saccharin and Body Weight studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

Excerpt	Relevance	Reference
" Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1."	9.30	A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019)
"Chronic social defeat stress for 21 days induced physiological and behavioral depression-relevant deficits and blunted response of dopaminergic and to some extent, serotonergic neurons to cocaine challenge in females."	7.77	Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. ( Debold, JF; Holly, EN; Miczek, KA; Shimamoto, A, 2011)
"We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates."	7.76	Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. ( Bura, SA; Burokas, A; Maldonado, R; Martín-García, E, 2010)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."	7.75	We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
"Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression."	7.73	Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. ( Berry, KJ; Cisneros, FJ; Ferguson, SA; Gough, B; Hanig, JP, 2005)
"Melatonin-treated rats that were then crossed over to control treatment for a further 12 weeks gained BW, whereas control rats that were crossed to melatonin treatment lost BW, but food intake did not change in either group."	5.31	Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. ( Matsumoto, AM; McCants, RL; Mitton, DR; Rasmussen, DD; Wilkinson, CW; Wolden-Hanson, T; Yellon, SM, 2000)
" Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1."	5.30	A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. ( Higgins, KA; Mattes, RD, 2019)
"To elucidate if artificial sweeteners modify fecal bacterial composition and the fecal and plasma metabolomes, Wistar rats from both sexes were treated for 28 days with acesulfame potassium (40 and 120 mg/kg body weight) and saccharin (20 and 100 mg/kg body weight)."	4.12	Investigating the gut microbiome and metabolome following treatment with artificial sweeteners acesulfame potassium and saccharin in young adult Wistar rats. ( Cameron, HJ; Driemert, P; Giri, V; Haake, V; Kamp, H; Murali, A; Rietjens, IM; Sperber, S; van Ravenzwaay, B; Walk, T; Zickgraf, FM, 2022)
"When accounting for body weight, female rats consumed more sucrose than water; but there was no sex difference in saccharin preference over a range of saccharin concentrations."	4.12	Sex differences in sucrose reinforcement in Long-Evans rats. ( Grimm, JW; Hopkins, M; Jiganti, K; MacDougall, D; McCoy, A; North, K; Sauter, F; Šulc, J, 2022)
"Following previous results indicating that low acceptance of saccharin-sweetened yoghurt was associated with slower weight gain, the aim of this experiment was to determine which of three measures of individual differences would predict subsequent chow consumption, body weight gain, and fat mass."	3.83	Individual differences in saccharin acceptance predict rats' food intake. ( Boakes, RA; Kendig, MD; Martire, SI; Rooney, KB, 2016)
" Repeated exposure to IMO protected from the negative consequences of an acute IMO on activity in an open-field, saccharin intake and body weight gain."	3.80	Prior exposure to repeated immobilization or chronic unpredictable stress protects from some negative sequels of an acute immobilization. ( Armario, A; Belda, X; Daviu, N; Gabriel-Salazar, M; Ginesta, M; Nadal, R; Ortega-Sánchez, JA; Pastor-Ciurana, J; Rabasa, C; Sanchís-Ollè, M, 2014)
"This study examined the effects of the bacterial endotoxin, lipopolysaccharide (LPS), on the establishment of anticipatory nausea and conditioned taste avoidance in a simultaneous conditioning paradigm using an intravascular/intraperitoneal saccharin taste."	3.78	Lipopolysaccharide inhibits the simultaneous establishment of LiCl-induced anticipatory nausea and intravascularly conditioned taste avoidance in the rat. ( Cloutier, CJ; Kavaliers, M; Ossenkopp, KP, 2012)
"Chronic social defeat stress for 21 days induced physiological and behavioral depression-relevant deficits and blunted response of dopaminergic and to some extent, serotonergic neurons to cocaine challenge in females."	3.77	Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. ( Debold, JF; Holly, EN; Miczek, KA; Shimamoto, A, 2011)
" To investigate whether nutritional status affects the preference for palatable solutions and alters sweet taste receptor gene expression in rats, we measured saccharin intake and preference using a two-bottle preference test, and changes in body weight, plasma leptin levels, and gene expression for the sweet taste receptor in taste buds in high-fat diet-induced obese rats and chronically diet-restricted rats."	3.76	Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds. ( Chen, K; Li, J; Lv, B; Suo, Y; Wang, Q; Yan, J, 2010)
"We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates."	3.76	Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. ( Bura, SA; Burokas, A; Maldonado, R; Martín-García, E, 2010)
" Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)."	3.75	We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009)
" Body weight gain, saccharin preference test and open field test were performed."	3.75	Findings of P300-like and CNV-like potentials in rat model of depression following repeatedly forced swim stress. ( Gao, D; Han, M; Sun, X; Tang, X; Zheng, Z, 2009)
"Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression."	3.73	Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. ( Berry, KJ; Cisneros, FJ; Ferguson, SA; Gough, B; Hanig, JP, 2005)
"Previous studies showed that the 5-HT2 receptor antagonist, amperozide, is somewhat more potent than the opiate antagonist, naltrexone, in reducing alcohol drinking in high alcohol-preferring (P) rats."	3.70	Naltrexone and amperozide modify chocolate and saccharin drinking in high alcohol-preferring P rats. ( Biggs, TA; Myers, RD, 1998)
"Saccharin aversions were conditioned using ethanol (EtOH) in rats of different body weights."	3.68	Effect of body weight on ethanol-induced taste aversion learning. ( Cannon, DS; Leeka, JK, 1990)
