saccharin has been researched along with Anxiety in 30 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In our study, we explored whether disruption of ghrelin receptor function though high-fat diet or genetic ablation affects fear processing, anxiety-like behavior and saccharin preference in mice." | 7.91 | Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice. ( Beckers, T; De Bundel, D; Fritz, EM; Muylle, K; Pierre, A; Regin, Y; Singewald, N; Smolders, IJ; Van Schuerbeek, A, 2019) |
| "In present study, effects of sucrose and sugar-substitute (saccharin) exposures and withdrawal on depression and anxiety-like behavior in type 2 diabetic mice were assessed." | 7.91 | Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects. ( Chail, M; Kumar, M, 2019) |
| "We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates." | 7.76 | Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. ( Bura, SA; Burokas, A; Maldonado, R; Martín-García, E, 2010) |
| " Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)." | 7.75 | We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009) |
| " Experiment 2 compared the effects of chronic administration of cannabis-derived Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD) and cannabigerol (CBG) in these models." | 5.39 | Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. ( Dashney, B; Limebeer, CL; O'Brien, LD; Parker, LA; Rock, EM; Segsworth, B; Wills, KL, 2013) |
| " Furthermore, we analyzed MS impacts on anxiety- and depressive-like behaviors and on locomotor and plasma corticosterone responses to intraperitoneal treatment with ethanol in adolescent mice." | 4.31 | Impacts of maternal separation stress on ethanol-related responses, anxiety- and depressive-like behaviors in adolescent mice. ( Anjos-Santos, A; Bertagna, NB; Bianchi, PC; Cruz, FC; Favoretto, CA; Righi, T; Rodolpho, BT; Silva, FBR, 2023) |
| " In our study, we explored whether disruption of ghrelin receptor function though high-fat diet or genetic ablation affects fear processing, anxiety-like behavior and saccharin preference in mice." | 3.91 | Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice. ( Beckers, T; De Bundel, D; Fritz, EM; Muylle, K; Pierre, A; Regin, Y; Singewald, N; Smolders, IJ; Van Schuerbeek, A, 2019) |
| " Silencing of miR-411 by infusing antagomiR-411 into the prefrontal cortex of female C57BL/6J mice reduced alcohol consumption and preference, without altering total fluid consumption, saccharin consumption, or anxiety-related behaviors." | 3.91 | Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice. ( Blednov, YA; Harris, RA; Mayfield, RD; Most, D; Salem, NA; Tiwari, GR, 2019) |
| "In present study, effects of sucrose and sugar-substitute (saccharin) exposures and withdrawal on depression and anxiety-like behavior in type 2 diabetic mice were assessed." | 3.91 | Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects. ( Chail, M; Kumar, M, 2019) |
| "Following previous results indicating that low acceptance of saccharin-sweetened yoghurt was associated with slower weight gain, the aim of this experiment was to determine which of three measures of individual differences would predict subsequent chow consumption, body weight gain, and fat mass." | 3.83 | Individual differences in saccharin acceptance predict rats' food intake. ( Boakes, RA; Kendig, MD; Martire, SI; Rooney, KB, 2016) |
