | Findings of P300-like and CNV-like potentials in rat model of depression following repeatedly forced swim stress. ( Gao, D; Han, M; Sun, X; Tang, X; Zheng, Z, 2009) |
| "Although the serotonin (5-HT)1A receptor agonist ipsapirone reduces ethanol intake in a variety of animal models of alcoholism, such effects have only been reported in models based on nonoperant behavior (e." | 3.70 | Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat. ( De Vry, J; Haussels, A; Manze, B; Schreiber, R, 1999) |
| "saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature." | 2.44 | Selective breeding for differential saccharin intake as an animal model of drug abuse. ( Anker, JJ; Carroll, ME; Dess, NK; Morgan, AD; Perry, JL, 2008) |
| "Morbidity and mortality attributed to type 2 diabetes have exponentially increased in the US." | 1.56 | Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model. ( Nazarian, A; O'Dell, LE; Richardson, JR, 2020) |
| "The neurobiological basis of memory deficits after prenatal alcohol exposure (PAE) is often linked to structural and functional alterations in the medial temporal lobe, including the hippocampus." | 1.51 | Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task. ( Clark, BJ; Davies, S; Goss, J; Hamilton, DA; Sanchez, LM; Savage, DD; Wagner, J, 2019) |
| "Symptoms of food allergy were defined as a change in body temperature and allergic diarrhoea." | 1.46 | Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy. ( Inagaki, N; Matsuhara, H; Matsui, T; Miotani, S; Sako, Y; Tanaka, H; Yamashita, H, 2017) |
| "Chronic pain is a multidimensional experience that not only includes changes in nociception but also impairments in emotional and cognitive functions, not often taken into account in preclinical research." | 1.40 | Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine. ( Ardid, D; Etienne, M; Grégoire, S; Marchand, F; Wattiez, AS, 2014) |
| " Experiment 2 compared the effects of chronic administration of cannabis-derived Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD) and cannabigerol (CBG) in these models." | 1.39 | Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. ( Dashney, B; Limebeer, CL; O'Brien, LD; Parker, LA; Rock, EM; Segsworth, B; Wills, KL, 2013) |
| "The anorexia was mediated by reductions in the number of licking bursts in the meal, intrameal ingestion rate, and meal duration; these measures have been associated with postingestive feedback inhibition of feeding." | 1.37 | Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes. ( Baird, JP; Grigg, LA; LaRiviere, M; Lim, C; Lord, J; Matute, E; Palacios, M, 2011) |
| " However, different dosing schedules were needed for the two drugs to induce this effect." | 1.35 | Attenuation of high sweet solution preference by mood stabilizers: a possible mouse model for the increased reward-seeking domain of mania. ( Einat, H; Flaisher-Grinberg, S; Overgaard, S, 2009) |
| "It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)." | 1.32 | The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003) |