" Exploratory behavior, body weight and fluid consumption of water, saccharin and quinine were monitored over 9 weeks of presentation of the special diets."	3.65	Behavior of immature and middle-aged mice as a function of dietary protein. ( Burright, RG; Church, DA; Donovick, PJ, 1977)
" Herein, we demonstrate that dose-response relationships existed with regard to administration of saccharin or sucrose to mice for 35 days, and this association involved testis-expressed sweet-tasting molecules (taste receptor type 1 subunit 3 [T1R3]; G protein alpha-gustducin [Galpha])."	1.43	Effects of Daily Exposure to Saccharin and Sucrose on Testicular Biologic Functions in Mice. ( Gong, T; Mao, DG; Nagaoka, K; Shi, FX; Taya, K; Watanabe, G; Wei, QW, 2016)
"Paradoxical sleep deprivation (PSD) induces increased energy expenditure in rats, insofar as rats eat more but loose weight throughout the deprivation period."	1.32	Palatable solutions during paradoxical sleep deprivation: reduction of hypothalamic-pituitary-adrenal axis activity and lack of effect on energy imbalance. ( Antunes, J; Suchecki, D; Tufik, S, 2003)
"It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)."	1.32	The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003)
"Melatonin-treated rats that were then crossed over to control treatment for a further 12 weeks gained BW, whereas control rats that were crossed to melatonin treatment lost BW, but food intake did not change in either group."	1.31	Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. ( Matsumoto, AM; McCants, RL; Mitton, DR; Rasmussen, DD; Wilkinson, CW; Wolden-Hanson, T; Yellon, SM, 2000)
" In addition, relative to both the chow only and saccharin conditions, chronic intake of the sucrose solution access significantly augmented morphine's antinociceptive properties."	1.31	Modulation of morphine-induced antinociception by palatable solutions in male and female rats. ( Homoleski, B; Kanarek, RB, 2000)
"Vinclozolin is a fungicide used on food crops with human exposure estimated at approximately 2 microg/kg/day from ingestion; occupational exposure, however, may be greater."	1.31	Behavioral responses of rats exposed to long-term dietary vinclozolin. ( Delclos, KB; Ferguson, SA; Flynn, KM; Newbold, RR, 2001)
"Treatment with imipramine can reduce these behavioural changes but is only effective when given repeatedly prior to onset of CMS."	1.31	Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine. ( Harkin, A; Houlihan, DD; Kelly, JP, 2002)
"Leptin is a protein that is produced primarily in fat tissue and is thought to be a lipostatic feedback signal for the regulation of body fat stores."	1.30	Intracerebroventricular (i.c.v.) administration of mouse leptin in rats: behavioral specificity and effects on meal patterns. ( Baile, CA; Hulsey, MG; Lu, H; Martin, RJ; Wang, T, 1998)
" The present results suggest that long-term intake of palatable nutritive solutions curbs tolerance to morphine-induced antinociception, whereas long-term intake of a nonnutritive, sweet saccharin solution does not."	1.30	Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake. ( D'Anci, KE, 1999)
"Ob/ob mice (OB) with B16 melanoma become anorectic, but lean mice (LN) do not."	1.29	Propensity to form conditioned taste aversions augments anorexia in obese (ob/ob) mice with B16 melanoma. ( Boha, SP; Kreider, JW; Margules, DL; Quirey, RA; Reitz, JA; Rejer, RE; Thompson, CI, 1993)
"Body weights were significantly depressed in NaS-treated litters by 4 days after birth, and were 35% lower than controls by 30 days when the animals were killed."	1.28	Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth. ( Cohen, SM; Ellwein, LB; Garland, EM; Khachab, M; Kraft, PL; Patil, K; Shapiro, R, 1991)
" However, sodium saccharin dosing did not result in an increased incidence of tumors in either the bladder or liver and is therefore not considered to be a promoter of carcinogenesis at these sites in the mouse."	1.28	The effect of lifetime sodium saccharin dosing on mice initiated with the carcinogen 2-acetylaminofluorene. ( Dooley, KL; Frederick, CB; Kadlubar, FF; Kodell, RL; Sheldon, WG, 1989)
"5%) for 6 weeks excreted increased amounts of p-cresol, but many excreted negligible amounts so that the overall dose-response relationship was bell shaped."	1.27	The effect of saccharin ingestion on the excretion of microbial amino acid metabolites in rat and man. ( Lawrie, CA; Renwick, AG, 1987)
"Aspirin is an inhibitor of prostaglandin H synthase and has been shown to inhibit FANFT-induced bladder carcinogenesis when coadministered in the diet."	1.27	Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats. ( Cohen, SM; Hasegawa, R; Johansson, SL; Sakata, T; Zenser, TV, 1986)
"Saccharin intake was increased with lithium treatment as was total caloric intake with sucrose available."	1.27	Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat. ( Atrens, DM; Gleeson, RM; Higson, FM; Smythe, GA; Storlien, LH, 1985)
"Pimozide treatment caused an equivalent suppression in the intake of the normal and VMH rats, in both the dynamic and static phases, whereas quinine adulteration caused a greater suppression in the intake of the VMH rats."	1.26	The dopaminergic mediation of a sweet reward in normal and VMH hyperphagic rats. ( Sclafani, A; Xenakis, S, 1982)
"Growth in uremia was studied using young growing male Sprague-Dawley rats made moderately uremic (SUN77 mg/100 ml) by partial nephrectomy."	1.26	Improved growth in growth retarded uremic rats with use of calorie supplementation. ( Adelman, RD; Holliday, MA, 1977)
" Since conversion to cyclohexylamine (CHA) was found to occur in many of the rats, particularly in the higher dosage groups, it was included as an added insult in the diets of about half the animals during the last quarter of the 2-year test period."	1.25	Chronic toxicity study of cyclamate: saccharin (10: 1) in rats. ( Carson, S; Cox, GE; Oser, BL; Sternberg, SS; Vogin, EE, 1975)

Research

Studies (179)

Authors

Clinical Trials (15)

Trial Overview

Trial Outcomes

Change in Abdominal Fat (DEXA).

Timeframe	Studies, this research(%)	All Research%
pre-1990	76 (42.46)	18.7374
1990's	34 (18.99)	18.2507
2000's	32 (17.88)	29.6817
2010's	32 (17.88)	24.3611
2020's	5 (2.79)	2.80

Authors	Studies
Grimm, JW	1
North, K	1
Hopkins, M	1
Jiganti, K	1
McCoy, A	1
Šulc, J	1
MacDougall, D	1
Sauter, F	1
Murali, A	1
Giri, V	1
Cameron, HJ	1
Sperber, S	1
Zickgraf, FM	1
Haake, V	1
Driemert, P	1
Walk, T	1
Kamp, H	1
Rietjens, IM	1
van Ravenzwaay, B	1
Ascencio Gutierrez, V	1
Carrillo, AA	1
Boersma, GJ	1
Tamashiro, KLK	1
Moran, TH	1
Iñiguez, SD	1
Treesukosol, Y	1
Dess, NK	5
Chapman, CD	1
Fouladi, F	1
Fodor, AA	1
Lyte, M	1
McCarthy, DM	1
Lowe, SE	1
Morgan, TJ	1
Cannon, EN	1
Biederman, J	1
Spencer, TJ	1
Bhide, PG	1
Freet, CS	2
Alexander, DN	2
Imperio, CG	1
Ruiz-Velasco, V	1
Grigson, PS	4
Lee, H	1
Jung, T	1
Kim, W	1
Noh, J	1
Murphy, M	1
Peters, KZ	1
Denton, BS	1
Lee, KA	1
Chadchankar, H	1
McCutcheon, JE	1
Kendig, MD	2
Fu, MX	1
Rehn, S	2
Martire, SI	3
Boakes, RA	3
Rooney, KB	2
Wang, QP	1
Browman, D	1
Herzog, H	1
Neely, GG	1
Higgins, KA	1
Mattes, RD	1
Arndt, A	1
Andrejić, BM	1
Mijatović, VM	1
Samojlik, IN	1
Horvat, OJ	1
Ćalasan, JD	1
Đolai, MA	1
Jaehne, EJ	1
Baune, BT	1
Parlee, SD	1
Simon, BR	1
Scheller, EL	1
Alejandro, EU	1
Learman, BS	1
Krishnan, V	1
Bernal-Mizrachi, E	1
MacDougald, OA	1
Pastor-Ciurana, J	1
Rabasa, C	1
Ortega-Sánchez, JA	2
Sanchís-Ollè, M	2
Gabriel-Salazar, M	1
Ginesta, M	1
Belda, X	2
Daviu, N	1
Nadal, R	2
Armario, A	2
Suez, J	1
Korem, T	1
Zeevi, D	1
Zilberman-Schapira, G	1
Thaiss, CA	1
Maza, O	1
Israeli, D	1
Zmora, N	1
Gilad, S	1
Weinberger, A	1
Kuperman, Y	1
Harmelin, A	1
Kolodkin-Gal, I	1
Shapiro, H	1
Halpern, Z	1
Segal, E	1
Elinav, E	1
Yasoshima, Y	1
Shimura, T	1
Westbrook, RF	1
Morris, MJ	1
Alkafafy, Mel-S	1
Ibrahim, ZS	1
Ahmed, MM	1
El-Shazly, SA	1
Nyland, JE	1
Gong, T	1
Wei, QW	1
Mao, DG	1
Nagaoka, K	1
Watanabe, G	1
Taya, K	1
Shi, FX	1
Gagliano, H	1
Ashkenazy, T	1
Einat, H	2
Kronfeld-Schor, N	2
Gomez-Serrano, MA	1
Kearns, DN	1
Riley, AL	2
Gao, D	1
Zheng, Z	1
Han, M	1
Tang, X	1
Sun, X	1
Schweizer, MC	1
Henniger, MS	1
Sillaber, I	1
Kozlov, AP	1
Nizhnikov, ME	2
Varlinskaya, EI	2
Spear, NE	4
Ramírez-Lugo, L	1
Jensen, MS	1
Søderman, A	1
West, MJ	1
