Compounds > s-adenosylmethionine
Page last updated: 2024-08-23

s-adenosylmethionine and Liver Steatosis

s-adenosylmethionine has been researched along with Liver Steatosis in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19906 (11.32)18.7374
1990's1 (1.89)18.2507
2000's18 (33.96)29.6817
2010's27 (50.94)24.3611
2020's1 (1.89)2.80

Authors

AuthorsStudies
Abdul Azees, PA; Barnes, JL; Das, F; Ghosh Choudhury, G; Kamat, A; Katz, MS; Pizzini, J; Shi, Y; Wang, H; Weintraub, ST; Yeh, CK; Zang, M1
Bennett, M; Charlton, M; Chung, C; Harrison, SA; Harting, E; Kayali, Z; Lai, M; Lawitz, EJ; Loomba, R; McColgan, BJ; Middleton, MS; Myers, RP; Noureddin, M; Ray, AS; Ruane, P; Subramanian, GM; Tarrant, JM; Wang, L1
Haga, H; Ishii, R; Katsumi, T; Kawata, S; Misawa, K; Nishise, Y; Okumoto, K; Saito, T; Sato, C; Tomita, K; Ueno, Y; Watanabe, H1
Eskelin, PM; Laitinen, KA; Tyni, TA1
Bonnefont, JP; Bouchireb, K; Brivet, M; de Lonlay, P; de Pontual, L; Gaudelus, J; Rigal, O; Sellier, N; Teychene, AM; Valayannopoulos, V1
Anderson, KA; Lin, F; Means, AR; Muehlbauer, MJ; Newgard, CB; Ribar, TJ; Stevens, RD1
Brockman, DA; Chen, X; Gallaher, DD1
Arenas, J; Castellano, G; Colina, F; Del Hoyo, P; Martín, A; Martín, MA; Pérez-Carreras, M; Rubio, JC; Solis-Herruzo, JA1
Cline, GW; Coleman, RA; Hammond, LE; Ilkayeva, OR; Muoio, DM; Neschen, S; Romanelli, AJ; Shulman, GI1
Chen, YH; Chen, YT; Cheng, CF; Huang, CC; Hung, SI; Kao, HJ; Kikuchi, T; Millington, D; Wu, JY1
Deng, L; Gong, QM; Kong, XF; La, DD; Li, HW; Peng, CH; Shen, BY; Shi, Q; Yu, YY; Zhang, XX; Zhu-Ge, CD1
Chisholm, CA; Frerman, FE; Lovell, MA; Roe, CR; Roe, DS; Sweetman, L; Vavelidis, F; Wilson, WG1
Mehedint, MG; Zeisel, SH1
Alonso, C; Aspichueta, P; Aurrekoetxea, I; Beraza, N; Buqué, X; Cano, A; Fernández-Ares, L; Finnell, RH; García-Rodríguez, JL; Lu, SC; Luka, Z; Martínez-Arranz, I; Martínez-Chantar, ML; Martínez-Uña, M; Mato, JM; Mestre, D; Varela-Rey, M; Wagner, C1
Kozlov, VK; Stel'makh, VV1
Obeid, R1
Alhonen, L; Asara, JM; Banks, AS; Bhanot, S; Cen, Y; Gong, F; Kahn, BB; Kong, D; Kraus, D; Monia, BP; Peroni, OD; Pirinen, E; Puigserver, P; Pulinilkunnil, TC; Rodgers, JT; Sauve, AA; Wang, YC; Yang, Q; Zhang, L1
Brosnan, JT; Brosnan, ME; da Silva, RP; Deminice, R; Jacobs, RL; Kelly, KB; Lamarre, SG1
Cardoso, JF; da Silva, LE; de Castro, GS; Deminice, R; Dos Reis Silveira, L; Frajacomo, FT; Francisco, LV; Jordao, AA; Teodoro, BG1
Kobayashi, Y; Nohara, K; Okamura, K; Sano, T; Takumi, S; Yanagisawa, H1
Aldámiz-Echevarría, L; Andrade, F; Aspichueta, P; Barbier-Torres, L; Beraza, N; Falcon-Perez, JM; Fernandez, ML; Fernández-Ramos, D; Fernandez-Tussy, P; García-Monzón, C; García-Rodríguez, JL; Juan, VG; Lage-Medina, S; Lopitz-Otsoa, F; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-Lopez, N; Martínez-Uña, M; Mato, JM; Varela-Rey, M; Wagner, C; Woodhoo, A; Zubiete-Franco, I1