| "We explored the impact of exposure to an obesogenic diet (High Fat-High Sucrose; HFS) during the post-weaning period on sweet preference and behaviors linked to reward and anxiety." | 3.83 | Behavioral consequences of exposure to a high fat diet during the post-weaning period in rats. ( Askevik, K; Babaei, CS; Dickson, SL; Rabasa, C; Vogel, H; Winsa-Jörnulf, J, 2016) |
| " The 2-bottle saccharin preference test for anhedonia revealed that dietary ZS also did not improve depression-like behaviors." | 3.78 | Use of zinc as a treatment for traumatic brain injury in the rat: effects on cognitive and behavioral outcomes. ( Cope, EC; Levenson, CW; Morris, DR; Scrimgeour, AG, 2012) |
| "We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates." | 3.76 | Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice. ( Bura, SA; Burokas, A; Maldonado, R; Martín-García, E, 2010) |
| " Animals were then tested for reward-seeking behaviour (saccharin consumption), anxiety (elevated plus-maze), aggression (resident-intruder test), and depression-like behaviour (FST)." | 3.75 | We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. ( Ashkenazy, T; Einat, H; Kronfeld-Schor, N, 2009) |
| "In humans, stroke is often accompanied by severe cognitive and psychiatric changes that are thought to arise as a consequence of this infarct-induced remodelling." | 1.46 | Alterations in anxiety and social behaviour in Npas4 deficient mice following photochemically-induced focal cortical stroke. ( Baune, BT; Jaehne, EJ; Klarić, TS; Koblar, SA; Lewis, MD, 2017) |
| " Experiment 2 compared the effects of chronic administration of cannabis-derived Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD) and cannabigerol (CBG) in these models." | 1.39 | Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability. ( Dashney, B; Limebeer, CL; O'Brien, LD; Parker, LA; Rock, EM; Segsworth, B; Wills, KL, 2013) |
| "Comorbid chronic stress and alcohol dependence may lead to a complicated and potentially severe treatment profile." | 1.39 | Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress. ( Bahi, A, 2013) |
| "Treatment with SNAP 37889 (30 mg/kg, i." | 1.37 | The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. ( Ash, BL; Djouma, E; Lawrence, AJ; Williams, SJ; Zanatta, SD, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 22 (73.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Favoretto, CA | 1 |
| Bertagna, NB | 1 |
| Righi, T | 1 |
| Rodolpho, BT | 1 |
| Anjos-Santos, A | 1 |
| Silva, FBR | 1 |
| Bianchi, PC | 1 |
| Cruz, FC | 1 |
| Pierre, A | 1 |
| Regin, Y | 1 |
| Van Schuerbeek, A | 1 |
| Fritz, EM | 1 |
| Muylle, K | 1 |
| Beckers, T | 1 |
| Smolders, IJ | 1 |
| Singewald, N | 1 |
| De Bundel, D | 1 |
| Mietlicki-Baase, EG | 1 |
| McGrath, LE | 1 |
| Koch-Laskowski, K | 1 |
| Krawczyk, J | 1 |
| Reiner, DJ | 1 |
| Pham, T | 1 |
| Nguyen, CTN | 1 |
| Turner, CA | 1 |
| Olivos, DR | 1 |
| Wimmer, ME | 1 |
| Schmidt, HD | 1 |
| Hayes, MR | 1 |
| Fernández, MS | 1 |
| Báez, B | 1 |
| Bordón, A | 1 |
| Espinosa, L | 1 |
| Martínez, E | 1 |
| Pautassi, RM | 2 |
| Lee, H | 1 |
| Jung, T | 1 |
| Kim, W | 1 |
| Noh, J | 1 |
| Most, D | 1 |
| Salem, NA | 1 |
| Tiwari, GR | 1 |
| Blednov, YA | 1 |
| Mayfield, RD | 1 |
| Harris, RA | 1 |
| Rehn, S | 1 |
| Boakes, RA | 2 |
| Kumar, M | 1 |
| Chail, M | 1 |
| Bahi, A | 2 |
| Miranda-Morales, RS | 1 |
| Shoval, G | 1 |