Swithers, SE	4
Baker, CR	1
Davidson, TL	3
Ashkenazy-Frolinger, T	1
Juetten, J	1
Chen, K	1
Yan, J	1
Suo, Y	1
Li, J	1
Wang, Q	1
Lv, B	1
Vendruscolo, LF	1
Gueye, AB	1
Darnaudéry, M	1
Ahmed, SH	1
Cador, M	1
Bura, SA	1
Burokas, A	1
Martín-García, E	1
Maldonado, R	1
Polyák, E	1
Gombos, K	1
Hajnal, B	1
Bonyár-Müller, K	1
Szabó, S	1
Gubicskó-Kisbenedek, A	1
Marton, K	1
Ember, I	1
Lensu, S	1
Tuomisto, JT	1
Tuomisto, J	2
Pohjanvirta, R	2
Shimamoto, A	1
Debold, JF	1
Holly, EN	1
Miczek, KA	1
Cloutier, CJ	1
Kavaliers, M	1
Ossenkopp, KP	1
Laboy, AF	1
Clark, K	1
Cooper, S	1
Duclos, M	1
Ouerdani, A	1
Mormède, P	1
Konsman, JP	1
Sample, CH	2
Katz, DP	1
Ackroff, K	1
Sclafani, A	5
Ballok, DA	1
Szechtman, H	1
Sakic, B	1
Suchecki, D	1
Antunes, J	1
Tufik, S	1
June, HL	1
Foster, KL	1
McKay, PF	1
Seyoum, R	1
Woods, JE	1
Harvey, SC	1
Eiler, WJ	1
Grey, C	1
Carroll, MR	1
McCane, S	1
Jones, CM	1
Yin, W	1
Mason, D	1
Cummings, R	1
Garcia, M	1
Ma, C	1
Sarma, PV	1
Cook, JM	1
Skolnick, P	1
Smith, JC	1
McCaughey, SA	1
Forestell, CA	1
Tordoff, MG	2
Sharma, A	1
Haksar, A	1
Chawla, R	1
Kumar, R	1
Arora, R	1
Singh, S	1
Prasad, J	1
Islam, F	1
Arora, MP	1
Kumar Sharma, R	1
Ferguson, SA	2
Cisneros, FJ	1
Gough, B	1
Hanig, JP	1
Berry, KJ	1
Weitemier, AZ	1
Ryabinin, AE	1
Bennett, R	1
Adams, B	1
French, A	1
Neggers, Y	1
Vincent, JB	1
Baillie, SR	1
Prendergast, BJ	1
Kang, HM	1
Zaitlen, NA	1
Wade, CM	1
Kirby, A	1
Heckerman, D	1
Daly, MJ	1
Eskin, E	1
Leth, T	1
Jensen, U	1
Fagt, S	1
Andersen, R	1
Kramer, TH	1
Kindya, K	1
Pezner, M	1
Hasegawa, R	3
St John, MK	3
Cano, M	3
Issenberg, P	1
Klein, DA	1
Walker, BA	1
Jones, JW	1
Schnell, RC	1
Merrick, BA	1
Davies, MH	1
Westland, JA	1
Helton, ED	1
Martin, JC	2
Martin, DC	2
Sigman, G	2
Day-Pfeiffer, H	1
Anderström, C	1
Johansson, SL	4
Fukushima, S	3
Hagiwara, A	1
Ogiso, T	1
Shibata, M	1
Ito, N	2
Renwick, AG	4
Sims, J	1
Arai, M	1
Nakanowatari, J	1
Hibino, T	1
Okuda, M	1
Xenakis, S	1
Liau, HP	1
Peng, MT	1
Murasaki, G	2
Greenfield, RE	1
Cohen, SM	9
Cory-Slechta, DA	1
Weiss, B	1
Green, U	1
Schneider, P	1
Deutsch-Wenzel, R	1
Brune, H	1
Althoff, J	1
Mook, DG	1
Cseh, CL	1
Taylor, JM	1
Weinberger, MA	1
Friedman, L	1
Hooson, J	1
Hicks, RM	2
Grasso, P	1
Chowaniec, J	2
Exton, MS	1
Bull, DF	1
King, MG	1
Garland, EM	4
St John, M	1
Arnold, LL	1
Minor, TR	1
Ben-David, E	1
Chang, WC	1
Reid, M	1
