Compounds > s-adenosylmethionine
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s-adenosylmethionine and Cancer of Liver

s-adenosylmethionine has been researched along with Cancer of Liver in 93 studies

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-199017 (18.28)18.7374
1990's6 (6.45)18.2507
2000's22 (23.66)29.6817
2010's36 (38.71)24.3611
2020's12 (12.90)2.80

Authors

AuthorsStudies
Chen, Y; Cheng, X; Li, M; Liang, Z; Tan, X; Wang, W; Weng, X; Wu, M; Wu, X; Zhang, Z; Zhu, P; Zhu, R1
Achaintre, D; Agnoli, C; Agudo, A; Ardanaz, E; Arriola, L; Bachlechner, U; Bamia, C; Boeing, H; Bueno-de-Mesquita, B; Carayol, M; Ferrari, P; Hansen, L; Huerta, JM; Jenab, M; Kaaks, R; Key, TJ; Khaw, KT; Kühn, T; Leitzmann, MF; Melander, O; Nilsson, J; Overvad, K; Palli, D; Panico, S; Peeters, PH; Quirós, JR; Rinaldi, S; Sánchez-Cantalejo, E; Scalbert, A; Schmidt, JA; Stepien, M; Tjønneland, A; Travis, RC; Trichopoulou, A; Tumino, R; Vineis, P; Wareham, N; Zamora-Ros, R1
Arita, J; Enooku, K; Fujiwara, N; Fukayama, M; Hasegawa, K; Hayashi, A; Hayata, Y; Hikiba, Y; Hirata, Y; Hirschfield, H; Hoshida, Y; Koike, K; Kudo, Y; Misumi, K; Nakagawa, H; Nakatsuka, T; Otsuka, M; Shibahara, J; Tanaka, M; Tanaka, Y; Tateishi, K; Tateishi, R1
Chen, N; Chen, Y; Lou, B; Lv, J; Mao, W; Wang, P; Wang, W1
Bai, Y; Li, Y; Lu, X; Nie, H; Shi, X; Wang, Y; Zhan, C; Zhang, K; Zhang, X; Zhang, Y; Zhao, J1
Enooku, K; Fujiwara, N; Hoshida, Y; Koike, K; Kondo, M; Minami, T; Nakagawa, H; Shibahara, J; Tateishi, R1
Gopalan, V; Lee, SS; Othman, R; Phang, BH; Sabapathy, K; Teoh, WW; Toh, HC; Velan, SS; Verma, SK; Wang, WW; Yaligar, J1
Elsemman, IE; Mardinoglu, A; Nielsen, J; Shoaie, S; Soliman, TH1
Chen, S; Lin, X; Lu, X; Wang, Q; Wu, Z; Xing, W; Xu, G; Yin, P; Zhang, Y; Zhou, L1
Duan, S; Qi, Y; Zhang, M; Zhang, Q; Zhong, C1
Calvisi, DF; Feo, CF; Feo, F; Pascale, RM; Simile, MM1
Merali, C; Merali, S; Quinn, C; Rico, MC1
Chen, C; Deng, H; Gao, Q; Gou, D; Huang, A; Li, Z; Liu, R; Liu, Y; Shan, X; Tang, N; Wang, K; Xiang, J1
Ameneiro, C; Aransay, AM; Aspichueta, P; Ayuso-García, P; Bao-Caamano, A; Beiroa, D; Bernardo-Seisdedos, G; Bilbao-García, J; Bizkarguenaga, M; Blanco, MG; Blazquez-Vicens, J; Borzacchiello, L; Buqué, X; Buyan, M; Cabrera, D; Cañas-Martín, J; Capelo-Diz, A; Crujeiras, AB; Delgado, TC; Díaz-Lagares, Á; Dziechciarz, B; Falcon-Perez, JM; Fernández-Ramos, D; Fernández-Susavila, H; Fidalgo, M; Fondevila, MF; Goikoetxea-Usandizaga, N; Gomez-Santos, B; González-Rellan, MJ; González-Romero, F; Gutierrez de Juan, V; Lachiondo-Ortega, S; Lama-Díaz, T; López, M; Lopitz-Otsoa, F; Martínez-Chantar, ML; Matute, C; Millet, O; Montiel-Duarte, C; Mosca, L; Müller, TD; Nogueiras, R; Pajares, MA; Porcelli, M; Riobello-Suárez, C; Rodríguez-Agudo, R; Rodríguez-Cuesta, J; Ruiz, A; Sáenz de Urturi, D; Sánchez-Rueda, A; Senra, A; Serrano-Maciá, M; Simon, J; Soriano-Navarro, M; Tamayo-Carro, M; Tinahones-Ruano, A; van Liempd, S; Varela-Rey, M; Velasco-Avilés, S; Villa-Bellosta, R; Woodhoo, A1
Barbier-Torres, L; Fan, W; Lu, SC; Mato, JM; Murray, B1
Chagoya De Sánchez, V; Chávez, E; Domínguez-López, M; Lozano-Rosas, MG; Martínez-Pérez, L; Velasco-Loyden, G1
Battaglia-Hsu, SF; Chen, B; Feng, J; Gong, C; Guo, D; Guo, T; Li, Z; Liu, P; Liu, Z; Wang, H; Wu, P; Xiao, Y; Yao, Y1
Chen, Y; Fan, W; Li, M; Li, TWH; Li, Y; Liu, T; Lu, L; Lu, SC; Mato, JM; Peng, H; Seki, E; Steggerda, J; Tu, J; Wang, J; Xiong, T; Yang, H; Zhang, J; Zhou, ZG1
Cammas, F; Fabbrizio, E; Mancini, M; Mangé, A; Papon, L1
Budhu, A; Chaisaingmongkol, J; Chang, CW; Diggs, LP; Forgues, M; Greten, TF; Heinrich, S; Hung, MH; Lee, JS; Ma, C; Ma, L; Ruchirawat, M; Ruppin, E; Wang, XW1
Abeynayake, A; Barbier-Torres, L; Berlind, J; Binek, A; Erbay, E; Fan, W; Lu, SC; Mato, JM; Nissen, NN; Noureddin, M; Ramani, K; Robinson, AE; Van Eyk, JE; Yildirim, Z1
Du, Z; Gao, Y; Luo, Y; Wang, N; Wang, P; Wu, G; Yang, B; Zhang, Y; Zhu, Z1
Zeisel, S1
Annamalai, A; Fan, W; Li, TWH; Liu, T; Liu, Z; Lu, SC; Maldonado, SS; Mato, JM; Noureddin, M; Seki, E; Shen, H; Steggerda, J; Tu, J; Wang, J; Xiong, T; Yang, H; Yang, J1
Antonyuk, SV; Bradley-Clarke, J; Hasnain, SS; Mato, JM; O'Neill, PM; Panmanee, J1
Chu, YD; Huang, YH; Lai, HY; Liang, KH; Lin, YH; Pai, LM; Yeh, CT1
Boix, L; Bruix, J; Fernández, AF; Ferrero, C; Fraga, MF; García-Rodríguez, JL; Huidobro, C; Martínez-Camblor, P; Martínez-Chantar, ML; Mato, JM; Rodríguez, RM; Toraño, EG; Urdinguio, RG; Varela-Rey, M1
