rutin and Fibrosarcoma

Low-grade fibromyxoid sarcoma (LGFMS) is a pathological type of fibrosing fibrosarcoma that appears as a distinctive soft tissue masse with bland histological features. It is mostly located in the deep soft tissues of the extremities. Computed tomography (CT) plays an important role in diagnosing fibrosing fibrosarcoma in the abdomen. To date, several studies in the literature have reported on CT features of LGFMS.. We report another case of LGFMS, which presented with certain unique CT feature. The anterolateral region and the wall of the cystic nodules showed gradual enhancement and several nourishing vessels were seen after contrast administration. These imaging features were consistent with the histologic findings of LGFMS.. The patient underwent tumorectomy and implantation of radioactive implants. Two years after the operation, 1 metastasis mass occur in the right psoas major.. These CT features in LGFMS may be useful to assess the histological characteristics of LGFMS to facilitate preoperative diagnosis in the clinical setting and provide the supplemental imaging knowledge for future studies.

Topics: Brachytherapy; Combined Modality Therapy; Fibrosarcoma; Humans; Hydroxyethylrutoside; Male; Middle Aged; Retroperitoneal Neoplasms; Retroperitoneal Space; Tomography, X-Ray Computed

The flavanoid derivative troxerutin, used clinically for treating venous disorders, protected biomembranes and cellular DNA against the deleterious effects of gamma-radiation. The peroxidation of lipids (measured as thiobarbituric acid-reacting substances, or TBARS) in rat liver microsomal and mitochondrial membranes resulting from gamma-irradiation up to doses of 500 Gy in vitro was prevented by 0.2 mM troxerutin. The administration of troxerutin (175 mg/kg body weight) to tumor-bearing mice by ip one hour prior to 4 Gy whole-body gamma-irradiation significantly decreased the radiation-induced peroxidation of lipids in tissues such as liver and spleen, but there was no reduction of lipid peroxidation in tumor. The effect of troxerutin in gamma-radiation-induced DNA strand breaks in different tissues of tumor-bearing mice was studied by comet assay. The administration of troxerutin to tumor-bearing animals protected cellular DNA against radiation-induced strand breaks. This was evidenced from decreases in comet tail length, tail moment, and percent of DNA in the tails in cells of normal tissues such as blood leukocytes and bone marrow, and these parameters were not altered in cells of fibrosarcoma tumor. The results revealed that troxerutin could preferentially protect normal tissues against radiation-induced damages in tumor-bearing animals.

Topics: Animals; Cell Membrane; DNA; DNA Damage; Dose-Response Relationship, Radiation; Fibrosarcoma; Gamma Rays; Hydroxyethylrutoside; Injections, Intraperitoneal; Liver; Male; Mice; Microsomes, Liver; Mitochondria; Organ Specificity; Radiation Injuries; Radiation Protection; Radiation-Protective Agents; Rats; Spleen