ruboxistaurin has been researched along with Disease Exacerbation in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, X; Luo, S; Pang, C; Qin, H; Wen, L; Zhang, X; Zhu, B | 1 |
| Gilbert, RE; Gow, RM; Hepper, C; Jaworski, K; Kelly, DJ; Kemp, BE; Wilkinson-Berka, JL; Zhang, Y | 1 |
| Tuttle, KR; Williams, ME | 1 |
| Angioi-Duprez, K | 1 |
| Aiello, LP; Davis, MD; Girach, A; Kles, KA; Milton, RC; Sheetz, MJ; Vignati, L; Zhi, XE | 1 |
| Shah, SV; Swaminathan, S | 1 |
3 review(s) available for ruboxistaurin and Disease Exacerbation
| Article | Year |
|---|---|
The next generation of diabetic nephropathy therapies: an update.
Topics: Animals; Diabetic Nephropathies; Disease Progression; Enzyme Inhibitors; Glycation End Products, Advanced; Glycosaminoglycans; Humans; Indoles; Maleimides; Models, Animal; Protein Kinase C; Pyridoxamine; Renal Agents; Thiazoles | 2005 |
[Retinopathy, a major cause of blindness in the adult diabetic].
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Biphenyl Compounds; Blindness; Causality; Diabetic Retinopathy; Disease Progression; Fluorescein Angiography; Humans; Indoles; Laser Therapy; Light Coagulation; Macular Edema; Maleimides; Octreotide; Ophthalmology; Protein Kinase C; Retinal Detachment; Severity of Illness Index; Tetrazoles; Tomography, Optical Coherence; Vision Screening; Visual Acuity; Vitrectomy | 2006 |
Novel approaches targeted toward oxidative stress for the treatment of chronic kidney disease.
Topics: Biomarkers; Chronic Disease; Diabetic Nephropathies; Disease Progression; Drugs, Investigational; Glycation End Products, Advanced; Humans; Indoles; Iron; Kidney; Kidney Diseases; Maleimides; Oxidative Stress; Protein Kinase C; Protein Kinase Inhibitors; Pyridoxamine; Reactive Oxygen Species; Treatment Outcome; Vitamin B Complex | 2008 |
3 trial(s) available for ruboxistaurin and Disease Exacerbation
| Article | Year |
|---|---|
The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical
Topics: Adult; Aged; Aged, 80 and over; Diabetic Retinopathy; Disease Progression; Enzyme Inhibitors; Female; Humans; Indoles; Male; Maleimides; Middle Aged; Patient Selection; Placebos; Protein Kinase C; Protein Kinase C beta; Treatment Outcome; Vision Disorders | 2005 |
Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Diabetic Retinopathy; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Indoles; Macular Edema; Male; Maleimides; Middle Aged; Protein Kinase C; Protein Kinase C beta; Vision Disorders; Visual Acuity | 2006 |
Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Indoles; Laser Coagulation; Macular Edema; Male; Maleimides; Middle Aged; Prospective Studies; Protein Kinase C; Protein Kinase C beta; Treatment Outcome; Visual Acuity | 2007 |
2 other study(ies) available for ruboxistaurin and Disease Exacerbation
| Article | Year |
|---|---|
Ruboxistaurin maintains the bone mass of subchondral bone for blunting osteoarthritis progression by inhibition of osteoclastogenesis and bone resorption activity.
Topics: Animals; Bone Density; Bone Remodeling; Bone Resorption; Cells, Cultured; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Femur; Indoles; Male; Maleimides; Mice; Mice, Inbred C57BL; Osteoarthritis; Osteoclasts; Osteogenesis | 2020 |
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension.
Topics: Albuminuria; Animals; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Disease Progression; Enzyme Inhibitors; Female; Hypertension; Immunohistochemistry; Indoles; Kidney; Kidney Glomerulus; Maleimides; Organ Size; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Mutant Strains; Reference Values | 2003 |