s-adenosylmethionine has been researched along with CBS Deficiency in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 12 (42.86) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Caggana, M; Cohen-Pfeffer, JL; Diaz, GA; Kirmse, BM; McGuire, PJ; Morrissey, MA; Salveson, BR; Sunny, S; Wasserstein, MP; Weisfeld-Adams, JD; Yu, C | 1 |
| Alberti, C; Benoist, JF; de Baulny, HO; Feillet, F; Garcia-Segarra, N; Guilmin-Crépon, S; Haignere, J; Imbard, A; Kaguelidou, F; Kuster, A; Magréault, S; Perronneau, I; Schiff, M; Schlemmer, D; Toumazi, A | 1 |
| Kožich, V; Stabler, S | 1 |
| Bottiglieri, T; Caudill, MA; Cosín-Tomás, M; Leclerc, D; Luan, Y; Malysheva, OV; Rozen, R; Wasek, B | 1 |
| Huse, K; Olecka, M; Platzer, M | 1 |
| Bahous, RH; Bedell, BJ; Caudill, MA; Cosín-Tomás, M; Deng, L; Ho, MK; Kaliman, P; Leclerc, D; Malysheva, O; Pallàs, M; Rozen, R | 1 |
| Blom, HJ; Colaço, HG; Janssen, MC; Kluijtmans, LA; Leandro, P; Mendes, MI; Pop, A; Ramos, RJ; Rivera, I; Salomons, GS; Smith, DE; Tavares de Almeida, I; van Dooren, SJ | 1 |
| Dayal, S; French, SW; Geng, Y; Halsted, CH; Hodzic, E; Kharbanda, KK; LaSalle, JM; Medici, V; Peerson, J; Schroeder, DI; Shibata, NM; Tillman, B; Tsukamoto, H; Woods, R | 1 |
| Blom, HJ; Colaço, HG; de Almeida, IT; Leandro, P; Lino, PR; Mendes, MI; Rivera, I; Salomons, GS; Santos, AS; Smith, DE; Vicente, JB | 1 |
| Kraus, JP; Majtan, T; Pey, AL | 1 |
| Andrews, AJ; Gupta, S; Kruger, WD; Kuo, YM; Lee, HO; Li, YS; Slifker, MJ; Wang, L | 1 |
| Blom, HJ; Boulanger, Y; Debray, FG; Decarie, JC; Jakobs, C; Khiat, A; Lambert, M; Levy, E; Lortie, A; Mitchell, GA; Orquin, J; Ramos, F; Roy, MS; Struys, E; Verhoeven, NM | 1 |
| Hnízda, A; Kluijtmans, LA; Kopecká, J; Kožich, V; Krijt, J; Mayne, P; Moat, S | 1 |
| Banerjee, R; Xie, P; Yadav, PK | 1 |
| Kraus, JP; Majtan, T; Pey, AL; Sanchez-Ruiz, JM | 1 |
| Caudill, M; Jiang, X; Mikael, LG; Pancer, J; Rozen, R; Wu, Q | 1 |
| Favier, A; Galan, P; Guilland, JC; Hercberg, S; Potier de Courcy, G | 1 |
| Allen, RH; Bodamer, O; Kozich, V; Kraus, JP; Kvasnicka, J; Orendác, M; Stabler, SP; Stöckler-Ipsiroglu, S; Zeman, J | 1 |
| Blom, HJ; Boers, GH; Heil, SG; Riksen, NP; Smulders, Y | 1 |
| Banerjee, R; Sen, S | 1 |
| Benevenga, NJ | 2 |
| Blom, HJ; Boers, GH; Kluijtmans, LA; Kraus, JP; Renier, WO; Stevens, EM; Trijbels, FJ; van den Heuvel, LP | 1 |
| Banerjee, R; Kabil, O | 1 |
| Finkelstein, JD | 1 |
| Christopher, SA; James, SJ; Kruger, WD; Melnyk, S | 1 |
| Cotton, RC; Danks, DM; Goldsmith, D; Patrick, MG | 1 |
| Abou-Saleh, MT; Coppen, A | 1 |
5 review(s) available for s-adenosylmethionine and CBS Deficiency
| Article | Year |
|---|---|
Lessons Learned from Inherited Metabolic Disorders of Sulfur-Containing Amino Acids Metabolism.