| " In this study, we subjected these rats to several long-term administration protocols suggested to favour the development of alcohol dependence, including multiple alcohol concentrations or sweetened alcohol solutions (ethanol 10% or 20%+saccharin), and deprivation periods." | 1.32 | The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence. ( Jones, BC; Mormède, P; Terenina-Rigaldie, E, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (10.20) | 18.7374 |
| 1990's | 7 (7.14) | 18.2507 |
| 2000's | 20 (20.41) | 29.6817 |
| 2010's | 54 (55.10) | 24.3611 |
| 2020's | 7 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Houck, CA | 1 |
| Carron, CR | 1 |
| Millie, LA | 1 |
| Grahame, NJ | 1 |
| Richardson, JR | 1 |
| O'Dell, LE | 1 |
| Nazarian, A | 1 |
| Sünderhauf, A | 1 |
| Pagel, R | 1 |
| Künstner, A | 1 |
| Wagner, AE | 1 |
| Rupp, J | 1 |
| Ibrahim, SM | 1 |
| Derer, S | 1 |
| Sina, C | 1 |
| Qin, X | 1 |
| Bezerra-Karounis, MA | 1 |
| Krahe, TE | 1 |
| Maisonnette, S | 1 |
| Landeira-Fernandez, J | 1 |
| Pittman, DW | 1 |
| Dong, G | 1 |
| Brantly, AM | 1 |
| He, L | 1 |
| Nelson, TS | 1 |
| Kogan, S | 1 |
| Powell, J | 1 |
| McCluskey, LP | 1 |
| Wang, YC | 1 |
| Chiu, WC | 1 |
| Cheng, CN | 1 |
| Lee, C | 1 |
| Chih Wei Huang, A | 1 |
| Yamashita, H | 1 |
| Matsuhara, H | 1 |
| Miotani, S | 1 |
| Sako, Y | 1 |
| Matsui, T | 1 |
| Tanaka, H | 1 |
| Inagaki, N | 1 |
| He, AB | 1 |
| Chang, YC | 1 |
| Meng, AWY | 1 |
| Huang, ACW | 1 |
| Zeeb, FD | 1 |
| Li, Z | 1 |
| Fisher, DC | 1 |
| Zack, MH | 1 |
| Fletcher, PJ | 1 |
| Lee, H | 1 |
| Jung, T | 1 |
| Kim, W | 1 |
| Noh, J | 1 |
| Ross, JL | 1 |
| Queme, LF | 1 |
| Lamb, JE | 1 |
| Green, KJ | 1 |
| Ford, ZK | 1 |
| Jankowski, MP | 1 |
| Yu, H | 1 |
| Li, M | 3 |
| Zhou, D | 1 |
| Lv, D | 1 |
| Liao, Q | 1 |
| Lou, Z | 1 |
| Shen, M | 2 |
| Wang, Z | 1 |
| Xiao, X | 1 |
| Zhang, Y | 1 |
| Wang, C | 1 |
| Sanchez, LM | 1 |
| Goss, J | 1 |
| Wagner, J | 1 |
| Davies, S | 1 |
| Savage, DD | 1 |
| Hamilton, DA | 1 |
| Clark, BJ | 1 |
| Shbiro, L | 2 |
| Hen-Shoval, D | 1 |
| Hazut, N | 2 |
| Rapps, K | 1 |
| Dar, S | 1 |
| Zalsman, G | 2 |
| Mechoulam, R | 2 |
| Weller, A | 2 |
| Shoval, G | 2 |
| Cason, AM | 1 |
| Grigson, PS | 3 |
| Engeln, M | 1 |
| Fasano, S | 1 |
| Ahmed, SH | 3 |
| Cador, M | 1 |
| Baekelandt, V | 1 |
| Bezard, E | 1 |
| Fernagut, PO | 1 |
| Lenoir, M | 1 |
| Augier, E | 2 |
| Vouillac, C | 1 |
| Wang, XC | 1 |
| Shi, ZH | 1 |
| Bian, K | 1 |
| Zhang, L | 1 |
| Xue, JH | 1 |
| Yang, GQ | 1 |
| Ge, XS | 1 |
| Zhang, ZM | 1 |
| Grégoire, S | 1 |
| Wattiez, AS | 1 |
| Etienne, M | 1 |
| Marchand, F | 1 |
| Ardid, D | 1 |
| Mo, C | 1 |
| Renoir, T | 1 |
| Hannan, AJ | 1 |
| Paumier, KL | 1 |
| Sortwell, CE | 1 |
| Madhavan, L | 1 |
| Terpstra, B | 1 |
| Celano, SL | 1 |
| Green, JJ | 1 |
| Imus, NM | 1 |
| Marckini, N | 1 |
| Daley, B | 1 |
| Steece-Collier, K | 1 |
| Collier, TJ | 1 |
