s-1-(combination) and Paget-Disease--Extramammary

Topics: Aged; Antineoplastic Agents; Biosimilar Pharmaceuticals; Delayed Diagnosis; Docetaxel; Drug Combinations; Drug Therapy, Combination; Humans; Male; Oxonic Acid; Paget Disease, Extramammary; Prognosis; Skin Neoplasms; Tegafur; Trastuzumab

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Combinations; Female; Humans; Male; Middle Aged; Oxonic Acid; Paget Disease, Extramammary; Progression-Free Survival; Retrospective Studies; Salvage Therapy; Skin Neoplasms; Survival Rate; Tegafur

Topics: Adenocarcinoma of Lung; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Docetaxel; Drug Combinations; Humans; Lung Neoplasms; Male; Oxonic Acid; Paget Disease, Extramammary; Pneumonectomy; Positron-Emission Tomography; Skin Neoplasms; Tegafur; Treatment Outcome

S-1, a 5-fluorouracil (5-FU)-based anti-cancer agent, is an important drug for treating metastatic extramammary Paget's disease (EMPD). Although intratumor expression levels of 5-FU metabolism enzymes have been studied widely in many solid tumors, no studies have examined on the expression levels of thymidylate synthase (TS), orotate phosphoribosyl-transferase (OPRT) or dihydropyrimidine dehydrogenase (DPD) in skin cancers. The aim of this study was to estimate the intratumoral mRNA expression levels of these genes in EMPD by real time PCR. Intratumoral DPD mRNA levels were decreased in EMPD compared to those in normal skin, but its intratumoral DPD mRNA expression levels were not correlated with clinical manifestations. Intratumoral DPD mRNA levels were positively correlated with OPRT mRNA levels in EMPD. Based on these results, low expression of intratumoral DPD mRNA in EMPD may contribute to the pathogenesis of this disease.

Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Female; Humans; Male; Middle Aged; Orotate Phosphoribosyltransferase; Oxonic Acid; Paget Disease, Extramammary; RNA, Messenger; Skin Neoplasms; Tegafur; Thymidylate Synthase

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Combinations; Fatal Outcome; Humans; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Oxonic Acid; Paget Disease, Extramammary; Prognosis; Spinal Neoplasms; Tegafur

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Docetaxel; Drug Combinations; Humans; Lymphatic Metastasis; Male; Oxonic Acid; Paget Disease, Extramammary; Taxoids; Tegafur

Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Combinations; Genital Neoplasms, Male; Humans; Male; Oxonic Acid; Paget Disease, Extramammary; Tegafur

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Docetaxel; Drug Combinations; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Oxonic Acid; Paget Disease, Extramammary; Skin Neoplasms; Taxoids; Tegafur; Tomography, X-Ray Computed; Urinary Bladder Neoplasms