Giordano, P; Lu, SC; Mato, JM; Ryoo, M; Skay, A; Tomasi, I; Tomasi, ML1
Feo, F; Frau, M; Pascale, RM1
Chrudinová, M; Demianová, Z; Jiráček, J; Kořínek, M; Mládková, J; Selicharová, I1
Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC1
Li, CS; Li, T; Liu, QY; Liu, WJ; Liu, ZS; Ren, JG; Yu, GZ; Zhang, J1
Ge, YS; Jia, WD; Liu, GY; Ma, JL; Meng, FL; Sun, QK; Wang, W; Xu, GL; Yu, JH1
Corn, DJ; Kuang, Y; Lee, Z; Tian, H; Wang, F1
Kurniawidjaja, S; Li, TW; Lu, SC; Mato, JM; Panthaki, P; Peng, H; Yang, H; Zheng, Y1
Noureddin, M; Rinella, ME1
Giordano, P; Lu, SC; Mato, JM; Ramani, K; Ryoo, M; Tomasi, I; Tomasi, ML1
Cheng, X; Jin, Z; Ma, D; Peng, C; Qiu, W; Seewoo, V; Shen, B; Tong, H; Yang, W1
Liu, QY; Liu, ZS; Pan, DY; Qian, Q; Sun, Q; Wang, Q1
Feo, F; Iglesias-Ara, A; Lu, SC; Martínez-Chantar, ML; Mato, JM; Pascale, MR; Ramani, K; Tomasi, ML; Yang, H1
Elias, MS; Green, RM; Henkel, AS1
Anglim, PP; Caballería, J; Embade, N; Fernández-Ramos, D; Finnell, RH; Gorospe, M; Laird-Offringa, IA; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-Lopez, N; Mato, JM; Varela-Rey, M; Vázquez-Chantada, M; Wagner, C; Woodhoo, A1
Chen, SY; Chen, YM; Chiang, EP; Tang, FY; Wang, YC1
Chen, J; He, Y; Liu, L; Liu, Q; Liu, Z; Wang, D; Wu, J; Zhang, J; Zhang, Z; Zhao, Y1
Cheng, ML; Chiu, DT; Ho, HY; Shiao, MS; Tang, HY; Weng, SF1
Bigaud, E; Corrales, FJ; Fernández-Irigoyen, J; Lu, SC; Mato, JM; Prieto, J; Renández-Alcoceba, R; Schröder, PC; Serna, A1
Brozzetti, S; Calvisi, DF; Daino, L; Demartis, MI; Feo, CF; Feo, F; Frau, M; Latte, G; Pascale, RM; Salis, F; Seddaiu, MA; Simile, MM; Solinas, G; Tomasi, ML; Ushijima, T; Yamashita, S1
Giordano, P; Lu, SC; Mato, JM; Pascale, RM; Ramani, K; Tomasi, I; Tomasi, ML; Xu, J1
Bardag-Gorce, F; Buslon, V; French, BA; French, SW; Li, J; Oliva, J; Zhong, J1
Du, H; Li, H; Lin, A; Peng, C; Qiu, W; Seewoo, V; Shen, B; Wang, J; Yang, W1
Lu, SC; Mato, JM3
De Miglio, MR; Feo, F; Pascale, RM; Simile, MM1
Avila, MA; García-Trevijano, ER; Latasa, MU; Lu, SC; Martínez-Chantar, ML; Mato, JM; Varela-Rey, M1
Cotterman, RF; Esfandiari, F; Green, R; James, SJ; Miller, JW; Pogribny, IP1
Bae, W; Chen, L; Li, M; Lu, SC; Mato, JM; Ou, X; Runnegar, MT; Sadda, MR; Yang, H; Zeng, Y1
Asara, G; Brignole, C; Calvisi, DF; De Miglio, MR; Feo, F; Frau, M; Muroni, MR; Pagnan, G; Pascale, RM; Pastorino, F; Ponzoni, M; Seddaiu, MA; Simile, MM1
McKillop, IH; Schrum, LW1
Avila, MA; Berasain, C; Corrales, FJ; Fernandez-Irigoyen, J; Lu, SC; Mato, JM; Mora, MI; Muñoz, J; Prieto, J; Santamaría, E; Sesma, L1
Banerjee, R; Bauman, Z; Braun, A; Lu, SC; Prudova, A; Vitvitsky, V1
Herrera, LA; Hock, R; Ramírez, T; Stopper, H1
Hermes, M; Kloor, D; Osswald, H1
Chu, PG; Luh, F; Qiu, W; Yen, Y; Zhou, B1
Chan, C; Ji, C; Kaplowitz, N; Kuhlenkamp, J; Shinohara, M1
Aransay, AM; Ariz, U; Calvisi, DF; Capdevila, A; Esteller, M; Fraga, M; Lu, SC; Luka, Z; Martínez, N; Martínez-Chantar, ML; Mato, JM; Matthiesen, R; Rodríguez, J; Varela, M; Vázquez-Chantada, M; Wagner, C; Yang, H1
Arellanes-Robledo, J; Beltrán-Ramírez, O; Fattel-Fazenda, S; García-Román, R; Rosas, S; Salazar-González, D; Villa-Treviño, S1
Poirier, LA; Shivapurkar, N; Wilson, MJ1
Poirier, LA1
Huang, HY; Lu, SC1
De Miglio, MR; Feo, F; Malvaldi, G; Muroni, MR; Nufris, A; Pascale, RM; Saviozzi, M; Simile, MM1
Allen, PT; Poirier, LA1
Avila, MA; Huang, ZZ; Lu, SC; Mato, JM; Tsukamoto, H; Yang, H1
Chen, C; Huang, ZZ; Lu, SC; Selby, RR; Yang, H; Zeng, Z1
Ansorena, E; Avila, MA; Chen, L; García-Trevijano, ER; Huang, ZZ; Iraburu, M; Lu, SC; Martínez-Chantar, ML; Mato, JM1
Hunt, ME; Hurlbert, RB; Liau, MC1
Rogachevsky, LM; Sneider, TW; Teague, WM1
Kuchino, Y; Nishimura, S; Yasuda, T1
Busch, H; Gupta, KK; Hirsch, F; Rao, M; Spohn, W; Wu, BC1
Altman, NH; Brada, Z; Bulba, S1
Gnegy, ME; Lotspeich, FJ1
Swann, PF1
Bennati, S; Carta, M; Daino, L; Feo, F; Marras, V; Massarelli, G; Pascale, RM; Pinna, G; Seddaiu, MA; Simile, MM1
Lyn-Cook, B; Poirier, LA; Zapisek, W1
Creasia, D; Hoover, KL; Mikol, YB; Poirier, LA; Shivapurkar, N; Wilson, MJ1
Lee, HW; Morris, HP; Paik, WK1
Hurlbert, RB; Liau, MC; O'Rourke, CM1
Kerr, SJ1
Coppoc, GL; Geroch, ME; Jänne, J; Schenone, A; Williams-Ashman, HG1
Sharma, OK1
Hancock, RL1
Heady, JE; Kerr, SJ1
Craddock, VM; Turberville, C1

