saccharin has been researched along with Cell Transformation, Neoplastic in 13 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Saccharin is a known promoter of cell transformation in C3H/10T1/2 cell cultures, but unlike 12-O-tetradecanoylphorbol 13-acetate (TPA) or mezerein, PLF mRNA abundance increases were inconsistently detected following simple addition of saccharin to the culture medium." | 1.32 | Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation. ( Parfett, CL, 2003) |
| "The ANFT-treated cells followed by control medium or urea and cells treated with ANFT, NaS and urea were tumorigenic when transplanted to nude mice, whereas NaS or ANFT followed by NaS treatment were not." | 1.28 | In vitro transformation of rat bladder epithelium by 2-amino-4-(5-nitro-2-furyl)thiazole. ( Borgeson, CD; Chlapowski, FJ; Cohen, SM; Mann, AM; Masui, T; Okamura, T, 1991) |
| "The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has already led to a greater knowledge of its pathogenesis." | 1.27 | Modifying factors in urinary bladder carcinogenesis. ( Fukushima, S; Hasegawa, R; Imaida, K; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| "Saccharin alone was not effective in inducing the growth of colonies in soft agar (anchorage-independent growth)." | 1.27 | Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts. ( Kadlubar, FF; Kumari, L; Lehman, TA; Milo, GE; Noyes, I; Oldham, JW; West, RW, 1988) |
| "The BALB/c-3T3 cell neoplastic transformation system was modified to examine the tumor promoting activity of a set of substances." | 1.26 | Cell culture tumor promotion experiments with saccharin, phorbol myristate acetate and several common food materials. ( Sivak, A; Tu, AS, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parfett, CL | 1 |
| Greenfield, RE | 1 |
| Ellwein, LB | 1 |
| Cohen, SM | 2 |
| Ito, N | 1 |
| Fukushima, S | 1 |
| Shirai, T | 1 |
| Nakanishi, K | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Miska, D | 1 |
| Bosmann, HB | 1 |
| Sivak, A | 1 |
| Tu, AS | 1 |
| Marx, JL | 1 |
| Ashby, J | 1 |
| Styles, JA | 1 |
| Anderson, D | 1 |
| Paton, D | 1 |
| Saxholm, HJ | 1 |
| Iversen, OH | 1 |
| Reith, A | 1 |
| Brøgger, A | 1 |
| Mondal, S | 1 |
| Brankow, DW | 1 |
| Heidelberger, C | 1 |
| Mann, AM | 1 |
| Masui, T | 1 |
| Chlapowski, FJ | 1 |
| Okamura, T | 1 |
| Borgeson, CD | 1 |
| Knowles, MA | 1 |
| Jani, H | 1 |
| Milo, GE | 1 |
| Oldham, JW | 1 |
| Noyes, I | 1 |
| Lehman, TA | 1 |
| Kumari, L | 1 |
| West, RW | 1 |
| Kadlubar, FF | 1 |
| Bertram, JS | 1 |
1 review available for saccharin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Neoplastic transformation in cell cultures: in-vitro/in-vivo correlations.
Topics: Animals; Antigens, Neoplasm; Ascorbic Acid; Biotransformation; Calcium; Carcinogens; Cell Adhesion; | 1985 |
12 other studies available for saccharin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, | 2003 |
A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; FANFT; Mathematics; Mitosis; Models, Biologica | 1984 |
Modifying factors in urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Cell Transformation, Neoplastic; Neoplasms, Expe | 1983 |
Resting state depth and saturation density as modulated by tumor promoters and culture conditions: relationship to chemical transformation in C3H/10T1/2 cells.
Topics: Animals; Carcinogens; Cell Count; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Mice; Mice | 1982 |
Cell culture tumor promotion experiments with saccharin, phorbol myristate acetate and several common food materials.
Topics: Animals; Ascorbic Acid; Cell Transformation, Neoplastic; Cells, Cultured; Mice; Pantothenic Acid; Ph | 1980 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
Saccharin: an epigenetic carcinogen/mutagen?
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; DNA, Neoplasm; Genotype; Mutagens; Saccharin; | 1978 |
Carcinogenesis testing of saccharin. No transformation or increased sister chromatid exchange observed in two mammalian cell systems.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Crossing Over, Genetic; Drug | 1979 |
Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin.
Topics: Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Embryo, Mammalia | 1978 |
In vitro transformation of rat bladder epithelium by 2-amino-4-(5-nitro-2-furyl)thiazole.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Synergism; Epithelial C | 1991 |
Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclamates; Epithelium; Femal | 1986 |
Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts.
Topics: Antigens, Neoplasm; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Ethylnitroso | 1988 |