Compounds > s-adenosylmethionine
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s-adenosylmethionine and Acute Liver Injury, Drug-Induced

s-adenosylmethionine has been researched along with Acute Liver Injury, Drug-Induced in 57 studies

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-19906 (10.53)18.7374
1990's6 (10.53)18.2507
2000's16 (28.07)29.6817
2010's26 (45.61)24.3611
2020's3 (5.26)2.80

Authors

AuthorsStudies
Fang, JH; Gonzalez, FJ; Huang, JF; Li, F; Liu, XM; Xiao, XR; Yang, XN; Yang, XW; Zhu, X1
Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD1
Beger, RD; Bhattacharyya, S; Gill, P; James, LP; Kearns, GL; Letzig, LG; Marshall, JD; Pence, L; Reed, MD; Simpson, PM; Sullivan, JE; Van Den Anker, JN; Yan, K1
Chen, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Shah, YM1
Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T1
Evengard, B; Kanakura, Y; Kawata, S; Kitani, T; Kuratsune, H; Långström, B; Lindh, G; Machii, T; Matsumura, K; Takahashi, M; Takaishi, J; Watanabe, Y; Yamaguti, K1
Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H1
Cho, E; Jung, S; Kim, J; Ko, KS1
Arthur, I; Jones, BR; Langner, K; Merritt, A; Reese, S; Rossi, G; Stephens, N; Yang, W1
Antonelli-Incalzi, R; Galvano, A; Russo, A; Santini, D; Terenzio, A; Tonini, G; Vespasiani-Gentilucci, U; Vincenzi, B; Vorini, F1
Sukhanov, DS2
Dou, LP; Jing, Y; Tian, YM; Yao, S; Yao, ZL; Yu, L; Zhang, QF1
Al-muzafar, HM; Amin, KA; Hashem, KS; Taha, EM1
Okovityĭ, SV; Sukhanov, DS; Vasil'eva, SN; Vinogradova, TI; Vitovskaia, ML; Zabolotnykh, NV1
Batishcheva, GA; Buzlama, AV; Chernov, IuN; Muzalevskaia, EN; Nikolaevskiĭ, VA; Somova, MN1
Iablonskiĭ, PK; Pavlova, MV; Sukhanov, DS; Vinogradova, TI1
Bazhanova, ED; Sukhanov, DS; Teplyĭ, DL1
French, SW; Kharbanda, KK; Orlicky, DJ; Osna, NA; Thomes, PG; Todero, SL; Tuma, DJ1
Ball, JG; Brown, JM; Kuhlman, C; Labenski, MT; Lamyaithong, AB; Lau, SS; Terneus, MV; Valentovic, MA1
Hovda, LR; Schmid, RD1
Dvornichenko, VV; Morikov, DD; Morikova, EG1
Beger, RD; Chen, M; Dragan, Y; Holland, RD; Schnackenberg, LK; Sun, J; Tong, W; Welsh, W1
Beger, RD; Schnackenberg, LK; Sun, J1
Brown, CS; Heath, TD; Krugner-Higby, L; Mather, JR; Scholcoff, C; Wagner, EJ1
Ball, JG; Brown, JM; Hogsett, A; Valentovic, M; Williams, T1
Khaletskaia, OV; Rozhdenkin, EA; Sadovnikova, IV; Shilenok, IG; Voevodkina, IF1
Chen, DW; Dong, Y; Gan, Y; Jia, WZ; Tang, HM; Wang, LM; Xu, ZQ; Zhang, HF; Zhu, SS1
Berti, P; Daniele, S; Frezza, AM; Picardi, A; Tonini, G; Vespasiani, U; Vincenzi, B1
Berti, P; Frezza, AM; Picardi, A; Santini, D; Tonini, G; Vespasiani, U; Vincenzi, B1
Aritsuka, T; Fukushima, M; Han, KH; Ishii, H; Kawakami, S; Nakamura, Y; Ohba, K; Okada, T; Sekikawa, M; Shimada, K; Uchino, H1
Kovalenko, AL; Romantsov, MG; Sukhanov, DS; Vasil'eva, SN; Vinogradova, TI; Zabolotnykh, NV1
Ball, JG; Michael Brown, J; Valentovic, MA; Van Meter, S; Wright, MS1
Sivolap, IuP1
Fettman, MJ; Mason, G; Twedt, DC; Webb, CB1
Chen, T; McClain, CJ; Song, Z1
Kim, SK; Kim, YC1
Antelava, NA; Gogolauri, MI1
Cederbaum, AI; Wang, X2
Caro, AA; Cederbaum, AI; Dey, A1
Antelava, NA; Gogoluari, LI; Gogoluari, MI; Okudzhava, MV; Pirtskhalaĭshvili, NN1
Shank, RC1
Aylagas, H; Miró-Obradors, MJ; Osada, J; Palacios-Alaiz, E1
Alvarez, L; Mato, JM; Ortiz, P; Pajares, MA1
Polunina, TE1
Bushma, MI; Legon'kova, LF; Vasil'ev, AV; Zverinskiĭ, IV1
Il'chenko, LIu; Vinnitskaia, EV1
Avila, MA; Chen, L; Corrales, FJ; García-Trevijano, ER; Huang, ZZ; Kanel, G; Lu, SC; Martínez-Chantar, ML; Martínez-Cruz, LA; Mato, JM1
Galli-Kienle, M; Pezzoli, C; Stramentinoli, G1
Chiba, T; Horiuchi, M; Koike, F1
Gualano, M; Ideo, G; Stramentinoli, G1
Catto, E; Pezzoli, C; Stramentinoli, G1
Budillon, G; Cantoni, L; Cuomo, R; Di Padova, C; Le Grazie, C; Rizzardini, M; Rodinò, S1
Kodama, K; Oguchi, K; Tsuji, M1
Durigato, S1

