s-adenosylmethionine has been researched along with Disease Models, Animal in 139 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.60) | 18.7374 |
| 1990's | 4 (2.88) | 18.2507 |
| 2000's | 46 (33.09) | 29.6817 |
| 2010's | 64 (46.04) | 24.3611 |
| 2020's | 20 (14.39) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Borradaile, N; Bureau, Y; Dunlop, K; Hadway, J; Lee, TY; Nygard, K; Regnault, TRH; Richardson, BS; Sarr, O; Stachura, N; Thompson, JA; Zhao, L | 1 |
| Aboulouard, S; Cardon, T; Devos, D; Fournier, I; Kobeissy, F; Mallah, K; Quanico, J; Raffo-Romero, A; Salzet, M; Zibara, K | 1 |
| Houten, SM; Ranea-Robles, P; van Vlies, N; Vaz, FM; Yu, C | 1 |
| Funao, H; Ishihama, H; Ishii, K; Isogai, N; Kuramoto, T; Matsumoto, M; Nakamura, M; Shiono, Y; Yoshioka, K | 1 |
| Jung, YS; Kim, KS; Kim, S; Kim, SH; Kwon, D; Lee, S; Lee, W; Lee, YH; Seo, MS; Son, SW | 1 |
| Ito, S; Kaneko, M; Kawana, Y; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sekimoto, A; Shimma, S; Takahashi, N; Tsunokuni, Y | 1 |
| Caterino, M; Costanzo, M; De Pasquale, V; Fedele, R; Pavone, LM; Ruoppolo, M | 1 |
| Becker, LB; Choi, J; Choudhary, RC; Hayashida, K; Kim, J; Kim, N; Nishikimi, M; Shoaib, M; Stevens, JF; Yagi, T; Yin, T | 1 |
| Caudal, A; Kolwicz, SC; McMillen, TS; Ritterhoff, J; Senn, T; Tian, R; Villet, O; Young, S | 1 |
| Gahr, BM; Just, S; Krause, J; Park, DD; Rottbauer, W; Zeller, T | 1 |
| Iannucci, LF; Kovalik, JP; Leow, MK; Liao, XH; Ohba, K; Refetoff, S; Singh, BK; Sinha, RA; Sng, JCG; Yen, PM; Zhou, J | 1 |
| Arita, J; Enooku, K; Fujiwara, N; Fukayama, M; Hasegawa, K; Hayashi, A; Hayata, Y; Hikiba, Y; Hirata, Y; Hirschfield, H; Hoshida, Y; Koike, K; Kudo, Y; Misumi, K; Nakagawa, H; Nakatsuka, T; Otsuka, M; Shibahara, J; Tanaka, M; Tanaka, Y; Tateishi, K; Tateishi, R | 1 |
| Cusmano-Ozog, K; McGuire, PJ; Tarasenko, TN | 1 |
| Bouchard, B; Burelle, Y; Cuillerier, A; Daneault, C; Des Rosiers, C; Deschênes, S; Forest, A; Frayne, IR; Legault, JT; Rioux, JD; Ruiz, M; Vaz, FM | 1 |
| Bakermans, AJ; Denis, S; Houten, SM; Nicolay, K; Prompers, JJ; van Weeghel, M | 1 |
| Heredia-Antúnez, A; Hernández-González, R; Hernández-Vázquez, A; Ibarra-González, I; Ortega-Cuellar, D; Pindolia, K; Velázquez-Arellano, A; Wolf, B | 1 |
| Chen, S; Dai, W; Gao, P; Hu, C; Jia, Z; Kong, H; Wei, C; Wu, Y; Xu, G | 1 |
| Ali, S; Begley, P; Cooper, GJ; Dowsey, AW; Dunn, WB; Freeman, OJ; Gardiner, NJ; Hollywood, KA; Petersen, RS; Rustogi, N; Unwin, RD | 1 |
| Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K | 1 |
| Cusi, K; Garrett, TJ; Kalavalapalli, S; Martinez, J; Mathew, JT; McDougall, DJ; Nautiyal, M; Patterson, RE; Reinhard, MK; Rocca, JR; Sunny, NE; Williams, CM; Yost, RA | 1 |
| Elliott, CT; Graham, SF; Green, BD; Hölscher, C; Kehoe, PG; McClean, PL; McGuinness, B; Nasaruddin, MB; Pan, X; Passmore, AP | 1 |
| Gopalan, V; Lee, SS; Othman, R; Phang, BH; Sabapathy, K; Teoh, WW; Toh, HC; Velan, SS; Verma, SK; Wang, WW; Yaligar, J | 1 |
| Harder, U; Hellmuth, C; Kirchberg, FF; Koletzko, B; Nathanielsz, PW; Peissner, W; Uhl, O | 1 |
| Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M | 1 |
| Bhanu Prakash, KN; Gopalan, V; Hirayama, M; Horiguchi, T; Ishino, S; Kamiguchi, H; Kaneko, M; Lee, SS; Michael, N; Nishimoto, T; Sadananthan, SA; Satomi, Y; Velan, SS; Yaligar, J; Yang, AY; Zhou, Z; Zhu, B | 1 |
| Bakker, BM; Bleeker, A; Derks, TG; Gerding, A; Groen, AK; Heiner, RM; Martines, AM; Niezen-Koning, KE; Permentier, H; Reijngoud, DJ; van Eunen, K; van Rijt, WJ; Volker-Touw, CM; Wolters, JC | 1 |
| Aponte, A; Balaban, RS; French, S; Harris, RA; Johnson, DT | 1 |
| Foley, KA; MacFabe, DF; Mepham, JR; Possmayer, F; Thomas, RH; Tichenoff, LJ | 1 |
| Haas, D; Hoffmann, GF; Merle, U; Okun, JG; Opp, S; Sauer, SW; Stremmel, W | 1 |
| Brockman, DA; Chen, X; Gallaher, DD | 1 |
| Bakr, S; Bergmann, SR; Hwang, YC; Ramasamy, R | 1 |
| Duran, M; Ijlst, L; Mayatepek, E; Overmars, H; Spiekerkoetter, U; Strauss, AW; Tokunaga, C; van Vlies, N; Vaz, FM; Wanders, RJ; Wendel, U; Wijburg, FA | 1 |
| Crnic, LR; Fricker, G; Goodman, SI; Harding, CO; Hoffmann, GF; Hörster, F; Koeller, DM; Kölker, S; Mahringer, A; Mühlhausen, C; Müller, I; Okun, JG; Sauer, SW | 1 |
| Acott, PD; Al-Khalidi, M; Crocker, JF; Dooley, K; Geldenhuys, L; Lee, SH; Murphy, MG; O'Regan, P | 1 |
| Chandler, MP; Foster, AB; Fujioka, H; Hoit, BD; Hoppel, CL; McElfresh, TA; Minkler, PE; Okere, IC; Patel, HV; Patel, KK; Rennison, JH; Stoll, MS; Young, ME | 1 |
| Harashima, H; Hayashi, M; Horiuchi, M; Kamido, H; Kudo, T; Kuwajima, M; Lu, K; Ono, A; Ozaki, K; Saheki, T; Sei, M; Shima, K | 1 |
| Merali, C; Merali, S; Quinn, C; Rico, MC | 1 |
| Abaev, K; Becker, M; Ornoy, A; Pinhasov, A | 1 |
| Becker, M; Gorobets, D; Ornoy, A; Weinstein-Fudim, L | 1 |
| Barbier-Torres, L; Fan, W; Lu, SC; Mato, JM; Murray, B | 1 |