Reviews

16 review(s) available for s-adenosylmethionine and Cancer of Liver

ArticleYear
LINC00662: A new oncogenic lncRNA with great potential.
    Journal of cellular physiology, 2022, Volume: 237, Issue:2

    Topics: Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Oncogenes; RNA, Long Noncoding; S-Adenosylmethionine; Wnt Signaling Pathway

2022
S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent.
    Cells, 2022, 01-25, Volume: 11, Issue:3

    Topics: Animals; Antiviral Agents; Betaine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Colorectal Neoplasms; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Non-alcoholic Fatty Liver Disease; Rats; Ribavirin; S-Adenosylmethionine

2022
Methionine adenosyltransferases in liver cancer.
    World journal of gastroenterology, 2019, Aug-21, Volume: 25, Issue:31

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Dedifferentiation; Cell Transformation, Neoplastic; Disease Models, Animal; Disease Progression; Down-Regulation; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Isoenzymes; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; S-Adenosylmethionine

2019
Choline, Other Methyl-Donors and Epigenetics.
    Nutrients, 2017, Apr-29, Volume: 9, Issue:5

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cyclin-Dependent Kinase Inhibitor Proteins; Diet; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Liver Neoplasms; Meta-Analysis as Topic; Mice; Models, Animal; Phenotype; S-Adenosylhomocysteine; S-Adenosylmethionine

2017
Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.
    Journal of hepatology, 2013, Volume: 59, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Disease Progression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Prognosis; Prohibitins; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction

2013
Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma.
    Clinics in liver disease, 2015, Volume: 19, Issue:2

    Topics: Carcinoma, Hepatocellular; Chemoprevention; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Incidence; Inflammation; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Leptin; Liver Neoplasms; Metformin; Non-alcoholic Fatty Liver Disease; Obesity; Risk Factors; S-Adenosylmethionine; Toll-Like Receptors

2015
S-adenosylmethionine in liver health, injury, and cancer.
    Physiological reviews, 2012, Volume: 92, Issue:4

    Topics: Animals; Humans; Liver; Liver Diseases; Liver Neoplasms; Methionine Adenosyltransferase; S-Adenosylmethionine

2012
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
    Alcohol (Fayetteville, N.Y.), 2002, Volume: 27, Issue:3

    Topics: Animals; Antineoplastic Agents; Humans; Liver Neoplasms; S-Adenosylmethionine

2002
Alcohol and liver cancer.
    Alcohol (Fayetteville, N.Y.), 2005, Volume: 35, Issue:3

    Topics: Alcoholism; Animals; Antioxidants; Carcinoma, Hepatocellular; Central Nervous System Depressants; Disease Progression; Ethanol; Glutathione; Hepatocytes; Humans; Liver; Liver Neoplasms; S-Adenosylmethionine; Signal Transduction; Silymarin

2005
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer.
    Alcohol (Fayetteville, N.Y.), 2005, Volume: 35, Issue:3