| Yasoshima, Y | 1 |
| Shimura, T | 1 |
| Freet, CS | 1 |
| Ballard, SM | 1 |
| Alexander, DN | 1 |
| Cox, TA | 1 |
| Imperio, CG | 1 |
| Anosike, N | 1 |
| Carter, AB | 1 |
| Mahmoud, S | 1 |
| Ruiz-Velasco, V | 1 |
| Sclafani, A | 1 |
| Touzani, K | 1 |
| Ackroff, K | 1 |
| Murgatroyd, CA | 1 |
| Taliefar, M | 1 |
| Bradburn, S | 1 |
| Carini, LM | 1 |
| Babb, JA | 1 |
| Nephew, BC | 1 |
| Wald, HS | 1 |
| Myers, KP | 1 |
| Radke, AK | 1 |
| Zlebnik, NE | 2 |
| Holtz, NA | 1 |
| Carroll, ME | 4 |
| Huynh, C | 1 |
| Fam, J | 1 |
| Clemens, KJ | 1 |
| Rock, EM | 2 |
| Limebeer, CL | 4 |
| Parker, LA | 5 |
| Xu, LH | 1 |
| Tang, GR | 1 |
| Yang, JJ | 1 |
| Liu, HX | 1 |
| Li, JC | 1 |
| Jiang, ZL | 1 |
| Refsgaard, LK | 1 |
| Hoffmann-Petersen, J | 1 |
| Sahlholt, M | 1 |
| Pickering, DS | 1 |
| Andreasen, JT | 1 |
| Hershkovitz, L | 1 |
| Tang, MM | 1 |
| Lin, WJ | 1 |
| Pan, YQ | 1 |
| Guan, XT | 1 |
| Li, YC | 1 |
| Dulman, RS | 1 |
| Rauffenbart, C | 1 |
| Augier, G | 1 |
| Cross, AJ | 1 |
| Heilig, M | 1 |
| Wang, L | 1 |
| Jiang, C | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Sanchís-Ollé, M | 1 |
| Ortega-Sánchez, JA | 1 |
| Belda, X | 1 |
| Gagliano, H | 1 |
| Nadal, R | 1 |
| Armario, A | 1 |
| Ge, F | 1 |
| Wang, N | 1 |
| Cui, C | 1 |
| Li, Y | 1 |
| Liu, Y | 1 |
| Ma, Y | 1 |
| Liu, S | 1 |
| Zhang, H | 1 |
| Sun, X | 2 |
| Morgan, AD | 1 |
| Anker, JJ | 3 |
| Perry, JL | 1 |
| Dess, NK | 1 |
| Lyons, AM | 1 |
| Lowery, EG | 1 |
| Sparta, DR | 1 |
| Thiele, TE | 1 |
| Flaisher-Grinberg, S | 1 |
| Overgaard, S | 1 |
| Einat, H | 2 |
| Sabino, V | 1 |
| Cottone, P | 1 |
| Zhao, Y | 1 |
| Iyer, MR | 1 |
| Steardo, L | 2 |
| Rice, KC | 1 |
| Conti, B | 1 |
| Koob, GF | 2 |
| Zorrilla, EP | 1 |
| Lin, JY | 1 |
| Roman, C | 1 |
| St Andre, J | 1 |
| Reilly, S | 1 |
| Gao, D | 1 |
| Zheng, Z | 1 |
| Han, M | 1 |
| Tang, X | 1 |
| Ramírez-Lugo, L | 1 |
| Jensen, MS | 1 |
| Søderman, A | 1 |
| West, MJ | 1 |
| Gliddon, LA | 1 |
| Dencker, D | 1 |
| Husum, H | 1 |
| Ashkenazy-Frolinger, T | 1 |
| Kronfeld-Schor, N | 1 |
| Juetten, J | 1 |
| Larsen, MH | 1 |
| Mikkelsen, JD | 1 |
| Hay-Schmidt, A | 1 |
| Sandi, C | 1 |
| Frisch, P | 1 |
| Bilkei-Gorzó, A | 1 |
| Rácz, I | 1 |
| Zimmer, A | 1 |
| Vemuri, VK | 1 |
| Bedard, H | 1 |
| Lang, ST | 1 |
| Ossenkopp, KP | 2 |
| Makriyannis, A | 1 |
| Oberlin, B | 1 |
| Best, C | 1 |
| Matson, L | 1 |
| Henderson, A | 1 |
| Grahame, N | 1 |
| Loi, B | 1 |
| Lobina, C | 1 |
| Maccioni, P | 1 |
| Fantini, N | 1 |
| Carai, MA | 1 |
| Gessa, GL | 1 |
| Colombo, G | 1 |
| Crabbe, JC | 1 |
| Spence, SE | 1 |
| Brown, LL | 1 |
| Metten, P | 1 |
| Pastor, R | 1 |
| Reed, C | 1 |
| Burkhart-Kasch, S | 1 |
| Li, N | 1 |
| Sharpe, AL | 1 |
| Coste, SC | 1 |
| Stenzel-Poore, MP | 1 |
| Phillips, TJ | 1 |
| Shimamoto, A | 1 |
| Debold, JF | 1 |
| Holly, EN | 1 |
| Miczek, KA | 1 |
| Baird, JP | 1 |
| Palacios, M | 1 |
| LaRiviere, M | 1 |
| Grigg, LA | 1 |
| Lim, C | 1 |
| Matute, E | 1 |
| Lord, J | 1 |