| Corrales, F; Franco, L; Guerrero, L; López-Rodas, G; Martí-Andrés, P; Paradela, A; Pérez, S; Rius-Pérez, S; Sastre, J; Taléns-Visconti, R; Torres, L; Torres-Cuevas, I | 1 |
| Ergaz, Z; Ornoy, A; Szyf, M; Turgeman, G; Weinstein-Fudim, L; Yanai, J | 1 |
| Alexandrova, A; Dimitrova, A; Galabov, A; Georgieva, A; Krastev, D; Mileva, M; Tsvetanova, E | 1 |
| Cui, J; Guo, C; Li, L; Ma, B; Sun, J; Wan, X; Wang, X | 1 |
| Abookasis, D; Kozhuhov, A; Ornoy, A; Tfilin, M; Turgeman, G; Yanai, J | 1 |
| Goto, H; Hidoh, Y; Ishii, Y; Nishimura, Y; Sato, M; Takeuchi, K; Yokouchi, C | 1 |
| Barbotin, AL; Boutillier, AL; Catteau-Jonard, S; Giacobini, P; Le Gras, S; Mimouni, NEH; Paiva, I; Pigny, P; Plassard, D; Prevot, V; Simon, V; Ternier, G; Timzoura, FE | 1 |
| Osborne, DM; Vander Velden, JW | 1 |
| Arsene, D; Lu, SC; Maldonado, LY; Mato, JM | 1 |
| Bottiglieri, T; Casero, RA; Dunworth, M; Gambello, MJ; Kapfhamer, D; Kinchen, JM; McKenna, J; Murray-Stewart, T; Wasek, B | 1 |
| Arning, E; Bahous, RH; Bottiglieri, T; Caudill, MA; Christensen, KE; Deng, L; Hou, W; Jerome-Majewska, LA; Malysheva, OV; Rozen, R | 1 |
| Parker, JA; Schmeisser, K | 1 |
| Arufe, MC; de Toro, J; Fafián-Labora, J; Lesende-Rodriguez, I; Mateos, J; Monserrat, L; Morente-López, M; Ódena, MA; Oliveira, E | 1 |
| Fujii, T; Izu, H; Matsubara, K; Okuda, M; Shibata, S | 1 |
| Geisel, J; Happ, DF; Mikkelsen, PF; Obeid, R; Tillmann, S; Wegener, G | 1 |
| Ergaz, Z; Ornoy, A; Weinstein-Fudim, L | 1 |
| Chang, S; Li, B; Li, R; Liang, L; Liu, C; Niu, B; Qin, C; Wang, L; Wang, X; Zhang, L; Zhang, M; Zhang, T | 1 |
| Alonso, C; Aspichueta, P; Aurrekoetxea, I; Beraza, N; Buqué, X; Cano, A; Fernández-Ares, L; Finnell, RH; García-Rodríguez, JL; Lu, SC; Luka, Z; Martínez-Arranz, I; Martínez-Chantar, ML; Martínez-Uña, M; Mato, JM; Mestre, D; Varela-Rey, M; Wagner, C | 1 |
| Obeid, R | 1 |
| Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z | 1 |
| Bataller, R; Casanova, J | 1 |
| Butov, MA; Mnikhovich, MV; Nikiforov, AA; Uzbekova, DG; Vasilevskaia, AS | 1 |
| Ball, JG; Brown, JM; Kuhlman, C; Labenski, MT; Lamyaithong, AB; Lau, SS; Terneus, MV; Valentovic, MA | 1 |
| Cui, W; Liu, J; Sun, X; Xie, X; Zhang, D; Zhu, Y | 1 |
| Aspichueta, P; Aurrekoetxea, I; Buqué, X; Fernández-Ares, L; Fernandez-Ramos, D; Finnell, RH; Fresnedo, O; García-Monzón, C; García-Orad, A; Gutiérrez-de Juan, V; Lu, SC; Luka, Z; Martin-Guerrero, I; Martínez-Chantar, ML; Martínez-Uña, M; Mato, JM; Mestre, D; Varela-Rey, M; Wagner, C | 1 |
| Cavallaro, RA; Desiderio, C; Di Napoli, A; Fuso, A; Gervasoni, J; Giardina, B; Nicolia, V; Persichilli, S; Scarpa, S | 1 |
| Lu, SC; Mato, JM; Noureddin, M | 1 |
| Huang, G; Li, W; Liu, H; Wilson, JX; Yu, M; Zhang, M; Zhang, X | 1 |
| Aldámiz-Echevarría, L; Andrade, F; Aspichueta, P; Barbier-Torres, L; Beraza, N; Falcon-Perez, JM; Fernandez, ML; Fernández-Ramos, D; Fernandez-Tussy, P; García-Monzón, C; García-Rodríguez, JL; Juan, VG; Lage-Medina, S; Lopitz-Otsoa, F; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-Lopez, N; Martínez-Uña, M; Mato, JM; Varela-Rey, M; Wagner, C; Woodhoo, A; Zubiete-Franco, I | 1 |
| Cui, J; Fang, C; Li, L; Li, Q; Zhang, X | 1 |
| Cao, J; Guo, X; He, Y; Jiang, Y; Kong, F; Liu, Z; Ma, S; Tian, J; Wang, Y; Xu, H; Yang, A; Yang, X; Zhang, H; Zhang, M | 1 |
| Cho, YS; Hong, GH; Kim, TB; Kwon, HS; Moon, HB; Park, S; Park, SY; Shin, B; Yoon, SY | 1 |
| Andrews, AJ; Gupta, S; Kruger, WD; Kuo, YM; Lee, HO; Li, YS; Slifker, MJ; Wang, L | 1 |
| Andringa, KK; Bailey, SM; Dunham-Snary, KJ; Griguer, CE; King, AL; Mantena, SK; Millender-Swain, T; Oliva, CR | 1 |
| Czarnecka, A; Jaźwiec, R; Milewski, K; Zielińska, M | 1 |
| Cuello, AC; Do Carmo, S; Grégoire, S; Millecamps, M; Naso, L; Stone, LS; Szyf, M | 1 |
| Arjona, A; Barcos, M; Cruz, A; Espejo, I; González, R; Herencia, C; Montilla, P; Muñoz-Castañeda, JR; Muntané, J; Padillo, FJ; Ramírez, LM; Ranchal, I; Túnez, I | 1 |
| Iglesia-Ara, A; Ko, K; Lu, SC; Luka, Z; Mato, JM; Noureddin, M; Wagner, C; Xia, M; Yang, H | 1 |
| Attia, RR; Gardner, LA; Geller, A; Kotb, M; Legros, L; Mahrous, E; Rowe, S; Taxman, DJ; Ting, JP | 1 |
| Ariz, U; Embade, N; Fernandez-Ramos, D; Gomez-Santos, L; Lu, SC; Martinez-Chantar, ML; Martínez-López, N; Mato, JM; Varela-Rey, M; Vazquez-Chantada, M | 1 |
| Blom, H; Linnebank, M; Moskau, S; Semmler, A; Smith, D; Smulders, Y; Struys, E | 1 |
| Garcia, P; Herrmann, M; Herrmann, W; Hübner, U; Ross, S; Schorr, H; Taban-Shomal, O; Umanskaya, N; Wagner, A; Wildemann, B; Wolny, M | 1 |
| Chan, A; Levasseur, J; Perry, S; Shea, TB | 1 |
| Deussen, A; Henle, T; Herrmann, M; Pexa, A; Taban-Shomal, O | 1 |
| Cavallaro, RA; Fiorenza, MT; Fuso, A; Nicolia, V; Pasqualato, A; Scarpa, S | 1 |
| Capurso, A; Capurso, C; Colacicco, AM; D'Introno, A; Di Palo, A; Frisardi, V; Imbimbo, BP; Panza, F; Solfrizzi, V; Vendemiale, G | 1 |
