saccharin has been researched along with Chronic Disease in 21 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice." | 7.96 | Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. ( Derer, S; Ibrahim, SM; Künstner, A; Pagel, R; Rupp, J; Sina, C; Sünderhauf, A; Wagner, AE, 2020) |
| " Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modulating properties, we hypothesized oral saccharin intake to influence intestinal inflammation and aimed at delineating its effect on acute and chronic colitis activity in mice." | 3.96 | Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. ( Derer, S; Ibrahim, SM; Künstner, A; Pagel, R; Rupp, J; Sina, C; Sünderhauf, A; Wagner, AE, 2020) |
| " Saccharin-based anhedonia and maternal aggression were increased and lactation was also impaired on day 16 of lactation." | 3.81 | Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression. ( Babb, JA; Bradburn, S; Carini, LM; Murgatroyd, CA; Nephew, BC; Taliefar, M, 2015) |
| " Our results indicate that intermittent and daily SDS procedures attenuated body weight gain, induced adrenal hypertrophy, and reduced the preference for saccharin, a sweet solution preferred by normal rats." | 3.77 | 5-HT1B mRNA expression after chronic social stress. ( Furay, AR; McDevitt, RA; Miczek, KA; Neumaier, JF, 2011) |
| " Saccharine tests performed prior to and after the catheterization in patients with acute and chronic sinusitis confirmed inhibition of transport function of nasal ciliated epithelium (TF) in these affections." | 3.69 | [Impact of controlled pressure on ciliary transport in the nasal epithelium]. ( Derzhavina, LL; Kozlov, VS, 1997) |
| "The saccharin test is a simple, cost-effective, and valuable diagnostic tool to assess the mucociliary function of the ET." | 1.35 | Assessment of eustachian tube function in tympanoplasty. ( Hegde, MC; Meyappan, H; Prasad, KC; Prasad, SC, 2009) |
| "A saccharin transit test was performed before and after the operation for each subject." | 1.33 | Mucosal healing and mucociliary transport change after endoscopic sinus surgery in children with chronic maxillary sinusitis. ( Cheng, JJ; Huang, HM; Lin, KN; Liu, CM, 2006) |
| "A saccharin/charcoal test was performed in 20 children treated with radiotherapy of the head and in 20 controls, age-matched and gender-matched." | 1.31 | Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer. ( Conti, V; Lucarelli, A; Mappa, L; Muggeo, P; Muggeo, V; Novielli, C; Rigillo, N; Surico, G, 2001) |
| "Chronic rhinitis is the manifestation of a heterogeneous group of disease entities and often proves difficult to manage successfully." | 1.30 | Assessment of mucociliary transport in patients with chronic mucoid rhinitis. ( Anderson, P; Boivin, CM; Drake-Lee, AB; Prior, MJ; Schofield, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Chitsuthipakorn, W | 1 |
| Kanjanawasee, D | 1 |
| Hoang, MP | 1 |
| Seresirikachorn, K | 1 |
| Snidvongs, K | 1 |
| Sünderhauf, A | 1 |
| Pagel, R | 1 |
| Künstner, A | 1 |
| Wagner, AE | 1 |
| Rupp, J | 1 |
| Ibrahim, SM | 1 |
| Derer, S | 1 |
| Sina, C | 1 |
| Kurtgöz, S | 1 |
| Kökten, N | 1 |
| Tekin, M | 1 |
| Murgatroyd, CA | 1 |
| Taliefar, M | 1 |
| Bradburn, S | 1 |
| Carini, LM | 1 |
| Babb, JA | 1 |
| Nephew, BC | 1 |
| Ikehata, M | 1 |
| Ohta, S | 1 |
| Mishiro, Y | 1 |
| Katsura, H | 1 |
| Miuchi, S | 1 |
| Tsuzuki, K | 1 |
| Sakagami, M | 1 |
| Schweizer, MC | 1 |
| Henniger, MS | 1 |
| Sillaber, I | 1 |
| Prasad, KC | 1 |
| Hegde, MC | 1 |
| Prasad, SC | 1 |
| Meyappan, H | 1 |
| Furay, AR | 1 |
| McDevitt, RA | 1 |
| Miczek, KA | 1 |
| Neumaier, JF | 1 |
| Kubuschok, B | 1 |
| Xie, X | 1 |
| Jesnowski, R | 1 |
| Preuss, KD | 1 |
| Romeike, BF | 1 |
| Neumann, F | 1 |
| Regitz, E | 1 |
| Pistorius, G | 1 |
| Schilling, M | 1 |
| Scheunemann, P | 1 |
| Izbicki, JR | 1 |
| Löhr, JM | 1 |
| Pfreundschuh, M | 1 |
| Grønli, J | 1 |
| Murison, R | 1 |
| Fiske, E | 1 |
| Bjorvatn, B | 1 |
| Sørensen, E | 1 |
| Portas, CM | 1 |
| Ursin, R | 1 |
| Huang, HM | 1 |
| Cheng, JJ | 1 |
| Liu, CM | 1 |
| Lin, KN | 1 |
| Lindberg, S | 1 |
| Cervin, A | 1 |
| Runer, T | 1 |
| Kozlov, VS | 1 |
| Derzhavina, LL | 1 |
| Hagan, JJ | 1 |
| Hatcher, JP | 1 |
| Prior, MJ | 1 |
| Schofield, K | 1 |
| Boivin, CM | 1 |
| Anderson, P | 1 |
| Drake-Lee, AB | 1 |
| Asai, K | 1 |
| Haruna, S | 1 |
| Otori, N | 1 |
| Yanagi, K | 1 |
| Fukami, M | 1 |
| Moriyama, H | 1 |
| Surico, G | 1 |
| Muggeo, P | 1 |
| Mappa, L | 1 |
| Muggeo, V | 1 |
| Conti, V | 1 |
| Lucarelli, A | 1 |
| Novielli, C | 1 |
| Rigillo, N | 1 |
| Hadas, E | 1 |
| Sadé, J | 1 |
| Giménez Vaíllo, F | 1 |
| Marco Algarra, J | 1 |
| Del Campo Biosca, J | 1 |
| Deitmer, T | 1 |
| Brookshire, KH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?[NCT01239199] | 86 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for saccharin and Chronic Disease
| Article | Year |
|---|---|
Benefits of nasal saline treatment in acute rhinosinusitis: Systematic review and meta-analysis.
