rutin has been researched along with Arthritis* in 1 studies
1 other study(ies) available for rutin and Arthritis
| Article | Year |
|---|---|
Bioflavonoid-mediated stabilization of collagen in adjuvant-induced arthritis.
In rats with adjuvant-induced arthritis, the effect of (+)-catechin (CA) and 0-(beta-hydroxyethyl) rutosides (HR) on the crosslinking of collagen was studied. Compared with controls the arthritic group showed an increase in the reversibility of neutral salt-soluble collagen gel, solubility of acid-insoluble collagen to denaturing agents and the ratio of alpha/beta subunits of neutral salt-soluble collagen. These results suggest an impaired maturation of collagen in arthritic animals. Administration of CA or HR to the arthritic animals caused a decrease in the reversibility of collagen gel and in the solubility of acid-insoluble collagen to denaturing agents and to pronase. In addition, the electrophoretic patterns of neutral salt-soluble collagen on SDS polyacrylamide gels also showed a decrease in the alpha/beta ratio. All these results may collectively indicate that both flavonoids promote the crosslinking of collagen in arthritic animals. Topics: Animals; Arthritis; Arthritis, Experimental; Catechin; Collagen; Flavonoids; Hydroxyethylrutoside; In Vitro Techniques; Male; Rats; Skin | 1983 |