s-1-(combination) and Mandibular-Neoplasms

We report a 53-year-old female patient with an unresectable metastasis to the supraclavicular lymph node from a primary gingival carcinoma of the mandible. The patient had a history of tongue carcinoma and had undergone a radical neck dissection for the treatment of gingival carcinoma. She underwent combined chemotherapy consisting of S-1 (80 mg on days 1-14, followed by a 7-day rest), docetaxel (35mg/m2 by intravenous infusion on days 1 and 8), and CDDP (10mg/m2 by intravenous infusion on days 1 and 8) every 3 weeks. After three courses of the above chemotherapy regimen, a computerized tomography examination revealed a complete response. The patient did not experience any severe side effects during the course of chemotherapy. Combined S-1, docetaxel, and CDDP chemotherapy can thus be effective for unresectable recurrences of oral cancer in lymph nodes.

Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clavicle; Docetaxel; Drug Combinations; Female; Gingival Neoplasms; Humans; Lymphatic Metastasis; Mandibular Neoplasms; Middle Aged; Oxonic Acid; Remission Induction; Taxoids; Tegafur; Tomography, X-Ray Computed