saccharin has been researched along with Aging in 32 studies
Saccharin: Flavoring agent and non-nutritive sweetener.
saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression." | 7.73 | Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. ( Berry, KJ; Cisneros, FJ; Ferguson, SA; Gough, B; Hanig, JP, 2005) |
| "We explored the impact of exposure to an obesogenic diet (High Fat-High Sucrose; HFS) during the post-weaning period on sweet preference and behaviors linked to reward and anxiety." | 3.83 | Behavioral consequences of exposure to a high fat diet during the post-weaning period in rats. ( Askevik, K; Babaei, CS; Dickson, SL; Rabasa, C; Vogel, H; Winsa-Jörnulf, J, 2016) |
| "Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression." | 3.73 | Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. ( Berry, KJ; Cisneros, FJ; Ferguson, SA; Gough, B; Hanig, JP, 2005) |
| "Voluntary drinking of 20 % ethanol in an every-other-day (EOD) availability pattern and the dose-response relationship of ethanol conditioned taste aversion (CTA) were assessed in male and female adolescent and adult rats." | 1.40 | Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats. ( Francis, R; Keistler, C; Kuhn, CM; MacDonald, A; O'Neill, L; Schramm-Sapyta, NL, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (25.00) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 8 (25.00) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ngekure M X, K | 1 |
| Jiang, J | 1 |
| Enayatullah, H | 1 |
| Ennab, W | 1 |
| Mustafa, S | 1 |
| Rodeni, S | 1 |
| Wei, Q | 1 |
| Shi, F | 1 |
| Cole, RD | 1 |
| Wolsh, C | 1 |
| Zimmerman, M | 1 |
| Harrington, E | 1 |
| Gould, TJ | 1 |
| Parikh, V | 1 |
| Anderson, RI | 2 |
| Morales, M | 2 |
| Spear, LP | 2 |
| Varlinskaya, EI | 2 |
| Coccurello, R | 1 |
| Bielawski, A | 1 |
| Zelek-Molik, A | 1 |
| Vetulani, J | 1 |
| Kowalska, M | 1 |
| D'Amato, FR | 1 |
| Nalepa, I | 1 |
| Schramm-Sapyta, NL | 1 |
| Francis, R | 1 |
| MacDonald, A | 1 |
| Keistler, C | 1 |
| O'Neill, L | 1 |
| Kuhn, CM | 1 |
| Schatz, KC | 1 |
| Miranda-Morales, RS | 1 |
| Pautassi, RM | 1 |
| Toalston, JE | 1 |
| Deehan, GA | 1 |
| Hauser, SR | 1 |
| Engleman, EA | 1 |
| Bell, RL | 1 |
| Murphy, JM | 1 |
| McBride, WJ | 1 |
| Rodd, ZA | 1 |
| Rabasa, C | 1 |
| Winsa-Jörnulf, J | 1 |
| Vogel, H | 1 |
| Babaei, CS | 1 |
| Askevik, K | 1 |
| Dickson, SL | 1 |
| Hulin, MW | 1 |
| Amato, RJ | 1 |
| Winsauer, PJ | 1 |
| Puhl, MD | 1 |
| Blum, JS | 1 |
| Acosta-Torres, S | 1 |
| Grigson, PS | 1 |
| Palmer, AA | 1 |
| Sharpe, AL | 1 |
| Burkhart-Kasch, S | 1 |
| McKinnon, CS | 1 |
| Coste, SC | 1 |
| Stenzel-Poore, MP | 1 |
| Phillips, TJ | 1 |
| Ikeda, M | 1 |
| Mitsui, T | 1 |
| Setani, K | 1 |
| Tamura, M | 1 |
| Kakeyama, M | 1 |
| Sone, H | 1 |
| Tohyama, C | 1 |
| Tomita, T | 1 |
| Ferguson, SA | 1 |
| Cisneros, FJ | 1 |
| Gough, B | 1 |
| Hanig, JP | 1 |
| Berry, KJ | 1 |
| Sunwoo, Y | 1 |
| Chou, C | 1 |
| Takeshita, J | 1 |
| Murakami, M | 1 |
| Tochihara, Y | 1 |
| Perry, JL | 1 |
| Anderson, MM | 1 |
| Nelson, SE | 1 |
| Carroll, ME | 1 |
| Truxell, EM | 1 |
| Molina, JC | 1 |
| Spear, NE | 2 |
| Minnier, E | 1 |
| Misanin, JR | 3 |
| Hinderliter, CF | 3 |
| Kucharski, D | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Sigman, G | 1 |
| Day-Pfeiffer, H | 1 |
| Calcagnetti, DJ | 1 |
| Reid, LD | 1 |
| Liau, HP | 1 |
| Peng, MT | 1 |
| Sweatman, TW | 1 |
| Renwick, AG | 1 |
| Easterby-Smith, V | 1 |
| Besford, J | 1 |
| Heath, MR | 1 |
| Wilson, HA | 1 |
| Schwarz, PR | 1 |
| Tuschak, JB | 1 |
| Hany, J | 1 |
| Lilienthal, H | 1 |
| Sarasin, A | 1 |
| Roth-Härer, A | 1 |
| Fastabend, A | 1 |
| Dunemann, L | 1 |
| Lichtensteiger, W | 1 |
| Winneke, G | 1 |
| Collins, M | 1 |
| Rushanan, S | 1 |
| Anderson, MJ | 1 |
| Goodhart, M | 1 |
| Nisbett, RE | 1 |
| Braver, A | 1 |
| Jusela, G | 1 |
| Kezur, D | 1 |
| Manning, CA | 1 |
| Parsons, MW | 1 |
| Gold, PE | 1 |
| Gorczynski, RM | 2 |
| Kutscher, CL | 1 |
| Miller, DG | 1 |
1 trial available for saccharin and Aging
| Article | Year |
|---|---|
Physiological and subjective responses to low relative humidity in young and elderly men.