Reviews

6 review(s) available for s-adenosylmethionine and Acute Liver Injury, Drug-Induced

ArticleYear
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
    Drug safety, 2022, Volume: 45, Issue:11

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid

2022
The use of SAMe in chemotherapy-induced liver injury.
    Critical reviews in oncology/hematology, 2018, Volume: 130

    Topics: Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Neoplasms; S-Adenosylmethionine

2018
[Drug-induced liver damage and the problem of its pharmacological correction].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:9

    Topics: Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Liver; Plant Preparations; Prescription Drugs; Protective Agents; S-Adenosylmethionine; Ursodeoxycholic Acid; Xenobiotics

2013
Toxicity-induced aberrant methylation of DNA and its repair.
    Pharmacological reviews, 1984, Volume: 36, Issue:2 Suppl

    Topics: Alkylation; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; DNA; DNA Repair; Formaldehyde; Guanine; Hydrazines; Methylation; Methylhydrazines; S-Adenosylmethionine

1984
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.
    Pharmacology & therapeutics, 1997, Volume: 73, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Gene Expression Regulation, Enzymologic; Humans; Liver; Liver Diseases; Methionine; Methionine Adenosyltransferase; Methylation; S-Adenosylmethionine; Species Specificity

1997
[Metabolism pathways and use of heptral in chronic liver diseases].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2002, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Clinical Trials as Topic; Hepatitis, Viral, Human; Humans; Liver; Liver Diseases; S-Adenosylmethionine

2002

Trials

5 trial(s) available for s-adenosylmethionine and Acute Liver Injury, Drug-Induced

ArticleYear
[Protective effect of ademetionine 1, 4-butanedisulfonate on liver injury caused by chemotherapeutic agents].
    Zhongguo shi yan xue ye xue za zhi, 2013, Volume: 21, Issue:5

    Topics: Adult; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Female; Glycyrrhizic Acid; Humans; Leukemia; Male; Middle Aged; S-Adenosylmethionine; Young Adult

2013
[Comparative efficacy of clinical use of reamberin, remaxol and ademethionine in patients with tuberculosis of the respiratory organs and liver drug-injury].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2013, Volume: 58, Issue:1-2

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Meglumine; Middle Aged; S-Adenosylmethionine; Succinates; Tuberculosis, Pulmonary

2013
[Efficacy and safety of ademetionine for treatment of drug-induced liver disease in children].
    Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2010, Volume: 24, Issue:2

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Male; S-Adenosylmethionine; Treatment Outcome

2010
S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury.
    Journal of feline medicine and surgery, 2003, Volume: 5, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Erythrocytes; Glutathione; Glutathione Disulfide; Liver; S-Adenosylmethionine; Thiobarbituric Acid Reactive Substances; Time Factors

2003
[S-adenosylmethionine in the therapy of liver insufficiency during a course of pulmonary tuberculosis].
    Minerva medica, 1972, Dec-19, Volume: 63, Issue:91

    Topics: Adult; Aged; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; S-Adenosylmethionine; Tuberculosis, Pulmonary

1972

Other Studies

46 other study(ies) available for s-adenosylmethionine and Acute Liver Injury, Drug-Induced

ArticleYear
PPARα Mediates the Hepatoprotective Effects of Nutmeg.
    Journal of proteome research, 2018, 05-04, Volume: 17, Issue:5