Topics: Acute Disease; Adult; Chronic Disease; Humans; Quality of Life; Rhinitis; Saccharin; Saline Solution | 2022 |
20 other studies available for saccharin and Chronic Disease
| Article | Year |
|---|---|
Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice.
Topics: Acute Disease; Administration, Oral; Animals; Bacillus cereus; Chronic Disease; Colitis; Dextran Sul | 2020 |
Assessment of nasal airway resistances and nasal mucociliary activities of patients with unilateral chronic otitis media by acoustic rhinometry and saccharin test.
Topics: Adult; Airway Resistance; Case-Control Studies; Chronic Disease; Female; Humans; Male; Middle Aged; | 2014 |
Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression.
Topics: Aggression; Anhedonia; Animals; Anxiety Disorders; Brain; Chronic Disease; Depression, Postpartum; D | 2015 |
Usefulness of the Saccharin Test for Assessment of Eustachian Tube Function in Patients With Chronic Otitis Media With Perforation.
Topics: Adult; Chronic Disease; Diagnostic Techniques, Otological; Ear, Middle; Eustachian Tube; Female; Hum | 2017 |
Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity.
Topics: Animals; Anxiety; Body Weight; Chronic Disease; Consummatory Behavior; Drinking Behavior; Light; Mal | 2009 |
Assessment of eustachian tube function in tympanoplasty.
Topics: Adolescent; Adult; Chronic Disease; Endoscopy; Eustachian Tube; Female; Humans; Male; Methylene Blue | 2009 |
5-HT1B mRNA expression after chronic social stress.
Topics: Adrenal Glands; Anhedonia; Animals; Chronic Disease; Corpus Striatum; Eating; In Situ Hybridization; | 2011 |
Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis.
Topics: Acetaminophen; Adenocarcinoma; Antigens, Neoplasm; Chronic Disease; DNA-Binding Proteins; Female; Ge | 2004 |
Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions.
Topics: Analysis of Variance; Animals; Chronic Disease; Depression; Disease Models, Animal; Drinking Behavio | 2005 |
Mucosal healing and mucociliary transport change after endoscopic sinus surgery in children with chronic maxillary sinusitis.
Topics: Adolescent; Case-Control Studies; Child; Chronic Disease; Cilia; Endoscopy; Goblet Cells; Humans; Ma | 2006 |
Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways.
Topics: Chronic Disease; Humans; Mucociliary Clearance; Nasal Mucosa; Nitric Oxide; Respiratory Tract Infect | 1997 |
[Impact of controlled pressure on ciliary transport in the nasal epithelium].
Topics: Adolescent; Adult; Chronic Disease; Epithelium; Female; Humans; Male; Middle Aged; Mucociliary Clear | 1997 |
Revised CMS model.
Topics: Animals; Chronic Disease; Depressive Disorder; Disease Models, Animal; Eating; Environment; Rats; Sa | 1997 |
Assessment of mucociliary transport in patients with chronic mucoid rhinitis.
Topics: Chronic Disease; Humans; Kartagener Syndrome; Mucociliary Clearance; Mucus; Nasal Mucosa; Radiopharm | 1999 |
Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery.
Topics: Adolescent; Adult; Aged; Carbon; Chronic Disease; Coloring Agents; Endoscopy; Female; Humans; Male; | 2000 |
Impairment of nasal mucociliary clearance after radiotherapy for childhood head cancer.
Topics: Administration, Intranasal; Adolescent; Case-Control Studies; Charcoal; Child; Child, Preschool; Chr | 2001 |
Clearance by the mucociliary system in 'simple chronic otitis media'.
Topics: Chronic Disease; Cilia; Ear, Middle; Humans; Mucous Membrane; Otitis Media; Otitis Media, Suppurativ | 1979 |
[Prognostic value of tubo-tympanic mucociliary clearance in surgery of chronic otitis media].
Topics: Adolescent; Adult; Child; Chronic Disease; Ear, Middle; Eustachian Tube; Female; Humans; Male; Middl | 1991 |
A modification of the saccharine test for nasal mucociliary clearance.
Topics: Animals; Anion Exchange Resins; Chronic Disease; Ciliary Motility Disorders; Common Cold; Dogs; Huma | 1986 |
Changes in the rats preference for saccharin and sodium chloride solutions following injection of alloxan monohydrate.
Topics: Age Factors; Alloxan; Animals; Appetite; Avoidance Learning; Blood Glucose; Body Weight; Chronic Dis | 1974 |