rubusoside and Ovarian-Neoplasms

Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to the pronounced hydrophobicity of Cer. Missense mutations of the protein p53, which have been detected in approximately 42% of cancer cases, not only lose the tumor suppression activity of wild-type p53, but also gain oncogenic functions promoting tumor progression and drug resistance. Our previous works showed that cellular Cer can eradicate cancer cells that carry a p53 deletion-mutation by modulating alternative pre-mRNA splicing, restoring wild-type p53 protein expression. Here, we report that new ceramide-rubusoside (Cer-RUB) nanomicelles considerably enhance Cer

Topics: Animals; Cell Line, Tumor; Ceramides; Diterpenes, Kaurane; Female; Glucosides; Humans; Mice; Mice, Nude; Mice, Transgenic; Micelles; Mutation, Missense; Nanoparticles; Ovarian Neoplasms; Random Allocation; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays