s-777469 and Disease-Models--Animal

s-777469 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for s-777469 and Disease-Models--Animal

Article	Year
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported. The structure-activity relationship around this template lead to the identification of S-777469 as a selective CB2 receptor agonist, which exhibited the significant inhibition of scratching induced by Compound 48/80 at 1.0 mg/kg po and 10 mg/kg po (55% and 61%, respectively). Topics: Administration, Oral; Animals; Antipruritics; CHO Cells; Cricetinae; Disease Models, Animal; Inhibitory Concentration 50; Ligands; Mice; Mice, Inbred ICR; Molecular Structure; Protein Binding; Pyridones; Receptor, Cannabinoid, CB2	2012

Article

Year

Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.

Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported. The structure-activity relationship around this template lead to the identification of S-777469 as a selective CB2 receptor agonist, which exhibited the significant inhibition of scratching induced by Compound 48/80 at 1.0 mg/kg po and 10 mg/kg po (55% and 61%, respectively).

Topics: Administration, Oral; Animals; Antipruritics; CHO Cells; Cricetinae; Disease Models, Animal; Inhibitory Concentration 50; Ligands; Mice; Mice, Inbred ICR; Molecular Structure; Protein Binding; Pyridones; Receptor, Cannabinoid, CB2

2012