Chmiel, KJ; Halsted, CH; Kharbanda, KK; Kim, K; Medici, V; Olson, K; Rutledge, JC; Shibata, NM; Su, RJ; Syed, R; Yokoyama, A1
Feng, D; French, SW; Ganesan, M; Kharbanda, KK; Maillacheruvu, PF; Orlicky, DJ; Osna, NA; Tuma, DJ1
Walker, AK1
Herrmann, W; Obeid, R1
Elias, MS; Green, RM; Henkel, AS1
Caballeria, J; Caballero, F; Elena, M; Fernández, A; Fernández-Checa, JC; Fucho, R; García-Ruiz, C; Martínez, L; Matías, N; Morales, A1
Moreno-Otero, R; Trapero-Marugán, M1
Calvisi, DF; Embade, N; Esteller, M; Fernández-Ramos, D; Frades, I; Fraga, MF; Julve, J; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-López, N; Mato, JM; Rodríguez, J; Rodríguez-Millán, E; Torres, L; Varela-Rey, M; Wagner, C; Woodhoo, A1
Aspichueta, P; Aurrekoetxea, I; Buqué, X; Cano, A; García-Rodríguez, JL; Lu, SC; Martínez-Chantar, ML; Martínez-Uña, M; Mato, JM; Menor, A; Ochoa, B1
Dilger, RN; Garrow, TA; Gupta, S; Kruger, WD; Li, L; Strakova, J; Tryon, K1
Garrow, TA; Mehedint, MG; Teng, YW; Zeisel, SH1
Brosnan, JT; Brosnan, ME; Brown, C; da Silva, RP; Deminice, R; Furey, GN; Jacobs, RL; Jordao, AA; Kelly, KB; King-Jones, K; Lamarre, SG; McCarter, SA1
Dettmer, K; Gronwald, W; Hellerbrand, C; Klein, MS; Oefner, PJ; Reinders, J; Stevens, AP; Thomas, A1
Kozlov, VK; Nekrasova, AS; Radchenko, VG; Stel'makh, VV1
Barak, AJ; Beckenhauer, HC; Kharbanda, KK; Mailliard, ME; Rogers, DD; Siford, GL; Sorrell, MF; Tuma, DJ1
Green, RM; Igolnikov, AC1
Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS1
Al-Osaimi, AM; Argo, CK; Caldwell, SH; Chang, CY1
Banerjee, R; Bauman, Z; Braun, A; Lu, SC; Prudova, A; Vitvitsky, V1
Barve, S; Cave, M; Deaciuc, I; Joshi-Barve, S; McClain, C; Mendez, C; Song, Z1
Chan, C; Ji, C; Kaplowitz, N; Kuhlenkamp, J; Shinohara, M1
Devaraj, S; Esfandiari, F; French, SW; Halsted, CH; Villanueva, JA; White, ME1
Copple, BL; Gyamfi, M; He, L; Wan, YJ; Wortham, M1
Aransay, AM; Ariz, U; Calvisi, DF; Capdevila, A; Esteller, M; Fraga, M; Lu, SC; Luka, Z; Martínez, N; Martínez-Chantar, ML; Mato, JM; Matthiesen, R; Rodríguez, J; Varela, M; Vázquez-Chantada, M; Wagner, C; Yang, H1
Fiaccadori, F; Ghinelli, F; Magnani, G; Pelosi, G; Sacchini, D; Tedeschi, F1
Fujiwara, Y; Kaneshiro, Y; Kigawa, G; Kitamura, N; Kumada, K; Kuzume, M; Matsumoto, F; Nagasaki, H; Nakano, H; Sasaki, J; Takeuchi, S; Yamaguchi, M; Yoshida, K1
Lieber, CS1
Andreana, A; Galletti, P; Porcelli, M; Ruggiero, G; Zappia, V1
Angioli, D; Arcangeli, A; Auteri, A; Boggiano, CA; Boncompagni, P; Camarri, E; Candidi Tommasi, A; Caremani, M; Di Perri, T; Forconi, A; Lomi, M; Magnolfi, F; Mazzanti, R; Motta, R; Pippi, L; Salvadori, G; Smorlesi, C; Soldi, A; Toti, M1
Gasbarrini, GB; Labò, G1
Henning, SM; McKee, RW; Swendseid, ME1
Gasbarrini, G; Labò, G; Miglio, F1

