saccharin has been researched along with Cocarcinogenesis in 32 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 7.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| " In contrast, nongenotoxic chemicals, such as chemicals causing urinary calculi or sodium saccharin and related sodium and potassium salts, frequently are carcinogenic only at high doses and/or only in specific species." | 4.79 | Human relevance of animal carcinogenicity studies. ( Cohen, SM, 1995) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 3.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| "Saccharin is known to have a tumor-promoting effect on bladder cancer in rats, but its mechanism of action is unknown." | 3.66 | Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens. ( Kakizoe, T; Kawachi, T; Komatsu, H; Niijima, T; Sugimura, T, 1981) |
| "A co-carcinogenicity experiment was conducted with female Sprague-Dawley rats in which the effects of short-term sodium saccharin dosing and initiation with a direct-acting carcinogen were examined in the urinary bladder." | 1.29 | Study of sodium saccharin co-carcinogenicity in the rat. ( Allen, RR; Gaylor, DW; Kadlubar, FF; Sheldon, WG; West, RW, 1994) |
| "Saccharin alone was not effective in inducing the growth of colonies in soft agar (anchorage-independent growth)." | 1.27 | Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts. ( Kadlubar, FF; Kumari, L; Lehman, TA; Milo, GE; Noyes, I; Oldham, JW; West, RW, 1988) |
| "Saccharin has been found to be a carcinogen only in rats and only if administered over two generations." | 1.27 | Saccharin: past, present, and future. ( Cohen, SM, 1986) |
| "Aspirin is an inhibitor of prostaglandin H synthase and has been shown to inhibit FANFT-induced bladder carcinogenesis when coadministered in the diet." | 1.27 | Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats. ( Cohen, SM; Hasegawa, R; Johansson, SL; Sakata, T; Zenser, TV, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (87.50) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pereira, MA | 1 |
| Herren, SL | 1 |
| Britt, AL | 1 |
| Lee, LS | 1 |
| Hicks, RM | 2 |
| Murasaki, G | 4 |
| Cohen, SM | 11 |
| Tsuda, H | 2 |
| Fukushima, S | 4 |
| Imaida, K | 1 |
| Kurata, Y | 1 |
| Ito, N | 4 |
| Nakanishi, K | 3 |
| Hagiwara, A | 1 |
| Tamano, S | 1 |
| El-Gerzawi, S | 1 |
| Heatfield, BM | 1 |
| Trump, BF | 1 |
| Greenfield, RE | 2 |
| Tatematsu, M | 1 |
| Friedell, GH | 1 |
| Jacobs, JB | 1 |
| Kakizoe, T | 1 |
| Komatsu, H | 1 |
| Niijima, T | 1 |
| Kawachi, T | 1 |
| Sugimura, T | 1 |
| Hirose, M | 1 |
| Ogiso, T | 1 |
| Hasegawa, R | 4 |
| Arai, M | 1 |
| Boynton, AL | 1 |
| Whitfield, JF | 1 |
| Theiss, JC | 1 |
| Arnold, LJ | 1 |
| Shimkin, MB | 1 |
| West, RW | 2 |
| Sheldon, WG | 1 |
| Gaylor, DW | 1 |
| Allen, RR | 1 |
| Kadlubar, FF | 2 |
| Marx, JL | 1 |
| Mondal, S | 1 |
| Brankow, DW | 1 |
| Heidelberger, C | 1 |
| Smith, RJ | 1 |
| Boyland, E | 2 |
| St John, MK | 1 |
| Zenser, TV | 2 |
| Knowles, MA | 1 |
| Jani, H | 1 |
| Milo, GE | 1 |
| Oldham, JW | 1 |
| Noyes, I | 1 |
| Lehman, TA | 1 |
| Kumari, L | 1 |
| Ellwein, LB | 1 |
| Sakata, T | 1 |
| Johansson, SL | 1 |
| Suzuki, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intestinal Sweet Taste Receptor Function and Adaptation to Dietary Sugars and Sweeteners[NCT02835859] | 10 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors[NCT03032640] | 102 participants (Actual) | Interventional | 2017-01-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for saccharin and Cocarcinogenesis
| Article | Year |
|---|---|
Promotion: is saccharin a promoter in the urinary bladder?