| Cloutier, CJ | 1 |
| Cross-Mellor, SK | 1 |
| Kavaliers, M | 1 |
| Gámiz, F | 1 |
| Gallo, M | 1 |
| Tuerke, KJ | 1 |
| Winters, BD | 1 |
| Cope, EC | 1 |
| Morris, DR | 1 |
| Scrimgeour, AG | 1 |
| Levenson, CW | 1 |
| Kim, A | 1 |
| Feng, P | 1 |
| Ohkuri, T | 1 |
| Sauers, D | 1 |
| Cohn, ZJ | 1 |
| Chai, J | 1 |
| Nelson, T | 1 |
| Bachmanov, AA | 1 |
| Huang, L | 1 |
| Wang, H | 1 |
| Salinas, AG | 1 |
| Nguyen, CT | 1 |
| Ahmadi-Tehrani, D | 1 |
| Morrisett, RA | 1 |
| O'Brien, LD | 1 |
| Wills, KL | 1 |
| Segsworth, B | 1 |
| Dashney, B | 1 |
| Nyland, JE | 1 |
| Horovitz, O | 1 |
| Tsoory, MM | 1 |
| Yovell, Y | 1 |
| Richter-Levin, G | 1 |
| Kesby, JP | 1 |
| Hubbard, DT | 1 |
| Markou, A | 1 |
| Semenova, S | 1 |
| Ballok, DA | 1 |
| Szechtman, H | 1 |
| Sakic, B | 1 |
| Ingman, K | 1 |
| Honkanen, A | 1 |
| Hyytiä, P | 1 |
| Huttunen, MO | 1 |
| Korpi, ER | 1 |
| Hori, H | 1 |
| Fujii, W | 1 |
| Hatanaka, Y | 1 |
| Suwa, Y | 1 |
| June, HL | 1 |
| Foster, KL | 1 |
| McKay, PF | 1 |
| Seyoum, R | 1 |
| Woods, JE | 1 |
| Harvey, SC | 1 |
| Eiler, WJ | 1 |
| Grey, C | 1 |
| Carroll, MR | 1 |
| McCane, S | 1 |
| Jones, CM | 1 |
| Yin, W | 1 |
| Mason, D | 1 |
| Cummings, R | 1 |
| Garcia, M | 1 |
| Ma, C | 1 |
| Sarma, PV | 1 |
| Cook, JM | 1 |
| Skolnick, P | 1 |
| Terenina-Rigaldie, E | 1 |
| Jones, BC | 1 |
| Mormède, P | 1 |
| Guitton, MJ | 1 |
| Dudai, Y | 1 |
| Grønli, J | 1 |
| Murison, R | 1 |
| Fiske, E | 1 |
| Bjorvatn, B | 1 |
| Sørensen, E | 1 |
| Portas, CM | 1 |
| Ursin, R | 1 |
| Cai, YL | 1 |
| Ma, WL | 1 |
| Ouyang, RY | 1 |
| Hu, L | 1 |
| Sun, YL | 1 |
| Ji, D | 1 |
| Gilpin, NW | 1 |
| Richardson, HN | 1 |
| Rivier, CL | 1 |
| Quintanilla, ME | 1 |
| Perez, E | 1 |
| Tampier, L | 1 |
| Smith, BK | 1 |
| Barker, K | 1 |
| Schork, MA | 1 |
| Kluger, MJ | 1 |
| Cohen, SM | 1 |
| Pucilowski, O | 1 |
| Overstreet, DH | 2 |
| Rezvani, AH | 2 |
| Janowsky, DS | 1 |
| Hagan, JJ | 1 |
| Hatcher, JP | 1 |
| Rudski, J | 1 |
| Gurmankin, C | 1 |
| Schreiber, R | 1 |
| Manze, B | 1 |
| Haussels, A | 1 |
| De Vry, J | 1 |
| Dyr, W | 1 |
| Kostowski, W | 1 |
| Parsian, A | 1 |
| Speth, G | 1 |
| Falk, JL | 1 |
| Samson, HH | 1 |
| Isselbacher, KJ | 1 |
| Cole, P | 1 |
| Gilbert, RM | 1 |
| Grasso, P | 1 |
| Lester, D | 1 |
| Freed, EX | 1 |
| Nisbett, RE | 1 |
| Hanson, LR | 1 |
| Harris, A | 1 |
| Stair, A | 1 |
| Kutscher, CL | 1 |
| Miller, DG | 1 |
| Gold, RM | 1 |
| Proulx, DM | 1 |
| Cicero, TJ | 1 |
| Snider, SR | 1 |
| Perez, VJ | 1 |
| Swanson, LW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cannabidiol for Treatment Resistant Depression[NCT04732169] | Phase 4 | 0 participants (Actual) | Interventional | 2021-07-01 | Withdrawn (stopped due to Investigator decided not to do study, due to insufficient funding.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for saccharin and Disease Models, Animal
| Article | Year |
|---|---|
Selective breeding for differential saccharin intake as an animal model of drug abuse.