Reviews

7 review(s) available for s-adenosylmethionine and Liver Steatosis

ArticleYear
Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:3

    Topics: Animals; Choline; Diet; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid; Gene Expression; Histones; Humans; Liver; Liver Cirrhosis; Models, Animal; Polymorphism, Genetic; S-Adenosylmethionine

2013
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
    Nutrients, 2013, Sep-09, Volume: 5, Issue:9

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine

2013
1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver.
    Trends in endocrinology and metabolism: TEM, 2017, Volume: 28, Issue:1

    Topics: Animals; Carbon Cycle; Diabetes Mellitus, Type 2; Fatty Liver; Humans; Lipogenesis; Phosphatidylcholines; S-Adenosylmethionine

2017
Homocysteine and lipids: S-adenosyl methionine as a key intermediate.
    FEBS letters, 2009, Apr-17, Volume: 583, Issue:8

    Topics: Alcoholism; Dyslipidemias; Fatty Liver; Homeostasis; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; S-Adenosylmethionine

2009
Therapy of NAFLD: antioxidants and cytoprotective agents.
    Journal of clinical gastroenterology, 2006, Volume: 40 Suppl 1

    Topics: Acetylcysteine; Antioxidants; Betaine; Cholagogues and Choleretics; Disease Progression; Fatty Liver; Humans; Lipid Peroxidation; S-Adenosylmethionine; Ursodeoxycholic Acid; Vitamin E

2006
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.
    The Journal of nutritional biochemistry, 2007, Volume: 18, Issue:3

    Topics: Betaine; Cytokines; Dietary Supplements; Environmental Exposure; Fatty Liver; Female; Humans; Insulin Resistance; Life Style; Liver; Liver Cirrhosis; Metabolic Syndrome; Methionine; Middle Aged; Mitochondrial Diseases; Oxidative Stress; S-Adenosylmethionine; United States; Vitamin E; Xenobiotics; Zinc

2007
Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment.
    The American journal on addictions, 2001, Volume: 10, Issue:s1

    Topics: beta Carotene; Ethanol; Fatty Liver; Hepatitis C; Hepatitis, Alcoholic; Humans; Lipid Peroxidation; Liver Cirrhosis; NAD; Nutritional Status; Oxidative Stress; Phosphatidylcholines; S-Adenosylmethionine; Vitamin A

2001

Trials

2 trial(s) available for s-adenosylmethionine and Liver Steatosis

ArticleYear
GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.
    Gastroenterology, 2018, Volume: 155, Issue:5

    Topics: Acetyl-CoA Carboxylase; Biomarkers; Carnitine; Double-Blind Method; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Isobutyrates; Liver Cirrhosis; Magnetic Resonance Imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oxazoles; Pyrimidines

