Page last updated: 2024-11-04

saccharin and Asthma

saccharin has been researched along with Asthma in 4 studies

Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)."3.67Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985)
"Inhaled bitter tastants decreased airway obstruction in a mouse model of asthma."1.36Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. ( An, SS; Deshpande, DA; Liggett, SB; McIlmoyle, EL; Robinett, KS; Schillinger, RM; Sham, JS; Wang, WC, 2010)
"The saccharin method was used for the study."1.28Abnormal mucociliary action in asthma and bronchiectasis. ( Awotedu, AA; Babalola, OO; Hart, PD; Lawani, EO, 1990)
"The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance."1.28Measurement of nasal mucociliary clearance. ( Agabiti, N; Bonfitto, P; Cole, PJ; Corbo, GM; Foresi, A; Mugnano, A, 1989)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deshpande, DA1
Wang, WC1
McIlmoyle, EL1
Robinett, KS1
Schillinger, RM1
An, SS1
Sham, JS1
Liggett, SB1
Awotedu, AA1
Babalola, OO1
Lawani, EO1
Hart, PD1
Corbo, GM1
Foresi, A1
Bonfitto, P1
Mugnano, A1
Agabiti, N1
Cole, PJ2
Stanley, PJ1
Wilson, R1
Greenstone, MA1
Mackay, IS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Collection of Gastrointestinal Tissue Samples for the Characterization and ex Vivo Functional Assessment of Chemoreceptors[NCT02859116]8 participants (Actual)Observational2016-07-21Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for saccharin and Asthma

ArticleYear
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.
    Nature medicine, 2010, Volume: 16, Issue:11

    Topics: Airway Obstruction; Animals; Asthma; Bronchi; Bronchoconstriction; Calcium Signaling; Cell Separatio

2010
Abnormal mucociliary action in asthma and bronchiectasis.
    African journal of medicine and medical sciences, 1990, Volume: 19, Issue:3

    Topics: Adult; Asthma; Bronchiectasis; Female; Humans; Male; Mucociliary Clearance; Rhinitis, Allergic, Pere

1990
Measurement of nasal mucociliary clearance.
    Archives of disease in childhood, 1989, Volume: 64, Issue:4

    Topics: Adolescent; Asthma; Child; Female; Humans; Male; Mucociliary Clearance; Nasal Mucosa; Reference Valu

1989
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
    British journal of diseases of the chest, 1985, Volume: 79, Issue:1

    Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh

1985