s-1-(combination) and Eyelid-Neoplasms

Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Cheek; Drug Combinations; Erythema; Eyelid Neoplasms; Facial Neoplasms; Humans; Lymphadenopathy; Male; Neck; Oxaliplatin; Oxonic Acid; Purpura; Skin Neoplasms; Tegafur

Topics: Administration, Oral; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Drug Combinations; Eyelid Neoplasms; Female; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Neoplasm Invasiveness; Oxonic Acid; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Tegafur

We report a 68-year-old female with a history of repeated right cervical lymph node metastasis secondary to eyelid sebaceous carcinoma. She had undergone right neck dissection due to lymph node metastasis at the department of surgery in an other local hospital. After the orbital exenteration, she underwent multiple operations, including 2 right partial parotidectomy and then total parotidectomy, 4 right cervical lymph node excisions and 1 left upper neck dissection due to lymph node metastasis. Adjuvant chemotherapy with S-1(at a dose of 80 mg per day)alone was applied as tumor dormancy therapy on an outpatient basis. Any adverse events during S-1 medication were observed. New metastatic lesions were not found until 29 months after the beginning of chemotherapy with S-1 alone. Although the effectiveness of S-1 for eyelid sebaceous carcinoma has not been demonstrated, S-1 might be useful in patients with recurrent eyelid sebaceous carcinoma based on our patient's recurrence-free survival.

Topics: Aged; Drug Combinations; Eyelid Neoplasms; Female; Humans; Lymphatic Metastasis; Oxonic Acid; Positron-Emission Tomography; Sebaceous Gland Neoplasms; Tegafur; Tomography, X-Ray Computed