rutin and Arthritis--Rheumatoid

The high-mobility group box (HMGB) family includes four members: HMGB1, 2, 3 and 4. HMGB proteins have two functions. In the nucleus, HMGB proteins bind to DNA in a DNA structure-dependent but nucleotide sequence-independent manner to function in chromatin remodeling. Extracellularly, HMGB proteins function as alarmins, which are endogenous molecules released upon tissue damage to activate the immune system. HMGB1 acts as a late mediator of inflammation and contributes to prolonged and sustained systemic inflammation in subjects with rheumatoid arthritis. By contrast, Hmgb2

Topics: Alarmins; Animals; Arthritis, Rheumatoid; Cartilage, Articular; Chondrocytes; Chromatin Assembly and Disassembly; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; DNA; Gene Expression; HMGB1 Protein; HMGB2 Protein; Humans; Hydroxyethylrutoside; Hypertrophy; Inflammation Mediators; Lymphoid Enhancer-Binding Factor 1; Mice; Osteoarthritis; Protein Binding; Wnt Signaling Pathway