| Blom, HJ; Hooijmans, CR; Kiliaan, AJ; Oppenraaij-Emmerzaal, D; Ritskes-Hoitinga, M | 1 |
| Ahmed, A; Lee, S; Shea, TB; Suchy, J | 1 |
| Elias, MS; Green, RM; Henkel, AS | 1 |
| Bardag-Gorce, F; French, BA; French, SW; Li, J; Lin, A; Oliva, J | 1 |
| Bardag-Gorce, F; French, BA; French, SW; Li, J; Oliva, J | 1 |
| Bardag-Gorce, F; French, BA; French, SW; Li, J; Lu, SC; Oliva, J | 1 |
| Copple, BL; Jaeschke, H; Klaassen, CD | 1 |
| Cavallaro, RA; Fuso, A; Nicolia, V; Scarpa, S | 1 |
| Lin, DM; MacFarlane, AJ; McEntee, MF; Perry, CA; Stover, PJ | 1 |
| Chefu, SG; Iagmurov, OD; Kovalenko, AL; Smirnova, NG; Vlasov, TD | 1 |
| Cho, BJ; Choi, SH; Chung, MH; Jang, HC; Kim, M; Kim, TH; Kim, YB; Ko, SH; Lee, IK; Lim, S; Moon, MK; Park, HS; Park, KS; Shin, H | 1 |
| Frost, JL; Lee, S; Lemere, CA; Shea, TB | 1 |
| Brozzetti, S; Calvisi, DF; Daino, L; Demartis, MI; Feo, CF; Feo, F; Frau, M; Latte, G; Pascale, RM; Salis, F; Seddaiu, MA; Simile, MM; Solinas, G; Tomasi, ML; Ushijima, T; Yamashita, S | 1 |
| Beattie, JH; Duthie, SJ; Gordon, MJ; McNeil, CJ; Pirie, LP | 1 |
| Cederbaum, AI | 1 |
| Lieber, CS | 1 |
| Li, JS; Li, N; Ren, JA; Wang, SH; Zhang, HH; Zhu, WM | 1 |
| Brown, LA; Elbahesh, H; Gauthier, TW; Harris, FL; Ping, XD; Wong, M | 1 |
| Barak, AJ; Beckenhauer, HC; Kharbanda, KK; Mailliard, ME; Rogers, DD; Siford, GL; Sorrell, MF; Tuma, DJ | 1 |
| Costa, E; Davis, J; Dong, E; Doueiri, MS; Grayson, DR; Guidotti, A; Pinna, G; Rodriguez-Menendez, V; Tremolizzo, L; Tueting, P | 1 |
| Escario, JA; Gómez-Barrio, A; Martínez-Fernández, AR; Montero-Pereira, D; Nogal-Ruiz, JJ | 1 |
| Chen, TS; de Villiers, WJ; McClain, CJ; Oz, HS | 1 |
| Graves, M; Ortiz, D; Rogers, E; Shea, TB; Tchantchou, F | 1 |
| Bergasa, NV | 1 |
| Green, RM; Igolnikov, AC | 1 |
| Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS | 1 |
| Amanlou, M; Dehpour, AR; Ghahremani, MH; Goliaei, A; Mandegary, A; Payabvash, S; Shafaroodi, H | 1 |
| Chan, A; Shea, TB | 1 |
| Bottiglieri, T; Cross, JC; Elmore, CL; Gravel, RA; Krupenko, NI; Krupenko, SA; Leclerc, D; Matthews, RG; Rozen, R; Watson, ED; Wu, X | 1 |
| Abdelmalek, MF; Barve, S; Benevenga, NJ; Halsted, CH; Kaplowitz, N; Kharbanda, KK; Liu, QY; Lu, SC; McClain, CJ; Purohit, V; Swanson, C; Zakhari, S | 1 |
| Elmore, CL; Matthews, RG | 1 |
| Devaraj, S; Esfandiari, F; French, SW; Halsted, CH; Villanueva, JA; White, ME | 1 |
| Chen, YJ; Chen, YM; Chiang, EP; Hsiao, M; Huang, SF; Hwang, SF; Lee, YH; Li, AF; Li, YS; Liu, SP; Tsai, TF | 1 |
| Muriel, P; Rivera-Espinoza, Y | 1 |
| Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN | 1 |
| Clemens, MG; Karaa, A; McKillop, IH; Schrum, LW; Thompson, KJ | 1 |
| Amidi, F; Bardag-Gorce, F; Dedes, J; Fraley, S; French, B; French, SW; Li, J; Oliva, J; Villegas, J | 1 |
| Copple, BL; Gyamfi, M; He, L; Wan, YJ; Wortham, M | 1 |
| Limas, CJ | 1 |
| Bottiglieri, T; Hyland, K; Reynolds, EH | 1 |
| Benelli, A; Bertolini, A; Filaferro, M; Genedani, S | 1 |
| Charlton, CG; Lamango, NS; Nesby, RA | 1 |
| Arning, E; Bottiglieri, T; Dayal, S; Faraci, FM; Heistad, DD; Lentz, SR; Maeda, N; Malinow, MR; Sigmund, CD | 1 |
| Benelli, A; Bertolini, A; Filaferro, M; Genedani, S; Saltini, S | 1 |
| Avila, MA; Corrales, FJ; Lu, SC; Mato, JM | 1 |
| Cuerda, MA; De La Cruz, JP; González-Correa, JA; Guerrero, A; Sánchez De La Cuesta, F; Villalobos, MA | 1 |
| Delabar, U; Kloor, D; Luippold, G; Mühlbauer, B; Osswald, H | 1 |
| Budillon, G; Cantoni, L; Cuomo, R; Di Padova, C; Le Grazie, C; Rizzardini, M; Rodinò, S | 1 |
| Ohno, M; Ueki, S; Yamamoto, T; Yatsugi, S | 1 |
| Inamura, K; Katayama, Y; Memezawa, H; Minamisawa, H; Mizoguchi, M; Nagazumi, A; Shimizu, J; Sugimoto, S; Terashi, A | 1 |
| Hariyama, H; Horita, I; Moriguchi, K; Nakano, M; Ushijima, T | 1 |
| Domschke, S; Domschke, W | 1 |
18 review(s) available for s-adenosylmethionine and Disease Models, Animal
| Article | Year |
|---|---|
Sex-Related Changes in the Clinical, Genetic, Electrophysiological, Connectivity, and Molecular Presentations of ASD: A Comparison between Human and Animal Models of ASD with Reference to Our Data.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Humans; Male; Mice; S-Adenosylmethionine; Social Interaction; Valproic Acid | 2023 |
Methionine adenosyltransferases in liver cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Down-Regulation; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Isoenzymes; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; S-Adenosylmethionine | 2019 |
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy.
Topics: Animals; Disease Models, Animal; Humans; Methionine Adenosyltransferase; Neoplasms; S-Adenosylmethionine | 2018 |
Prevention or Amelioration of Autism-Like Symptoms in Animal Models: Will it Bring Us Closer to Treating Human ASD?