    Topics: Animals; Cell Death; Central Nervous System Depressants; Ethanol; Female; Hepatocytes; Humans; Isoenzymes; Liver; Liver Diseases, Alcoholic; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; S-Adenosylmethionine

2005
S-Adenosylmethionine in cell growth, apoptosis and liver cancer.
    Journal of gastroenterology and hepatology, 2008, Volume: 23 Suppl 1

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Hepatocytes; Humans; Liver Neoplasms; S-Adenosylmethionine

2008
Methyl group deficiency in hepatocarcinogenesis.
    Drug metabolism reviews, 1994, Volume: 26, Issue:1-2

    Topics: Animals; Choline Deficiency; Diet; Folic Acid Deficiency; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methionine; Methylation; Oncogenes; S-Adenosylmethionine

1994
Structural and functional studies on the "5'-cap": a survey method for mRNA.
    Progress in nucleic acid research and molecular biology, 1976, Volume: 19

    Topics: Aged; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Humans; Kinetics; Liver; Liver Neoplasms; Models, Biological; Neoplasms, Experimental; Ovalbumin; Oxidation-Reduction; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine

1976
Physiological methylation in carcinogenesis.
    Progress in clinical and biological research, 1990, Volume: 340D

    Topics: Animals; Choline Deficiency; DNA; Humans; Liver Neoplasms; Methionine; Methylation; Oxidation-Reduction; S-Adenosylmethionine

1990
New aspects of polyamine biosynthesis in eukaryotic organisms.
    Advances in enzyme regulation, 1972, Volume: 10

    Topics: Animals; Azotobacter; Carboxy-Lyases; Carcinoma, Hepatocellular; Catalysis; Chickens; Escherichia coli; Female; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Macromolecular Substances; Magnesium; Male; Polyamines; Propylamines; Prostate; Putrescine; Rabbits; Rats; S-Adenosylmethionine; Saccharomyces cerevisiae; Spermidine; Spermine; Transferases; Xenopus

1972
Modulation of tRNA methyltransferase activity by competing enzyme systems.
    Advances in enzyme regulation, 1974, Volume: 12

    Topics: Animals; Brain; Carcinoma, Hepatocellular; Catechol O-Methyltransferase; Estrogens; Female; Fetus; Glycine; Kinetics; Liver; Liver Neoplasms; Methyltransferases; Rabbits; Rats; S-Adenosylmethionine; tRNA Methyltransferases; Uterus

1974

Other Studies

77 other study(ies) available for s-adenosylmethionine and Cancer of Liver

ArticleYear
Long-Chain Acylcarnitines Induce Senescence of Invariant Natural Killer T Cells in Hepatocellular Carcinoma.
    Cancer research, 2023, 02-15, Volume: 83, Issue:4

    Topics: Antigens, CD1d; Carcinoma, Hepatocellular; Carnitine; Cellular Senescence; Galactosylceramides; Humans; Liver Neoplasms; Natural Killer T-Cells

2023
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
    Journal of proteome research, 2017, 09-01, Volume: 16, Issue:9

    Topics: Adult; Amino Acids; Bile Duct Neoplasms; Biogenic Amines; Blood Proteins; Body Mass Index; Carcinoma; Carnitine; Case-Control Studies; Diabetes Mellitus; Europe; Gene Expression; Hexoses; Humans; Linear Models; Liver Neoplasms; Longitudinal Studies; Male; Metabolome; Middle Aged; Nutrition Assessment; Obesity; Phosphatidylcholines; Risk Factors; Sphingomyelins

2017
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
    Gut, 2018, Volume: 67, Issue:8

    Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Disease Models, Animal; Female; Humans; Liver Neoplasms; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity

2018
Dysregulated serum metabolites in staging of hepatocellular carcinoma.
    Clinical biochemistry, 2018, Volume: 61

    Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Carnitine; China; Cohort Studies; Docosahexaenoic Acids; Female; Humans; Linolenic Acids; Liver Neoplasms; Lymphatic Metastasis; Lysophosphatidylcholines; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Principal Component Analysis; Prognosis; Proof of Concept Study; Sensitivity and Specificity; Up-Regulation; Young Adult

2018
Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:5

    Topics: Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Carnitine; Carnitine O-Palmitoyltransferase; Case-Control Studies; Cell Proliferation; Follow-Up Studies; Humans; Liver Neoplasms; Metabolome; Prognosis; RNA, Small Interfering; Tumor Cells, Cultured

2019
Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma.
    Scientific reports, 2019, 07-23, Volume: 9, Issue:1

    Topics: Adult; Age Factors; Aged; Carcinoma, Hepatocellular; Carnitine; Disease Progression; Female; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Non-alcoholic Fatty Liver Disease

2019
Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection.
    Scientific reports, 2016, Feb-02, Volume: 6

    Topics: Animals; Biomarkers; Carcinoma, Hepatocellular; Carnitine; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Early Detection of Cancer; Gene Expression Profiling; Humans; Liver Neoplasms; Mice; Mice, Transgenic; Molecular Imaging; Tumor Burden

2016
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
    Molecular bioSystems, 2016, 04-26, Volume: 12, Issue:5

    Topics: Acyl Coenzyme A; Acyltransferases; Carcinoma, Hepatocellular; Carnitine; Chromosomes, Human, Pair 1; Collagen; Diglycerides; DNA Copy Number Variations; Hepacivirus; Hepatitis C; Humans; Keratan Sulfate; Lipid Metabolism; Liver Cirrhosis; Liver Neoplasms; Models, Biological; S-Adenosylmethionine; Systems Biology; Transaminases; Virus Assembly

2016
Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases.
    Analytical and bioanalytical chemistry, 2012, Volume: 403, Issue:1

    Topics: Carcinoma, Hepatocellular; Carnitine; Chromatography, Liquid; Chronic Disease; Fatty Acids; Humans; Liver Diseases; Liver Neoplasms; Mass Spectrometry; Metabolomics