2018
[Metabolic correction of dyslipidemia in patients with nonalcoholic fatty liver disease as a new therapy policy].
    Terapevticheskii arkhiv, 2013, Volume: 85, Issue:4

    Topics: Adult; Aged; Dyslipidemias; Fatty Liver; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Non-alcoholic Fatty Liver Disease; S-Adenosylmethionine; Succinates; Treatment Outcome; Young Adult

2013

Other Studies

44 other study(ies) available for s-adenosylmethionine and Liver Steatosis

ArticleYear
    American journal of physiology. Endocrinology and metabolism, 2021, 07-01, Volume: 321, Issue:1

    Topics: Adrenergic beta-2 Receptor Agonists; Animals; Carnitine; Fatty Liver; Formoterol Fumarate; Gene Expression; Hepatic Stellate Cells; Lipid Metabolism; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidate Phosphatase; Receptors, Adrenergic, beta-2; Triglycerides

2021
Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance.
    BMC gastroenterology, 2013, Jul-10, Volume: 13

    Topics: Adult; Aged; Carnitine; Fasting; Fatty Acids; Fatty Liver; Female; Hepatitis C, Chronic; Homeostasis; Humans; Insulin; Insulin Resistance; Ketone Bodies; Male; Middle Aged; Mitochondria; Oxidation-Reduction; Viral Core Proteins; Viral Load; Young Adult

2013
Elevated hydroxyacylcarnitines in a carrier of LCHAD deficiency during acute liver disease of pregnancy - a common feature of the pregnancy complication?
    Molecular genetics and metabolism, 2010, Volume: 100, Issue:2

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acute Disease; Adult; Carnitine; Fatty Liver; Female; Humans; Lipid Metabolism, Inborn Errors; Liver Diseases; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third

2010
Post-mortem MRI reveals CPT2 deficiency after sudden infant death.
    European journal of pediatrics, 2010, Volume: 169, Issue:12

    Topics: Carnitine; Carnitine O-Palmitoyltransferase; Cause of Death; Diagnosis; Fatty Liver; Hepatomegaly; Humans; Infant; Magnetic Resonance Imaging; Male; Metabolism, Inborn Errors; Postmortem Changes; Sudden Infant Death

2010
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.
    Molecular endocrinology (Baltimore, Md.), 2012, Volume: 26, Issue:2

    Topics: Adenylate Kinase; Animals; Antigens, Neoplasm; Blood Glucose; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carnitine; Catecholamines; Cells, Cultured; Diet, High-Fat; Eating; Fatty Liver; Gene Knockout Techniques; Gluconeogenesis; Glucose; Glucose Intolerance; Hepatocytes; Homeostasis; Intra-Abdominal Fat; Lipid Metabolism; Liver; Mice; Mice, Knockout; Phospholipases A1; Primary Cell Culture; Signal Transduction

2012
Consumption of a high β-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat.
    European journal of nutrition, 2013, Volume: 52, Issue:7

    Topics: Adiponectin; Animals; beta-Glucans; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diabetes Mellitus, Type 2; Dietary Fiber; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Flour; Glucose Tolerance Test; Hordeum; Insulin; Insulin Resistance; Intestine, Small; Ketones; Liver; Obesity; Organ Size; Postprandial Period; Rats; Rats, Zucker; Thiobarbituric Acid Reactive Substances; Triglycerides

2013
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:4

    Topics: Adult; Body Mass Index; Carnitine; Electron Transport; Fatty Acids; Fatty Liver; Female; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Liver; Oxidation-Reduction; Reactive Oxygen Species

2003
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Animals; Carnitine; Coenzyme A; Dietary Fats; Dietary Sucrose; Fatty Liver; Female; Glycerol-3-Phosphate O-Acyltransferase; Insulin Resistance; Ketones; Lipids; Liver; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Obesity; Oxidation-Reduction; Triglycerides; Weight Gain

