Compounds > saccharin
Page last updated: 2024-11-04

saccharin and Chemical Dependence

saccharin has been researched along with Chemical Dependence in 16 studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Research Excerpts

ExcerptRelevanceReference
"saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature."2.44Selective breeding for differential saccharin intake as an animal model of drug abuse. ( Anker, JJ; Carroll, ME; Dess, NK; Morgan, AD; Perry, JL, 2008)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's3 (18.75)18.2507
2000's5 (31.25)29.6817
2010's2 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Radke, AK1
Zlebnik, NE2
Holtz, NA2
Carroll, ME4
Mierzejewski, P1
Olczak, M1
Rogowski, A1
Kostowski, W1
Samochowiec, J1
Filip, M1
Przegalinski, E1
Bienkowski, P1
Morgan, AD1
Anker, JJ1
Perry, JL1
Dess, NK1
Foynes, MM1
Riley, AL2
Roma, PG1
Flint, WW1
Higley, JD1
Lenoir, M1
Serre, F1
Cantin, L1
Ahmed, SH1
Comer, SD1
Hunt, VR1
Rudski, J1
Gurmankin, C1
Tang, M1
Falk, JL3
Samson, HH2
Chan, AW1
Langan, MC1
Leong, FW1
Penetrante, ML1
Schanley, DL1
LeBlanc, AE1
Cappell, H1
Guy-Grand, B1
Dorf, G1
Duchier, J1
Aimez, P1
Cicero, TJ1
Snider, SR1
Perez, VJ1
Swanson, LW1

Reviews

2 reviews available for saccharin and Chemical Dependence

ArticleYear
Selective breeding for differential saccharin intake as an animal model of drug abuse.
    Behavioural pharmacology, 2008, Volume: 19, Issue:5-6

    Topics: Alcoholism; Animals; Arousal; Disease Models, Animal; Female; Genotype; Male; Mice; Mice, Inbred Str

2008
Schedule-induced physical dependence on ethanol.
    Pharmacological reviews, 1975, Volume: 27, Issue:4

    Topics: Alcohol Drinking; Animals; Disease Models, Animal; Drinking Behavior; Drug Administration Schedule;

1975

Other Studies

14 other studies available for saccharin and Chemical Dependence

ArticleYear
Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake.
    Behavioural pharmacology, 2016, Volume: 27, Issue:2-3 Spec I

    Topics: Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Electric

2016
Effects of cycloheximide on extinction in an appetitively motivated operant conditioning task depend on re-exposure duration.
    Neuroscience letters, 2008, Aug-29, Volume: 441, Issue:3

    Topics: Animals; Appetitive Behavior; Conditioning, Operant; Cues; Cycloheximide; Extinction, Psychological;

2008
Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake.
    Neuroscience letters, 2012, Jul-26, Volume: 522, Issue:1

    Topics: Animals; Breeding; Cell Count; Cocaine; Female; Food Preferences; Hypothalamus; Intracellular Signal

2012
Lithium-chloride-induced conditioned taste aversions in the Lewis and Fischer 344 rat strains.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2

    Topics: Animals; Cocaine; Conditioning, Psychological; Female; Lithium Chloride; Morphine; Rats; Rats, Inbre

2004
Assessment of the aversive and rewarding effects of alcohol in Fischer and Lewis rats.
    Psychopharmacology, 2006, Volume: 189, Issue:2

    Topics: Alcohol Drinking; Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Central Nervous S

2006
Intense sweetness surpasses cocaine reward.
    PloS one, 2007, Aug-01, Volume: 2, Issue:8

    Topics: Animals; Cocaine; Conditioning, Operant; Corpus Striatum; Diet; Dopamine; Dopamine Uptake Inhibitors

2007
Effects of concurrent saccharin availability and buprenorphine pretreatment on demand for smoked cocaine base in rhesus monkeys.
    Psychopharmacology, 1994, Volume: 115, Issue:1-2

    Topics: Animals; Buprenorphine; Conditioning, Operant; Crack Cocaine; Injections, Intramuscular; Macaca mula

1994
Withdrawal of presession saccharin suppresses food-maintained responding in rats.
    Perceptual and motor skills, 1998, Volume: 86, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drinking; Feeding Behavior

1998
Ethanol dependence as a determinant of fluid preference.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 7, Issue:5

    Topics: Animals; Ethanol; Food Preferences; Glucose; Humans; Male; Rats; Saccharin; Sodium Chloride; Substan

1977
Partial cross-dependence on ethanol in mice dependent on chlordiazepoxide.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:2

    Topics: Animals; Chlordiazepoxide; Ethanol; Flumazenil; Generalization, Stimulus; Male; Mice; Mice, Inbred C

1990
Attenuation of punishing effects of morphine and amphetamine by chronic prior treatment.
    Journal of comparative and physiological psychology, 1974, Volume: 87, Issue:4

    Topics: Amphetamine; Animals; Avoidance Learning; Conditioning, Psychological; Drug Tolerance; Humans; Male;

1974
Alteration of fluid preference in ethanol-dependent animals.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 190, Issue:2

    Topics: Animals; Body Weight; Diet; Drinking Behavior; Ethanol; Glucose; Humans; Male; Rats; Saccharin; Subs

1974
[Dietetics and nutrition in 1972].
    La Revue du praticien, 1972, Feb-21, Volume: 22, Issue:6

    Topics: Adipose Tissue; Alcoholic Intoxication; Anorexia Nervosa; Caffeine; Calcium; Catecholamines; Coffee;

1972
Physical dependence on and tolerance to alcohol in the rat.
    Physiology & behavior, 1971, Volume: 6, Issue:2

    Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Eth

1971