s-adenosylhomocysteine has been researched along with Lymphoma--Non-Hodgkin* in 1 studies
1 other study(ies) available for s-adenosylhomocysteine and Lymphoma--Non-Hodgkin
| Article | Year |
|---|---|
[Effect of methylglyoxal bis(guanylhydrazone) in combination with antifolic acid preparations on the biochemical indices and growth of Pliss lymphosarcoma in rats].
It was shown in experiments with Pliss' lymphosarcoma in rats that antifolates--cis-2,5-bis (aminohydroxymethyl)-piperazine-3,6-dione and methotrexate--cause tumor cell spermidine level to drop. Also, treatment with antifolates prevented the undesirable accumulation of S-adenosylmethionine in tumor cells induced by methyl-glyoxal-bis (guanylhydrazone) which inhibits polyamine biosynthesis. In chemotherapeutic experiments with rat lymphosarcoma, antifolates markedly potentiated the antitumor effect of methylglyoxal-bis (guanylhydrazone). The data suggest that the combination of polyamine biosynthesis inhibitors such as methylglyoxal-bis (guanylhydrazone) and alpha-difluoromethylornithine and antifolates may be useful in tumor chemotherapy. Topics: Adenosylmethionine Decarboxylase; Animals; Cycloserine; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Lymphoma, Non-Hodgkin; Male; Methotrexate; Mitoguazone; Neoplasm Transplantation; Polyamines; Rats; S-Adenosylhomocysteine; Time Factors | 1986 |