2005
ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.
    Human molecular genetics, 2006, Dec-15, Volume: 15, Issue:24

    Topics: Adipose Tissue; Animals; Base Sequence; Blotting, Western; Carnitine; Chromosome Mapping; Ethylnitrosourea; Fatty Liver; Female; Fibrosis; Lipid Metabolism Disorders; Male; Mice; Mice, Inbred C57BL; Mitochondrial Trifunctional Protein; Mitochondrial Trifunctional Protein, alpha Subunit; Mitochondrial Trifunctional Protein, beta Subunit; Multienzyme Complexes; Mutagenesis; Myocardium; Point Mutation; Polymerase Chain Reaction; Pregnancy; Tandem Mass Spectrometry

2006
No mutation was found in the alpha-subunit of the mitochondrial tri-functional protein in one patient with severe acute fatty liver of pregnancy and her relatives.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:12

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adult; Carnitine; Cytosine; Family; Fatty Liver; Female; Guanine; Humans; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase; Mass Spectrometry; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Mutation; Polymorphism, Restriction Fragment Length; Pregnancy; Pregnancy Complications; Protein Subunits; Sequence Analysis, DNA

2007
Prenatal diagnosis of multiple acyl-CoA dehydrogenase deficiency: association with elevated alpha-fetoprotein and cystic renal changes.
    Prenatal diagnosis, 2001, Volume: 21, Issue:10

    Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; alpha-Fetoproteins; Amniocentesis; Amniotic Fluid; Carnitine; Diagnosis, Differential; Fatty Liver; Female; Fetal Diseases; Fetal Growth Retardation; Gestational Age; Humans; Oligohydramnios; Polycystic Kidney Diseases; Pregnancy; Prenatal Diagnosis; Ultrasonography, Prenatal

2001
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:4

    Topics: Animals; Disease Models, Animal; Fatty Liver; Female; Glycine N-Methyltransferase; Homeostasis; Lipid Metabolism; Liver; Male; Membrane Proteins; Mice; Mice, Knockout; Perilipin-2; Phosphatidylcholines; Phosphatidylethanolamines; S-Adenosylmethionine; Triglycerides

2013
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
    Nature, 2014, Apr-10, Volume: 508, Issue:7495

    Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Diet; Energy Metabolism; Fatty Liver; Gene Knockdown Techniques; Glucose Intolerance; Glucose Transporter Type 4; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; S-Adenosylmethionine; Sirtuin 1; Spermine; Thinness

2014
Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism.
    Amino acids, 2015, Volume: 47, Issue:4

    Topics: Acyltransferases; Animals; Betaine; Carbon; Diet, High-Fat; Dietary Supplements; Fatty Liver; Glycine N-Methyltransferase; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides

2015
Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism.
    The Journal of nutritional biochemistry, 2015, Volume: 26, Issue:4

    Topics: Animals; Carbon; Carnitine O-Palmitoyltransferase; Cholesterol; Choline; Choline Deficiency; Creatine; Diet; Dietary Supplements; Fatty Liver; Ion Channels; Lipid Metabolism; Liver; Male; Malondialdehyde; Mitochondrial Proteins; PPAR alpha; PPAR gamma; Rats; Rats, Wistar; S-Adenosylmethionine; Triglycerides; Uncoupling Protein 2

2015
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:12

    Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine

2015
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
    Journal of hepatology, 2016, Volume: 64, Issue:2

    Topics: Animals; Autophagy; Cell Culture Techniques; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Methionine; Methylation; Mice; Protein Phosphatase 2; S-Adenosylmethionine

2016
Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice.
    Metabolic syndrome and related disorders, 2016, Volume: 14, Issue:4

    Topics: Animals; Choline; Diet; Dietary Fats; Dietary Sucrose; Dietary Supplements; Fatty Liver; Feeding Behavior; Female; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; S-Adenosylmethionine