Topics: Animals; Carcinogens; Cell Membrane; Cocarcinogenesis; Enzyme Induction; Epithelium; Humans; Organ C | 1984 |
Promotion in bladder cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Cyclophosphamide; Humans; Hyperplasia; Mice; Neo | 1982 |
Human relevance of animal carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Disease Models, Animal; FAN | 1995 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
Saccharin and its salts.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cricetinae; Epidemiologic Studies; Female; Food Additives; G | 1999 |
28 other studies available for saccharin and Cocarcinogenesis
| Article | Year |
|---|---|
Effect of dibutylnitrosamine and saccharin on glutamyl transpeptidase-positive foci and liver cancer.
Topics: Animals; Cocarcinogenesis; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental | 1983 |
Inhibition of epidermal growth factor binding by phorbol esters, saccharin, and cyclamate and its implications in the mechanism of tumor promotion.
Topics: Carcinogens; Cocarcinogenesis; Cyclamates; Dose-Response Relationship, Drug; Epidermal Growth Factor | 1982 |
Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder.
Topics: Animals; Cocarcinogenesis; Diet; FANFT; Growth; Male; Neoplasms, Experimental; Rats; Saccharin; Thia | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Promotion in urinary bladder carcinogenesis.
Topics: Animals; Cell Division; Cocarcinogenesis; FANFT; Neoplasms, Experimental; Rats; Saccharin; Ulcer; Ur | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
N-Methyl-N-nitrosourea and saccharin: effects on epithelium of normal human urinary bladder in vitro.
Topics: Cocarcinogenesis; Culture Techniques; Epithelium; Humans; Hyperplasia; Methylnitrosourea; Nitrosoure | 1982 |
Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclophosphamide; FANFT; Hyperplasia; Male; Rats; Rats, In | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; FANFT; Male; Neoplasms, Experimental; Rats; | 1981 |
Maintenance by saccharin of membrane alterations of rat bladder cells induced by subcarcinogenic treatment with bladder carcinogens.
Topics: Animals; Butylhydroxybutylnitrosamine; Cell Aggregation; Cell Membrane; Cocarcinogenesis; Concanaval | 1981 |
Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Caffeine; Cocarcinogenesis; Male; Microscopy, Electron; Neopl | 1980 |
Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Calcium; Cell Cycle; Cells, Cultured; Cocarcinogenesis; DNA; Liver; Phenobarbital; Phorbol | 1980 |
Effect of commercial saccharin preparations on urethan-induced lung tumorigenesis in strain A mice.
Topics: Adenoma; Animals; Cocarcinogenesis; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Experimen | 1980 |
Study of sodium saccharin co-carcinogenicity in the rat.
Topics: Animals; Carcinogenicity Tests; Carcinoma, Transitional Cell; Cocarcinogenesis; Dose-Response Relati | 1994 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
Urinary bladder carcinogenesis: initiation-promotion.
Topics: Animals; Cocarcinogenesis; FANFT; Humans; Neoplasms, Experimental; Rats; Saccharin; Schistosomiasis; | 1979 |
Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Embryo, Mammalia | 1978 |
NAS saccharin report sweetens FDA position, but not by much.
Topics: Age Factors; Carcinogens; Cocarcinogenesis; Female; Humans; Male; Risk; Saccharin; United States; Un | 1978 |
Saccharin: from carcinogen to promoter.
Topics: Animals; Biotransformation; Cocarcinogenesis; Neoplasms, Experimental; Saccharin; Urinary Bladder Ne | 1979 |
Evaluation of nitrofurantoin on the two stages of urinary bladder carcinogenesis in the rat.
Topics: Administration, Oral; Animals; Autoradiography; Benzidines; Body Weight; Cocarcinogenesis; FANFT; Ma | 1990 |
Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclamates; Epithelium; Femal | 1986 |
Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts.
Topics: Antigens, Neoplasm; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Ethylnitroso | 1988 |
A cellular dynamics model of experimental bladder cancer: analysis of the effect of sodium saccharin in the rat.
Topics: Animals; Cell Survival; Cocarcinogenesis; Computer Simulation; FANFT; Mitosis; Models, Biological; N | 1988 |
Estimation of acceptable levels of tumour promoters.
Topics: Animals; Carcinogens; Cocarcinogenesis; Humans; Maximum Allowable Concentration; Rats; Risk; Sacchar | 1987 |
Saccharin: past, present, and future.
Topics: Animals; Chemical Phenomena; Chemistry; Cocarcinogenesis; Humans; Rats; Risk; Saccharin; Urinary Bla | 1986 |
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats.
Topics: Animals; Aspirin; Body Weight; Cocarcinogenesis; FANFT; Hydrogen-Ion Concentration; Male; Rats; Rats | 1986 |
Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Freezing; Hyperplasia; Male; Rats; Rats, In | 1985 |