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Fatty Acids, Omega-3; Humans; S-Adenosylmethionine; Valproic Acid | 2019 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Alcoholic hepatitis: Prognosis and treatment.
Topics: Alcohol Deterrents; Animals; Antibodies, Monoclonal; Disease Models, Animal; Etanercept; Fatty Liver, Alcoholic; Hepatitis, Alcoholic; Humans; Immunoglobulin G; Incidence; Infliximab; Liver; Liver Failure; Liver Transplantation; Malnutrition; Pentoxifylline; Prednisolone; Prognosis; Receptors, Tumor Necrosis Factor; S-Adenosylmethionine; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2014 |
Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine.
Topics: Animals; Biomarkers; Disease Models, Animal; Humans; Liver; Mice; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Phosphatidylethanolamines; S-Adenosylmethionine; United States | 2015 |
Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; Dementia; Dietary Supplements; Disease Models, Animal; Fatty Acids, Unsaturated; Humans; S-Adenosylmethionine; Treatment Outcome | 2009 |
Oxidative stress and the pathogenesis of cholestasis.
Topics: Animals; Cholestasis; Disease Models, Animal; Humans; Inflammation Mediators; Lipid Peroxidation; Liver; Liver Cirrhosis; Mitochondria, Liver; Neutrophils; Oxidative Stress; Reactive Oxygen Species; S-Adenosylmethionine | 2010 |
CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment.
Topics: Animals; Cytochrome P-450 CYP2E1; Disease Models, Animal; Ethanol; Humans; Liver Diseases; Liver Diseases, Alcoholic; Mice; Mice, Knockout; Obesity; Oxidative Stress; S-Adenosylmethionine | 2012 |
S-Adenosyl-L-methionine and alcoholic liver disease in animal models: implications for early intervention in human beings.
Topics: Animals; Disease Models, Animal; Humans; Liver Diseases, Alcoholic; S-Adenosylmethionine | 2002 |
The pruritus of cholestasis.
Topics: Animals; Antipruritics; Bile Acids and Salts; Cholestasis; Disease Models, Animal; Humans; Pruritus; S-Adenosylmethionine | 2005 |
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
Topics: Animals; Betaine; Disease Models, Animal; Folic Acid; Humans; Liver Diseases, Alcoholic; Methionine; S-Adenosylmethionine | 2007 |
The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Ferredoxin-NADP Reductase; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Models, Biological; Molecular Structure; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Beneficial drugs for liver diseases.
Topics: Adrenal Cortex Hormones; Animals; Colchicine; Curcumin; Disease Models, Animal; Drug Combinations; Glycyrrhizic Acid; Humans; Interferons; Liver Diseases; Nitric Oxide; Plant Extracts; Resveratrol; S-Adenosylmethionine; Silymarin; Stilbenes; Thalidomide | 2008 |
The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders.
Topics: AIDS Dementia Complex; Animals; Brain Diseases; Dementia; Disease Models, Animal; Epilepsy; Humans; Metabolism, Inborn Errors; Methotrexate; Methylation; Multiple Sclerosis; Neurotransmitter Agents; Parkinson Disease; Receptors, Neurotransmitter; S-Adenosylmethionine; Spinal Cord Diseases | 1994 |
S-Adenosylmethionine: a control switch that regulates liver function.
Topics: Animals; Cell Differentiation; Cell Division; Disease Models, Animal; Humans; Liver; Liver Diseases; Methionine Adenosyltransferase; Mice; Models, Biological; Protein Processing, Post-Translational; S-Adenosylmethionine | 2002 |
Polyamines and the liver.
Topics: Animals; Carboxy-Lyases; Disease Models, Animal; DNA; Liver; Liver Regeneration; Polyamines; Putrescine; Rats; RNA; S-Adenosylmethionine; Spermidine; Spermine; Starvation; Tyrosine Decarboxylase | 1972 |
121 other study(ies) available for s-adenosylmethionine and Disease Models, Animal
| Article | Year |
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Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Differential and Synergistic Effects of Low Birth Weight and Western Diet on Skeletal Muscle Vasculature, Mitochondrial Lipid Metabolism and Insulin Signaling in Male Guinea Pigs.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Blood Glucose; Carnitine; Diet, Western; Disease Models, Animal; Female; Fetal Growth Retardation; Guinea Pigs; Insulin; Lipid Metabolism; Male; Mitochondria; Muscle, Skeletal; Placental Insufficiency; Pregnancy; Signal Transduction | 2021 |
Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Carnitine; Disease Models, Animal; Image Processing, Computer-Assisted; Lipid Metabolism; Lipids; Male; Microglia; Palmitoylcarnitine; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2019 |
Slc22a5 haploinsufficiency does not aggravate the phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Disease Models, Animal; Fatty Acids; Female; Haploinsufficiency; Hyperammonemia; Lipid Metabolism; Liver; Male; Mice; Mice, Knockout; Muscular Diseases; Myocardium; Phenotype; Solute Carrier Family 22 Member 5 | 2020 |
Potential osteomyelitis biomarkers identified by plasma metabolome analysis in mice.
Topics: Animals; Biomarkers; Carnitine; Citric Acid Cycle; Disease Models, Animal; Fatty Acids; Ketoglutaric Acids; Luminescent Measurements; Male; Metabolome; Mice, Inbred BALB C; Osteomyelitis; Sphingolipids; Sphingosine; Staphylococcal Infections; Staphylococcus aureus; Succinic Acid; Surgical Wound Infection | 2020 |
Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection.
Topics: Acute Disease; Animals; Body Weight; Carnitine; Colitis; Colon; Discriminant Analysis; Disease Models, Animal; Gastrointestinal Tract; Least-Squares Analysis; Liver; Male; Metabolome; Metabolomics; Mice, Inbred BALB C; Multivariate Analysis; Proton Magnetic Resonance Spectroscopy; Rats; Sulfates | 2020 |
Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1.
Topics: Animals; Carnitine; Cell Line; Disease Models, Animal; Fatty Acids; Female; Fetal Growth Retardation; Glycolysis; Humans; Metabolomics; Mice; Mice, Inbred ICR; Placenta; Pre-Eclampsia; Pregnancy; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 | 2020 |
Targeted Metabolomic Analysis of a Mucopolysaccharidosis IIIB Mouse Model Reveals an Imbalance of Branched-Chain Amino Acid and Fatty Acid Metabolism.
Topics: Amino Acids, Aromatic; Amino Acids, Branched-Chain; Animals; Carnitine; Disease Models, Animal; Humans; Lipid Metabolism; Liver; Male; Metabolomics; Mice; Mucopolysaccharidosis III; Myocardium | 2020 |
Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.
Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Carnitine; Disease Models, Animal; Fatty Acids; Heart Arrest; Humans; Kynurenic Acid; Male; Metabolomics; Phospholipids; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Tryptophan | 2020 |
Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts.
Topics: Acetyl-CoA Carboxylase; Animals; Carnitine; Disease Models, Animal; Energy Metabolism; Fatty Acids; Female; Gene Deletion; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Oxidation-Reduction; PPAR alpha; Sex Factors; Signal Transduction; Tamoxifen | 2021 |
Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish.
