rutin and Arteriosclerosis-Obliterans

The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.

Topics: Adult; Analgesics; Anticoagulants; Arteriosclerosis Obliterans; Aspirin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hydroxyethylrutoside; Ischemia; Leg; Male; Middle Aged; Plethysmography; Rutin

Deformability of red cells and plasma levels of cAMP and cGMP were studied in patients with arteriosclerosis obliterans of lower limbs. Deformability of red cells and plasma levels of cAMP were found to be decreased in these patients. Venous injection of HR (Venoruton) in one dose (1,000 mg) to patients, led to an increase of red cell deformability and normalisation of cAMP plasma level. The plasma level of cGMP was not changed. The beneficial effect of HR in arteriosclerosis obliterans depends, first of all, on improving the deformability of red cells. The decreased deformability observed in arteriosclerosis seems to be a result of disturbances in the rate of spectrin phosphorylation of the erythrocyte membrane. By normalising the plasma level of cAMP HR had a considerable influence on the appropriate state of elasticity of the red cell membrane.

Topics: Aged; Arteriosclerosis Obliterans; Erythrocyte Deformability; Female; Humans; Hydroxyethylrutoside; Leg; Male; Middle Aged; Rutin

Topics: Aged; Anticoagulants; Arteriosclerosis Obliterans; Cell Adhesion; Female; Humans; Hydroxyethylrutoside; Leg; Leukocytes; Male; Middle Aged; Rutin

Topics: Adult; Aged; Arteriosclerosis Obliterans; Female; Humans; Hydroxyethylrutoside; Intermittent Claudication; Leg; Male; Middle Aged; Rutin