s-1108 and Hyperammonemia

Pivoxil-containing cephalosporins can result in symptomatic hypocarnitinemia in children. We herein report a case of an 85-year-old man at risk of carnitine deficiency who developed relapsing symptomatic hypoglycemia after treatment with cefcapene pivoxil for urinary tract infection. On admission, laboratory tests showed low blood carnitine concentrations with low normal blood ketone levels. The patient was successfully treated by the oral administration of levocarnitine and dietary modification, including aggressive consumption of meat and dairy products, and remained symptom-free for nine months after the correction of carnitine concentrations. Healthcare providers should be cautious when prescribing pivoxil-containing antimicrobials to patients at high risk of hypocarnitinemia.

Topics: Administration, Oral; Aged, 80 and over; Blood Glucose; Cardiomyopathies; Carnitine; Cephalosporins; Humans; Hyperammonemia; Hypoglycemia; Male; Muscular Diseases; Recurrence; Urinary Tract Infections