Topics: Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Fatty Acids; Heart; Heart Diseases; Humans; Mitochondria, Heart; Myocytes, Cardiac; Oxidation-Reduction; Zebrafish | 2021 |
Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Topics: Adipogenesis; Animals; Body Weight; Carnitine; Chronic Disease; Disease Models, Animal; Gene Expression Regulation; Hyperthyroidism; Lipogenesis; Liver; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Thyroid Hormone Receptors beta; Thyroid Hormones; Time Factors; Triiodothyronine | 2017 |
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Disease Models, Animal; Female; Humans; Liver Neoplasms; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity | 2018 |
Tissue acylcarnitine status in a mouse model of mitochondrial β-oxidation deficiency during metabolic decompensation due to influenza virus infection.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Cardiomyopathies; Carnitine; Congenital Bone Marrow Failure Syndromes; Disease Models, Animal; Fatty Acids; Female; Humans; Hypoglycemia; Lipid Metabolism, Inborn Errors; Lipid Peroxidation; Liver; Liver Failure; Metabolic Diseases; Mice; Mitochondrial Diseases; Muscle, Skeletal; Muscular Diseases; Myocardium; Oxidation-Reduction | 2018 |
Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder.
Topics: Adolescent; Animals; Bile Acids and Salts; Biomarkers; Carnitine; Case-Control Studies; Disease Models, Animal; Female; Humans; Leigh Disease; Lipid Metabolism; Lipidomics; Liver; Male; Mice; Mice, Knockout; Mitochondria; Mutation; Neoplasm Proteins; Peroxisomes; Plasmalogens; Prospective Studies; Young Adult | 2019 |
Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Carnitine; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Triglycerides | 2013 |
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder.
Topics: Animals; Biotin; Biotinidase Deficiency; Blood Glucose; Body Weight; Carbon; Carnitine; Diet; Disease Models, Animal; Energy Metabolism; Gene Expression; Humans; Liver; Mice; Mice, Knockout; RNA, Messenger | 2013 |
Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry.
Topics: Allium; Animals; Antidepressive Agents; Carnitine; Chromatography, High Pressure Liquid; Depression; Disease Models, Animal; Lipids; Male; Mass Spectrometry; Medicine, Chinese Traditional; Metabolome; Principal Component Analysis; Rats; Rats, Wistar | 2014 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Energy Metabolism; Fructose; Ganglia, Spinal; Glucose; Homeostasis; Inositol; Lipid Metabolism; Lumbar Vertebrae; Metabolomics; Mitochondria; Neural Conduction; Oxidative Phosphorylation; Oxidative Stress; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Trigeminal Ganglion | 2016 |
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Fatty Acids; gamma-Aminobutyric Acid; Gene Expression; Glucose; Insulin; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Muscles; Physical Conditioning, Animal; PPAR alpha; Quaternary Ammonium Compounds; Signal Transduction | 2016 |
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
Topics: Animals; Carbon Isotopes; Carnitine; Ceramides; Chromatography, Liquid; Citric Acid Cycle; Dietary Fats; Dietary Sucrose; Diglycerides; Disease Models, Animal; Fatty Acids, Nonesterified; Fructose; Glucose Clamp Technique; Inflammation; Insulin Resistance; Liver; Magnetic Resonance Spectroscopy; Metabolome; Mice; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Real-Time Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Tandem Mass Spectrometry; Trans Fatty Acids; Transcriptome | 2016 |
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome.
Topics: Aging; Alzheimer Disease; Amino Acids, Branched-Chain; Amino Acids, Essential; Animals; Biogenic Polyamines; Brain; Carnitine; Disease Models, Animal; Male; Metabolome; Mice, Transgenic; Phospholipids; Serotonin | 2016 |
Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection.
Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Carnitine; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Early Detection of Cancer; Gene Expression Profiling; Humans; Liver Neoplasms; Mice; Mice, Transgenic; Molecular Imaging; Tumor Burden | 2016 |
Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation.
Topics: Adaptation, Physiological; Animals; Biomarkers; Caloric Restriction; Carnitine; Chromatography, Liquid; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Fetus; Gestational Age; Gluconeogenesis; Humans; Liver; Malnutrition; Mass Spectrometry; Maternal Nutritional Physiological Phenomena; Metabolome; Metabolomics; Papio; Phospholipids; Pregnancy | 2016 |
Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice.
Topics: Amino Acids; Analysis of Variance; Animals; Biomarkers; Blood Glucose; Carnitine; Cluster Analysis; Diet, High-Fat; Disease Models, Animal; Female; Glucose Intolerance; Glucose Tolerance Test; Insulin Resistance; Male; Metabolome; Metabolomics; Mice; Obesity; Phenotype; Prognosis; Propensity Score | 2016 |
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.
Topics: Animals; Caloric Restriction; Carnitine; Diet, High-Fat; Disease Models, Animal; Fatty Acid Desaturases; Humans; Insulin Resistance; Liver; Male; Muscle, Skeletal; Obesity; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Treatment Outcome | 2016 |
Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine; Computational Biology; Computer Simulation; Disease Models, Animal; Fatty Acids; Humans; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Oxidation-Reduction; Proteomics; Substrate Specificity | 2016 |
Proteomic changes associated with diabetes in the BB-DP rat.
Topics: Animals; Carnitine; Citrate (si)-Synthase; Diabetes Mellitus, Type 1; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gluconeogenesis; Glycolysis; Liver; Male; Methionine; Muscle, Skeletal; Myocardium; Proteomics; Rats; Rats, Inbred BB; Reactive Oxygen Species | 2009 |
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
Topics: Animals; Behavior, Animal; Brain; Carnitine; Child; Child Development Disorders, Pervasive; Chromatography, Thin Layer; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intraventricular; Male; Motor Activity; Phospholipids; Propionates; Rats; Rats, Long-Evans; Spectrometry, Mass, Electrospray Ionization; Stereotyped Behavior | 2010 |
Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease.
Topics: Aconitate Hydratase; Adenosine Triphosphatases; Alanine; Animals; Brain; Carnitine; Cation Transport Proteins; Cholesterol; Copper; Copper-Transporting ATPases; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Gene Knockout Techniques; Glutathione; Hepatolenticular Degeneration; Humans; Liver; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria; Oxidative Stress; Superoxide Dismutase | 2011 |
Consumption of a high β-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat.
Topics: Adiponectin; Animals; beta-Glucans; Blood Glucose; Body Weight; Carnitine; Cholesterol; Diabetes Mellitus, Type 2; Dietary Fiber; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Flour; Glucose Tolerance Test; Hordeum; Insulin; Insulin Resistance; Intestine, Small; Ketones; Liver; Obesity; Organ Size; Postprandial Period; Rats; Rats, Zucker; Thiobarbituric Acid Reactive Substances; Triglycerides | 2013 |
Relative importance of enhanced glucose uptake versus attenuation of long-chain acyl carnitines in protecting ischemic myocardium.
Topics: Animals; Carnitine; Creatine Kinase; Cytochalasin B; Disease Models, Animal; Glucose; Models, Cardiovascular; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacin; Oxygen Consumption; Rats; Recovery of Function; Stroke Volume; Vasodilator Agents; Ventricular Pressure | 2002 |
Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Bile; Carnitine; Disease Models, Animal; Homeostasis; Humans; Lipid Metabolism, Inborn Errors; Liver; Mice; Mice, Knockout; Muscle, Skeletal; Phenotype | 2005 |
Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency.