Topics: Amino Acids, Sulfur; Animals; Brain Diseases; Cysteine; Glutathione; Homocysteine; Homocystinuria; Humans; Hydrogen Sulfide; Liver; Metabolic Diseases; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Sulfites; Sulfur; Sulfur Compounds | 2020 |
[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data].
Topics: Animals; Arteriosclerosis; Biomarkers; Cystathionine beta-Synthase; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Nitric Oxide; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Rats; Risk Factors; S-Adenosylmethionine; Signal Transduction; Thrombophilia; Vascular Diseases; Vasodilation; Vitamin B 6 Deficiency | 2003 |
Evidence for alternative pathways of methionine catabolism.
Topics: Animals; Betaine; Carbon Dioxide; Choline; Decarboxylation; Diet; Homocystinuria; Humans; Liver; Methionine; Models, Biological; Oxidation-Reduction; Propionates; S-Adenosylmethionine; Sarcosine; Transaminases | 1984 |
Homocysteine: a history in progress.
Topics: History, 19th Century; History, 20th Century; Homocysteine; Homocystinuria; Humans; Insulin; Methionine; Neural Tube Defects; North America; Research; S-Adenosylmethionine; Workforce | 2000 |
The biology of folate in depression: implications for nutritional hypotheses of the psychoses.
Topics: Anorexia Nervosa; Biogenic Amines; Brain; Depressive Disorder; Diet; Folic Acid; Folic Acid Deficiency; Homocystinuria; Humans; Models, Theoretical; Pellagra; Pterins; S-Adenosylmethionine; Schizophrenia; Tryptophan; Vitamin B 12 Deficiency | 1986 |
1 trial(s) available for s-adenosylmethionine and CBS Deficiency
| Article | Year |
|---|---|
Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial.
Topics: Betaine; Child; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; Methionine; Prospective Studies; S-Adenosylmethionine; Vitamin B 12 Deficiency | 2022 |
22 other study(ies) available for s-adenosylmethionine and CBS Deficiency
| Article | Year |
|---|---|
Newborn screening and early biochemical follow-up in combined methylmalonic aciduria and homocystinuria, cblC type, and utility of methionine as a secondary screening analyte.
Topics: Algorithms; Carnitine; Demography; False Positive Reactions; Female; Follow-Up Studies; Genetic Association Studies; Homocystinuria; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Methionine; Methylmalonic Acid; Neonatal Screening; New York; Propionates; Referral and Consultation; Vitamin B 12 | 2010 |
Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.
Topics: Animals; Dietary Supplements; DNA Methylation; Female; Folic Acid; Gene Expression; Homocystinuria; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Muscle Spasticity; Phthalic Acids; Placenta; Pregnancy; Psychotic Disorders; S-Adenosylmethionine; Sex Factors; Transcriptome | 2021 |
The high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) may explain naked mole-rat's distinct methionine metabolite profile compared to mouse.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Enzyme Activation; Homocysteine; Homocystinuria; Methionine; Mice; Mole Rats; S-Adenosylhomocysteine; S-Adenosylmethionine | 2018 |
Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Topics: Aging; Amyloid beta-Peptides; Animals; Anxiety; Brain; Cell Survival; Cerebral Cortex; Choline; CpG Islands; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Glutamic Acid; Homocystinuria; Liver; Male; Memory Disorders; Memory, Short-Term; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice, Inbred BALB C; Muscle Spasticity; Nerve Growth Factors; Neurons; Phospholipids; Psychotic Disorders; RNA, Messenger; S-Adenosylmethionine; Synaptic Transmission | 2019 |
Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.
Topics: Alleles; Cells, Cultured; Cystathionine beta-Synthase; Escherichia coli; Fibroblasts; Genotype; Homocystinuria; Humans; Mutation; Recombinant Proteins; Retrospective Studies; S-Adenosylmethionine | 2014 |
Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.
Topics: Animals; Betaine; Dietary Supplements; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Ethanol; Fatty Liver, Alcoholic; Gene Expression Regulation; Homocystinuria; Liver; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; PPAR alpha; S-Adenosylhomocysteine; S-Adenosylmethionine | 2014 |
Insights into the regulatory domain of cystathionine Beta-synthase: characterization of six variant proteins.