2012
Dysregulation of S-adenosylmethionine Metabolism in Nonalcoholic Steatohepatitis Leads to Polyamine Flux and Oxidative Stress.
    International journal of molecular sciences, 2022, Feb-11, Volume: 23, Issue:4

    Topics: Adult; Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Female; Glycine N-Methyltransferase; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; Polyamines; Proteomics; S-Adenosylmethionine

2022
Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression.
    The Journal of clinical investigation, 2023, 07-03, Volume: 133, Issue:13

    Topics: Carcinoma, Hepatocellular; Epigenesis, Genetic; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); S-Adenosylmethionine

2023
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.
    Cell metabolism, 2023, 08-08, Volume: 35, Issue:8

    Topics: Adenosine Triphosphate; Animals; Fasting; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylmethionine

2023
Diminished S-adenosylmethionine biosynthesis and its metabolism in a model of hepatocellular carcinoma is recuperated by an adenosine derivative.
    Cancer biology & therapy, 2020, Volume: 21, Issue:1

    Topics: Adenosine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Rats; Rats, Wistar; RNA-Binding Proteins; S-Adenosylmethionine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
LINC00662 promotes hepatocellular carcinoma progression via altering genomic methylation profiles.
    Cell death and differentiation, 2020, Volume: 27, Issue:7

    Topics: 3' Untranslated Regions; 5-Methylcytosine; Adenosylhomocysteinase; Adult; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Proteolysis; RNA, Long Noncoding; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Survival Analysis; Ubiquitin; Up-Regulation

2020
Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer.
    Hepatology (Baltimore, Md.), 2020, Volume: 72, Issue:5

    Topics: Animals; Carcinogenesis; Cell Line, Tumor; Datasets as Topic; Feedback, Physiological; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Liver; Liver Neoplasms; Male; Methionine Adenosyltransferase; Mice; Mice, Knockout; NF-kappa B; Primary Cell Culture; Promoter Regions, Genetic; Pyridines; S-Adenosylmethionine; Sulfonamides; Thiophenes; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2020
HP1s modulate the S-Adenosyl Methionine synthesis pathway in liver cancer cells.
    The Biochemical journal, 2020, 03-13, Volume: 477, Issue:5

    Topics: Biosynthetic Pathways; Carcinoma, Hepatocellular; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HEK293 Cells; Hep G2 Cells; Humans; Liver Neoplasms; S-Adenosylmethionine

2020
Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma.
    Nature communications, 2021, 03-05, Volume: 12, Issue:1

    Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Line, Tumor; CRISPR-Cas Systems; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Liver; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylmethionine; T-Lymphocytes; Transcriptome

2021
S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells.
    Hepatology (Baltimore, Md.), 2022, Volume: 75, Issue:2

    Topics: Animals; Autoantigens; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinase 2; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Mice; Mice, Knockout; Mutation; Non-alcoholic Fatty Liver Disease; Oligonucleotides; Phosphorylation; Protein Biosynthesis; Proteomics; Ribonucleoproteins; Ribosomal Proteins; RNA-Binding Proteins; RNA, Messenger; S-Adenosylmethionine; SS-B Antigen; TOR Serine-Threonine Kinases

2022
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:5

    Topics: Adenosine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Proliferation; Cellular Senescence; Chromatin; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Epigenomics; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53

2017
Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.
    Gastroenterology, 2018, Volume: 155, Issue:2

    Topics: Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholangiocarcinoma; Cholestasis; Cholic Acids; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; MafG Transcription Factor; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Small Interfering; S-Adenosylmethionine; Up-Regulation; Xenograft Model Antitumor Assays

2018
Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds.
    The FEBS journal, 2019, Volume: 286, Issue:11

    Topics: Amino Acid Metabolism, Inborn Errors; Apoptosis; Carcinoma, Hepatocellular; Catalytic Domain; Cell Proliferation; DNA Methylation; DNA Replication; Gene Expression Regulation, Enzymologic; Glycine N-Methyltransferase; Humans; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Multiprotein Complexes; Mutation; Protein Interaction Domains and Motifs; Quinolones; S-Adenosylmethionine

2019
The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine.
    Cell death & disease, 2019, 03-11, Volume: 10, Issue:3

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caveolin 1; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Deoxyadenosines; Dioxygenases; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Prognosis; Promoter Regions, Genetic; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous

2019
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.
    Journal of molecular medicine (Berlin, Germany), 2013, Volume: 91, Issue:8

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Methylation; Epigenetic Repression; Glycine N-Methyltransferase; Histones; Humans; Liver Neoplasms; RNA, Messenger; S-Adenosylmethionine

2013
Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
    Experimental cell research, 2013, Jul-15, Volume: 319, Issue:12

    Topics: Aged; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Middle Aged; Ornithine Decarboxylase; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Putrescine; RNA, Small Interfering; S-Adenosylmethionine; Transcription Factor AP-1; Transcription, Genetic

2013
Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome.
    Biochimica et biophysica acta, 2013, Volume: 1834, Issue:8

    Topics: Apolipoprotein A-I; Apoptosis; Betaine-Homocysteine S-Methyltransferase; Blotting, Western; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; Electrophoresis, Gel, Two-Dimensional; Fibrinogen; Hepatocytes; Homocysteine; Humans; Hyperhomocysteinemia; Liver Neoplasms; Male; Metabolomics; Middle Aged; Protein Multimerization; Proteome; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2013
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
    International journal of cancer, 2014, Feb-15, Volume: 134, Issue:4

    Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil

2014
5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:11

    Topics: Apoptosis; Azacitidine; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Proto-Oncogene Proteins c-bcl-2; S-Adenosylmethionine; Up-Regulation

2013
Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection.
    World journal of surgical oncology, 2014, Feb-02, Volume: 12

    Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Hepatectomy; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Reperfusion Injury; S-Adenosylmethionine

2014
In vitro characterization of uptake mechanism of L-[methyl-(3)H]-methionine in hepatocellular carcinoma.
    Molecular imaging and biology, 2014, Volume: 16, Issue:4

    Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Cell Cycle; Cell Line, Tumor; Cell Survival; Liver Neoplasms; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; Radionuclide Imaging; S-Adenosylmethionine; Transfection

2014
S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer.
    Molecular pharmacology, 2015, Volume: 87, Issue:1

    Topics: Animals; beta Catenin; Cell Line, Tumor; Colonic Neoplasms; Deoxyadenosines; Gene Expression Regulation, Neoplastic; HCT116 Cells; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Neoplasms, Experimental; S-Adenosylmethionine; Signal Transduction; Thionucleosides

2015
Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
    Oncotarget, 2015, Nov-10, Volume: 6, Issue:35

    Topics: Amino Acid Sequence; Base Sequence; Blotting, Western; Carcinoma, Hepatocellular; Chromatin Immunoprecipitation; Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Immunoprecipitation; Liver Neoplasms; Methionine Adenosyltransferase; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Sumoylation; Transcriptional Activation; Tumor Cells, Cultured; Ubiquitin-Conjugating Enzymes

2015
GADD45β induction by S-adenosylmethionine inhibits hepatocellular carcinoma cell proliferation during acute ischemia-hypoxia.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: Antigens, Differentiation; Apoptosis; Autophagy; Autophagy-Related Protein 7; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Down-Regulation; Hep G2 Cells; Hepatocytes; Humans; Hypoxia; Ischemia; Liver Neoplasms; RNA Interference; RNA, Small Interfering; S-Adenosylmethionine; Tumor Suppressor Protein p53

2016
Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma.
    World journal of gastroenterology, 2008, Aug-07, Volume: 14, Issue:29

    Topics: Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Gene Expression Regulation, Neoplastic; Humans; Lentivirus; Liver Neoplasms; Methionine Adenosyltransferase; RNA Interference; S-Adenosylmethionine; Transfection

2008
S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.
    Gastroenterology, 2009, Volume: 136, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Expression Regulation, Neoplastic; Genomic Instability; Hepatocytes; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylmethionine; Transfection

2009
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
    The Journal of biological chemistry, 2009, Nov-13, Volume: 284, Issue:46

    Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response

2009
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
    Gastroenterology, 2010, Volume: 138, Issue:5

    Topics: 3' Untranslated Regions; Animals; Antigens, Surface; Binding Sites; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; ELAV Proteins; ELAV-Like Protein 1; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Glycine N-Methyltransferase; Half-Life; Hepatocytes; Heterogeneous Nuclear Ribonucleoprotein D0; Heterogeneous-Nuclear Ribonucleoprotein D; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; RNA Interference; RNA Processing, Post-Transcriptional; RNA Stability; RNA-Binding Proteins; RNA, Messenger; S-Adenosylmethionine; Signal Transduction; Transfection

2010
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation.
    The Journal of nutrition, 2011, Volume: 141, Issue:5

    Topics: Carcinoma, Hepatocellular; Cysteine; Cytidine; DNA Methylation; DNA Modification Methylases; Gene Expression; Glycine N-Methyltransferase; Hep G2 Cells; Hepatocytes; Homeostasis; Homocysteine; Humans; Kinetics; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Methylation; Osmolar Concentration; S-Adenosylhomocysteine; S-Adenosylmethionine

2011
Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:6

    Topics: Binding Sites; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Transformed; Chromatin Immunoprecipitation; CpG Islands; DNA; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histone Deacetylase 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Methionine Adenosyltransferase; Mutagenesis, Site-Directed; p300-CBP Transcription Factors; Promoter Regions, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Microenvironment; Up-Regulation

2011
Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics.
    Biochemical pharmacology, 2011, Dec-01, Volume: 82, Issue:11

    Topics: Anticarcinogenic Agents; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Chromatography, Liquid; Dehydroepiandrosterone; Glucosephosphate Dehydrogenase; Humans; Liver Neoplasms; Metabolome; Methionine Adenosyltransferase; Mitochondria; Oxidative Stress; Phosphatidylcholines; Phosphorylcholine; S-Adenosylmethionine

2011
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.
    Journal of proteomics, 2012, Jun-06, Volume: 75, Issue:10

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; DEAD-box RNA Helicases; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Microarray Analysis; Models, Biological; Proteome; Proteomics; S-Adenosylmethionine; Transfection

2012
Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:1

    Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Disease Models, Animal; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression Regulation, Enzymologic; Humans; Liver; Liver Neoplasms; Methionine Adenosyltransferase; Multivariate Analysis; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Rats; Rats, Inbred BN; Rats, Inbred F344; RNA, Messenger; S-Adenosylmethionine; Statistics, Nonparametric; Transcriptional Activation; Tumor Cells, Cultured

2012
S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:3

    Topics: Animals; Cell Line, Tumor; Humans; Liver Neoplasms; Mice; S-Adenosylmethionine; Sumoylation; Ubiquitin-Conjugating Enzymes

2012
Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.
    Experimental and molecular pathology, 2012, Volume: 92, Issue:3

    Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Nucleus; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Hepatitis, Alcoholic; Hepatocytes; Histones; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Lysine; Mallory Bodies; Methylation; Mice; Microscopy, Electron; Polycomb Repressive Complex 2; Proliferating Cell Nuclear Antigen; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine; Transcription Factors

2012
The different induction mechanisms of growth arrest DNA damage inducible gene 45 β in human hepatoma cell lines.
    Chemotherapy, 2012, Volume: 58, Issue:2

    Topics: Antigens, Differentiation; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Survival; E2F1 Transcription Factor; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Phenylurea Compounds; Pyridines; S-Adenosylmethionine; Sorafenib; Tumor Suppressor Protein p53