Topics: Amino Acids; Animals; Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Carnitine; Cells, Cultured; Dicarboxylic Acids; Disease Models, Animal; Endothelial Cells; Glucose; Glutarates; Glutaryl-CoA Dehydrogenase; Heart; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Muscles; Neurodegenerative Diseases; Risk Factors; Statistics, Nonparametric; Swine; Time Factors; Tissue Distribution | 2006 |
Carnitine, acylcarnitine and amino acid profiles analyzed by tandem mass spectrometry in a surfactant/virus mouse model of acute hepatic encephalopathy.
Topics: Amino Acids; Animals; Carnitine; Disease Models, Animal; Hepatic Encephalopathy; Influenza B virus; Mice; Surface-Active Agents; Tandem Mass Spectrometry; Time Factors | 2007 |
Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure.
Topics: Acyl-CoA Dehydrogenase; Adiponectin; Animals; Blood Glucose; Carnitine; Dietary Fats; Disease Models, Animal; Electron Transport Chain Complex Proteins; Fatty Acids, Nonesterified; Heart Failure; Insulin; Leptin; Male; Mitochondria, Heart; Myocardial Contraction; Rats; Rats, Wistar; Triglycerides | 2008 |
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Carnitine; Disease Models, Animal; Half-Life; Injections, Intraperitoneal; Lipid Metabolism; Mice; Mice, Inbred Strains; Myocardium; Organ Size; Time Factors | 1999 |
Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress.
Topics: Adult; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Female; Glycine N-Methyltransferase; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; Polyamines; Proteomics; S-Adenosylmethionine | 2022 |
S-Adenosyl-Methionine alleviates sociability aversion and reduces changes in gene expression in a mouse model of social hierarchy.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Gene Expression; Hierarchy, Social; Humans; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; S-Adenosylmethionine | 2022 |
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase.
Topics: Animals; Ceruletide; Cystathionine; Cystathionine beta-Synthase; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Male; Mice; Nitric Oxide Synthase Type II; Pancreatitis; S-Adenosylmethionine; Up-Regulation | 2020 |
Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?
Topics: Animals; Autistic Disorder; Disease Models, Animal; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; S-Adenosylmethionine; Sex Factors; Valproic Acid | 2019 |
Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.
Topics: Animals; Antioxidants; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Influenza A Virus, H3N2 Subtype; Influenza, Human; Lung; Male; Mice; Mice, Inbred BALB C; Oseltamivir; Oxidative Stress; S-Adenosylmethionine; Virus Replication | 2020 |
S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Brain; Disease Models, Animal; Glutathione; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; S-Adenosylmethionine | 2020 |
Implementation of a six-around-one optical probe based on diffuse light spectroscopy for study of cerebral properties in a murine mouse model of autism spectrum disorder.
Topics: Algorithms; Animals; Anticonvulsants; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Fiber Optic Technology; Hemodynamics; Light; Male; Mice; Mice, Inbred ICR; Neuropsychological Tests; Optical Fibers; S-Adenosylmethionine; Scattering, Radiation; Sex Factors; Spectroscopy, Near-Infrared; Valproic Acid | 2020 |
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydralazine; Lipid Droplets; Liver; Male; Methionine; Niacinamide; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; S-Adenosylmethionine; Triglycerides | 2021 |
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.
Topics: Animals; Anti-Mullerian Hormone; Case-Control Studies; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Humans; Luteinizing Hormone; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Ovary; Polycystic Ovary Syndrome; Prenatal Care; Proto-Oncogene Proteins; S-Adenosylmethionine; Transcriptome | 2021 |
Obesity Prevents S-Adenosylmethionine-Mediated Improvements in Age-Related Peripheral and Hippocampal Outcomes.
Topics: Aging; Animals; Anxiety; Blood Glucose; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Glutathione; Hippocampus; Humans; Inflammation; Insulin Resistance; Liver; Male; Mice; Mice, Obese; Obesity; S-Adenosylmethionine; Transforming Growth Factor beta1 | 2021 |
Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.
Topics: Animals; Brain; Cystathionine; Cystathionine beta-Synthase; Disease Models, Animal; DNA Methylation; Eflornithine; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Methionine Adenosyltransferase; Mice; Neurons; Polyamines; Putrescine; S-Adenosylmethionine; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein | 2018 |
Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.
Topics: Animals; Congenital Abnormalities; Diet; Disease Models, Animal; DNA Methylation; Female; Fetal Development; Fetal Growth Retardation; Folic Acid; Folic Acid Deficiency; Formate-Tetrahydrofolate Ligase; Genotype; Ligases; Liver; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Mice; Multifunctional Enzymes; Placenta; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy, Animal; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2018 |
Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy.
Topics: Animals; Animals, Genetically Modified; Autophagy; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Dopamine; Humans; Longevity; Methyltransferases; Mutagenesis, Site-Directed; Neurodegenerative Diseases; Neurons; Nicotinamide N-Methyltransferase; S-Adenosylmethionine | 2018 |
Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging.
Topics: Adult; Animals; beta-Galactosidase; Cell Line; Cell Proliferation; Child; Computational Biology; Disease Models, Animal; Female; Founder Effect; Gene Expression Profiling; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Lamin Type A; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Progeria; Purines; Ribose-Phosphate Pyrophosphokinase; RNA, Messenger; S-Adenosylmethionine | 2018 |
Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-A
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Disease Models, Animal; Drinking Water; Drug Combinations; Eating; Glycerylphosphorylcholine; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Leptin; Male; Mice; Mice, Transgenic; Obesity; S-Adenosylmethionine; Triglycerides | 2019 |
Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression.
Topics: Animals; Antidepressive Agents; Brain; Cognition; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; Hippocampus; Imipramine; Male; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serotonin; Spatial Memory | 2019 |
Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model.
Topics: Animals; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Fetus; Folic Acid; Folic Acid Deficiency; Long Interspersed Nucleotide Elements; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 2019 |
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
Topics: Animals; Disease Models, Animal; Fatty Liver; Female; Glycine N-Methyltransferase; Homeostasis; Lipid Metabolism; Liver; Male; Membrane Proteins; Mice; Mice, Knockout; Perilipin-2; Phosphatidylcholines; Phosphatidylethanolamines; S-Adenosylmethionine; Triglycerides | 2013 |
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects.
Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2014 |
[Hepatoprotectors in treatment of alcoholic liver disease].
Topics: Animals; Biological Products; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Phosphatidylcholines; Rats; Rats, Wistar; S-Adenosylmethionine; Treatment Outcome | 2013 |
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
Topics: Acetaminophen; Aldehydes; Animals; Antioxidants; Carbamoyl-Phosphate Synthase (Ammonia); Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytoprotection; Disease Models, Animal; Liver; Male; Mice, Inbred BALB C; Mitochondria, Liver; Oxidative Stress; Protein Carbonylation; Protein Processing, Post-Translational; S-Adenosylmethionine; Sarcosine Dehydrogenase; Tandem Mass Spectrometry | 2014 |
Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.