Topics: Allosteric Site; Amino Acid Sequence; Catalytic Domain; Cystathionine beta-Synthase; Homocystinuria; Humans; Kinetics; Mutation; Protein Structure, Tertiary; Recombinant Proteins; S-Adenosylmethionine | 2014 |
Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria.
Topics: Cystathionine beta-Synthase; Enzyme Stability; Homocystinuria; Humans; Kinetics; S-Adenosylmethionine | 2016 |
Lack of global epigenetic methylation defects in CBS deficient mice.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Epigenomics; Homocysteine; Homocystinuria; Kidney; Liver; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 2017 |
Reduced brain choline in homocystinuria due to remethylation defects.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Choline Deficiency; Creatine; Female; Homocysteine S-Methyltransferase; Homocystinuria; Humans; Magnetic Resonance Spectroscopy; Male; Methylation; S-Adenosylmethionine | 2008 |
Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency.
Topics: Blood Chemical Analysis; Calibration; Case-Control Studies; Chromatography, Liquid; Cystathionine beta-Synthase; Enzyme Stability; Homocystinuria; Humans; Immunoenzyme Techniques; Plasma; Pyridoxal Phosphate; S-Adenosylmethionine; Tandem Mass Spectrometry | 2011 |
Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.
Topics: Allosteric Regulation; Binding Sites; Cystathionine beta-Synthase; Heme; Homocystinuria; Humans; Hydrogen Peroxide; Iron; Isomerism; Kinetics; Mutation; Oxidation-Reduction; Protein Carbonylation; Pyridoxal Phosphate; S-Adenosylmethionine; Spectrometry, Fluorescence; Threonine | 2012 |
Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM.
Topics: Binding Sites; Cystathionine beta-Synthase; Enzyme Activation; Homocystinuria; Humans; Protein Binding; Protein Stability; S-Adenosylmethionine | 2013 |
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Topics: Animals; Apolipoprotein A-I; Betaine; Choline; Diet; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuria; Interferon-gamma; Liver; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Transgenic; Muscle Spasticity; Placenta; Pregnancy; Pregnancy Complications; Psychotic Disorders; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 2013 |
Homocystinuria due to cystathionine beta-synthase deficiency: novel biochemical findings and treatment efficacy.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Homocystinuria; Humans; Male; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients.
Topics: Chromatography, Liquid; Cystathionine beta-Synthase; DNA; DNA Methylation; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA; Spectrometry, Mass, Electrospray Ionization | 2007 |
A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer.
Topics: Allosteric Regulation; Amino Acid Sequence; Catalytic Domain; Cystathionine beta-Synthase; Dimerization; Homocystinuria; Humans; Models, Molecular; Protein Conformation; Protein Structure, Quaternary; S-Adenosylmethionine | 2007 |
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects.
Topics: Betaine; Dietary Supplements; Folic Acid; Homocysteine; Homocystinuria; Humans; Methionine; Methylation; Neural Tube Defects; Nutritional Physiological Phenomena; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B Complex | 2007 |
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.
Topics: Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Cystathionine beta-Synthase; DNA; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Heterozygote; Homocystinuria; Homozygote; Humans; Male; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Pyridoxine; Reference Values; S-Adenosylmethionine | 1996 |
Deletion of the regulatory domain in the pyridoxal phosphate-dependent heme protein cystathionine beta-synthase alleviates the defect observed in a catalytic site mutant.
Topics: Catalytic Domain; Cystathionine beta-Synthase; Hemeproteins; Homocysteine; Homocystinuria; Humans; Models, Molecular; Protein Structure, Tertiary; Pyridoxal Phosphate; S-Adenosylmethionine; Sequence Deletion; Suppression, Genetic | 1999 |
S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase.
Topics: Chromatography, High Pressure Liquid; Culture Media; Cystathionine beta-Synthase; Homocysteine; Homocystinuria; Humans; S-Adenosylhomocysteine; S-Adenosylmethionine; Yeasts | 2002 |
A screening test for sulphur-containing metabolites in urine using auxotrophic mutants of Escherichia coli K12.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Biological Assay; Cystathionine; Cystinuria; Escherichia coli; Homocystinuria; Humans; Infant, Newborn; Methods; Mutation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur | 1975 |