ryanodine and Cell-Transformation--Neoplastic

Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels displays the regenerative process of calcium-induced calcium release responsible for the complex spatiotemporal patterns of calcium waves and oscillations. Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling.

Topics: Animals; Calcium; Calcium Channels; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Female; Fertilization; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Models, Biological; Neuronal Plasticity; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Cytoplasmic and Nuclear; Ryanodine; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems; Signal Transduction; Synapses