Page last updated: 2024-08-23

s-adenosylmethionine and Colorectal Neoplasms

s-adenosylmethionine has been researched along with Colorectal Neoplasms in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.09)18.2507
2000's2 (9.09)29.6817
2010's11 (50.00)24.3611
2020's7 (31.82)2.80

Authors

AuthorsStudies
Aquarius, M; Arts, ICW; Bours, MJL; Breukink, SO; Gicquiau, A; Gunter, MJ; Keulen, ETP; Leitzmann, MF; Rinaldi, S; Scalbert, A; van Delden, L; van Roekel, EH; Viallon, V; Vineis, P; Weijenberg, MP1
Cao, Y; Fang, Z; Gao, P; Jing, Y; Li, C; Wang, Q; Wu, J; Wu, X; Zhu, Z1
Bathe, OF; Buie, WD; Farshidfar, F; Hilsden, R; Kopciuk, KA; MacLean, A; Mazurak, VC; McGregor, SE; Vogel, HJ1
Boeing, H; Floegel, A; Johnson, T; Kaaks, R; Kühn, T; Otto, W; Rolle-Kampczyk, U; Sookthai, D; von Bergen, M1
Borzacchiello, L; Cacciapuoti, G; Mele, L; Mosca, L; Pagano, M; Porcelli, M; Russo, A; Russo, G1
Gao, H; Li, D; Li, S; Li, X; Liang, J; Wang, S; Wang, X; Wei, P; Yang, W; Yu, G; Yu, H; Zhang, J; Zhang, Y1
Calvisi, DF; Feo, CF; Feo, F; Pascale, RM; Simile, MM1
Barták, BK; Felletár, I; Galamb, O; Igaz, P; Kalmár, A; Márkus, E; Micsik, T; Molnár, B; Nagy, ZB; Papp, M; Szigeti, KA; Takács, I; Tulassay, Z; V Patai, Á; Valcz, G; Zsigrai, S1
Arpino, R; Borzacchiello, L; Cacciapuoti, G; Grillo, R; Mosca, L; Porcelli, M; Veglia Tranchese, R1
Barna, G; Barták, BK; Csabai, I; Dankó, T; Galamb, O; Igaz, P; Kalmár, A; Medgyes-Horváth, A; Molnár, B; Nagy, ZB; Pipek, O; Sebestyén, A; Szabó, V; Szigeti, KA; Takács, I; Tulassay, Z; Valcz, G; Zsigrai, S1
Almajhdi, FN; Hussain, Z; Khan, MI; Shahid, M1
Chrudinová, M; Demianová, Z; Jiráček, J; Kořínek, M; Mládková, J; Selicharová, I1
Chen, Q; Gross, SS; Kopelovich, L; Lipkin, SM; Witherspoon, M1
Asimakopoulou, A; Chao, C; Coletta, C; Hellmich, MR; Módis, K; Papapetropoulos, A; Szabo, C; Szczesny, B1
Adams, PD; Labuschagne, CF; Maddocks, OD; Vousden, KH1
Berti, P; Daniele, S; Frezza, AM; Picardi, A; Tonini, G; Vespasiani, U; Vincenzi, B1
Berti, P; Frezza, AM; Picardi, A; Santini, D; Tonini, G; Vespasiani, U; Vincenzi, B1
Baurley, J; Crott, JW; Figueiredo, JC; Haile, RW; Levine, AJ1
Robertson, KD; Yokochi, T1
Alonso-Aperte, E; González, MP; Póo-Prieto, R; Varela-Moreiras, G1
Christman, JK; Cravo, ML; Fleet, JC; Kim, YI; Mason, JB; Ordovas, J; Salomon, RN; Selhub, J; Smith, D1
Duthie, SJ1

Reviews

3 review(s) available for s-adenosylmethionine and Colorectal Neoplasms

ArticleYear
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent.
    Cells, 2022, 01-25, Volume: 11, Issue:3

    Topics: Animals; Antiviral Agents; Betaine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Colorectal Neoplasms; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Non-alcoholic Fatty Liver Disease; Rats; Ribavirin; S-Adenosylmethionine

2022
Folate-genetics and colorectal neoplasia: what we know and need to know next.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Risk Factors; S-Adenosylmethionine; Thymidylate Synthase

2013
Folic acid deficiency and cancer: mechanisms of DNA instability.
    British medical bulletin, 1999, Volume: 55, Issue:3

    Topics: Animals; Chromosome Breakage; Colorectal Neoplasms; Cricetinae; DNA; DNA Methylation; DNA Repair; Female; Folic Acid Deficiency; Humans; Male; Proto-Oncogenes; Rats; S-Adenosylmethionine

1999

Other Studies

19 other study(ies) available for s-adenosylmethionine and Colorectal Neoplasms

ArticleYear
Longitudinal associations of physical activity with plasma metabolites among colorectal cancer survivors up to 2 years after treatment.
    Scientific reports, 2021, 07-02, Volume: 11, Issue:1

    Topics: Aged; Arginine; Cancer Survivors; Carnitine; Citrulline; Colorectal Neoplasms; Exercise; Female; Histidine; Humans; Longitudinal Studies; Lysophosphatidylcholines; Male; Metabolome; Middle Aged; Quality of Life; Self Report; Sphingomyelins; Tandem Mass Spectrometry