    Topics: Animals; Carnitine; Chemical and Drug Induced Liver Injury; Lipids; Metabolomics; Mice; Mice, Knockout; Myristica; Oxidative Stress; PPAR alpha; Protective Agents; Thioacetamide

2018
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria

2014
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
    Biomarkers in medicine, 2014, Volume: 8, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Sex Factors

2014
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
    Chemical research in toxicology, 2009, Volume: 22, Issue:4

    Topics: Acetaminophen; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytochrome P-450 CYP2E1; Fatty Acids; Glutathione; Liver Diseases; Mass Spectrometry; Metabolomics; Mice; Mice, Knockout; PPAR alpha; Time Factors

2009
Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS.
    Epilepsia, 2007, Volume: 48, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Humans; Infant; Longitudinal Studies; Male; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Valproic Acid

2007
Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.
    International journal of molecular medicine, 1998, Volume: 2, Issue:1

    Topics: Acute Disease; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Fatigue Syndrome, Chronic; Female; Galactosamine; Hepatitis C, Chronic; Humans; Japan; Male; Mice; Mice, Inbred C3H; Neoplasms; Sweden

1998
The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Hepatoprotection by S-Adenosylmethionine in AML12 Cells.
    Journal of microbiology and biotechnology, 2022, Dec-28, Volume: 32, Issue:11

    Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Prohibitins; S-Adenosylmethionine

2022
First case of a dog infected with
    New Zealand veterinary journal, 2020, Volume: 68, Issue:4

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Itraconazole; S-Adenosylmethionine; Western Australia

2020
[Antioxidant properties of remaxol, reamberin, and ademetionine in patients with drug-induced liver injury on the background of antituberculous therapy].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:4

    Topics: Adolescent; Adult; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Female; Glutathione Peroxidase; Glutathione Transferase; Humans; Male; Meglumine; Middle Aged; S-Adenosylmethionine; Succinates; Superoxide Dismutase; Tuberculosis

2013
Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E.
    Journal of complementary & integrative medicine, 2014, Jan-10, Volume: 11, Issue:1

    Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Monocrotaline; Oxidants; Oxidative Stress; Oxidoreductases; Rats; S-Adenosylmethionine; Thioctic Acid; Vitamin E

2014
[Pharmacological activity of runihol and S-adenosyl-L-methionine in rats with experimental liver damage by reserve antituberculosis drugs].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:9

    Topics: Aminosalicylic Acid; Animals; Animals, Outbred Strains; Antitubercular Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Cholesterol; Cycloserine; Hepatocytes; Inosine; Liver; Male; Methionine; Protective Agents; Prothionamide; Rats; S-Adenosylmethionine; Succinic Acid; Taurine; Triglycerides

2013
[Mechanism of hepatocyte apoptosis in experimental toxic liver injury].
    Morfologiia (Saint Petersburg, Russia), 2013, Volume: 144, Issue:6

    Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Chemical and Drug Induced Liver Injury; fas Receptor; Gene Expression Regulation; Hepatocytes; Isoniazid; Protective Agents; Pyrazinamide; Rats; S-Adenosylmethionine; Signal Transduction; Tumor Suppressor Protein p53

2013
Increased methylation demand exacerbates ethanol-induced liver injury.
    Experimental and molecular pathology, 2014, Volume: 97, Issue:1

    Topics: Alcohol Drinking; Amidinotransferases; Animals; Chemical and Drug Induced Liver Injury; Diet; Ethanol; Fatty Liver, Alcoholic; Glycine; Guanidinoacetate N-Methyltransferase; Homocysteine; Liver; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides

2014
S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
    Toxicology and applied pharmacology, 2014, Dec-01, Volume: 281, Issue:2

    Topics: Acetaminophen; Aldehydes; Animals; Antioxidants; Carbamoyl-Phosphate Synthase (Ammonia); Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cytoprotection; Disease Models, Animal; Liver; Male; Mice, Inbred BALB C; Mitochondria, Liver; Oxidative Stress; Protein Carbonylation; Protein Processing, Post-Translational; S-Adenosylmethionine; Sarcosine Dehydrogenase; Tandem Mass Spectrometry

2014
Acute Hepatic Failure in a Dog after Xylitol Ingestion.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2

    Topics: Acetylcysteine; Animals; Animals, Inbred Strains; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Disseminated Intravascular Coagulation; Dogs; Hypoglycemia; Liver Failure, Acute; Male; S-Adenosylmethionine; Sweetening Agents; Treatment Outcome; Xylitol