Hammersley, R	1
Moufid-Bellancourt, S	1
Velley, L	2
Uwagawa, S	1
Saito, K	1
Okuno, Y	1
Kawasaki, H	1
Yoshitake, A	1
Yamada, H	1
Thompson, CI	1
Margules, DL	1
Kreider, JW	1
Boha, SP	1
Rejer, RE	1
Quirey, RA	1
Reitz, JA	1
Khachab, M	4
Ellwein, LB	3
Yirmiya, R	1
Parker, DR	1
Gonzalez, S	1
Derby, CA	1
Gans, KM	1
Lasater, TM	1
Carleton, RA	1
Bailey, CJ	1
Day, C	1
Knapper, JM	1
Turner, SL	1
Flatt, PR	1
Thiele, TE	3
Van Dijk, G	2
Campfield, LA	1
Smith, FJ	1
Burn, P	2
Woods, SC	1
Bernstein, IL	1
Seeley, RJ	2
Lane, JR	1
Starbuck, EM	1
Fitts, DA	1
Harris, RB	1
Zhou, J	1
Youngblood, BD	1
Smagin, GN	1
Ryan, DH	1
Touzani, K	1
Taghzouti, K	1
Hatcher, JP	1
Bell, DJ	1
Reed, TJ	1
Hagan, JJ	1
Yagaloff, KA	1
Fisher, SL	1
Schwartz, M	1
Biggs, TA	1
Myers, RD	1
Badia-Elder, NE	1
Kiefer, SW	1
Blizard, DA	1
Hulsey, MG	1
Lu, H	1
Wang, T	1
Martin, RJ	1
Baile, CA	1
D'Anci, KE	1
Wolden-Hanson, T	1
Mitton, DR	1
McCants, RL	1
Yellon, SM	1
Wilkinson, CW	1
Matsumoto, AM	1
Rasmussen, DD	1
Goodwin, FL	2
Bergeron, N	1
Amit, Z	2
Twining, RC	1
Carelli, RM	1
Kanarek, RB	2
Homoleski, B	1
Flynn, KM	1
Delclos, KB	1
Newbold, RR	1
Garnier-Sagne, I	1
Leblanc, JC	1
Verger, P	1
Carroll, ME	1
Morgan, AD	1
Lynch, WJ	1
Campbell, UC	1
Petrov, ES	1
Pautassi, RM	1
Godoy, JC	1
Molina, JC	2
Harkin, A	1
Houlihan, DD	1
Kelly, JP	1
Anderson, RL	5
Coulston, F	1
McChesney, E	1
Benitz, KF	1
Lygre, DG	1
Rosenman, K	1
Radow, B	1
Kline, J	1
Stein, ZA	1
Susser, M	1
Warburton, D	1
Weinstein, L	2
Ramirez, I	3
Sprott, RL	1
Adelman, RD	1
Holliday, MA	1
Church, DA	1
Donovick, PJ	1
Burright, RG	1
Fuller, JL	1
Pinel, JP	1
Huang, E	1
Hamilton, LW	2
Timmons, CR	1
Marks, HE	2
Davison, C	1
Boyle, PC	1
Keesey, RE	1
Munro, IC	1
Moodie, CA	1
Krewski, D	1
Grice, HC	1
Oser, BL	1
Carson, S	1
Cox, GE	1
Vogin, EE	1
Sternberg, SS	1
Mathieu, A	1
Liebermeister, H	1
Orlik, P	1
Wagner, MW	1
Homma, Y	1
Kondo, Y	1
Kakizoe, T	1
Aso, Y	1
Nagase, S	1
Kraft, PL	2
Shapiro, R	2
Patil, K	2
Mattson, BJ	1
Parr, JM	1
Okamura, T	1
Masui, T	1
Smith, RA	2
Wehner, JM	1
Chappel, CI	1
Schoenig, GP	1
Rolls, BJ	1
Ferrari, CM	1
O'Connor, DA	1
Heaton, GD	1
Cannon, DS	1
Leeka, JK	1
Zenser, TV	2
Fisher, MJ	1
Sakata, T	2
Tibbels, TS	1
Frederick, CB	1
Dooley, KL	1
Kodell, RL	1
Sheldon, WG	1
Kadlubar, FF	1
Linseman, MA	1
Hoffmann, H	1
Kucharski, D	1
Marks-Kaufman, R	1
Maurer, JK	3

