saccharin has been researched along with Carcinoma, Transitional Cell in 12 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 7.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| "Protein and DNA were extracted from 89 bladder tumors [87 transitional cell carcinomas (TCC), 1 papilloma, and 1 sarcoma] from 86 rats p21 expression was examined by Western blotting using a monoclonal antibody against p21 (NCC-RAS-004)." | 5.28 | H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. ( Cohen, SM; Fujii, H; Garland, EM; Macatee, TL; Mann, AM; Masui, T; Okamura, T; Pelling, JC, 1991) |
| "Sodium saccharin was previously shown to induce a significant incidence of transitional cell carcinoma of the bladder when administered to rats either immediately or beginning 2 weeks after ulceration of the bladder epithelium induced by freezing or cyclophosphamide injection." | 3.67 | Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. ( Cohen, SM; Greenfield, RE; Hasegawa, R; Murasaki, G; Suzuki, T, 1985) |
| "A co-carcinogenicity experiment was conducted with female Sprague-Dawley rats in which the effects of short-term sodium saccharin dosing and initiation with a direct-acting carcinogen were examined in the urinary bladder." | 1.29 | Study of sodium saccharin co-carcinogenicity in the rat. ( Allen, RR; Gaylor, DW; Kadlubar, FF; Sheldon, WG; West, RW, 1994) |
| "Protein and DNA were extracted from 89 bladder tumors [87 transitional cell carcinomas (TCC), 1 papilloma, and 1 sarcoma] from 86 rats p21 expression was examined by Western blotting using a monoclonal antibody against p21 (NCC-RAS-004)." | 1.28 | H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. ( Cohen, SM; Fujii, H; Garland, EM; Macatee, TL; Mann, AM; Masui, T; Okamura, T; Pelling, JC, 1991) |
| "The relationship between bladder cancer and alcohol consumption was investigated in a case-control study conducted in 506 patients (453 males and 53 females) with diagnoses of papillary urothelial carcinoma during 1978-1982 at "La Paz" hospital (Madrid), and an equal number of controls matched for age, sex and date of admission to the hospital." | 1.27 | Bladder cancer and the consumption of alcoholic beverages in Spain. ( Bravo, MP; Conde, M; Del Rey Calero, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andreatta, MM | 1 |
| Muñoz, SE | 1 |
| Lantieri, MJ | 1 |
| Eynard, AR | 1 |
| Navarro, A | 1 |
| Fukushima, S | 1 |
| Friedell, GH | 1 |
| Jacobs, JB | 1 |
| Cohen, SM | 4 |
| Masui, T | 2 |
| Mann, AM | 2 |
| Borgeson, CD | 1 |
| Garland, EM | 2 |
| Okamura, T | 2 |
| Fujii, H | 2 |
| Pelling, JC | 2 |
| West, RW | 1 |
| Sheldon, WG | 1 |
| Gaylor, DW | 1 |
| Allen, RR | 1 |
| Kadlubar, FF | 1 |
| Morimoto, S | 1 |
| Hicks, RM | 2 |
| Chowaniec, J | 2 |
| Armstrong, B | 1 |
| Garrod, A | 1 |
| Doll, R | 1 |
| Macatee, TL | 1 |
| Bittard, M | 1 |
| Bravo, MP | 1 |
| Del Rey Calero, J | 1 |
| Conde, M | 1 |
| Hasegawa, R | 1 |
| Greenfield, RE | 1 |
| Murasaki, G | 1 |
| Suzuki, T | 1 |
| Wakefield, JS | 1 |
1 review available for saccharin and Carcinoma, Transitional Cell
| Article | Year |
|---|---|
[Prognosis of primary tumors of the bladder].
Topics: Aged; Alkylating Agents; Amines; Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Clofi | 1985 |
11 other studies available for saccharin and Carcinoma, Transitional Cell
| Article | Year |
|---|---|
Artificial sweetener consumption and urinary tract tumors in Cordoba, Argentina.
Topics: Aged; Argentina; Aspartame; Carcinoma, Transitional Cell; Case-Control Studies; Cyclamates; Female; | 2008 |
Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; FANFT; Male; Neoplasms, Experimental; Rats; | 1981 |
Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Transitional Cell; Codon; DNA Primers; DNA, | 1993 |
Study of sodium saccharin co-carcinogenicity in the rat.
Topics: Animals; Carcinogenicity Tests; Carcinoma, Transitional Cell; Cocarcinogenesis; Dose-Response Relati | 1994 |
Alteration of intercellular communication in a human urothelial carcinoma cell-line by tumor-promoting agents.
Topics: Adult; Anticonvulsants; Antioxidants; Butylated Hydroxyanisole; Carcinogens; Carcinoma, Transitional | 1996 |
The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
Topics: 2-Naphthylamine; Animals; Carcinogens; Carcinogens, Environmental; Carcinoma, Transitional Cell; Cyc | 1977 |
A retrospective study of renal cancer with special reference to coffee and animal protein consumption.
Topics: Adenocarcinoma; Adult; Aged; Analgesics; Carcinoma, Transitional Cell; Coffee; Dietary Proteins; Eng | 1976 |
H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.
Topics: Animals; Ascorbic Acid; Base Sequence; Blotting, Western; Carcinogens; Carcinoma; Carcinoma, Transit | 1991 |
Bladder cancer and the consumption of alcoholic beverages in Spain.
Topics: Age Factors; Aged; Alcohol Drinking; Carcinoma, Transitional Cell; Cyclamates; Epidemiologic Methods | 1987 |
Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Freezing; Hyperplasia; Male; Rats; Rats, In | 1985 |
Letter: Co-carcinogenic action of saccharin in the chemical induction of bladder cancer.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Hyperplasia; N | 1973 |