| Shbiro, L | 1 |
| Hershkovitz, L | 1 |
| Hazut, N | 1 |
| Zalsman, G | 1 |
| Mechoulam, R | 1 |
| Weller, A | 1 |
| Martire, SI | 1 |
| Rooney, KB | 1 |
| Kendig, MD | 1 |
| Ben-Hamo, M | 1 |
| Tal, K | 1 |
| Paz-Cohen, R | 1 |
| Kronfeld-Schor, N | 3 |
| Einat, H | 3 |
| Wang, L | 1 |
| Shen, M | 1 |
| Jiang, C | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Rabasa, C | 1 |
| Winsa-Jörnulf, J | 1 |
| Vogel, H | 1 |
| Babaei, CS | 1 |
| Askevik, K | 1 |
| Dickson, SL | 1 |
| Klarić, TS | 1 |
| Jaehne, EJ | 1 |
| Koblar, SA | 1 |
| Baune, BT | 1 |
| Lewis, MD | 1 |
| Ashkenazy, T | 1 |
| Schweizer, MC | 1 |
| Henniger, MS | 1 |
| Sillaber, I | 1 |
| Ashkenazy-Frolinger, T | 1 |
| Juetten, J | 1 |
| Bura, SA | 1 |
| Burokas, A | 1 |
| Martín-García, E | 1 |
| Maldonado, R | 1 |
| Ash, BL | 1 |
| Zanatta, SD | 1 |
| Williams, SJ | 1 |
| Lawrence, AJ | 1 |
| Djouma, E | 1 |
| Cope, EC | 1 |
| Morris, DR | 1 |
| Scrimgeour, AG | 1 |
| Levenson, CW | 1 |
| O'Brien, LD | 1 |
| Wills, KL | 1 |
| Segsworth, B | 1 |
| Dashney, B | 1 |
| Rock, EM | 1 |
| Limebeer, CL | 1 |
| Parker, LA | 1 |
| Horovitz, O | 1 |
| Tsoory, MM | 1 |
| Yovell, Y | 1 |
| Richter-Levin, G | 1 |
| Guitton, MJ | 1 |
| Dudai, Y | 1 |
| Zhu, H | 1 |
| Lee, M | 1 |
| Agatsuma, S | 1 |
| Hiroi, N | 1 |
| Fahey, B | 1 |
| Hickey, B | 1 |
| Kelleher, D | 1 |
| O'Dwyer, AM | 1 |
| O'Mara, SM | 1 |
| Blakley, GG | 1 |
| Pohorecky, LA | 1 |
| Benjamin, D | 1 |
| van Dijken, HH | 1 |
| Mos, J | 1 |
| van der Heyden, JA | 1 |
| Tilders, FJ | 1 |
30 other studies available for saccharin and Anxiety
| Article | Year |
|---|---|
Impacts of maternal separation stress on ethanol-related responses, anxiety- and depressive-like behaviors in adolescent mice.
Topics: Animals; Anxiety; Corticosterone; Ethanol; Female; Male; Maternal Deprivation; Mice; Mice, Inbred C5 | 2023 |
Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice.
Topics: Animals; Anxiety; Conditioning, Psychological; Fear; Food Preferences; Gene Deletion; Ghrelin; Hyper | 2019 |
Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior.
Topics: Amylin Receptor Agonists; Angiotensin II; Animals; Anxiety; Calcitonin; Choice Behavior; Dietary Car | 2017 |
Short-term selection for high and low ethanol intake yields differential sensitivity to ethanol's motivational effects and anxiety-like responses in adolescent Wistar rats.
Topics: Alcohol-Related Disorders; Animals; Anxiety; Central Nervous System Depressants; Ethanol; Feeding Be | 2017 |
Alteration of adolescent aversive nicotine response and anxiety-like behavior in nicotine-exposed rats during late lactation period.
Topics: Age Factors; Analysis of Variance; Animals; Anxiety; Avoidance Learning; Body Weight; Choice Behavio | 2018 |
Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice.
Topics: Alcohol Drinking; Amidohydrolases; Animals; Antagomirs; Anxiety; Argonaute Proteins; Behavior, Anima | 2019 |
Bingeing in rats: Persistence of high intakes of palatable solutions induced by 1-day-in-4 intermittent access.
Topics: Animals; Anxiety; Binge-Eating Disorder; Body Weight; Conditioning, Operant; Energy Intake; Feeding | 2019 |
Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects.
Topics: Animals; Anxiety; Brain; Depression; Diabetes Mellitus, Experimental; Female; Male; Mice; Reward; Sa | 2019 |
Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice.