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effect of Low Calorie Sweetener Consumption on Body Weight, Body Composition, Appetite, and Energy Intake[NCT02928653]		187 participants (Actual)	Interventional	2015-12-31	Completed
Changes in Gut Microbiota and Postprandial GLP-1 Concentration Due to Sucralose Consumption[NCT06094894]		40 participants (Anticipated)	Interventional	2023-06-01	Recruiting
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility[NCT02890108]		10 participants (Anticipated)	Interventional	2016-08-31	Recruiting
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis[NCT02580435]		520 participants (Anticipated)	Observational	2015-12-31	Not yet recruiting
Effects of Sucralose on Insulin Sensitivity, Pancreatic Response and Appetite Regulating Hormones[NCT02589002]		66 participants (Actual)	Interventional	2015-07-31	Completed
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)[NCT03407079]	Phase 2	26 participants (Actual)	Interventional	2018-04-05	Suspended (stopped due to The status was on admin hold with the prev. PI. The new PI (Dr. Joseph) would like to continue to keep the study on admin hold until after reviewing the study)
A Randomized Controlled Trial of the Effect of Replacing Sugar-sweetened Beverages With Non-nutritive Sweetened Beverages or Water on Gut Microbiome and Metabolic Outcomes: STOP Sugars NOW Trial[NCT03543644]		81 participants (Actual)	Interventional	2018-05-31	Completed
The Effect of Regular Consumption of Low/No Calorie Sweeteners on Glycemic Response and Glucagon Like Peptide-1 Secretion in Healthy Adults: A Randomized Controlled Trial[NCT04904133]		42 participants (Actual)	Interventional	2019-04-02	Completed
Changes in Insulin Sensitivity in Liver and Esqueletal Muscle Due to Sucralose Consumption[NCT04182464]		24 participants (Actual)	Interventional	2019-11-01	Completed
Effect of Acute or Chronic Ingestion of Sucralose on Serum Insulin in Young and Healthy Adults: a Randomized, Double-blind, Placebo-controlled Trial[NCT03703141]		95 participants (Actual)	Interventional	2016-09-27	Completed
Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors[NCT03032640]		102 participants (Actual)	Interventional	2017-01-26	Completed
Metabolic Effects of Non-nutritive Sweeteners[NCT02413424]		38 participants (Actual)	Interventional	2015-04-30	Completed
A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207]		160 participants (Anticipated)	Observational	2019-10-01	Recruiting
[NCT00005151]		0 participants	Observational	1980-08-31	Completed
Phase IV Study of Ramelteon as an Adjunct Therapy in Non-Diabetic Patients With Schizophrenia[NCT00595504]	Phase 4	25 participants (Actual)	Interventional	2008-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A comparison between the ramelteon group and the placebo group of change in abdominal fat measured by a DEXA scan, assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Insulin Resistance as Measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Intervention	g (Mean)
Ramelteon	3934.86
Placebo (Sugar Pill)	5120.92

