rutascorbin and Cholestasis

The blood flow in the portal vein and hepatic artery was studied by means of ultrasonic Doppler flow measurement to investigate organic and regional hemodynamics of the liver in purulent cholangitis. The blood flow in the portal vein was found to be significantly diminished in patients with acute cholangitis and hepatic failure. Hepatic microcirculation was studied on a experimental model of obstructive jaundice and obstructive purulent cholangitis in rats by polarographic measurement of hydrogen clearance. Considerable reduction of the volume rate of the local blood flow was noted, and the degree of the reduction was related to the severity and duration of the disease. Decompression of the biliary tract by external drainage improved the local blood flow rate which, however, diminished again in prolonged external drainage. The use of pharmacological agents for correction of microcirculation in decompression of the biliary tract led to total and rapid correction of the volume rate of the local blood flow.

Topics: Acute Disease; Animals; Aprotinin; Ascorbic Acid; Aspirin; Cholangitis; Cholestasis; Dextrans; Dipyridamole; Drainage; Drug Combinations; Heparin; Humans; Liver Circulation; Male; Microcirculation; Pentoxifylline; Pyridinolcarbamate; Rats; Rutin; Suppuration; Ultrasonography; Xanthinol Niacinate