2021
Rapid differentiating colorectal cancer and colorectal polyp using dried blood spot mass spectrometry metabolomic approach.
    IUBMB life, 2017, Volume: 69, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Carnitine; Colonic Polyps; Colorectal Neoplasms; Dried Blood Spot Testing; Female; Humans; Male; Metabolomics; Middle Aged; Reproducibility of Results

2017
A quantitative multimodal metabolomic assay for colorectal cancer.
    BMC cancer, 2018, 01-04, Volume: 18, Issue:1

    Topics: Adenoma; Aged; Amino Acids; Biomarkers, Tumor; Carnitine; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Male; Mass Spectrometry; Metabolome; Metabolomics; Middle Aged; Phosphatidylcholines; Sphingomyelins

2018
Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study.
    BMC medicine, 2016, Jan-28, Volume: 14

    Topics: Biomarkers, Tumor; Breast Neoplasms; Carnitine; Cohort Studies; Colorectal Neoplasms; Female; Humans; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Male; Middle Aged; Neoplasms; Prospective Studies; Prostatic Neoplasms

2016
S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation.
    International journal of molecular sciences, 2021, Aug-27, Volume: 22, Issue:17

    Topics: Antimetabolites, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; S-Adenosylmethionine; Tumor Cells, Cultured

2021
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
    The Journal of clinical investigation, 2021, 11-01, Volume: 131, Issue:21

    Topics: Cell Movement; Colorectal Neoplasms; Cullin Proteins; DNA-Binding Proteins; HCT116 Cells; HEK293 Cells; Humans; Neoplasm Metastasis; Neoplasm Proteins; Phosphoglycerate Dehydrogenase; S-Adenosylmethionine; Ubiquitination

2021
Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content.
    BMC cancer, 2022, Jun-02, Volume: 22, Issue:1

    Topics: Adenoma; Colorectal Neoplasms; DNA; DNA Methylation; Folate Receptor 2; Folic Acid; Humans; Inflammatory Bowel Diseases; Liquid Biopsy; RNA, Messenger; S-Adenosylmethionine

2022
S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway.
    International journal of molecular sciences, 2022, Jul-12, Volume: 23, Issue:14

    Topics: Caco-2 Cells; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; S-Adenosylmethionine; Signal Transduction

2022
S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression.
    Cells, 2020, 08-09, Volume: 9, Issue:8

    Topics: Antineoplastic Agents; Carcinoma; Colorectal Neoplasms; DNA Methylation; DNA Repair; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; S-Adenosylmethionine

2020
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.
    Genetics and molecular research : GMR, 2013, Apr-10, Volume: 12, Issue:2

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; S-Adenosylmethionine; Tissue Inhibitor of Metalloproteinase-2

2013
Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome.
    Biochimica et biophysica acta, 2013, Volume: 1834, Issue:8

    Topics: Apolipoprotein A-I; Apoptosis; Betaine-Homocysteine S-Methyltransferase; Blotting, Western; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; Electrophoresis, Gel, Two-Dimensional; Fibrinogen; Hepatocytes; Homocysteine; Humans; Hyperhomocysteinemia; Liver Neoplasms; Male; Metabolomics; Middle Aged; Protein Multimerization; Proteome; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2013
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.
    Cancer discovery, 2013, Volume: 3, Issue:9

    Topics: Animals; Cell Line, Tumor; Chemoprevention; Colorectal Neoplasms; Eflornithine; Enzyme Inhibitors; HT29 Cells; Humans; Mice; Ornithine Decarboxylase Inhibitors; S-Adenosylmethionine; Thymidine

2013
Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.
    Nitric oxide : biology and chemistry, 2014, Sep-15, Volume: 41

    Topics: Cell Line; Cell Proliferation; Colorectal Neoplasms; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Energy Metabolism; Gene Silencing; HCT116 Cells; Humans; Hydrogen Sulfide; Mitochondria; RNA, Small Interfering; S-Adenosylmethionine

2014
Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.
    Molecular cell, 2016, Jan-21, Volume: 61, Issue:2

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Homocysteine; Humans; Methionine; Neoplasms; RNA; S-Adenosylmethionine; Serine; Stress, Physiological

2016
The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Fluorouracil; Humans; Liver Function Tests; Oxaloacetates; Retrospective Studies; S-Adenosylmethionine

2012
The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; gamma-Glutamyltransferase; Humans; Leucovorin; Liver; Male; Middle Aged; Organoplatinum Compounds; Retrospective Studies; S-Adenosylmethionine

2011
Doxorubicin inhibits DNMT1, resulting in conditional apoptosis.
    Molecular pharmacology, 2004, Volume: 66, Issue:6

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Doxorubicin; Humans; Intercalating Agents; Kinetics; Recombinant Proteins; S-Adenosylmethionine

2004
Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans.
    European journal of clinical nutrition, 2008, Volume: 62, Issue:2

    Topics: Adenocarcinoma; Aged; Colon; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Intestinal Mucosa; Male; Nutritional Status; S-Adenosylhomocysteine; S-Adenosylmethionine

2008
Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats.
    The American journal of clinical nutrition, 1995, Volume: 61, Issue:5

    Topics: Animals; Body Weight; Colon; Colorectal Neoplasms; DNA; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation, Neoplastic; Genes, myc; Liver; Male; Methionine; Methylation; Proto-Oncogene Proteins c-myc; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine

1995