2012
L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.
    The Journal of biological chemistry, 2003, May-30, Volume: 278, Issue:22

    Topics: Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; RNA, Messenger; S-Adenosylmethionine; Tumor Cells, Cultured

2003
Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver.
    Carcinogenesis, 2003, Volume: 24, Issue:12

    Topics: Animals; Blotting, Western; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-Histone; CpG Islands; DNA; DNA Methylation; DNA-Binding Proteins; DNA, Complementary; Liver; Liver Neoplasms; Male; Metallothionein; Methyl-CpG-Binding Protein 2; Rats; Rats, Inbred F344; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Time Factors

2003
S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
    Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:1

    Topics: Acetylation; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Histones; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Protein Isoforms; Protein Phosphatase 1; Proto-Oncogene Proteins c-bcl-2; S-Adenosylmethionine; Sarcoplasmic Reticulum; Thionucleosides; Tubercidin

2004
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.
    Carcinogenesis, 2005, Volume: 26, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Transformation, Neoplastic; Cyclin D1; Fenretinide; I-kappa B Proteins; Liposomes; Liver; Liver Neoplasms; Male; Methionine Adenosyltransferase; NF-KappaB Inhibitor alpha; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344; S-Adenosylmethionine; Vascular Endothelial Growth Factor A

2005
Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.
    Journal of proteome research, 2006, Volume: 5, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Liver Diseases; Liver Neoplasms; Mass Spectrometry; Mice; Mice, Knockout; Middle Aged; Peptide Mapping; Protein Array Analysis; Proteome; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tumor Burden; Up-Regulation

2006
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Apr-25, Volume: 103, Issue:17

    Topics: Allosteric Regulation; Animals; Carcinoma, Hepatocellular; Cell Line; Cystathionine beta-Synthase; Enzyme Stability; Fatty Liver; Gene Silencing; Humans; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Mice; Mice, Knockout; Oxidation-Reduction; Recombinant Proteins; S-Adenosylmethionine

2006
Prevention of aneuploidy by S-adenosyl-methionine in human cells treated with sodium arsenite.
    Mutation research, 2007, Apr-01, Volume: 617, Issue:1-2

    Topics: Aneuploidy; Arsenites; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cells, Cultured; Centromere; Chromosome Aberrations; DNA Damage; DNA Probes; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Histones; Humans; In Situ Hybridization, Fluorescence; Infant; Liver Neoplasms; Micronuclei, Chromosome-Defective; Micronucleus Tests; Protein Serine-Threonine Kinases; S-Adenosylmethionine; Skin; Sodium Compounds; Tumor Suppressor Proteins

2007
Adenosine metabolism and its effect on methylation potential in cultured cells: methodological considerations.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, Jan-21, Volume: 52 Suppl

    Topics: Adenine Nucleotides; Adenosine; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Chelating Agents; Culture Media; Edetic Acid; Humans; Inosine; Kinetics; Liver Neoplasms; Methylation; S-Adenosylmethionine; Time Factors; Trypsin

2007
The induction of growth arrest DNA damage-inducible gene 45 beta in human hepatoma cell lines by S-adenosylmethionine.
    The American journal of pathology, 2007, Volume: 171, Issue:1

    Topics: Antigens, Differentiation; Binding Sites; Carcinoma, Hepatocellular; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; I-kappa B Kinase; Liver Neoplasms; NF-kappa B; Polymerase Chain Reaction; Promoter Regions, Genetic; S-Adenosylmethionine; Transfection; Tumor Cells, Cultured

2007
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.
    Hepatology (Baltimore, Md.), 2007, Volume: 46, Issue:5

    Topics: Animals; Apolipoproteins B; Betaine; Betaine-Homocysteine S-Methyltransferase; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Fatty Liver; Gene Transfer Techniques; Hepatocytes; Homocysteine; Humans; Lipid Metabolism; Liver Neoplasms; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Sterol Regulatory Element Binding Protein 1

2007
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Glycine N-Methyltransferase; Histones; Janus Kinases; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Mice; Mice, Knockout; Promoter Regions, Genetic; ras Proteins; S-Adenosylmethionine; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins; Transaminases; Tumor Suppressor Proteins

2008
The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.
    Free radical research, 2008, Volume: 42, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers, Tumor; Gene Expression Regulation; Lipid Peroxidation; Liver Neoplasms; Male; NF-kappa B; Oxidative Stress; Quercetin; Rats; Rats, Inbred F344; S-Adenosylmethionine; Signal Transduction

2008
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
    The Biochemical journal, 1984, Mar-15, Volume: 218, Issue:3

    Topics: Animals; Cell Nucleus; Choline Deficiency; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine

1984
Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes.
    Biochemical pharmacology, 1994, Mar-02, Volume: 47, Issue:5

    Topics: Adenosine Triphosphate; Amino Acids, Sulfur; Animals; Cell Count; Cysteine; Cystine; Glutathione; Hepatoblastoma; Humans; Liver; Liver Neoplasms; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Tumor Cells, Cultured

1994
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats.
    Carcinogenesis, 1996, Volume: 17, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Gene Expression; Genes, myc; Genes, ras; Liver; Liver Neoplasms; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; RNA, Messenger; S-Adenosylmethionine; Thioamides; Time Factors

1996
Suppression by phenobarbital of ethionine-induced hepatocellular carcinoma formation and hepatic S-adenosylethionine levels.
    Carcinogenesis, 1997, Volume: 18, Issue:5

    Topics: Adenosine; Animals; Body Weight; Ethionine; Liver; Liver Neoplasms; Male; Methylation; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; S-Adenosylmethionine

