s-adenosylhomocysteine and Metabolic-Syndrome

Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B

Topics: Adult; Animals; Biomarkers; Cross-Sectional Studies; Denmark; Diet Records; Diet, Healthy; Fatty Acids, Unsaturated; Female; Fishes; Humans; Hyperhomocysteinemia; Male; Metabolic Syndrome; Middle Aged; Nutrition Surveys; Patient Compliance; Principal Component Analysis; Risk; S-Adenosylhomocysteine; Seafood; Whole Grains; Young Adult