saccharin has been researched along with Alcoholism in 36 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additional experiments assessed the influence of (i) adulteration with quinine of the alcohol solution (Experiment 2) and (ii) concurrent presentation of a saccharin solution (Experiment 3) on alcohol drinking under the CA10% and IA20% conditions." | 3.76 | Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol. ( Carai, MA; Colombo, G; Fantini, N; Gessa, GL; Lobina, C; Loi, B; Maccioni, P, 2010) |
| "Although the serotonin (5-HT)1A receptor agonist ipsapirone reduces ethanol intake in a variety of animal models of alcoholism, such effects have only been reported in models based on nonoperant behavior (e." | 3.70 | Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat. ( De Vry, J; Haussels, A; Manze, B; Schreiber, R, 1999) |
| "saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature." | 2.44 | Selective breeding for differential saccharin intake as an animal model of drug abuse. ( Anker, JJ; Carroll, ME; Dess, NK; Morgan, AD; Perry, JL, 2008) |
| "Here we determine the effects of alcohol dependence on the choice between alcohol and a non-drug reward, saccharin, using the discrete choice model in food-restricted male rats." | 1.48 | Effects of alcohol dependence on discrete choice between alcohol and saccharin. ( Coen, K; Funk, D; Lê, AD; Loughlin, A; Russo, M, 2018) |
| "Comorbid chronic stress and alcohol dependence may lead to a complicated and potentially severe treatment profile." | 1.39 | Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress. ( Bahi, A, 2013) |
| "Epidemiological studies suggest that alcohol abuse during the adolescent developmental period may result in long-term changes such as an increased susceptibility to alcohol-related problems in adulthood." | 1.34 | The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood. ( Diaz-Granados, JL; Graham, DL, 2007) |
| "It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)." | 1.32 | The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003) |
| " In this study, we subjected these rats to several long-term administration protocols suggested to favour the development of alcohol dependence, including multiple alcohol concentrations or sweetened alcohol solutions (ethanol 10% or 20%+saccharin), and deprivation periods." | 1.32 | The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence. ( Jones, BC; Mormède, P; Terenina-Rigaldie, E, 2004) |
| "The study of alcohol abuse traditionally has placed great emphasis on the development of tolerance and dependence as key factors." | 1.29 | Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. ( Heinrichs, SC; Hyytiä, P; Koob, GF; Schulteis, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (22.22) | 18.7374 |
| 1990's | 3 (8.33) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 7 (19.44) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, MR | 1 |
| Hernández, M | 1 |
| Kasten, CR | 1 |
| Boehm, SL | 1 |
| Chandler, CM | 1 |
| Shaykin, JD | 1 |
| Peng, H | 1 |
| Pauly, JR | 1 |
| Nixon, K | 1 |
| Bardo, MT | 1 |
| Doyle, MR | 1 |
| Dirik, S | 1 |
| Martinez, AR | 1 |
| Hughes, TE | 1 |
| Iyer, MR | 2 |
| Sneddon, EA | 1 |
| Seo, H | 1 |
| Cohen, SM | 1 |
| de Guglielmo, G | 1 |
| Bezerra-Karounis, MA | 1 |
| Krahe, TE | 1 |
| Maisonnette, S | 1 |
| Landeira-Fernandez, J | 1 |
| Ezquer, F | 1 |
| Quintanilla, ME | 3 |
| Moya-Flores, F | 1 |
| Morales, P | 1 |
| Munita, JM | 1 |
| Olivares, B | 1 |
| Landskron, G | 1 |
| Hermoso, MA | 1 |
| Ezquer, M | 1 |
| Herrera-Marschitz, M | 1 |
| Israel, Y | 1 |
| He, AB | 1 |
| Chang, YC | 1 |
| Meng, AWY | 1 |
| Huang, ACW | 1 |
| Russo, M | 1 |
| Funk, D | 1 |
| Loughlin, A | 1 |
| Coen, K | 1 |