Topics: Alcoholism; Animals; Arousal; Disease Models, Animal; Female; Genotype; Male; Mice; Mice, Inbred Str | 2008 |
Human relevance of animal carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Disease Models, Animal; FAN | 1995 |
The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism.
Topics: Alcoholism; Animals; Depression; Disease Models, Animal; Maze Learning; Phenotype; Rats; Rats, Inbre | 2002 |
Schedule-induced physical dependence on ethanol.
Topics: Alcohol Drinking; Animals; Disease Models, Animal; Drinking Behavior; Drug Administration Schedule; | 1975 |
94 other studies available for saccharin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Innate and Acquired Quinine-Resistant Alcohol, but not Saccharin, Drinking in Crossed High-Alcohol-Preferring Mice.
Topics: Alcohol Drinking; Animals; Disease Models, Animal; Female; Male; Mice; Quinine; Saccharin | 2019 |
Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model.
Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Nicot | 2020 |
Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice.
Topics: Acute Disease; Administration, Oral; Animals; Bacillus cereus; Chronic Disease; Colitis; Dextran Sul | 2020 |
Inhibition of Experimental Colitis by Saccharin in Animals: Should We Dismiss or Raise Concerns Regarding Possible Adverse Effects of Saccharin on Human Gut Microbiota and Health?
Topics: Animals; Colitis; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Saccharin | 2020 |
Alcohol intake in Carioca High- and Low-conditioned Freezing rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety Disorders; Conditioning, Psychological; Disease Model | 2020 |
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.
Topics: Animals; Behavior, Animal; Chorda Tympani Nerve; Disease Models, Animal; Female; Inflammatory Bowel | 2020 |
Examination of neuroinflammatory cytokine interleukin-1 beta expression in the medial prefrontal cortex, amygdala, and hippocampus for the paradoxical effects of reward and aversion induced by morphine.
Topics: Amygdala; Animals; Conditioning, Operant; Disease Models, Animal; Hippocampus; Humans; Interleukin-1 | 2021 |
Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.
Topics: Administration, Oral; Allergens; Animals; Antigen-Presenting Cells; Biomarkers; Chemotaxis; Disease | 2017 |
Re-evaluation of the reward comparison hypothesis for alcohol abuse.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Conditioning, Psychological; Disease Models | 2017 |
Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Decision Making; Disease Models, Animal; Ga | 2017 |
Alteration of adolescent aversive nicotine response and anxiety-like behavior in nicotine-exposed rats during late lactation period.
Topics: Age Factors; Analysis of Variance; Animals; Anxiety; Avoidance Learning; Body Weight; Choice Behavio | 2018 |
Interleukin 1β inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity.
Topics: Acid Sensing Ion Channels; Adenosine Triphosphate; Animals; Disease Models, Animal; Food Preferences | 2018 |
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice.
Topics: Animals; Antidepressive Agents; Cholinergic Antagonists; Depression; Disease Models, Animal; Dose-Re | 2018 |
Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task.
