saccharin and Asthma
saccharin has been researched along with Asthma in 4 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nasal mucociliary clearance was measured using a saccharin technique in 172 patients with perennial rhinitis (76 also had asthma) and in 121 patients with chronic infected rhinosinusitis (40 had asthma, 35 had bronchiectasis)." | 3.67 | Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease. ( Cole, PJ; Greenstone, MA; Mackay, IS; Stanley, PJ; Wilson, R, 1985) |
| "Inhaled bitter tastants decreased airway obstruction in a mouse model of asthma." | 1.36 | Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. ( An, SS; Deshpande, DA; Liggett, SB; McIlmoyle, EL; Robinett, KS; Schillinger, RM; Sham, JS; Wang, WC, 2010) |
| "The saccharin method was used for the study." | 1.28 | Abnormal mucociliary action in asthma and bronchiectasis. ( Awotedu, AA; Babalola, OO; Hart, PD; Lawani, EO, 1990) |
| "The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance." | 1.28 | Measurement of nasal mucociliary clearance. ( Agabiti, N; Bonfitto, P; Cole, PJ; Corbo, GM; Foresi, A; Mugnano, A, 1989) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Deshpande, DA | 1 |
| Wang, WC | 1 |
| McIlmoyle, EL | 1 |
| Robinett, KS | 1 |
| Schillinger, RM | 1 |
| An, SS | 1 |
| Sham, JS | 1 |
| Liggett, SB | 1 |
| Awotedu, AA | 1 |
| Babalola, OO | 1 |
| Lawani, EO | 1 |
| Hart, PD | 1 |
| Corbo, GM | 1 |
| Foresi, A | 1 |
| Bonfitto, P | 1 |
| Mugnano, A | 1 |
| Agabiti, N | 1 |
| Cole, PJ | 2 |
| Stanley, PJ | 1 |
| Wilson, R | 1 |
| Greenstone, MA | 1 |
| Mackay, IS | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Collection of Gastrointestinal Tissue Samples for the Characterization and ex Vivo Functional Assessment of Chemoreceptors[NCT02859116] | 8 participants (Actual) | Observational | 2016-07-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Other Studies
4 other studies available for saccharin and Asthma
| Article | Year |
|---|---|
Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.
Topics: Airway Obstruction; Animals; Asthma; Bronchi; Bronchoconstriction; Calcium Signaling; Cell Separatio | 2010 |
Abnormal mucociliary action in asthma and bronchiectasis.
Topics: Adult; Asthma; Bronchiectasis; Female; Humans; Male; Mucociliary Clearance; Rhinitis, Allergic, Pere | 1990 |
Measurement of nasal mucociliary clearance.
Topics: Adolescent; Asthma; Child; Female; Humans; Male; Mucociliary Clearance; Nasal Mucosa; Reference Valu | 1989 |
Abnormal nasal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest disease.
Topics: Adolescent; Adult; Asthma; Bronchiectasis; Cilia; Female; Humans; Male; Middle Aged; Mucus; Nose; Rh | 1985 |