s-1-(combination) and Sepsis

We report a case of a 32-year-old woman with a septic pulmonary embolism-related implanted central venous port. She was treated with S-1/cisplatin(CDDP)chemotherapy for recurrent gastric cancer. Her disease was progressive after five courses of S-1/CDDP combination therapy. Because of peritonitis carcinomatosa, her oral intake was poor, so we placed an implanted central venous port in her right subclavian vein. We administered 5-FU/Leucovorin/paclitaxel combination therapy and total parenteral nutrition from the port. Chemotherapy was effective, so we stopped total parenteral nutrition after one month. Two months later, multiple nodular shadows appeared in her left lung fields without apparent symptoms. Because we suspected septic pulmonary embolism related to the venous port, we removed the venous port promptly and administered antibiotics with a broad spectrum. Pulmonary shadows disappeared immediately, and no recurrence was observed afterward.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Catheterization, Central Venous; Catheters, Indwelling; Cisplatin; Drug Combinations; Female; Humans; Neoplasm Recurrence, Local; Oxonic Acid; Pulmonary Embolism; Sepsis; Stomach Neoplasms; Tegafur