ruboxistaurin has been researched along with Disease Models, Animal in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, Y; Gong, L; Jing, T; Li, X; Lu, H; Ma, D; Tang, Y; Wu, S; Xiao, X; Xu, H; Zhang, J; Zhao, H; Zhou, Q | 1 |
| Advani, A; Connelly, KA; Cox, AJ; Edgley, AJ; Gilbert, RE; Kelly, DJ; Tan, SM; Thai, K; Whiteside, CI; Zhang, Y | 1 |
| Chen, X; Houser, SR; Kranias, EG; Leitges, M; Liu, Q; Lorenz, JN; Macdonnell, SM; Molkentin, JD | 1 |
| Chikaraishi, Y; Hara, H; Nakamura, S; Shimazawa, M; Tsuruma, K | 1 |
| Bu, X; Du, J; Li, J; Liang, J; Liu, Y; Xu, Q; Yang, X; Zhang, N | 1 |
| Cox, AJ; Gilbert, RE; Gow, RM; Kelly, DJ; Kim, S; Langham, RG; Tokuyama, H; Zhang, Y | 1 |
| Bean, JS; Kassab, GS; Lu, X; Rekhter, MD | 1 |
| Correll, RN; Hajjar, RJ; Houser, SR; Ishikawa, K; Kawase, Y; Ladage, D; Molkentin, JD; Tilemann, L | 1 |
| Kashiwagi, A; Koya, D | 1 |
| Andrassy, M; Fujita, T; Harja, E; Schmidt, AM; Yan, SF | 1 |
| Andrassy, M; Asai, T; Chang, JS; Homma, S; Huang, C; Kong, L; Leitges, M; Liu, R; Ramasamy, R; Schmidt, AM; Szabolcs, MJ; Yan, SD; Yan, SF; Zou, YS | 1 |
2 review(s) available for ruboxistaurin and Disease Models, Animal
| Article | Year |
|---|---|
[Progress on the drug therapy for diabetic microangiopathies: PKCbeta inhibitor].
Topics: Animals; Clinical Trials as Topic; Diabetic Angiopathies; Disease Models, Animal; Humans; Indoles; Maleimides; Protein Kinase C; Protein Kinase C beta; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2005 |
Protein kinase C beta/early growth response-1 pathway: a key player in ischemia, atherosclerosis, and restenosis.
Topics: Animals; Coronary Artery Disease; Coronary Restenosis; Diabetic Angiopathies; Diabetic Nephropathies; Disease Models, Animal; Early Growth Response Protein 1; Endothelium, Vascular; Humans; Indoles; Maleimides; Mice; Mitogen-Activated Protein Kinase Kinases; Myocardial Ischemia; Oxidative Stress; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Tunica Intima; Up-Regulation | 2006 |
9 other study(ies) available for ruboxistaurin and Disease Models, Animal
| Article | Year |
|---|---|
The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy.
Topics: Adenine; Animals; Autophagy; Case-Control Studies; Cell Line, Tumor; China; Disease Models, Animal; Down-Regulation; Female; Gene Expression Profiling; Humans; Indoles; Male; Maleimides; Maternal Age; Mice; Oligonucleotide Array Sequence Analysis; Pre-Eclampsia; Pregnancy; Protein Kinase C beta | 2020 |
Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Indoles; Kidney; Kidney Diseases; Male; Maleimides; Membrane Proteins; Mesangial Cells; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2009 |
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Signaling; Cardiomegaly; Disease Models, Animal; Fibrosis; Heart Failure; Indoles; Maleimides; Metoprolol; Mice; Mice, Knockout; Myocardial Contraction; Myocardial Infarction; Myocardium; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase Inhibitors; Pulmonary Edema; Time Factors | 2009 |
Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Indoles; Maleimides; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-akt; Retinal Neovascularization; Umbilical Veins; Vascular Endothelial Growth Factor A | 2010 |
Proteomic analysis of cPKCβII-interacting proteins involved in HPC-induced neuroprotection against cerebral ischemia of mice.
Topics: Animals; Brain Edema; Brain Infarction; Brain Ischemia; Databases, Protein; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Immunoprecipitation; In Situ Nick-End Labeling; Indoles; Intercellular Signaling Peptides and Proteins; Ischemic Preconditioning; Male; Maleimides; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; Neurologic Examination; Neuroprotective Agents; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Proteomics; Silver Staining; Time Factors | 2011 |
Protein kinase C β inhibition ameliorates experimental mesangial proliferative glomerulonephritis.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cell Proliferation; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Glomerulonephritis, Membranoproliferative; Immunoglobulin G; Indoles; Male; Maleimides; Mesangial Cells; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Proteinuria; Rats; Rats, Wistar; Thy-1 Antigens | 2011 |
Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Captopril; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Femoral Artery; Hypertension; Indoles; Insulin; Insulin Resistance; Male; Maleimides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myography; Protein Deficiency; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Telemetry; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.
Topics: Animals; Cardiac Output; Coronary Occlusion; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Heart; Heart Failure; Indoles; Maleimides; Myocardial Contraction; Myocardial Infarction; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyrroles; Stroke Volume; Swine | 2011 |
PKCbeta modulates ischemia-reperfusion injury in the heart.
Topics: Animals; Caspase 3; Cell Membrane; Coronary Vessels; Creatine Kinase; Disease Models, Animal; Enzyme Activation; Indoles; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Ligation; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Necrosis; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Transport; Recovery of Function; Signal Transduction; Time Factors; Ventricular Function, Left | 2008 |