Topics: Analysis of Variance; Animals; Discrimination, Psychological; Disease Models, Animal; Ethanol; Femal | 2019 |
Effects of cannabidiol in males and females in two different rat models of depression.
Topics: Animals; Antidepressive Agents; Cannabidiol; Depressive Disorder; Disease Models, Animal; Female; Fo | 2019 |
Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Drug Adm | 2013 |
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Topics: Adenoviridae; alpha-Synuclein; Animals; Antiparkinson Agents; Conditioning, Operant; Disease Models, | 2013 |
A choice-based screening method for compulsive drug users in rats.
Topics: Animals; Choice Behavior; Cocaine; Compulsive Behavior; Conditioning, Operant; Disease Models, Anima | 2013 |
The comparison of sensitivity of motion sickness between retinal degeneration fast mice and normal mice.
Topics: Animals; Anorexia; Conditioning, Psychological; Disease Models, Animal; Drinking; Male; Mice; Motion | 2014 |
Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Basolateral Nuclear Complex; Cognition; Cognit | 2014 |
Ethological endophenotypes are altered by elevated stress hormone levels in both Huntington's disease and wildtype mice.
Topics: Animals; Anti-Inflammatory Agents; Corticosterone; Disease Models, Animal; Dose-Response Relationshi | 2014 |
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.
Topics: Adrenergic Agents; Amitriptyline; Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Fact | 2015 |
A mouse model for binge-like sucrose overconsumption: Contribution of enhanced motivation for sweetener consumption.
Topics: Animals; Binge-Eating Disorder; Body Weight; Bulimia; Dietary Sucrose; Disease Models, Animal; Food | 2015 |
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.
Topics: Animals; Behavior, Addictive; Calcium Channels; Cells, Cultured; Cocaine; Cocaine-Related Disorders; | 2015 |
Intragastric fat self-administration is impaired in GPR40/120 double knockout mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Fats; | 2015 |
Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression.
Topics: Aggression; Anhedonia; Animals; Anxiety Disorders; Brain; Chronic Disease; Depression, Postpartum; D | 2015 |
Enhanced flavor-nutrient conditioning in obese rats on a high-fat, high-carbohydrate choice diet.
Topics: Animal Feed; Animals; Choice Behavior; Conditioning, Psychological; Diet, High-Fat; Dietary Fats; Di | 2015 |
Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake.
Topics: Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Electric | 2016 |
Rats quit nicotine for a sweet reward following an extensive history of nicotine use.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Choice Behavior; Disease Models, Animal; Male; Nicot | 2017 |
Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping.
Topics: Animals; Antiemetics; Cannabinoids; Conditioning, Psychological; Disease Models, Animal; Dronabinol; | 2015 |
AVP modulation of the vestibular nucleus via V1b receptors potentially contributes to the development of motion sickness in rat.
Topics: Afferent Pathways; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Axonal | 2015 |
Modelling affective pain in mice: Effects of inflammatory hypersensitivity on place escape/avoidance behaviour, anxiety and hedonic state.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Avoidance Learning; Disease Models, Animal; Female | 2016 |
Prohedonic Effect of Cannabidiol in a Rat Model of Depression.
Topics: Analysis of Variance; Anhedonia; Animals; Antidepressive Agents; Anxiety; Cannabidiol; Depressive Di | 2016 |
Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Cytokines; Depression; Disease Models, Animal; Encep | 2016 |
The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Cues; Disease Models, Animal; Dose-Response Relati | 2016 |
Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Central Amygdaloid Nucleus; Corticotropin-Releasing Horm | 2016 |
Lithium-induced malaise does not interfere with adaptation of the hypothalamic-pituitary-adrenal axis to stress.
Topics: Adaptation, Physiological; Adrenocorticotropic Hormone; Animals; Antimanic Agents; Body Weight; Cort | 2017 |
Glutamatergic Projections from the Entorhinal Cortex to Dorsal Dentate Gyrus Mediate Context-Induced Reinstatement of Heroin Seeking.
Topics: Analgesics, Opioid; Animals; Dentate Gyrus; Disease Models, Animal; Drug-Seeking Behavior; Entorhina | 2017 |
Effects of food availability and administration of orexigenic and anorectic agents on elevated ethanol drinking associated with drinking in the dark procedures.