2016
Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury.
    World journal of gastroenterology, 2016, Oct-14, Volume: 22, Issue:38

    Topics: Alanine Transaminase; Amidinotransferases; Animals; Aspartate Aminotransferases; Body Weight; Calcium-Binding Proteins; Cholesterol; Dietary Supplements; DNA-Binding Proteins; Ethanol; Fatty Acids; Fatty Liver; Glycine; Guanidinoacetate N-Methyltransferase; Homocysteine; Inflammation; Insulin; Liver; Liver Diseases; Male; Nerve Tissue Proteins; Nucleobindins; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides

2016
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
    The Journal of biological chemistry, 2009, Nov-13, Volume: 284, Issue:46

    Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response

2009
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
    The Journal of biological chemistry, 2010, Jun-11, Volume: 285, Issue:24

    Topics: Animal Feed; Animals; Ceramides; Choline; Fatty Liver; Glutathione; Inflammation; Lipids; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Prodrugs; S-Adenosylmethionine; Sphingomyelin Phosphodiesterase

2010
Hepatoprotective effects of antioxidants in chronic hepatitis C.
    World journal of gastroenterology, 2010, Apr-21, Volume: 16, Issue:15

    Topics: Acetylcysteine; Antioxidants; Disease Progression; Fatty Liver; Fibrosis; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Nitric Oxide; Oxidative Stress; S-Adenosylmethionine; Virus Replication

2010
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:1

    Topics: Animals; Fatty Liver; Gene Deletion; Gene Expression; Glycine N-Methyltransferase; Liver Cirrhosis; Mice; Mice, Knockout; Niacinamide; S-Adenosylmethionine

2010
Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice.
    Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:6

    Topics: Animals; Apolipoproteins B; Fatty Liver; Gene Deletion; Lipoproteins, VLDL; Liver; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Non-alcoholic Fatty Liver Disease; S-Adenosylmethionine; Triglycerides; Unfolded Protein Response

2011
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
    Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:7

    Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Cysteine; Diet; Enzyme Inhibitors; Fatty Liver; Glutathione; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; S-Adenosylmethionine

2011
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.
    The Journal of biological chemistry, 2011, Oct-21, Volume: 286, Issue:42

    Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Carcinoma, Hepatocellular; Choline; Fatty Liver; Gene Deletion; Humans; Lipoproteins, VLDL; Mice; Mice, Knockout; Neoplasm Proteins; Phospholipids; S-Adenosylmethionine; Triglycerides

2011
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet.
    The Journal of nutrition, 2011, Volume: 141, Issue:10

    Topics: Acyl-CoA Dehydrogenase, Long-Chain; Amidinotransferases; Animals; Carnitine O-Palmitoyltransferase; Creatine; Dietary Fats; Dietary Supplements; Fatty Liver; Gene Expression Regulation; Glycine; Kidney; Lipid Metabolism; Lipid Peroxidation; Liver; Male; PPAR alpha; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylmethionine

2011
Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet.
    Proteomics, 2012, Volume: 12, Issue:9

    Topics: Analysis of Variance; Animals; Cholesterol; Diet; Electrophoresis, Gel, Two-Dimensional; Fatty Liver; Female; Glycerol; Immunohistochemistry; Liver; Metabolomics; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteome; Proteomics; Reproducibility of Results; S-Adenosylmethionine

2012
[Pathogenetic therapy of metabolic syndrome at the stage of visceral lesions].
    Klinicheskaia meditsina, 2012, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Aged; Fatty Liver; Female; Humans; Infusions, Intravenous; Male; Metabolic Syndrome; Middle Aged; Non-alcoholic Fatty Liver Disease; S-Adenosylmethionine; Severity of Illness Index; Succinates; Treatment Outcome; Young Adult

2012
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
    The Journal of nutrition, 2005, Volume: 135, Issue:3

    Topics: Animals; Betaine; Disease Models, Animal; Ethanol; Fatty Liver; Hepatocytes; Male; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylmethionine

