saccharin has been researched along with Cocaine-Related Disorders in 24 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Saccharin was paired with one of three doses of non-contingent IV cocaine (0, 1, 3, 5 mg/kg) over five taste-drug pairings." | 1.31 | Conditioned saccharin aversion induced by self-administered cocaine negatively correlates with the rate of cocaine self-administration in rats. ( Gomez, F, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 15 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Steiner, N | 1 |
| Rossetti, C | 1 |
| Sakurai, T | 1 |
| Yanagisawa, M | 1 |
| de Lecea, L | 1 |
| Magistretti, PJ | 1 |
| Halfon, O | 1 |
| Boutrel, B | 1 |
| Haake, RM | 1 |
| West, EA | 1 |
| Wang, X | 1 |
| Carelli, RM | 1 |
| Cason, AM | 1 |
| Grigson, PS | 5 |
| Holtz, NA | 2 |
| Anker, JJ | 4 |
| Regier, PS | 1 |
| Claxton, A | 1 |
| Carroll, ME | 8 |
| Schank, JR | 1 |
| King, CE | 1 |
| Sun, H | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
| Heilig, M | 1 |
| Weinshenker, D | 1 |
| Schroeder, JP | 1 |
| Vanhille, N | 2 |
| Belin-Rauscent, A | 1 |
| Mar, AC | 1 |
| Ducret, E | 1 |
| Belin, D | 1 |
| Shimamoto, A | 1 |
| Holly, EN | 2 |
| Boyson, CO | 2 |
| DeBold, JF | 2 |
| Miczek, KA | 2 |
| Freet, CS | 2 |
| Ballard, SM | 1 |
| Alexander, DN | 1 |
| Cox, TA | 1 |
| Imperio, CG | 1 |
| Anosike, N | 1 |
| Carter, AB | 1 |
| Mahmoud, S | 1 |
| Ruiz-Velasco, V | 1 |
| Burke, AR | 1 |
| Montagud-Romero, S | 1 |
| Gliddon, LA | 2 |
| Steffen, C | 1 |
| Nestler, EJ | 1 |
| Zlebnik, NE | 1 |
| Cantin, L | 1 |
| Lenoir, M | 1 |
| Augier, E | 2 |
| Dubreucq, S | 1 |
| Serre, F | 1 |
| Vouillac, C | 2 |
| Ahmed, SH | 2 |
| Puhl, MD | 1 |
| Blum, JS | 1 |
| Acosta-Torres, S | 1 |
| Nyland, JE | 1 |
| Gomez, F | 1 |
| Morgan, AD | 2 |
| Dess, NK | 1 |
| Perry, JL | 2 |
| Anderson, MM | 2 |
| Nelson, SE | 2 |
| Davis, CM | 1 |
| Riley, AL | 1 |
| Schenk, S | 1 |
24 other studies available for saccharin and Cocaine-Related Disorders
| Article | Year |
|---|---|
Hypocretin/orexin deficiency decreases cocaine abuse liability.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, | 2018 |
Drug-induced dysphoria is enhanced following prolonged cocaine abstinence and dynamically tracked by nucleus accumbens neurons.
Topics: Affect; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug-Seeking Behavi | 2019 |
Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Drug Adm | 2013 |
Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex.
Topics: Animals; Behavior, Animal; Choice Behavior; Cocaine; Cocaine-Related Disorders; Female; Histamine; I | 2013 |
The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alcohol-Related Disorders; Animals; Behavior, Addictive; Br | 2014 |
High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction.
Topics: Animals; Animals, Inbred Strains; Behavior, Addictive; Choice Behavior; Cocaine; Cocaine-Related Dis | 2015 |
Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Depressive Disorder, Major; Dopamine; Female; Individua | 2015 |
Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.
Topics: Animals; Behavior, Addictive; Calcium Channels; Cells, Cultured; Cocaine; Cocaine-Related Disorders; | 2015 |
Maladaptive choices by defeated rats: link between rapid approach to social threat and escalated cocaine self-administration.
Topics: Aggression; Animals; Behavior, Animal; Choice Behavior; Cocaine; Cocaine-Related Disorders; Corticos | 2016 |
Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Feeding Behavior; Fem | 2008 |
Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice.
Topics: Analysis of Variance; Animals; Antimanic Agents; Cocaine; Cocaine-Related Disorders; Conditioning, O | 2009 |
Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure.
Topics: Animals; Choice Behavior; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination | 2009 |
Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction.
Topics: Animals; Behavior, Addictive; Choice Behavior; Cocaine; Cocaine-Related Disorders; Male; Rats; Rats, | 2010 |
Adolescent nicotine exposure sensitizes cue-induced reinstatement of cocaine seeking in rats bred for high and low saccharin intake.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Op | 2011 |
Diazepam promotes choice of abstinence in cocaine self-administering rats.
Topics: Administration, Cutaneous; Animals; Anti-Anxiety Agents; Behavior, Animal; Choice Behavior; Cocaine; | 2012 |
Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue.
Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Cues; Environment; Male; Rats; Rats, Sprague-Daw | 2012 |
A drug-paired taste cue elicits withdrawal and predicts cocaine self-administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Anim | 2013 |
Escalation of i.v. cocaine intake in peri-adolescent vs. adult rats selectively bred for high (HiS) vs. low (LoS) saccharin intake.
Topics: Age Factors; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Fem | 2013 |
Conditioned saccharin aversion induced by self-administered cocaine negatively correlates with the rate of cocaine self-administration in rats.
Topics: Animals; Avoidance Learning; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Re | 2002 |
Escalation of intravenous cocaine self-administration, progressive-ratio performance, and reinstatement in rats selectively bred for high (HiS) and low (LoS) saccharin intake.
Topics: Animals; Behavior, Addictive; Breeding; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; D | 2005 |
Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.
Topics: Aging; Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretat | 2007 |
Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Eating; Female; Food Preferences; Impulsive Behavior; M | 2007 |
The effects of cocaine preexposure on cocaine-induced taste aversion learning in Fischer and Lewis rat strains.
Topics: Animals; Avoidance Learning; Cocaine; Cocaine-Related Disorders; Genotype; Male; Rats; Rats, Inbred | 2007 |
Effects of the serotonin 5-HT(2) antagonist, ritanserin, and the serotonin 5-HT(1A) antagonist, WAY 100635, on cocaine-seeking in rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Mal | 2000 |