rutin and Acute-Disease

The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy.. One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were randomized to receive a mixture of diosmin, troxerutin and hesperidin (group A), and 68 a placebo (group B). The main symptoms, the use of oral painkillers and the Bristol scale score were recorded at each scheduled visit and compared using both Student's t test for independent samples and the ANOVA models for repeated measures. The presence of edema, prolapse and thrombosis were also recorded and compared using the Chi-square test. Furthermore, the trend of proportions during the time of the evaluations was assessed by the Chi-square test for linear trend.. Pain, bleeding and the proportion of patients who reported persistence of edema and thrombosis decreased significantly after 12 days of treatment in group A. After 6 days, the number of paracetamol tablets taken by patients in group A was significantly lower than the amount of flavonoid mixture.. The use of a mixture of diosmin, troxerutin and hesperidin is a safe and effective mean of managing symptoms of acute hemorrhoidal disease. Furthermore, in patients receiving treatment, there was faster control and lower persistence of edema and thrombosis.

Topics: Acute Disease; Adult; Aged; Analgesics; Anticoagulants; Chi-Square Distribution; Diosmin; Drug Combinations; Edema; Epidemiologic Research Design; Female; Hemorrhoids; Hesperidin; Humans; Hydroxyethylrutoside; Male; Middle Aged; Pain Measurement; Prospective Studies; Rectal Prolapse; Research Design; Thrombosis; Young Adult

The aim of this study was to assess the clinical efficacy, compliance and safety of Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of patients with acute hemorrhoidal attacks in Thailand.. In a prospective clinical study on hospital outpatients, the authors studied the effect of Ginko biloba--Troxerutin-Heptaminol Hce for a week in adults (18-70 years old) with acute hemorrhoidal attacks.. Twenty-two patients, with a mean age of 41.7 years were included in the study. The male to female ratio was 1 : 1.2. Most patients (77%) had grade 1 and 2 hemorrhoids with an average duration of attacks of 3 days. On intention to treat analysis, bleeding, pain, tenesmus and discharge were significantly improved. Treatment was well accepted and safe.. In the short-term, Ginko biloba--Troxerutin-Heptaminol Hce is effective, acceptable and safe in the treatment of patients with acute hemorrhoidal attacks.

Topics: Acute Disease; Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Follow-Up Studies; Ginkgo biloba; Hemorrhoids; Heptaminol; Humans; Hydroxyethylrutoside; Male; Middle Aged; Pain Measurement; Phytotherapy; Prospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome

In children at the age under 3 years with different forms of acute purulent destructive pneumonia, the positive effect of troxevasin on the platelet aggregation correlating with the pronounced positive clinical effect was revealed.

Topics: Acute Disease; Anticoagulants; Child, Preschool; Humans; Hydroxyethylrutoside; Infant; Platelet Aggregation; Pneumonia; Rutin