2016
[Pharmacoeconomic Analysis of the Use of Hepatoprotectors in Management of Drug-Associated Liver Injury Due to Hodgkin's Lymphoma Chemotherapy].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2015, Volume: 60, Issue:7-8

    Topics: Antineoplastic Agents; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Disease Management; Hodgkin Disease; Humans; Liver; Phosphatidylcholines; Protective Agents; Retrospective Studies; S-Adenosylmethionine; Succinates; Treatment Outcome

2015
Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies.
    Toxicology and applied pharmacology, 2009, Feb-15, Volume: 235, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Comet Assay; Creatine; Drug-Related Side Effects and Adverse Reactions; Gene Expression Profiling; Glutathione; Liver; Male; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Taurine

2009
Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics.
    Drug metabolism letters, 2009, Volume: 3, Issue:3

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Creatine; Dose-Response Relationship, Drug; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Metabolomics; Principal Component Analysis; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sulfates

2009
Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Liposomes; Liver; Male; Mice; Mice, Inbred C57BL; Phosphatidylglycerols; S-Adenosylmethionine

2010
Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity.
    Toxicology and applied pharmacology, 2010, Aug-15, Volume: 247, Issue:1

    Topics: Acetaminophen; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Drug Interactions; Intracellular Space; Liver; Male; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Organ Size; Protective Agents; S-Adenosylmethionine

2010
[Acute toxic hepatitis at mushroom poisoning of the young child].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2010, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Gastroenteritis; Humans; Infant; Male; Mushroom Poisoning; Prednisolone; S-Adenosylmethionine

2010
The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Fluorouracil; Humans; Liver Function Tests; Oxaloacetates; Retrospective Studies; S-Adenosylmethionine

2012
The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; gamma-Glutamyltransferase; Humans; Leucovorin; Liver; Male; Middle Aged; Organoplatinum Compounds; Retrospective Studies; S-Adenosylmethionine

2011
Amelioration of D-galactosamine-induced acute liver injury in rats by dietary supplementation with betaine derived from sugar beet molasses.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:7

    Topics: Adenosylhomocysteinase; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Beta vulgaris; Betaine; Chemical and Drug Induced Liver Injury; Dietary Supplements; Galactosamine; Glutathione; Glutathione Peroxidase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Molasses; Rats; S-Adenosylmethionine

2011
[Comparative study of hepatoprotective action of remaxol, reamberin and ademethionine in liver injury induced by antituberculosis drugs (experimental study)].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2011, Volume: 56, Issue:1-2

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Liver; Liver Regeneration; Male; Meglumine; Rats; S-Adenosylmethionine; Succinates; Time Factors

2011
Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.
    Toxicology letters, 2012, Aug-03, Volume: 212, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Antagonism; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Oxidoreductases; Protein Carbonylation; S-Adenosylmethionine

2012
[Hepatoprotectors in addictive medicine].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:5 Pt 2

    Topics: Chemical and Drug Induced Liver Injury; Ethanol; Humans; Liver; Protective Agents; Psychotropic Drugs; S-Adenosylmethionine; Substance-Related Disorders; Vitamin B 12; Vitamin B Complex

2012
[Effectiveness of the hepatoprotective activity of reamberine, remaxol, and ademethionine and risk assessment in their use in patients with respiratory tuberculosis and drug-induced liver injury].
    Terapevticheskii arkhiv, 2012, Volume: 84, Issue:11

    Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Drug Costs; Humans; Meglumine; Numbers Needed To Treat; Protective Agents; Risk Assessment; S-Adenosylmethionine; Severity of Illness Index; Succinates; Treatment Outcome; Tuberculosis, Pulmonary

2012
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice.
    Pharmacology, 2004, Volume: 71, Issue:4

    Topics: Acetaminophen; Analgesics; Animals; Cell Membrane Permeability; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; S-Adenosylmethionine

2004
Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice.
    Journal of hepatology, 2005, Volume: 42, Issue:6

    Topics: Amino Acids, Sulfur; Animals; Betaine; Chemical and Drug Induced Liver Injury; Chloroform; Cysteine; Glutathione; Kidney; Lipotropic Agents; Liver; Male; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred ICR; S-Adenosylmethionine; Solvents; Taurine

2005
[Effect of heptral and folic acid on the hepatic functions during toxic hepatitis].
    Georgian medical news, 2005, Issue:123

    Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Folic Acid; Male; Rats; S-Adenosylmethionine; Vasodilator Agents

2005
S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Apoptosis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Enzyme Induction; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Pyrazoles; S-Adenosylmethionine; Transaminases; Tumor Necrosis Factor-alpha