Topics: Animals; Anxiety; Choice Behavior; Drinking Behavior; Drinking Water; Ethanol; Maze Learning; Mice; | 2013 |
Pharmacological characterization of the nociceptin/orphanin FQ receptor on ethanol-mediated motivational effects in infant and adolescent rats.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Choice Behavior; Conditioning, Psychological; Ethanol; Fe | 2016 |
Prohedonic Effect of Cannabidiol in a Rat Model of Depression.
Topics: Analysis of Variance; Anhedonia; Animals; Antidepressive Agents; Anxiety; Cannabidiol; Depressive Di | 2016 |
Individual differences in saccharin acceptance predict rats' food intake.
Topics: Animals; Anxiety; Body Weight; Eating; Feeding Behavior; Individuality; Male; Maze Learning; Motor A | 2016 |
Differential effects of photoperiod length on depression- and anxiety-like behavior in female and male diurnal spiny mice.
Topics: Animals; Anxiety; Choice Behavior; Circadian Rhythm; Cohort Studies; Depression; Female; Male; Model | 2016 |
Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Central Amygdaloid Nucleus; Corticotropin-Releasing Horm | 2016 |
Behavioral consequences of exposure to a high fat diet during the post-weaning period in rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Brain; Diet, High-Fat; Feeding Behavior; Food; Food Prefe | 2016 |
Alterations in anxiety and social behaviour in Npas4 deficient mice following photochemically-induced focal cortical stroke.
Topics: Analysis of Variance; Animals; Anxiety; Basic Helix-Loop-Helix Transcription Factors; Exploratory Be | 2017 |
We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections.
Topics: Aggression; Animals; Anxiety; Body Weight; Data Interpretation, Statistical; Depression; Food Prefer | 2009 |
Chronic mild stress (CMS) in mice: of anhedonia, 'anomalous anxiolysis' and activity.
Topics: Animals; Anxiety; Body Weight; Chronic Disease; Consummatory Behavior; Drinking Behavior; Light; Mal | 2009 |
It is darkness and not light: Depression-like behaviors of diurnal unstriped Nile grass rats maintained under a short photoperiod schedule.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Darkness; Depression; Disease Models, Animal; Male; | 2010 |
Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice.
Topics: Animals; Anxiety; Behavior, Animal; Blood Glucose; Body Weight; Cholesterol; Dietary Fats; Drinking; | 2010 |
The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Indoles; Male; Rats; Re | 2011 |
Use of zinc as a treatment for traumatic brain injury in the rat: effects on cognitive and behavioral outcomes.
Topics: Anhedonia; Animals; Anxiety; Behavior, Animal; Brain Injuries; Cognition Disorders; Combined Modalit | 2012 |
Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability.
Topics: Animals; Anxiety; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabinoids; Dis | 2013 |
Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Behavior, Addictive; Choice Behavior; Conditioning, | 2013 |
A rat model of pre-puberty (juvenile) stress-induced predisposition to stress-related disorders: sex similarities and sex differences in effects and symptoms.
Topics: Age Factors; Anhedonia; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Fema | 2014 |
Anxiety-like state associates with taste to produce conditioned taste aversion.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Central Nervous System Depressants; Conditio | 2004 |
Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice.
Topics: Animals; Anxiety; Behavior, Animal; Blotting, Western; Caudate Nucleus; Corticosterone; Cotinine; Do | 2007 |
The widely-used anti-viral drug interferon-alpha induces depressive- and anxiogenic-like effects in healthy rats.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Chi-Square D | 2007 |
Bidirectional changes in ethanol consumption in rats with site-specific antisense down-regulation of 5-hydroxytryptamine2A receptors in brain.
Topics: Alcohol Drinking; Amphetamines; Animals; Anxiety; Autoradiography; Brain Chemistry; Corticosterone; | 2001 |
Characterization of stress-induced long-term behavioural changes in rats: evidence in favor of anxiety.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Defecation; Electroshock; Male; Noise; Rats; | 1992 |