rutin and Thrombophlebitis

Superficial vein thrombosis (SVT) is a common complication of varicose veins. Treatment may be surgical by removal of the superficial clots under local anesthetic or medical in association with elastic compression and mobilization. In this study 83 patients with SVT were randomised in treatments groups: A--superficial thrombectomy and elastic compression (EC); B--Ca Heparin (0.5 mgs b.i.b.) + EC; C--Venoruton (1 g, t.i.d.) + EC; D--Venoruton (1 g, t.i.d.) after superficial thrombectomy + EC; E--elastic compression. All treatments were applied for 8 weeks. The evolution of SVT was studied by a system, based on thermography, which analyse by a computerized system the variation of the hyperthermic areas (HA) on thermograms. This was associated with subjective and objective clinical evaluation. Results indicate a decrease of HA in all groups but patients treated with superficial thrombectomy show a significantly (p, 0.05) greater and faster reduction of HA. The reduction of HA produced by Venoruton was also significantly greater (p less than 0.05) than that observed in patients treated by Ca Heparin or elastic compression and it determined also a faster and greater (p less than 0.05) decrease of HA after thrombectomy. These results were confirmed by clinical observations. In conclusion results from this study indicate a positive effect of Venoruton in SVT in determining a faster decrease of hyperthermic areas probably by decreasing local inflammation.

Topics: Adult; Anticoagulants; Bandages; Combined Modality Therapy; Endarterectomy; Female; Heparin; Humans; Hydroxyethylrutoside; Image Processing, Computer-Assisted; Male; Middle Aged; Randomized Controlled Trials as Topic; Rutin; Thermography; Thrombophlebitis

Two highly sensitive models of arterial and venous thrombosis forming with the test of endothelial stability a complementary system with a maximum stress on the role of vascular lesion were used to test a series of four antithrombotic drugs (heparin, acetylsalicylic acid, dipyridamole, sulfinpyrazone) and four drugs with other indications but with an antithrombotic activity in experiment (prenylamine, troxerutin, ketanserin and pizotifen). All drugs, except heparin, were given orally. Whereas heparin, aspirin and prenylamine had mixed effects on both arterial thrombosis (i.e. mostly on platelet functions) as well as on endothelial stability, ketanserin and pizotifen had a predominant effect on the former while dipyridamole, troxerutin and sulfinpyrazone influenced mostly the latter function.

Topics: Animals; Anticoagulants; Arteries; Aspirin; Dipyridamole; Female; Hydroxyethylrutoside; Ketanserin; Piperidines; Pizotyline; Prenylamine; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thrombophlebitis; Thrombosis

Pain in the legs is a common diagnostic problem. Diagnosis is made on an anatomical basis and by a process of exclusion. Deep vein thrombosis is still an exceedingly difficult condition to diagnose; however, investigation by ultrasound with the Doppler Flow Meter often provides a definite answer. There is a large group of patients, nearly always female and in their twenties and thirties, in whom chronic leg pain without demonstrable underlying cause poses a problem. These cases respond very favourably to Paroven 250 mg three or four times daily, as well as light support pantyhose.

Topics: Adolescent; Adult; Age Factors; Aged; Child; Doppler Effect; Female; Humans; Hydroxyethylrutoside; Joint Diseases; Male; Medical History Taking; Pain; Pain Management; Physical Examination; Physicians, Family; Sex Factors; Thrombophlebitis; Wounds and Injuries

O-(beta-hydroxyethyl)-rutoside (HR) (Venoruton, Zyma AS, Nyon, Switzerland) has been investigated experimentally to evaluate the effect on microvascular permeability and thromboembolism. Permeability to macromolecules is diminished in a hamster cheek-pouch model. Haemostatic plug formation is impaired whereas laser-induced intravascular platelet aggregation is uninfluenced. There is a small but insignificant protection against sodium morrhuate (Eli Lilly and Co., Indianapolis, Indiana) induced femoral vein thrombosis.

Topics: Animals; Capillary Permeability; Cricetinae; Hemostasis; Hydroxyethylrutoside; Macromolecular Substances; Male; Microcirculation; Rutin; Sodium Morrhuate; Thrombophlebitis

Topics: Adult; Edema; Female; Humans; Hydroxyethylrutoside; Leg; Male; Middle Aged; Rutin; Thrombophlebitis; Varicose Veins

Topics: Humans; Hydroxyethylrutoside; Rutin; Thrombophlebitis; Varicose Veins; Vascular Diseases; Veins