A comparison between the ramelteon group and the placebo group of change in insulin resistance measured by the homeostatic model assessment of insulin resistance (HOMA-IR), assessed at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Change in Waist Circumference

Intervention	HOMA score (Mean)
Ramelteon	2.4
Placebo (Sugar Pill)	2.36

A comparison between the ramelteon group and the placebo group in change in waist circumference (measured in cm) measured at Baseline and Week 8. (NCT00595504)
Timeframe: Baseline and Week 8

Article	Year
Intense sweeteners, food intake, and the weight of a body of evidence. Physiology & behavior, 1994, Volume: 55, Issue:1 Topics: Appetite; Aspartame; Beverages; Blood Glucose; Body Weight; Eating; Energy Intake; Humans; Hunger; I	1994
Benefits of saccharin: a review. Environmental research, 1978, Volume: 15, Issue:1 Topics: Body Weight; Dental Caries; Diabetes Mellitus; Drug Compounding; Humans; Hyperlipidemias; Obesity; S	1978
Effects of intense sweeteners on hunger, food intake, and body weight: a review. The American journal of clinical nutrition, 1991, Volume: 53, Issue:4 Topics: Aspartame; Body Weight; Eating; Humans; Hunger; Saccharin; Sweetening Agents; Thiazines	1991
Factors influencing the effects of nutritive and non-nutritive sweeteners on energy intake and body weight in rats. Appetite, 1988, Volume: 11 Suppl 1 Topics: Animals; Body Weight; Dietary Carbohydrates; Dietary Proteins; Eating; Rats; Rats, Inbred Strains; S	1988
The cyclamate story unfolds. Food and cosmetics toxicology, 1970, Volume: 8, Issue:5 Topics: Animals; Behavior, Animal; Body Weight; Cyclamates; Embryo, Mammalian; Enzyme Induction; Female; Gro	1970

Article	Year
A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. The American journal of clinical nutrition, 2019, 05-01, Volume: 109, Issue:5 Topics: Adult; Aspartame; Beverages; Body Mass Index; Body Weight; Diet; Dietary Sucrose; Diterpenes, Kauran	2019
The effects of sucrose on everyday eating in normal weight men and women. Appetite, 1994, Volume: 22, Issue:3 Topics: Adult; Affect; Body Weight; Diet Records; Energy Intake; Feeding Behavior; Female; Humans; Male; Sac	1994

saccharin and Body Weight