| Lê, AD | 1 |
| Augier, E | 1 |
| Barbier, E | 1 |
| Dulman, RS | 1 |
| Licheri, V | 1 |
| Augier, G | 1 |
| Domi, E | 1 |
| Barchiesi, R | 1 |
| Farris, S | 1 |
| Nätt, D | 1 |
| Mayfield, RD | 1 |
| Adermark, L | 1 |
| Heilig, M | 1 |
| Dess, NK | 2 |
| Madkins, CD | 1 |
| Geary, BA | 1 |
| Chapman, CD | 1 |
| Dyr, W | 2 |
| Wyszogrodzka, E | 1 |
| Paterak, J | 1 |
| Siwińska-Ziółkowska, A | 1 |
| Małkowska, A | 1 |
| Polak, P | 1 |
| Carroll, ME | 1 |
| Morgan, AD | 1 |
| Anker, JJ | 1 |
| Perry, JL | 1 |
| Lyons, AM | 1 |
| Lowery, EG | 1 |
| Sparta, DR | 1 |
| Thiele, TE | 2 |
| Sabino, V | 1 |
| Cottone, P | 1 |
| Zhao, Y | 1 |
| Steardo, L | 2 |
| Rice, KC | 1 |
| Conti, B | 1 |
| Koob, GF | 2 |
| Zorrilla, EP | 1 |
| Tampier, L | 2 |
| Navarro, M | 1 |
| Cubero, I | 1 |
| Ko, L | 1 |
| Loi, B | 1 |
| Lobina, C | 1 |
| Maccioni, P | 1 |
| Fantini, N | 1 |
| Carai, MA | 1 |
| Gessa, GL | 1 |
| Colombo, G | 1 |
| Bahi, A | 1 |
| Ingman, K | 1 |
| Honkanen, A | 1 |
| Hyytiä, P | 2 |
| Huttunen, MO | 1 |
| Korpi, ER | 1 |
| June, HL | 1 |
| Foster, KL | 1 |
| McKay, PF | 1 |
| Seyoum, R | 1 |
| Woods, JE | 1 |
| Harvey, SC | 1 |
| Eiler, WJ | 1 |
| Grey, C | 1 |
| Carroll, MR | 1 |
| McCane, S | 1 |
| Jones, CM | 1 |
| Yin, W | 1 |
| Mason, D | 1 |
| Cummings, R | 1 |
| Garcia, M | 1 |
| Ma, C | 1 |
| Sarma, PV | 1 |
| Cook, JM | 1 |
| Skolnick, P | 1 |
| LESTER, D | 2 |
| GREENBERG, LA | 1 |
| Terenina-Rigaldie, E | 1 |
| Jones, BC | 1 |
| Mormède, P | 1 |
| Diaz-Granados, JL | 1 |
| Graham, DL | 1 |
| Rodd, ZA | 1 |
| Kimpel, MW | 1 |
| Edenberg, HJ | 1 |
| Bell, RL | 1 |
| Strother, WN | 1 |
| McClintick, JN | 1 |
| Carr, LG | 1 |
| Liang, T | 1 |
| McBride, WJ | 1 |
| Perez, E | 1 |
| Le Magnen, J | 2 |
| Marfaing-Jallat, P | 2 |
| Miceli, D | 1 |
| Crawford, D | 1 |
| Baker, TB | 1 |
| Schulteis, G | 1 |
| Heinrichs, SC | 1 |
| Cohen, C | 1 |
| Perrault, G | 1 |
| Sanger, DJ | 1 |
| Schreiber, R | 1 |
| Manze, B | 1 |
| Haussels, A | 1 |
| De Vry, J | 1 |
| Kostowski, W | 1 |
| Rezvani, AH | 1 |
| Parsian, A | 1 |
| Overstreet, DH | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Radow, B | 1 |
| Sigman, G | 1 |
| Froehlich, JC | 1 |
| Harts, J | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Freed, EX | 1 |
| Cicero, TJ | 1 |
| Snider, SR | 1 |
| Perez, VJ | 1 |
| Swanson, LW | 1 |
2 reviews available for saccharin and Alcoholism
| Article | Year |
|---|---|
Selective breeding for differential saccharin intake as an animal model of drug abuse.
Topics: Alcoholism; Animals; Arousal; Disease Models, Animal; Female; Genotype; Male; Mice; Mice, Inbred Str | 2008 |
The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism.
Topics: Alcoholism; Animals; Depression; Disease Models, Animal; Maze Learning; Phenotype; Rats; Rats, Inbre | 2002 |
34 other studies available for saccharin and Alcoholism
| Article | Year |
|---|---|
Systemic administration of racemic baclofen reduces both acquisition and maintenance of alcohol consumption in male and female mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Baclofen; Ethanol; Female; GABA-B Receptor Agonists; Male; Mi | 2022 |
Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Ethanol; Male; Rats; Saccharin; Social Isolation; Water | 2022 |
Catechol-O-Methyltransferase inhibition and alcohol use disorder: Evaluating the efficacy of tolcapone in ethanol-dependent rats.
Topics: Alcoholism; Animals; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhib | 2024 |
Alcohol intake in Carioca High- and Low-conditioned Freezing rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety Disorders; Conditioning, Psychological; Disease Model | 2020 |
Innate gut microbiota predisposes to high alcohol consumption.
