s-nitrosocysteine has been researched along with Nervous-System-Diseases* in 1 studies
1 other study(ies) available for s-nitrosocysteine and Nervous-System-Diseases
| Article | Year |
|---|---|
Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine.
Converging data suggest that nitric oxide (NO) production by cytokine-induced immune cells in demyelinating lesions is involved in multiple sclerosis (MS). High levels of NO may complex to suitable amino acids, causing an immune response against the formed neo-epitopes. By testing MS sera with chemically defined nitroso-amino acids conjugated to carrier protein in ELISA, we observed a significant antibody reaction against the S-nitroso-cysteine epitope. The MS antibody response was exclusively of IgM isotype with an avidity of 8 x 10(-7) M. Sera of all clinical MS forms showed a significantly elevated antibody titer versus sera from healthy subjects or from patients affected with other neurological and autoimmune diseases. The detection of circulating antibodies to a conjugated S-nitroso-cysteine epitope provides indirect evidence for NO involvement in MS. Topics: Adult; Antibodies; Autoimmune Diseases; Cysteine; Epitopes; Female; Humans; Immunoglobulin M; Male; Middle Aged; Multiple Sclerosis; Nervous System Diseases; Nitric Oxide; Reference Values; S-Nitrosothiols | 1995 |