Topics: Angiotensin II; Animals; Binding Sites; CCCTC-Binding Factor; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; DNA Methylation; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; S-Adenosylmethionine; Sp1 Transcription Factor; Telomerase; Telomere; Telomere Shortening; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2015 |
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
Topics: Adult; Aged; Aged, 80 and over; Animals; Diet, High-Fat; Disease Models, Animal; Female; Glycine N-Methyltransferase; Humans; Lipoproteins, VLDL; Liver; Male; Membrane Proteins; Mice; Mice, Knockout; Middle Aged; Models, Biological; Non-alcoholic Fatty Liver Disease; Perilipin-2; S-Adenosylmethionine; Triglycerides; Young Adult | 2015 |
Plasma thiols levels in Alzheimer's disease mice under diet-induced hyperhomocysteinemia: effect of S-adenosylmethionine and superoxide-dismutase supplementation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Chromatography; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; S-Adenosylmethionine; Sulfhydryl Compounds; Superoxide Dismutase | 2015 |
Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Gene Silencing; Hippocampus; Male; Mice; Mice, Transgenic; Molecular Sequence Data; Presenilin-1; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA | 2015 |
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
Topics: Animals; Autophagy; Cell Culture Techniques; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Methionine; Methylation; Mice; Protein Phosphatase 2; S-Adenosylmethionine | 2016 |
S-adenosylmethionine Administration Attenuates Low Brain-Derived Neurotrophic Factor Expression Induced by Chronic Cerebrovascular Hypoperfusion or Beta Amyloid Treatment.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Disease Models, Animal; Exons; Gene Expression Regulation; Hippocampus; Male; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylmethionine; Time Factors | 2016 |
Ratio of S-adenosylmethionine to S-adenosylhomocysteine as a sensitive indicator of atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Disease Models, Animal; DNA Methylation; Fatty Acid-Binding Proteins; Homocysteine; Interspersed Repetitive Sequences; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2016 |
S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress.
Topics: Airway Remodeling; Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Cells, Cultured; Chronic Disease; Disease Models, Animal; Female; Fibrosis; Inflammation; Lung; Mice; Mice, Inbred BALB C; Oxidative Stress; S-Adenosylmethionine | 2016 |
Lack of global epigenetic methylation defects in CBS deficient mice.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Homocysteine; Homocystinuria; Kidney; Liver; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease.
Topics: Animals; Biomarkers; Cell Respiration; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex IV; Ethanol; Fatty Liver, Alcoholic; Hypoxia; Liver; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nitric Oxide; Organelle Biogenesis; Rats; Reactive Oxygen Species; S-Adenosylmethionine | 2016 |
Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure.
Topics: Animals; Arginine; Cyclic GMP; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy; Liver Failure, Acute; Male; Prefrontal Cortex; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction | 2017 |
Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice.
Topics: Animals; Area Under Curve; Cognition Disorders; Disease Models, Animal; DNA Methylation; Frontal Lobe; Hypersensitivity; Male; Mice; Motor Activity; Pain Threshold; Peripheral Nerve Injuries; Physical Stimulation; Recognition, Psychology; S-Adenosylmethionine | 2017 |
Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Ferritins; Gene Expression; Jaundice, Obstructive; Lipid Peroxidation; Liver; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Receptors, Transferrin; RNA, Messenger; S-Adenosylmethionine; Transferrin | 2008 |
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice.
Topics: Animals; Disease Models, Animal; Endotoxemia; Glutamate-Cysteine Ligase; Glutathione; Male; Methionine Adenosyltransferase; Mice; S-Adenosylmethionine; Up-Regulation | 2008 |
Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Jurkat Cells; Leukemia; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; RNA Interference; S-Adenosylmethionine | 2008 |
S-adenosylmethionine and proliferation: new pathways, new targets.
Topics: AMP-Activated Protein Kinases; Animals; Antigens, Surface; Cell Proliferation; Disease Models, Animal; ELAV Proteins; ELAV-Like Protein 1; Hepatocytes; Humans; Liver; Liver Diseases; Methionine; Mice; Mice, Knockout; Multienzyme Complexes; Protein Serine-Threonine Kinases; RNA-Binding Proteins; S-Adenosylmethionine; Signal Transduction | 2008 |
Methionine metabolism in an animal model of sepsis.
Topics: Animals; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Lipopolysaccharides; Male; Methionine; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis | 2008 |
Experimental folate and vitamin B12 deficiency does not alter bone quality in rats.
Topics: Animals; Biomarkers; Biomechanical Phenomena; Body Weight; Bone and Bones; Bone Remodeling; Disease Models, Animal; Female; Folic Acid Deficiency; Homocysteine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2009 |
Dietary supplementation with S-adenosyl methionine was associated with protracted reduction of seizures in a line of transgenic mice.
Topics: Alzheimer Disease; Animals; Apolipoprotein E4; Behavior, Animal; Dietary Supplements; Disease Models, Animal; Humans; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Recombinant Proteins; S-Adenosylmethionine; Seizures | 2008 |
Experimental hyperhomocysteinaemia: differences in tissue metabolites between homocystine and methionine feeding in a rat model.
Topics: Analysis of Variance; Animal Feed; Animals; Cardiovascular Diseases; Dietary Supplements; Disease Models, Animal; Female; Homocystine; Hyperhomocysteinemia; Kidney; Liver; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylmethionine; Statistics, Nonparametric; Tissue Distribution | 2009 |
Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency.
Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Mutation; Presenilin-1; Promoter Regions, Genetic; RNA, Messenger; S-Adenosylmethionine; Sequence Analysis, DNA; Sulfites; Transfection; Vitamin B Deficiency | 2011 |
S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Presenilin-1; S-Adenosylhomocysteine; S-Adenosylmethionine; Tandem Mass Spectrometry | 2009 |
Dietary supplementation with S-adenosyl methionine delays the onset of motor neuron pathology in a murine model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Dietary Supplements; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Motor Activity; Motor Neurons; Nerve Degeneration; Oxidative Stress; S-Adenosylmethionine; Superoxide Dismutase; Superoxide Dismutase-1 | 2010 |
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response | 2009 |
SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes.
Topics: Animals; Base Sequence; Dihydropyridines; Disease Models, Animal; DNA Primers; Hepatocytes; Humans; Inclusion Bodies; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C3H; Myeloid Differentiation Factor 88; S-Adenosylmethionine; Signal Transduction; TNF Receptor-Associated Factor 6; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptors; Up-Regulation | 2010 |
SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model.
Topics: Animals; Base Sequence; Cysteine Endopeptidases; Dihydropyridines; Disease Models, Animal; DNA Primers; Gene Expression; Inclusion Bodies; Keratins; Liver; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred C3H; Multienzyme Complexes; Proteasome Endopeptidase Complex; S-Adenosylmethionine; Ubiquitin; Ubiquitins | 2010 |
The cyclic pattern of blood alcohol levels during continuous ethanol feeding in rats: the effect of feeding S-adenosylmethionine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Disease Models, Animal; Ethanol; Gene Expression; Histones; Liver; Liver Diseases, Alcoholic; Male; Methylation; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; S-Adenosylmethionine | 2010 |
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Carbon; Cell Line; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Epigenomics; Female; Folic Acid; Humans; Male; Methylation; Mice; Mice, 129 Strain; Mice, Transgenic; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency | 2011 |
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Topics: Aminohydrolases; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; DNA, Neoplasm; Female; Formate-Tetrahydrofolate Ligase; Gene Expression Profiling; Immunoenzyme Techniques; Male; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Multifunctional Enzymes; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Uracil | 2011 |
[Effect of infusion hepatoprotectors on hepatic function in experimental cholestasis].
Topics: Animals; Cholestasis; Cytoprotection; Disease Models, Animal; Jaundice, Obstructive; Liver; Male; Rats; Rats, Wistar; S-Adenosylmethionine; Succinates | 2010 |
Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats.