1997
Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Central Nervous System Depressants; Dietary Fats; DNA Methylation; Ethanol; Gene Expression Regulation, Enzymologic; Homeostasis; Liver; Liver Cirrhosis, Alcoholic; Liver Neoplasms; Male; Methionine Adenosyltransferase; Ornithine Decarboxylase; Proto-Oncogene Proteins c-myc; Rats; Rats, Wistar; RNA, Messenger; S-Adenosylmethionine

2000
Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:2

    Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Hepatocytes; Humans; Hydroxamic Acids; Isoenzymes; Liver Neoplasms; Methionine Adenosyltransferase; Methylation; Promoter Regions, Genetic; Rats; RNA, Messenger; S-Adenosylmethionine

2001
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.
    Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:2

    Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cells, Cultured; Cytochrome c Group; Deoxyadenosines; Enzyme Activation; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Okadaic Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; S-Adenosylmethionine; Species Specificity; Thionucleosides

2002
Role of ribosomal RNA methylases in the regulation of ribosome production in mammalian cells.
    Biochemistry, 1976, Jul-13, Volume: 15, Issue:14

    Topics: Adenosine Triphosphate; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Neoplasms; Neoplasms, Experimental; Oligoribonucleotides; Orotic Acid; Rats; Ribonucleotides; Ribosomes; S-Adenosylmethionine; Thioacetamide; tRNA Methyltransferases

1976
S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line.
    Nucleic acids research, 1975, Volume: 2, Issue:10

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; DNA (Cytosine-5-)-Methyltransferases; Kinetics; Liver Neoplasms; Methyltransferases; Neoplasms, Experimental; Rats; S-Adenosylmethionine; Structure-Activity Relationship

1975
Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells.
    Cancer research, 1977, Volume: 37, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Female; Homocysteine; Hydrolases; Liver; Liver Neoplasms; Methyltransferases; Neoplasms, Experimental; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine

1977
The influence of DL-methionine on the metabolism of S-adenosylethionine in rats chronically treated with DL-ethionine.
    Cancer research, 1976, Volume: 36, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Animals; Body Weight; Circadian Rhythm; Ethionine; Feeding Behavior; Female; Liver; Liver Neoplasms; Methionine; Neoplasms, Experimental; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine

1976
Inhibitors of tRNA methyltransferases. S-Adenosylsulfonium salts.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:10

    Topics: Animals; In Vitro Techniques; Kinetics; Liver; Liver Neoplasms; Male; Onium Compounds; Rats; S-Adenosylmethionine; Structure-Activity Relationship; Sulfonium Compounds; tRNA Methyltransferases

1976
The effect of ethionine on ribonucleic acid synthesis in rat liver.
    The Biochemical journal, 1975, Volume: 150, Issue:3

    Topics: Adenosine Triphosphate; Animals; Cycloheximide; Ethionine; Female; HeLa Cells; Inosine; Liver; Liver Neoplasms; Methionine; Methylation; Mitoguazone; Rats; RNA; RNA, Ribosomal; RNA, Transfer; S-Adenosylmethionine

1975
Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study.
    Cancer research, 1992, Sep-15, Volume: 52, Issue:18

    Topics: Animals; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mitotic Index; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Time Factors

1992
Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:1

    Topics: Animals; Body Weight; Choline; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; Male; Methionine; Methylation; Mice; Mice, Inbred C3H; Organ Size; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors

1986
Protein methylases in hepatomas.
    Cancer research, 1972, Volume: 32, Issue:1

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; DNA, Neoplasm; Histones; Liver Neoplasms; Methylation; Methyltransferases; Neoplasm Proteins; Neoplasms, Experimental; Rats; S-Adenosylmethionine

1972
Transfer ribonucleic acid methylases of nucleoli isolated from a rat tumor.
    Biochemistry, 1972, Feb-15, Volume: 11, Issue:4

    Topics: Ammonium Chloride; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Nucleolus; Chromatography, Ion Exchange; Chromatography, Paper; Cytoplasm; Escherichia coli; Kinetics; Liver Neoplasms; Magnesium; Methionine; Methyltransferases; Neoplasms, Experimental; Osmolar Concentration; Polynucleotides; Rats; RNA, Transfer; S-Adenosylmethionine; Structure-Activity Relationship; Subcellular Fractions; Tritium

1972
Competing methyltransferase systems.
    The Journal of biological chemistry, 1972, Jul-10, Volume: 247, Issue:13

    Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Glycine; Homocysteine; Kidney; Liver; Liver Neoplasms; Methylation; Methyltransferases; Mice; Molecular Weight; Pancreas; Rabbits; Rats; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine

1972
Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma.
    Biochimica et biophysica acta, 1973, Mar-28, Volume: 299, Issue:3

    Topics: Amino Acids; Ammonium Sulfate; Animals; Brain; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Chromatography, Gel; Escherichia coli; Female; Kidney; Liver; Liver Neoplasms; Methylation; Methyltransferases; Muscles; Mycoplasma; Neoplasms, Experimental; Rats; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Saccharomyces cerevisiae; Spleen

1973
Effect of ethionine on the synthesis and transfer of active methyl groups.
    Physiological chemistry and physics, 1972, Volume: 4, Issue:6

    Topics: Animals; Bacillus subtilis; Carcinoma, Hepatocellular; Cricetinae; Escherichia coli; Ethionine; Female; Liver; Liver Neoplasms; Male; Methylation; Mice; Quaternary Ammonium Compounds; Rats; RNA, Transfer; S-Adenosylmethionine; tRNA Methyltransferases

1972
Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo.
    The Biochemical journal, 1971, Volume: 124, Issue:4

    Topics: Alkylation; Amino Acids; Animals; Carbon Isotopes; Carcinogens; Chromatography, Ion Exchange; Chromatography, Paper; Female; Formaldehyde; Histones; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Methionine; Methylation; Necrosis; Nitrosamines; Rats; S-Adenosylmethionine; Sulfonic Acids; Tritium

1971