2005
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
    Journal of hepatology, 2006, Volume: 44, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biomarkers; Choline; Chromatography, High Pressure Liquid; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Heterozygote; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Up-Regulation

2006
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
    Journal of biochemical and molecular toxicology, 2006, Volume: 20, Issue:1

    Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Lipotropic Agents; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Thiazoles; Transaminases

2006
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Apr-25, Volume: 103, Issue:17

    Topics: Allosteric Regulation; Animals; Carcinoma, Hepatocellular; Cell Line; Cystathionine beta-Synthase; Enzyme Stability; Fatty Liver; Gene Silencing; Humans; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Mice; Mice, Knockout; Oxidation-Reduction; Recombinant Proteins; S-Adenosylmethionine

2006
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.
    Hepatology (Baltimore, Md.), 2007, Volume: 46, Issue:5

    Topics: Animals; Apolipoproteins B; Betaine; Betaine-Homocysteine S-Methyltransferase; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fatty Liver; Gene Transfer Techniques; Hepatocytes; Homocysteine; Humans; Lipid Metabolism; Liver Neoplasms; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Sterol Regulatory Element Binding Protein 1

2007
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:11

    Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature

2007
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:10

    Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated; Glutathione; Hepatitis; Homeostasis; Lipid Metabolism; Liver; Methionine; Mice; Mice, Mutant Strains; Mice, Obese; Obesity; S-Adenosylmethionine

2008
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Glycine N-Methyltransferase; Histones; Janus Kinases; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Mice; Mice, Knockout; Promoter Regions, Genetic; ras Proteins; S-Adenosylmethionine; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins; Transaminases; Tumor Suppressor Proteins

2008
[Clinico-pathogenetic problems and therapeutic approach in hepatic steatosis].
    Giornale di clinica medica, 1981, Volume: 62, Issue:5

    Topics: Adrenal Cortex Hormones; Alcoholism; Anabolic Agents; Fatty Liver; Humans; Hyperlipidemias; Liver Cirrhosis; S-Adenosylmethionine

1981
S-adenosyl-L-methionine attenuates ischemia-reperfusion injury of steatotic livers.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Fatty Liver; Glutathione; Glutathione Disulfide; Ischemia; L-Lactate Dehydrogenase; Liver; Male; Methionine; Mitochondria, Liver; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine

1998
Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver.
    FEBS letters, 1978, Jun-15, Volume: 90, Issue:2

    Topics: Biological Transport; Dinitrophenols; Fatty Liver; Kinetics; Liver; Methionine; S-Adenosylmethionine

1978
[The anti-steatosic effect of sulfo-adenosylmethionine (SAMe) in various forms of chronic hepatopathy. Multicentric research].
    Minerva medica, 1978, Oct-13, Volume: 69, Issue:48

    Topics: Adult; Aged; Chronic Disease; Drug Evaluation; Fatty Liver; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Middle Aged; S-Adenosylmethionine

1978
[Therapeutic action of S-adenosylmethionine in some chronic hepatopathies].
    Minerva medica, 1975, May-02, Volume: 66, Issue:33

    Topics: Adult; Aged; Chronic Disease; Fatty Liver; Female; Hepatitis; Humans; Jaundice; Liver Diseases; Male; Middle Aged; S-Adenosylmethionine

1975
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
    The Journal of nutrition, 1989, Volume: 119, Issue:10

    Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine

1989
[Various effects of SAM dependent transmethylations in hepatology].
    Minerva medica, 1972, May-09, Volume: 63, Issue:35

    Topics: Adenosine; Biopsy; Chronic Disease; Fatty Liver; Hepatitis; Humans; Injections, Intraperitoneal; Lipid Metabolism; Liver Cirrhosis; Liver Diseases; Liver Glycogen; Methionine; Methylation; S-Adenosylmethionine

1972