rutin and Coronary-Disease

Topics: Amino Acids; Anticoagulants; Choline; Coronary Disease; Folic Acid; Homocysteine; Humans; Hydroxyethylrutoside; Pyridoxine; Riboflavin; Vitamin B 12

Topics: Aspirin; Blood Platelets; Blood Proteins; Carboxyhemoglobin; Coronary Disease; Dipyridamole; Endothelium, Vascular; Female; Humans; Hydroxyethylrutoside; Male; Nicotine; Platelet Aggregation; Smoking; Tobacco Smoke Pollution

Elevated plasma homocysteine and lipid levels are risk factors for atherosclerosis. The plasma levels of homocysteine, determined in acid hydrolyzates of plasma, were found to be correlated with total cholesterol (r = 0.47, P less than 0.001), triglycerides (r = 0.40, P less than 0.01), and body mass index (r = 0.42, P less than 0.01) in 52 males, aged 30-60. A group of 12 male survivors of acute myocardial infarction was given pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin for 21 days. The plasma concentrations of homocysteine and alpha-amino adipic acid declined to 68% (P less than 0.001) and 57% (P less than 0.001) of the pretreatment values, and the cholesterol, triglycerides, and LDL apo B declined to 79% (P less than 0.001), 68% (P less than 0.01), and 63% (P less than 0.001) of the pretreatment values, respectively. The results suggest a new strategy for control of the metabolic abnormalities in atherosclerosis through the use of naturally occurring, non-toxic nutrients which minimize homocysteine accumulation.

Topics: Adult; Anticoagulants; Choline; Coronary Artery Disease; Coronary Disease; Drug Therapy, Combination; Folic Acid; Homocysteine; Humans; Hydroxyethylrutoside; Lipids; Male; Middle Aged; Pyridoxine; Riboflavin; Vitamin B 12

During ischemic perfusion and reperfusion of isolated rat hearts, OH and carbon-centered radicals were trapped in the perfusate. Both radicals were found to occur during LPO which was enhanced in the myocardium. The increase of LPO as well as of enzyme leakage were reduced by mannitol and the flavonoid troxerutin showing antioxidative action of greater than 500 and greater than 5 microM, respectively. The assumption is supported that radical-induced LPO is of pathogenetic relevance during myocardial reperfusion injury for which antioxidants could be of therapeutic advantage.

Topics: Animals; Antioxidants; Coronary Disease; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxyethylrutoside; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxides; Male; Mannitol; Myocardium; Rats; Rats, Inbred Strains

The endothelo-protective activity of a series of low-molecular oxygen-derived free radical scavengers (OFRS) was tested in rats. A model of endothelaemia provoked by intravenous administration of hydrogen peroxide was used. With each OFRS the activity in the hydrogen peroxide model was compared with that in the less specific model using the provocation by citrate as a calcium chelating agent. Relatively unspecific but biologically important OFRS, ascorbic acid, tocopherol, troxerutin and glutathione were tested in the first phase of the study. A marked optimum of endothelo-protective activity was shown with all agents, the optimum against hydrogen peroxide having been observed at doses from 3 to 50 times lower than against citrate. Ascorbic acid, troxerutin and the combination of both were also tested in another model based on leg ischaemia produced by ligature of the common femoral artery. Without OFRS, a marked increase of endothelaemia was observed after 30-60 min ischaemia showing a second peak after the release of the ligature. This second peak was completely abolished by the preventive administration of OFRS in a dose which was also effective in the hydrogen peroxide model.

Topics: alpha-Tocopherol; Animals; Anticoagulants; Ascorbic Acid; Aspirin; Coronary Disease; Endothelium; Female; Femoral Artery; Free Radicals; Heparin; Hydrogen Peroxide; Hydroxyethylrutoside; Kinetics; Lactates; Lactic Acid; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Rutin; Tocopherols; Vitamin E