Topics: Angioplasty, Balloon; Animals; Apoptosis; Biomarkers; Carotid Artery Diseases; Cell Division; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Insulin Resistance; Male; Muscle, Smooth, Vascular; Neointima; Oxidative Stress; Rats; Rats, Inbred OLETF; S-Adenosylmethionine; Vasculitis | 2011 |
Dietary supplementation with S-adenosyl methionine delayed amyloid-β and tau pathology in 3xTg-AD mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; Presenilin-1; S-Adenosylmethionine; tau Proteins; Tauopathies | 2012 |
Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Disease Models, Animal; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression Regulation, Enzymologic; Humans; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Multivariate Analysis; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Rats; Rats, Inbred BN; Rats, Inbred F344; RNA, Messenger; S-Adenosylmethionine; Statistics, Nonparametric; Transcriptional Activation; Tumor Cells, Cultured | 2012 |
Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Connective Tissue; Diet, Atherogenic; Disease Models, Animal; Fatty Acids; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Liver; Male; Mice; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Vitamin B Deficiency | 2012 |
S-adenosylmethionine in treatment of cholestasis after total parenteral nutrition: laboratory investigation and clinical application.
Topics: Animals; Bile Acids and Salts; Cholestasis; Disease Models, Animal; Male; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sepsis | 2002 |
Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability.
Topics: Alcohol Drinking; Animals; Apoptosis; Cell Survival; Central Nervous System Depressants; Disease Models, Animal; Epithelium; Ethanol; Female; Glutathione; Guinea Pigs; In Situ Nick-End Labeling; Lipid Peroxidation; Macrophages; Maternal Exposure; Oxidative Stress; Phagocytosis; S-Adenosylmethionine; Time Factors | 2005 |
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
Topics: Animals; Betaine; Disease Models, Animal; Ethanol; Fatty Liver; Hepatocytes; Male; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylmethionine | 2005 |
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blotting, Western; Cell Adhesion Molecules, Neuronal; Chromosome Mapping; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Extracellular Matrix Proteins; Frontal Lobe; GABA Modulators; Histones; Imidazoles; Immunohistochemistry; Interpersonal Relations; Male; Methionine; Methylation; Mice; Motor Activity; Nerve Tissue Proteins; Neural Inhibition; Promoter Regions, Genetic; Reelin Protein; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Schizophrenia; Serine Endopeptidases; Time Factors; Valproic Acid | 2005 |
Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascites; Dipyrone; Disease Models, Animal; Female; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Piroxicam; Random Allocation; S-Adenosylmethionine; Treatment Outcome; Trichomonas vaginalis; Trichomonas Vaginitis | 2005 |
Antioxidants as novel therapy in a murine model of colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Flavonoids; Mice; Oxidative Stress; Phenols; Polyphenols; S-Adenosylmethionine; Thiazoles | 2005 |
Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration.
Topics: Acetylcysteine; Animals; Apolipoproteins E; Cell Line, Tumor; Dietary Supplements; Disease Models, Animal; Folic Acid Deficiency; Glutathione; Glutathione Synthase; Maze Learning; Mice; Mice, Knockout; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; S-Adenosylmethionine; Thiobarbituric Acid Reactive Substances; Tubercidin; Vitamin E Deficiency | 2004 |
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biomarkers; Choline; Chromatography, High Pressure Liquid; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Heterozygote; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Up-Regulation | 2006 |
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Lipotropic Agents; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Thiazoles; Transaminases | 2006 |
Nitric oxide modulates glutathione synthesis during endotoxemia.
Topics: Animals; Body Weight; Catalase; Cysteine; Disease Models, Animal; Eating; Endotoxemia; Glutamate-Cysteine Ligase; Glutathione; Injections; Lipopolysaccharides; Liver; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase | 2006 |
Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress.
Topics: Acetylcholine; Age Factors; Alzheimer Disease; Animals; Antioxidants; Apolipoproteins E; Beverages; Brain; Disease Models, Animal; DNA Methylation; Folic Acid Deficiency; Gene Expression Regulation; Humans; Malus; Mice; Mutation; Neuroprotective Agents; Oxidative Stress; Presenilin-1; Reactive Oxygen Species; S-Adenosylmethionine; Vitamin E Deficiency | 2006 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet.
Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature | 2007 |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Topics: Alanine Transaminase; Animals; ATPases Associated with Diverse Cellular Activities; Chromosome Mapping; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Glycine N-Methyltransferase; Glycogen; Glycogen Storage Disease; Hepatitis, Chronic; Homocysteine; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex | 2007 |
S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Ethanol; Fibrosis; Hepatocytes; Humans; Inflammation Mediators; Lipopolysaccharides; Liver Cirrhosis, Alcoholic; Liver Function Tests; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 2008 |
Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice.
Topics: Acetylation; Animals; Carcinogens; Cell Fractionation; Cell Nucleus; Disease Models, Animal; Drug Antagonism; Drug Combinations; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Hepatocytes; Histones; Liver; Male; Methylation; Mice; Mice, Inbred C3H; Oligonucleotide Array Sequence Analysis; Proteins; RNA, Messenger; S-Adenosylmethionine | 2008 |
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated; Glutathione; Hepatitis; Homeostasis; Lipid Metabolism; Liver; Methionine; Mice; Mice, Mutant Strains; Mice, Obese; Obesity; S-Adenosylmethionine | 2008 |
Increased phospholipid methylation in the myocardium of hyperthyroid rats.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Hyperthyroidism; Male; Methylation; Microsomes; Myocardium; Phospholipids; Rats; S-Adenosylmethionine; Thyroxine | 1980 |
Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Castration; Chronic Disease; Conditioning, Operant; Depressive Disorder; Disease Models, Animal; Drinking Behavior; Female; Male; Rats; S-Adenosylmethionine; Stress, Physiological; Sucrose | 1999 |
Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Time Factors; Tremor | 2000 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression.
Topics: Animals; Antidepressive Agents; Biogenic Polyamines; Brain Chemistry; Chronic Disease; Depression; Dietary Sucrose; Disease Models, Animal; Eating; Female; Hippocampus; Nucleus Accumbens; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Stress, Physiological | 2001 |
Effects of S-adenosyl-L-methionine on lipid peroxidation and glutathione levels in rat brain slices exposed to reoxygenation after oxygen-glucose deprivation.
Topics: Animals; Brain; Disease Models, Animal; Free Radicals; Glutathione; Hypoxia-Ischemia, Brain; Lipid Peroxidation; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine; Thiobarbituric Acid Reactive Substances | 2002 |
Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.
Topics: Adenosine; Animals; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Ischemia; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Protective effect of S-adenosyl-L-methionine in hepatic uroporphyria. Evaluation in an experimental model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Hexachlorobenzene; Liver Diseases; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Skin Diseases; Uroporphyrinogen Decarboxylase | 1990 |
Inhibition of mouse-killing behavior by S-adenosyl-L-methionine in midbrain raphe-lesioned and olfactory-bulbectomized rats.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mesencephalon; Mice; Olfactory Bulb; Raphe Nuclei; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1989 |
[Effects of S-adenosyl-L-methionine on experimental cerebral ischemia].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Cyclic AMP; Disease Models, Animal; Energy Metabolism; Lactates; Lactic Acid; Male; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1985 |
[The effect of S-adenosyl-L-methionine sulfate tosylate (FO-1561) on survival time in various brain damage models].
Topics: Animals; Cerebral Infarction; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gerbillinae; Hypoxia, Brain; Male; Mice; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Time Factors | 1988 |