rumbrin has been researched along with Precursor-T-Cell-Lymphoblastic-Leukemia-Lymphoma* in 1 studies
1 other study(ies) available for rumbrin and Precursor-T-Cell-Lymphoblastic-Leukemia-Lymphoma
| Article | Year |
|---|---|
Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells.
T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with a high relapse rate. 20 analogs were synthesized based on the structures of two kinds of fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress the growth of T-ALL-derived cell line CCRF-CEM and tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Polyenes; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pyrroles; Structure-Activity Relationship | 2021 |