Topics: Acclimatization; Adult; Aged; Aging; Blinking; Body Temperature; Humans; Humidity; Male; Perception; | 2006 |
31 other studies available for saccharin and Aging
| Article | Year |
|---|---|
Sweet taste receptor agonists alter ovarian functions and ovarian cycles in aged mice.
Topics: Aging; Animals; Diterpenes, Kaurane; Estrous Cycle; Female; Gene Expression Regulation; Mice; Mice, | 2019 |
Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice.
Topics: Administration, Oral; Aging; Animals; Conditioning, Operant; Female; Male; Mice; Mice, Inbred C57BL; | 2019 |
Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats.
Topics: Aging; Animals; Avoidance Learning; Conditioning, Psychological; Dose-Response Relationship, Drug; M | 2014 |
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Fema | 2014 |
Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats.
Topics: Aging; Alcohol Drinking; Animals; Animals, Outbred Strains; Avoidance Learning; Central Nervous Syst | 2014 |
Conditioned taste aversion to ethanol in a social context: impact of age and sex.
Topics: Aging; Analysis of Variance; Animals; Central Nervous System Depressants; Conditioning, Classical; D | 2014 |
Pharmacological characterization of the nociceptin/orphanin FQ receptor on ethanol-mediated motivational effects in infant and adolescent rats.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Choice Behavior; Conditioning, Psychological; Ethanol; Fe | 2016 |
The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats.
Topics: Aging; Animals; Conditioning, Operant; Ethanol; Extinction, Psychological; Female; Rats; Rats, Inbre | 2015 |
Behavioral consequences of exposure to a high fat diet during the post-weaning period in rats.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Brain; Diet, High-Fat; Feeding Behavior; Food; Food Prefe | 2016 |
GABA(A) receptor modulation during adolescence alters adult ethanol intake and preference in rats.
Topics: Aging; Alcohol Drinking; Animals; Data Interpretation, Statistical; Dehydroepiandrosterone; Dose-Res | 2012 |
Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue.
Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Cues; Environment; Male; Rats; Rats, Sprague-Daw | 2012 |
Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol.
Topics: Aging; Alcohol Drinking; Animals; Avoidance Learning; Central Nervous System Depressants; Corticotro | 2004 |
In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Animals, Suckling; Aromatase; Brain; Brain C | 2005 |
Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Depression; Dose-Response Relationship, Drug; Drinkin | 2005 |
Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.
Topics: Aging; Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretat | 2007 |
Ethanol intake in the juvenile, adolescent, and adult rat: effects of age and prior exposure to ethanol.
Topics: Aging; Alcohol Drinking; Animals; Central Nervous System Depressants; Ethanol; Female; Male; Rats; R | 2007 |
Age and interstimulus interval in forward and backward long-trace taste-aversion conditioning.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditionin | 2007 |
Potentiation of a conditioned taste aversion in preweanling and adult rats.
Topics: Aging; Animals; Animals, Newborn; Avoidance Learning; Chlorides; Conditioning, Classical; Extinction | 1984 |
Saccharin preferences in food deprived aging rats are altered as a function of perinatal drug exposure.
Topics: Aging; Analysis of Variance; Animals; Body Weight; Drinking; Female; Fetus; Food Deprivation; Food P | 1983 |
Morphine and acceptability of putative reinforcers.
Topics: Aging; Animals; Male; Morphine; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Saccharin | 1983 |
Suppressive effects of estrogen on food intake and body weight in senile female rats.
Topics: Aging; Animals; Body Weight; Drinking; Eating; Estrogens; Female; Rats; Rats, Inbred Strains; Saccha | 1982 |
Tissue levels of saccharin in the rat during two-generation feeding studies.
Topics: Aging; Animals; Animals, Newborn; Female; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; R | 1982 |
The effect of age on the recognition thresholds of three sweeteners: sucrose, saccharin and aspartame.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Aspartame; Female; Humans; Male; Mid | 1994 |
Low body temperature affects associative processes in long-trace conditioned flavor aversion.
Topics: Aging; Animals; Association; Avoidance Learning; Biological Clocks; Body Temperature; Conditioning, | 1998 |
Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior.
Topics: Aging; Animals; Animals, Newborn; Aromatase; Birth Weight; Brain; Chlorodiphenyl (54% Chlorine); Env | 1999 |
Aging facilitates long-trace taste-aversion conditioning in rats.
Topics: Aging; Animals; Association Learning; Conditioning, Operant; Female; Lithium Chloride; Rats; Rats, W | 2002 |
Age and sex differences in behaviors mediated by the ventromedial hypothalamus.
Topics: Aging; Animals; Behavior, Animal; Circadian Rhythm; Dietary Carbohydrates; Dietary Fats; Discriminat | 1975 |
Anterograde and retrograde enhancement of 24-h memory by glucose in elderly humans.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Blood Glucose; Female; Glucose; Humans; Male; | 1992 |
Toward an understanding of the mechanisms of classical conditioning of antibody responses.
Topics: Aging; Animals; Antibody-Producing Cells; Conditioning, Classical; Cyclophosphamide; Immunoglobulin | 1991 |
Conditioned immunosuppression in young versus aged mice: differences in cells and responses to environmental stimuli lead to altered conditioning in aged animals.
Topics: Aging; Animals; Antibody Formation; Conditioning, Psychological; Cyclophosphamide; Immunization, Pas | 1987 |
Age-dependent polydipsia in the SWR-J mouse.
Topics: Aging; Animals; Circadian Rhythm; Diabetes Insipidus; Diabetic Nephropathies; Disease Models, Animal | 1974 |