Topics: Alcohol Drinking; Alcoholism; Animals; Appetite Depressants; Appetite Stimulants; Darkness; Disease | 2008 |
Attenuation of high sweet solution preference by mood stabilizers: a possible mouse model for the increased reward-seeking domain of mania.
Topics: Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Conditioning, Operant; Disease Mo | 2009 |
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Conditioning, Operant; Disease Models, Animal; Ethanol | 2009 |
Taste, olfactory and trigeminal neophobia in rats with forebrain lesions.
Topics: Amygdala; Animals; Avoidance Learning; Capsaicin; Cerebral Cortex; Denervation; Disease Models, Anim | 2009 |
Findings of P300-like and CNV-like potentials in rat model of depression following repeatedly forced swim stress.
Topics: Analysis of Variance; Animals; Behavior, Animal; beta-Fructofuranosidase; Body Weight; Contingent Ne | 2009 |
Deficits in aversive but not in safe taste memory in the APPswe/PS1dE9 mice.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; A | 2009 |
Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure.
Topics: Animals; Choice Behavior; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination | 2009 |
Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder.
Topics: Amphetamine; Analysis of Variance; Animals; Anticonvulsants; Antimanic Agents; Behavior, Animal; Bip | 2010 |
It is darkness and not light: Depression-like behaviors of diurnal unstriped Nile grass rats maintained under a short photoperiod schedule.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Darkness; Depression; Disease Models, Animal; Male; | 2010 |
Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; CA3 Region, Hippocampal; Cyclohex | 2010 |
Modulation of the CRH system by substance P/NKA in an animal model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Carrier Proteins; Cerebral Cortex; Depressive Disorder; Diseas | 2010 |
Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.
Topics: Administration, Oral; Animals; Brain; Conditioning, Classical; Disease Models, Animal; Dose-Response | 2010 |
Derivation and characterization of replicate high- and low-alcohol preferring lines of mice and a high-drinking crossed HAP line.
Topics: Alcohol Drinking; Alleles; Animals; Choice Behavior; Crosses, Genetic; Disease Models, Animal; Ethan | 2011 |
Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol.
Topics: Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Animals; Choice Behavior; Disease Models, Anim | 2010 |
Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Breeding; Choice Behavior; Darkness; Disease Models, An | 2011 |
Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intake.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Op | 2011 |
Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice.
Topics: Alcohol Drinking; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female | 2011 |
Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse.
Topics: Animals; Behavior, Animal; Body Weight; Cocaine; Depression; Disease Models, Animal; Dopamine; Estro | 2011 |
Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes.
Topics: alpha-MSH; Animals; Anorexia; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Simultaneous conditioning of "gaping" responses and taste avoidance in rats injected with LiCl and saccharin: examining the role of context and taste cues in the rodent model of anticipatory nausea.
Topics: Animals; Anticipation, Psychological; Antimanic Agents; Avoidance Learning; Behavior, Animal; Condit | 2011 |
Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats.
Topics: Amygdala; Animals; Avoidance Learning; Cell-Penetrating Peptides; Conditioning, Classical; Condition | 2011 |
Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats.
Topics: Analysis of Variance; Animals; Antiemetics; Avoidance Learning; Conditioning, Classical; Disease Mod | 2012 |
Use of zinc as a treatment for traumatic brain injury in the rat: effects on cognitive and behavioral outcomes.
Topics: Anhedonia; Animals; Anxiety; Behavior, Animal; Brain Injuries; Cognition Disorders; Combined Modalit | 2012 |
Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease.
Topics: Action Potentials; Animals; Autoimmune Diseases; Basic Helix-Loop-Helix Transcription Factors; Cell | 2012 |
Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.
Topics: Alcohol Drinking; Analgesics, Non-Narcotic; Animals; Appetitive Behavior; Brain; Choice Behavior; Di | 2014 |
Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
Topics: Animals; Anxiety; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoids; Dis | 2013 |
A drug-paired taste cue elicits withdrawal and predicts cocaine self-administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Anim | 2013 |
A rat model of pre-puberty (juvenile) stress-induced predisposition to stress-related disorders: sex similarities and sex differences in effects and symptoms.
Topics: Age Factors; Anhedonia; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Fema | 2014 |
Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice.