Topics: Alcoholism; Animals; Ethanol; Gastrointestinal Microbiome; Genotype; Male; Rats; Rats, Wistar; Sacch | 2021 |
Re-evaluation of the reward comparison hypothesis for alcohol abuse.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Conditioning, Psychological; Disease Models | 2017 |
Effects of alcohol dependence on discrete choice between alcohol and saccharin.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Choice Behavior; Ethanol; Male; Nicotine; N | 2018 |
A molecular mechanism for choosing alcohol over an alternative reward.
Topics: Alcoholism; Amygdala; Animals; Behavior, Addictive; Choice Behavior; Down-Regulation; Ethanol; GABA | 2018 |
"Jello® shots" and cocktails as ethanol vehicles: parametric studies with high- and low-saccharin-consuming rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Eating; Ethanol; Food Deprivation; Food Pre | 2013 |
Ethanol-induced conditioned taste aversion in Warsaw Alcohol High-Preferring (WHP) and Warsaw Alcohol Low-Preferring (WLP) rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Avoidance Learning; Choice Behavior; Conditioning, Classical; | 2016 |
Effects of food availability and administration of orexigenic and anorectic agents on elevated ethanol drinking associated with drinking in the dark procedures.
Topics: Alcohol Drinking; Alcoholism; Animals; Appetite Depressants; Appetite Stimulants; Darkness; Disease | 2008 |
The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Conditioning, Operant; Disease Models, Animal; Ethanol | 2009 |
Effect of concurrent saccharin intake on ethanol consumption by high-alcohol-drinking (UChB) rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Choice Behavior; Drinking; Female; Motivation; Rats; Rats, In | 2009 |
Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice.
Topics: Agouti-Related Protein; Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; C | 2009 |
Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol.
Topics: Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Animals; Choice Behavior; Disease Models, Anim | 2010 |
Increased anxiety, voluntary alcohol consumption and ethanol-induced place preference in mice following chronic psychosocial stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Anxiety; Behavior, Addictive; Choice Behavior; Conditioning, | 2013 |
Risperidone reduces limited access alcohol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine D2 Rec | 2003 |
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.
Topics: Alcoholism; Alcohols; Animals; Body Weight; Carbolines; Conditioning, Operant; Disease Models, Anima | 2003 |
Nutrition and the etiology of alcoholism; the effect of sucrose, saccharin and fat on the self-selection of ethyl alcohol by rats.
Topics: Alcoholism; Animals; Ethanol; Nutritional Physiological Phenomena; Nutritional Sciences; Nutritional | 1952 |
The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; E | 2004 |
The effects of continuous and intermittent ethanol exposure in adolesence on the aversive properties of ethanol during adulthood.
Topics: Administration, Inhalation; Age Factors; Alcohol Drinking; Alcoholism; Animals; Association Learning | 2007 |
Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats.
Topics: Alcoholism; Amygdala; Animals; Conditioning, Operant; Ethanol; Female; Gene Expression; Male; Models | 2008 |
Baclofen reduces ethanol intake in high-alcohol-drinking University of Chile bibulous rats.
Topics: Alcoholism; Animals; Baclofen; Behavior, Animal; Choice Behavior; Disease Models, Animal; Ethanol; L | 2008 |
A bioassay of ethanol-dependence in rats.
Topics: Alcoholism; Animals; Conditioning, Psychological; Humans; Male; Rats; Saccharin; Substance Withdrawa | 1980 |
Alcohol dependence and taste-mediated learning in the rat.
Topics: Alcoholism; Animals; Conditioning, Operant; Humans; Learning; Male; Rats; Saccharin; Stress, Psychol | 1982 |
Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Drug Tolerance; Ethanol; Male; Motivation; Rats; Rats, Wistar | 1996 |
Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Oral; Alcohol Drinking; | 1999 |
Effects of the 5-HT1A receptor agonist ipsapirone on operant self-administration of ethanol in the rat.
Topics: Alcoholism; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response | 1999 |
Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Rats; Rats, Wistar; Saccharin | 2000 |
Blood alcohol level and caloric intake in the gravid rat as a function of diurnal period, trimester, and vehicle.
Topics: Alcoholism; Animals; Body Weight; Circadian Rhythm; Diet; Energy Intake; Ethanol; Female; Fetus; Hum | 1978 |
Ethanol-induced taste aversion in ethanol-dependent and normal rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Avoidance Learning; Conditioning, Operant; Ethanol; Humans; M | 1979 |
Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference.
Topics: Alcohol Drinking; Alcoholism; Animals; Conditioning, Psychological; Drinking Behavior; Ethanol; Fema | 1988 |
A rat model of alcoholism?
Topics: Acetone; Alcohol Drinking; Alcoholism; Animal Nutritional Physiological Phenomena; Animals; Conditio | 1972 |
Physical dependence on and tolerance to alcohol in the rat.
Topics: Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Eth | 1971 |