s-1-(combination) and Hand-Dermatoses

s-1-(combination) has been researched along with Hand-Dermatoses* in 1 studies

Other Studies

1 other study(ies) available for s-1-(combination) and Hand-Dermatoses

Article	Year
[A patient with recurrent gastric cancer who developed TS-1 induced hand-foot syndrome]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5 Hand-foot syndrome (HFS) is a rare adverse reaction to oral fluoropyrimidine TS-1, which contains the dihydropyrimidine dehydrogenase (DPD) inhibitor. We treated a recurrent gastric cancer patient with chronic renal failure who developed grade 2 HFS, grade 2 conjunctivitis and grade 3 stomatitis soon after TS-1 administration. Those symptoms improved with the administration of vitamin B6, topical emollient therapy, and so on. We thought that the continuous elevation of serum 5-FU concentration, due to the accumulation of DPD inhibitor from the renal dysfunction, led to the development of HFS, although the participation of 5-FU metabolites such as F-beta-alanine cannot be ruled out. Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Conjunctivitis; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Male; Neoplasm Recurrence, Local; Oxonic Acid; Prodrugs; Pyridines; Stomach Neoplasms; Stomatitis; Syndrome; Tegafur; Vitamin B 6	2003

Article

Year

[A patient with recurrent gastric cancer who developed TS-1 induced hand-foot syndrome].

Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:5

Hand-foot syndrome (HFS) is a rare adverse reaction to oral fluoropyrimidine TS-1, which contains the dihydropyrimidine dehydrogenase (DPD) inhibitor. We treated a recurrent gastric cancer patient with chronic renal failure who developed grade 2 HFS, grade 2 conjunctivitis and grade 3 stomatitis soon after TS-1 administration. Those symptoms improved with the administration of vitamin B6, topical emollient therapy, and so on. We thought that the continuous elevation of serum 5-FU concentration, due to the accumulation of DPD inhibitor from the renal dysfunction, led to the development of HFS, although the participation of 5-FU metabolites such as F-beta-alanine cannot be ruled out.

Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Conjunctivitis; Drug Combinations; Foot Dermatoses; Hand Dermatoses; Humans; Male; Neoplasm Recurrence, Local; Oxonic Acid; Prodrugs; Pyridines; Stomach Neoplasms; Stomatitis; Syndrome; Tegafur; Vitamin B 6

2003