Topics: Amphetamine-Related Disorders; Analysis of Variance; Animals; Association Learning; Behavior, Animal | 2014 |
Taste responsiveness and diet preference in autoimmune MRL mice.
Topics: Animals; Body Weight; Diet; Disease Models, Animal; Drinking; Eating; Food Preferences; Interleukin- | 2003 |
Risperidone reduces limited access alcohol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine D2 Rec | 2003 |
Effects of fusel oil on animal hangover models.
Topics: Alcohol Drinking; Alcoholic Beverages; Alcohols; Animals; Avoidance Learning; Conditioning, Classica | 2003 |
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.
Topics: Alcoholism; Alcohols; Animals; Body Weight; Carbolines; Conditioning, Operant; Disease Models, Anima | 2003 |
The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; E | 2004 |
Anxiety-like state associates with taste to produce conditioned taste aversion.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditio | 2004 |
Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions.
Topics: Analysis of Variance; Animals; Chronic Disease; Depression; Disease Models, Animal; Drinking Behavio | 2005 |
[Behavioral changes of rats under rotation stimulation].
Topics: Animals; Aversive Therapy; Behavior, Animal; Disease Models, Animal; Eating; Kaolin; Motion Sickness | 2005 |
Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats.
Topics: Alcohol Deterrents; Animals; Behavior, Addictive; Conditioning, Operant; Disease Models, Animal; Dos | 2008 |
Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats.
Topics: Alcoholism; Animals; Baclofen; Behavior, Animal; Choice Behavior; Disease Models, Animal; Ethanol; L | 2008 |
Development of altered taste preferences in tumor-bearing rats.
Topics: Animals; Disease Models, Animal; Food Preferences; Male; Methylcholanthrene; Neoplasm Transplantatio | 1994 |
Chronic mild stress-induced anhedonia: greater effect in a genetic rat model of depression.
Topics: Animals; Arousal; Depressive Disorder; Disease Models, Animal; Food Preferences; Male; Models, Genet | 1993 |
Revised CMS model.
Topics: Animals; Chronic Disease; Depressive Disorder; Disease Models, Animal; Eating; Environment; Rats; Sa | 1997 |
Withdrawal of presession saccharin suppresses food-maintained responding in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drinking; Feeding Behavior | 1998 |
Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat.
Topics: Alcoholism; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response | 1999 |
Delta-9-tetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: a rat model of nausea.
Topics: Animals; Antiemetics; Avoidance Learning; Behavior, Animal; Conditioning, Classical; Cyclophosphamid | 1999 |
Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Rats; Rats, Wistar; Saccharin | 2000 |
Waiting for a philosopher king: making cancer policy until certainty arrives.
Topics: Animals; Carcinogens, Environmental; Disease Models, Animal; Drug Evaluation, Preclinical; Environme | 1978 |
Saccharin--the bitter sweet.
Topics: Animals; Disease Models, Animal; Female; Humans; In Vitro Techniques; Legislation, Drug; Male; Rats; | 1977 |
Shifts in the water and alcohol solution intake by rats under conditions of schedule induction.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Disease Models, Animal; Drinking Behavior; Ethanol | 1976 |
Epidemiology and experimental toxicology--is there a meeting ground? Discussion paper.
Topics: Animals; Dioxins; Disease Models, Animal; Epidemiology; Formaldehyde; Humans; Nickel; Predictive Val | 1989 |
A rat model of alcoholism?
Topics: Acetone; Alcohol Drinking; Alcoholism; Animal Nutritional Physiological Phenomena; Animals; Conditio | 1972 |
Taste responsiveness, weight loss, and the ponderostat.
Topics: Animals; Body Weight; Dietary Fats; Disease Models, Animal; Drinking; Eating; Feeding Behavior; Food | 1973 |
Age-dependent polydipsia in the SWR-J mouse.
Topics: Aging; Animals; Circadian Rhythm; Diabetes Insipidus; Diabetic Nephropathies; Disease Models, Animal | 1974 |
Bait-shyness acquisition is impaired by VMH lesions that produce obesity.
Topics: Animal Nutritional Physiological Phenomena; Animals; Apomorphine; Avoidance Learning; Behavior, Anim | 1972 |
Physical dependence on and tolerance to alcohol in the rat.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Eth | 1971 |