2006
[The impact of heptral, vitamin B6 and folic acid on the indices of hepatic biotransformation in toxic hepatitis].
    Georgian medical news, 2006, Issue:132

    Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Folic Acid; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6

2006
S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA Fragmentation; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria, Liver; Nitric Oxide Synthase Type II; Oxidative Stress; Pyrazoles; S-Adenosylmethionine

2007
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4].
    Georgian medical news, 2007, Issue:150

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Cytochromes b5; Disease Models, Animal; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Hepatocytes; Homocysteine; Male; Rats; S-Adenosylmethionine; Treatment Outcome; Vitamin B 6; Vitamin B Complex

2007
S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice.
    Archives of biochemistry and biophysics, 2008, Sep-01, Volume: 477, Issue:1

    Topics: Animals; Antibodies; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Ethanol; fas Receptor; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondrial Swelling; Nitric Oxide Synthase Type II; Oxidative Stress; S-Adenosylmethionine; Tumor Necrosis Factor-alpha

2008
Alterations in lipid characteristics of lysosomes are involved in liver necrosis induced by thioacetamide.
    Biological chemistry Hoppe-Seyler, 1993, Volume: 374, Issue:2

    Topics: Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholesterol; Lipid Metabolism; Lysosomes; Male; Membranes; Necrosis; Rats; Rats, Wistar; S-Adenosylmethionine; Thioacetamide

1993
[Drug-induced hepatitis].
    Terapevticheskii arkhiv, 1999, Volume: 71, Issue:12

    Topics: Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Bilirubin; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; gamma-Glutamyltransferase; Humans; Laparoscopy; Leukemia, Myeloid, Acute; Liver; Male; Middle Aged; S-Adenosylmethionine; Tomography, X-Ray Computed; Transaminases; Ultrasonography

1999
[Disturbed functioning of enzyme systems of microsomal oxidation, glucuro-, and glutathione conjugation of xenobiotics in the liver of rats intoxicated by deoxycholate and their correction].
    Biulleten' eksperimental'noi biologii i meditsiny, 2000, Volume: 129, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Deoxycholic Acid; Glucuronides; Glutathione; Microsomes, Liver; Nikethamide; Rats; S-Adenosylmethionine; Ursodeoxycholic Acid; Vitamin E; Xenobiotics

2000
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:10

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Diabetes Mellitus; Disease Susceptibility; Gene Expression Profiling; Hepatitis, Animal; Ion Channels; Liver; Liver Diseases; Liver Neoplasms, Experimental; Membrane Transport Proteins; Methionine Adenosyltransferase; Mice; Mice, Knockout; Mitochondrial Proteins; Models, Biological; Obesity; Oxidative Stress; Protein Biosynthesis; Proteins; RNA, Messenger; S-Adenosylmethionine; Uncoupling Protein 2

2002
Protective role of S-adenosyl-l-methionine against acetaminophen induced mortality and hepatotoxicity in mice.
    Biochemical pharmacology, 1979, Dec-15, Volume: 28, Issue:24

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzymes; Glutathione; Liver; Mice; Protein Binding; S-Adenosylmethionine

1979
[Effect of thiol compounds on experimental liver damage (IV). Detoxicating effect of tiopronin, glutathione and cysteine on ethionine induced lived damage (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1979, Volume: 75, Issue:7

    Topics: Alanine Transaminase; Amino Acids, Sulfur; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Cysteine; Ethionine; Female; Glutathione; In Vitro Techniques; Liver; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Tiopronin

1979
Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats.
    Biochemical pharmacology, 1978, May-15, Volume: 27, Issue:10

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Male; Methionine Adenosyltransferase; Prednisolone; Rats; S-Adenosylmethionine

1978
[Pharmacological aspects of S-adenosyl-L-methionone in hepatology. (A) Biochemical signs. (B) Acute, chronic and fetal toxicity. (C) Biochemical and morphohistochemical changes in control rats and rats treated with S-adenosyl-L-methionine after experiment
    Minerva medica, 1975, May-02, Volume: 66, Issue:33

    Topics: Adrenal Glands; Animals; Brain; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Fetus; Kidney; Lipoproteins; Liver; Male; Mice; Phospholipids; Pregnancy; Pregnancy, Animal; Proteins; Rabbits; Rats; S-Adenosylmethionine; Spleen

1975
Protective effect of S-adenosyl-L-methionine in hepatic uroporphyria. Evaluation in an experimental model.
    Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:10

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Hexachlorobenzene; Liver Diseases; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Skin Diseases; Uroporphyrinogen Decarboxylase

1990
Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cells, Cultured; Chemical and Drug Induced Liver Injury; Leucine; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylmethionine

1990